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10 similar compounds to monomer 50363325

Wt: 416.5
BDBM50363317
Wt: 430.5
BDBM50363318
Wt: 430.5
BDBM50363319
Wt: 390.4
BDBM50365255
Wt: 390.4
BDBM50365256
Wt: 404.5
BDBM50365257
Wt: 404.5
BDBM50365258
Wt: 404.5
BDBM50365259
Wt: 404.5
BDBM50365260
Wt: 418.5
BDBM50365261

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50363317,50363318,50363319,50365255,50365256,50365257,50365258,50365259,50365260,50365261   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365260
PNG
(CHEMBL1958333)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cc(=O)n(nc1C)-c1ccccn1
Show InChI InChI=1S/C24H28N4O2/c1-18-7-5-14-27(18)15-6-16-30-21-11-9-20(10-12-21)22-17-24(29)28(26-19(22)2)23-8-3-4-13-25-23/h3-4,8-13,17-18H,5-7,14-16H2,1-2H3/t18-/m1/s1
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1.70n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365258
PNG
(CHEMBL1958331)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(-c2cccc(C)n2)c(=O)c1
Show InChI InChI=1S/C24H28N4O2/c1-18-6-3-8-23(26-18)28-24(29)16-21(17-25-28)20-9-11-22(12-10-20)30-15-5-14-27-13-4-7-19(27)2/h3,6,8-12,16-17,19H,4-5,7,13-15H2,1-2H3/t19-/m1/s1
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1.80n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365259
PNG
(CHEMBL1958332)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(-c2ncccc2C)c(=O)c1
Show InChI InChI=1S/C24H28N4O2/c1-18-6-3-12-25-24(18)28-23(29)16-21(17-26-28)20-8-10-22(11-9-20)30-15-5-14-27-13-4-7-19(27)2/h3,6,8-12,16-17,19H,4-5,7,13-15H2,1-2H3/t19-/m1/s1
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2.5n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365261
PNG
(CHEMBL1958334)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cc(=O)n(nc1C)-c1ncccc1C
Show InChI InChI=1S/C25H30N4O2/c1-18-7-4-13-26-25(18)29-24(30)17-23(20(3)27-29)21-9-11-22(12-10-21)31-16-6-15-28-14-5-8-19(28)2/h4,7,9-13,17,19H,5-6,8,14-16H2,1-3H3/t19-/m1/s1
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3n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50363317
PNG
(CHEMBL1945848)
Show SMILES Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C25H28N4O2/c1-18-23(17-25(30)29(27-18)24-7-2-3-14-26-24)19-8-10-21(11-9-19)31-22-12-15-28(16-13-22)20-5-4-6-20/h2-3,7-11,14,17,20,22H,4-6,12-13,15-16H2,1H3
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3n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 1073-7 (2012)

