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16 similar compounds to monomer 50364923

Compile data set for download or QSAR
Wt: 391.5
BDBM50364922
Wt: 419.6
BDBM50364924
Wt: 407.5
BDBM50364925
Wt: 423.5
BDBM50364926
Wt: 365.5
BDBM50364927
Wt: 379.5
BDBM50364928
Wt: 393.5
BDBM50364929
Wt: 395.5
BDBM50364946
Wt: 381.5
BDBM50364947
Wt: 427.5
BDBM50364948
Wt: 419.6
BDBM50364949
Wt: 423.6
BDBM50364950
Wt: 421.5
BDBM50364951
Wt: 428.5
BDBM50364952
Wt: 428.5
BDBM50364953
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50364922,50364924,50364925,50364926,50364927,50364928,50364929,50364946,50364947,50364948,50364949,50364950,50364951,50364952,50364953   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50364922
PNG
(CHEMBL1950330)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(CC4CC4)Cc3c2c1
Show InChI InChI=1S/C25H33N3O/c1-3-11-28-23-7-6-20(25(29)27-13-8-18(2)9-14-27)15-21(23)22-17-26(12-10-24(22)28)16-19-4-5-19/h3,6-7,15,18-19H,1,4-5,8-14,16-17H2,2H3
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14n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Binding affinity to human CB2 receptor


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364925
PNG
(CHEMBL1950340)
Show SMILES CCCn1c2CCN(Cc2c2cc(ccc12)C(=O)N1CCC(C)CC1)C1CCCC1
Show InChI InChI=1S/C26H37N3O/c1-3-13-29-24-9-8-20(26(30)27-14-10-19(2)11-15-27)17-22(24)23-18-28(16-12-25(23)29)21-6-4-5-7-21/h8-9,17,19,21H,3-7,10-16,18H2,1-2H3
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15n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364928
PNG
(CHEMBL1950343)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(C)c3CCN(Cc3c2c1)C1CCCC1
Show InChI InChI=1S/C24H33N3O/c1-17-9-12-26(13-10-17)24(28)18-7-8-22-20(15-18)21-16-27(19-5-3-4-6-19)14-11-23(21)25(22)2/h7-8,15,17,19H,3-6,9-14,16H2,1-2H3
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32n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364929
PNG
(CHEMBL1950344)
Show SMILES CCn1c2CCN(Cc2c2cc(ccc12)C(=O)N1CCC(C)CC1)C1CCCC1
Show InChI InChI=1S/C25H35N3O/c1-3-28-23-9-8-19(25(29)26-13-10-18(2)11-14-26)16-21(23)22-17-27(15-12-24(22)28)20-6-4-5-7-20/h8-9,16,18,20H,3-7,10-15,17H2,1-2H3
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34n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364924
PNG
(CHEMBL1950335)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(Cc3c2c1)C1CCCCC1
Show InChI InChI=1S/C27H37N3O/c1-3-14-30-25-10-9-21(27(31)28-15-11-20(2)12-16-28)18-23(25)24-19-29(17-13-26(24)30)22-7-5-4-6-8-22/h3,9-10,18,20,22H,1,4-8,11-17,19H2,2H3
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56n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364926
PNG
(CHEMBL1950341)
Show SMILES CCCn1c2CCN(Cc2c2cc(ccc12)C(=O)N1CCC(C)CC1)C1CCOCC1
Show InChI InChI=1S/C26H37N3O2/c1-3-11-29-24-5-4-20(26(30)27-12-6-19(2)7-13-27)17-22(24)23-18-28(14-8-25(23)29)21-9-15-31-16-10-21/h4-5,17,19,21H,3,6-16,18H2,1-2H3
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58n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364946
PNG
(CHEMBL1950489)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(C)c3CCN(Cc3c2c1)C1CCOCC1
Show InChI InChI=1S/C24H33N3O2/c1-17-5-10-26(11-6-17)24(28)18-3-4-22-20(15-18)21-16-27(12-7-23(21)25(22)2)19-8-13-29-14-9-19/h3-4,15,17,19H,5-14,16H2,1-2H3
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76n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364922
PNG
(CHEMBL1950330)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(CC4CC4)Cc3c2c1
Show InChI InChI=1S/C25H33N3O/c1-3-11-28-23-7-6-20(25(29)27-13-8-18(2)9-14-27)15-21(23)22-17-26(12-10-24(22)28)16-19-4-5-19/h3,6-7,15,18-19H,1,4-5,8-14,16-17H2,2H3
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143n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364947
PNG
(CHEMBL1950490)
Show SMILES Cn1c2CCN(Cc2c2cc(ccc12)C(=O)N1CCCCC1)C1CCOCC1
Show InChI InChI=1S/C23H31N3O2/c1-24-21-6-5-17(23(27)25-10-3-2-4-11-25)15-19(21)20-16-26(12-7-22(20)24)18-8-13-28-14-9-18/h5-6,15,18H,2-4,7-14,16H2,1H3
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226n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364927
PNG
(CHEMBL1950342)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2[nH]c3CCN(Cc3c2c1)C1CCCC1
Show InChI InChI=1S/C23H31N3O/c1-16-8-11-25(12-9-16)23(27)17-6-7-21-19(14-17)20-15-26(13-10-22(20)24-21)18-4-2-3-5-18/h6-7,14,16,18,24H,2-5,8-13,15H2,1H3
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264n/an/an/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364927
PNG
(CHEMBL1950342)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2[nH]c3CCN(Cc3c2c1)C1CCCC1
Show InChI InChI=1S/C23H31N3O/c1-16-8-11-25(12-9-16)23(27)17-6-7-21-19(14-17)20-15-26(13-10-22(20)24-21)18-4-2-3-5-18/h6-7,14,16,18,24H,2-5,8-13,15H2,1H3
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n/an/an/an/a 4.25E+3n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364928
PNG
(CHEMBL1950343)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(C)c3CCN(Cc3c2c1)C1CCCC1
Show InChI InChI=1S/C24H33N3O/c1-17-9-12-26(13-10-17)24(28)18-7-8-22-20(15-18)21-16-27(19-5-3-4-6-19)14-11-23(21)25(22)2/h7-8,15,17,19H,3-6,9-14,16H2,1-2H3
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n/an/an/an/a 77n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364929
PNG
(CHEMBL1950344)
Show SMILES CCn1c2CCN(Cc2c2cc(ccc12)C(=O)N1CCC(C)CC1)C1CCCC1
Show InChI InChI=1S/C25H35N3O/c1-3-28-23-9-8-19(25(29)26-13-10-18(2)11-14-26)16-21(23)22-17-27(15-12-24(22)28)20-6-4-5-7-20/h8-9,16,18,20H,3-7,10-15,17H2,1-2H3
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n/an/an/an/a 63n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))
BDBM50364922
PNG
(CHEMBL1950330)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(CC4CC4)Cc3c2c1
Show InChI InChI=1S/C25H33N3O/c1-3-11-28-23-7-6-20(25(29)27-13-8-18(2)9-14-27)15-21(23)22-17-26(12-10-24(22)28)16-19-4-5-19/h3,6-7,15,18-19H,1,4-5,8-14,16-17H2,2H3
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n/an/an/an/a 1.44E+3n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at CB1 receptor in rat brain tissue


