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9 similar compounds to monomer 50362319

Compile data set for download or QSAR
Wt: 481.0
BDBM50362314
Wt: 466.9
BDBM50362315
Wt: 497.0
BDBM50362316
Wt: 483.0
BDBM50362317
Wt: 495.0
BDBM50362318
Wt: 468.9
BDBM50362320
Wt: 481.0
BDBM50362321
Wt: 483.0
BDBM50362325
Wt: 468.9
BDBM50362326

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50362314,50362315,50362316,50362317,50362318,50362320,50362321,50362325,50362326   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50362314
PNG
(CHEMBL1939953)
Show SMILES CN1CCC2(CCN(C2)C(=O)C[C@H]2N(C=CNC2=O)S(=O)(=O)c2cc(C)c(Cl)cc2C)C1
Show InChI InChI=1S/C22H29ClN4O4S/c1-15-11-19(16(2)10-17(15)23)32(30,31)27-9-6-24-21(29)18(27)12-20(28)26-8-5-22(14-26)4-7-25(3)13-22/h6,9-11,18H,4-5,7-8,12-14H2,1-3H3,(H,24,29)/t18-,22?/m1/s1
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n/an/a 1.53n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium le...


Bioorg Med Chem Lett 22: 1061-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.112
BindingDB Entry DOI: 10.7270/Q22J6CB2
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50362315
PNG
(CHEMBL1939952)
Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=O)C[C@H]1N(C=CNC1=O)S(=O)(=O)c1cc(C)c(Cl)cc1C
Show InChI InChI=1S/C21H27ClN4O4S/c1-13-7-19(14(2)6-17(13)22)31(29,30)26-5-4-23-21(28)18(26)8-20(27)25-11-15-9-24(3)10-16(15)12-25/h4-7,15-16,18H,8-12H2,1-3H3,(H,23,28)/t15-,16+,18-/m1/s1
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n/an/a 136n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium le...


Bioorg Med Chem Lett 22: 1061-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.112
BindingDB Entry DOI: 10.7270/Q22J6CB2
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50362316
PNG
(CHEMBL1939951)
Show SMILES CN(C)C1CCCCN(CC1)C(=O)C[C@H]1N(C=CNC1=O)S(=O)(=O)c1cc(C)c(Cl)cc1C
Show InChI InChI=1S/C23H33ClN4O4S/c1-16-14-21(17(2)13-19(16)24)33(31,32)28-12-9-25-23(30)20(28)15-22(29)27-10-6-5-7-18(8-11-27)26(3)4/h9,12-14,18,20H,5-8,10-11,15H2,1-4H3,(H,25,30)/t18?,20-/m1/s1
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n/an/a 4.75n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium le...


Bioorg Med Chem Lett 22: 1061-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.112
BindingDB Entry DOI: 10.7270/Q22J6CB2
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50362317
PNG
(CHEMBL1938412)
Show SMILES CN(C)C1CCCN(CC1)C(=O)C[C@H]1N(C=CNC1=O)S(=O)(=O)c1cc(C)c(Cl)cc1C
Show InChI InChI=1S/C22H31ClN4O4S/c1-15-13-20(16(2)12-18(15)23)32(30,31)27-11-8-24-22(29)19(27)14-21(28)26-9-5-6-17(7-10-26)25(3)4/h8,11-13,17,19H,5-7,9-10,14H2,1-4H3,(H,24,29)/t17?,19-/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium le...


Bioorg Med Chem Lett 22: 1061-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.112
BindingDB Entry DOI: 10.7270/Q22J6CB2
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50362326
PNG
(CHEMBL1939942)
Show SMILES Cc1cc(c(C)cc1Cl)S(=O)(=O)N1C=CNC(=O)[C@H]1CC(=O)N[C@H]1CCNCC1(C)C
Show InChI InChI=1S/C21H29ClN4O4S/c1-13-10-17(14(2)9-15(13)22)31(29,30)26-8-7-24-20(28)16(26)11-19(27)25-18-5-6-23-12-21(18,3)4/h7-10,16,18,23H,5-6,11-12H2,1-4H3,(H,24,28)(H,25,27)/t16-,18+/m1/s1
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n/an/a 0.310n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium le...


Bioorg Med Chem Lett 22: 1061-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.112
BindingDB Entry DOI: 10.7270/Q22J6CB2
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50362320
PNG
(CHEMBL1939948)
Show SMILES CN(C)C1CCN(CC1)C(=O)C[C@H]1N(C=CNC1=O)S(=O)(=O)c1cc(C)c(Cl)cc1C
Show InChI InChI=1S/C21H29ClN4O4S/c1-14-12-19(15(2)11-17(14)22)31(29,30)26-10-7-23-21(28)18(26)13-20(27)25-8-5-16(6-9-25)24(3)4/h7,10-12,16,18H,5-6,8-9,13H2,1-4H3,(H,23,28)/t18-/m1/s1
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n/an/a 152n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium le...


Bioorg Med Chem Lett 22: 1061-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.112
BindingDB Entry DOI: 10.7270/Q22J6CB2
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50362321
PNG
(CHEMBL1939947)
Show SMILES Cc1cc(c(C)cc1Cl)S(=O)(=O)N1C=CNC(=O)[C@H]1CC(=O)N1CC[C@@H](C1)N1CCCC1
Show InChI InChI=1S/C22H29ClN4O4S/c1-15-12-20(16(2)11-18(15)23)32(30,31)27-10-6-24-22(29)19(27)13-21(28)26-9-5-17(14-26)25-7-3-4-8-25/h6,10-12,17,19H,3-5,7-9,13-14H2,1-2H3,(H,24,29)/t17-,19+/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium le...


Bioorg Med Chem Lett 22: 1061-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.112
BindingDB Entry DOI: 10.7270/Q22J6CB2
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50362325
PNG
(CHEMBL1939943)
Show SMILES CN1CC[C@H](NC(=O)C[C@H]2N(C=CNC2=O)S(=O)(=O)c2cc(C)c(Cl)cc2C)C(C)(C)C1
Show InChI InChI=1S/C22H31ClN4O4S/c1-14-11-18(15(2)10-16(14)23)32(30,31)27-9-7-24-21(29)17(27)12-20(28)25-19-6-8-26(5)13-22(19,3)4/h7,9-11,17,19H,6,8,12-13H2,1-5H3,(H,24,29)(H,25,28)/t17-,19+/m1/s1
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n/an/a 0.280n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium le...


Bioorg Med Chem Lett 22: 1061-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.112
BindingDB Entry DOI: 10.7270/Q22J6CB2
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM50362318
PNG
(CHEMBL1939949)
Show SMILES Cc1cc(c(C)cc1Cl)S(=O)(=O)N1C=CNC(=O)[C@H]1CC(=O)N1CCC[C@@H](C1)N1CCCC1
Show InChI InChI=1S/C23H31ClN4O4S/c1-16-13-21(17(2)12-19(16)24)33(31,32)28-11-7-25-23(30)20(28)14-22(29)27-10-5-6-18(15-27)26-8-3-4-9-26/h7,11-13,18,20H,3-6,8-10,14-15H2,1-2H3,(H,25,30)/t18-,20+/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells assessed as inhibition of DAK-induced intracellular calcium le...


Bioorg Med Chem Lett 22: 1061-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.112
BindingDB Entry DOI: 10.7270/Q22J6CB2
More data for this
Ligand-Target Pair