More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50363319
PNG
(CHEMBL1945849)
Show SMILES Cc1cccc(n1)-n1nc(C)c(cc1=O)-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C26H30N4O2/c1-18-5-3-8-25(27-18)30-26(31)17-24(19(2)28-30)20-9-11-22(12-10-20)32-23-13-15-29(16-14-23)21-6-4-7-21/h3,5,8-12,17,21,23H,4,6-7,13-16H2,1-2H3
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4n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 1073-7 (2012)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(RAT)
BDBM50365258
PNG
(CHEMBL1958331)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(-c2cccc(C)n2)c(=O)c1
Show InChI InChI=1S/C24H28N4O2/c1-18-6-3-8-23(26-18)28-24(29)16-21(17-25-28)20-9-11-22(12-10-20)30-15-5-14-27-13-4-7-19(27)2/h3,6,8-12,16-17,19H,4-5,7,13-15H2,1-2H3/t19-/m1/s1
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4.40n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from rat cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(RAT)
BDBM50365260
PNG
(CHEMBL1958333)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cc(=O)n(nc1C)-c1ccccn1
Show InChI InChI=1S/C24H28N4O2/c1-18-7-5-14-27(18)15-6-16-30-21-11-9-20(10-12-21)22-17-24(29)28(26-19(22)2)23-8-3-4-13-25-23/h3-4,8-13,17-18H,5-7,14-16H2,1-2H3/t18-/m1/s1
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5n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from rat cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365257
PNG
(CHEMBL1958330)
Show SMILES O=c1cc(cnn1-c1ccccn1)-c1ccc(OCCCN2CCCCCC2)cc1
Show InChI InChI=1S/C24H28N4O2/c29-24-18-21(19-26-28(24)23-8-3-4-13-25-23)20-9-11-22(12-10-20)30-17-7-16-27-14-5-1-2-6-15-27/h3-4,8-13,18-19H,1-2,5-7,14-17H2
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5.30n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50363318
PNG
(CHEMBL1945850)
Show SMILES Cc1cccnc1-n1nc(C)c(cc1=O)-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C26H30N4O2/c1-18-5-4-14-27-26(18)30-25(31)17-24(19(2)28-30)20-8-10-22(11-9-20)32-23-12-15-29(16-13-23)21-6-3-7-21/h4-5,8-11,14,17,21,23H,3,6-7,12-13,15-16H2,1-2H3
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6n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 1073-7 (2012)

More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365256
PNG
(CHEMBL1958329)
Show SMILES O=c1cc(cnn1-c1ccccn1)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H26N4O2/c28-23-17-20(18-25-27(23)22-7-2-3-12-24-22)19-8-10-21(11-9-19)29-16-6-15-26-13-4-1-5-14-26/h2-3,7-12,17-18H,1,4-6,13-16H2
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7.80n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(RAT)
BDBM50365259
PNG
(CHEMBL1958332)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(-c2ncccc2C)c(=O)c1
Show InChI InChI=1S/C24H28N4O2/c1-18-6-3-12-25-24(18)28-23(29)16-21(17-26-28)20-8-10-22(11-9-20)30-15-5-14-27-13-4-7-19(27)2/h3,6,8-12,16-17,19H,4-5,7,13-15H2,1-2H3/t19-/m1/s1
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8.60n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from rat cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50363317
PNG
(CHEMBL1945848)
Show SMILES Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C25H28N4O2/c1-18-23(17-25(30)29(27-18)24-7-2-3-14-26-24)19-8-10-21(11-9-19)31-22-12-15-28(16-13-22)20-5-4-6-20/h2-3,7-11,14,17,20,22H,4-6,12-13,15-16H2,1H3
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9n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rat histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 1073-7 (2012)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50363319
PNG
(CHEMBL1945849)
Show SMILES Cc1cccc(n1)-n1nc(C)c(cc1=O)-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C26H30N4O2/c1-18-5-3-8-25(27-18)30-26(31)17-24(19(2)28-30)20-9-11-22(12-10-20)32-23-13-15-29(16-14-23)21-6-4-7-21/h3,5,8-12,17,21,23H,4,6-7,13-16H2,1-2H3
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10n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rat histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 1073-7 (2012)

More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365255
PNG
(CHEMBL1958328)
Show SMILES C[C@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(-c2ccccn2)c(=O)c1
Show InChI InChI=1S/C23H26N4O2/c1-18-6-4-13-26(18)14-5-15-29-21-10-8-19(9-11-21)20-16-23(28)27(25-17-20)22-7-2-3-12-24-22/h2-3,7-12,16-18H,4-6,13-15H2,1H3/t18-/m0/s1
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11n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(RAT)
BDBM50365257
PNG
(CHEMBL1958330)
Show SMILES O=c1cc(cnn1-c1ccccn1)-c1ccc(OCCCN2CCCCCC2)cc1
Show InChI InChI=1S/C24H28N4O2/c29-24-18-21(19-26-28(24)23-8-3-4-13-25-23)20-9-11-22(12-10-20)30-17-7-16-27-14-5-1-2-6-15-27/h3-4,8-13,18-19H,1-2,5-7,14-17H2
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12n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from rat cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(RAT)
BDBM50365256
PNG
(CHEMBL1958329)
Show SMILES O=c1cc(cnn1-c1ccccn1)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C23H26N4O2/c28-23-17-20(18-25-27(23)22-7-2-3-12-24-22)19-8-10-21(11-9-19)29-16-6-15-26-13-4-1-5-14-26/h2-3,7-12,17-18H,1,4-6,13-16H2
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16n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from rat cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(RAT)
BDBM50365261
PNG
(CHEMBL1958334)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cc(=O)n(nc1C)-c1ncccc1C
Show InChI InChI=1S/C25H30N4O2/c1-18-7-4-13-26-25(18)29-24(30)17-23(20(3)27-29)21-9-11-22(12-10-21)31-16-6-15-28-14-5-8-19(28)2/h4,7,9-13,17,19H,5-6,8,14-16H2,1-3H3/t19-/m1/s1
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17n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from rat cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50363318
PNG
(CHEMBL1945850)
Show SMILES Cc1cccnc1-n1nc(C)c(cc1=O)-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C26H30N4O2/c1-18-5-4-14-27-26(18)30-25(31)17-24(19(2)28-30)20-8-10-22(11-9-20)32-23-12-15-29(16-13-23)21-6-3-7-21/h4-5,8-11,14,17,21,23H,3,6-7,12-13,15-16H2,1-2H3
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17n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rat histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 1073-7 (2012)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(RAT)
BDBM50365255
PNG
(CHEMBL1958328)
Show SMILES C[C@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(-c2ccccn2)c(=O)c1
Show InChI InChI=1S/C23H26N4O2/c1-18-6-4-13-26(18)14-5-15-29-21-10-8-19(9-11-21)20-16-23(28)27(25-17-20)22-7-2-3-12-24-22/h2-3,7-12,16-18H,4-6,13-15H2,1H3/t18-/m0/s1
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29n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from rat cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50363318
PNG
(CHEMBL1945850)
Show SMILES Cc1cccnc1-n1nc(C)c(cc1=O)-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C26H30N4O2/c1-18-5-4-14-27-26(18)30-25(31)17-24(19(2)28-30)20-8-10-22(11-9-20)32-23-12-15-29(16-13-23)21-6-3-7-21/h4-5,8-11,14,17,21,23H,3,6-7,12-13,15-16H2,1-2H3
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp assay


Bioorg Med Chem Lett 22: 1073-7 (2012)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50363317
PNG
(CHEMBL1945848)
Show SMILES Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C25H28N4O2/c1-18-23(17-25(30)29(27-18)24-7-2-3-14-26-24)19-8-10-21(11-9-19)31-22-12-15-28(16-13-22)20-5-4-6-20/h2-3,7-11,14,17,20,22H,4-6,12-13,15-16H2,1H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp assay


Bioorg Med Chem Lett 22: 1073-7 (2012)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50363317
PNG
(CHEMBL1945848)
Show SMILES Cc1nn(-c2ccccn2)c(=O)cc1-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C25H28N4O2/c1-18-23(17-25(30)29(27-18)24-7-2-3-14-26-24)19-8-10-21(11-9-19)31-22-12-15-28(16-13-22)20-5-4-6-20/h2-3,7-11,14,17,20,22H,4-6,12-13,15-16H2,1H3
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of muscarinic M2 receptor


Bioorg Med Chem Lett 22: 1073-7 (2012)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50363319
PNG
(CHEMBL1945849)
Show SMILES Cc1cccc(n1)-n1nc(C)c(cc1=O)-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C26H30N4O2/c1-18-5-3-8-25(27-18)30-26(31)17-24(19(2)28-30)20-9-11-22(12-10-20)32-23-13-15-29(16-14-23)21-6-4-7-21/h3,5,8-12,17,21,23H,4,6-7,13-16H2,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp assay


Bioorg Med Chem Lett 22: 1073-7 (2012)

More data for this
Ligand-Target Pair