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50364946
PNG
(CHEMBL1950489)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(C)c3CCN(Cc3c2c1)C1CCOCC1
Show InChI InChI=1S/C24H33N3O2/c1-17-5-10-26(11-6-17)24(28)18-3-4-22-20(15-18)21-16-27(12-7-23(21)25(22)2)19-8-13-29-14-9-19/h3-4,15,17,19H,5-14,16H2,1-2H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Inhibition of human Erg by voltage ion flux electrophysiological assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364926
PNG
(CHEMBL1950341)
Show SMILES CCCn1c2CCN(Cc2c2cc(ccc12)C(=O)N1CCC(C)CC1)C1CCOCC1
Show InChI InChI=1S/C26H37N3O2/c1-3-11-29-24-5-4-20(26(30)27-12-6-19(2)7-13-27)17-22(24)23-18-28(14-8-25(23)29)21-9-15-31-16-10-21/h4-5,17,19,21H,3,6-16,18H2,1-2H3
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n/an/an/an/a 103n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364925
PNG
(CHEMBL1950340)
Show SMILES CCCn1c2CCN(Cc2c2cc(ccc12)C(=O)N1CCC(C)CC1)C1CCCC1
Show InChI InChI=1S/C26H37N3O/c1-3-13-29-24-9-8-20(26(30)27-14-10-19(2)11-15-27)17-22(24)23-18-28(16-12-25(23)29)21-6-4-5-7-21/h8-9,17,19,21H,3-7,10-16,18H2,1-2H3
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n/an/an/an/a 45n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364953
PNG
(CHEMBL1950338)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(Cc4ccccn4)Cc3c2c1
Show InChI InChI=1S/C27H32N4O/c1-3-13-31-25-8-7-21(27(32)30-15-9-20(2)10-16-30)17-23(25)24-19-29(14-11-26(24)31)18-22-6-4-5-12-28-22/h3-8,12,17,20H,1,9-11,13-16,18-19H2,2H3
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n/an/an/an/a 5.42E+3n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364952
PNG
(CHEMBL1950337)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(Cc4cccnc4)Cc3c2c1
Show InChI InChI=1S/C27H32N4O/c1-3-12-31-25-7-6-22(27(32)30-14-8-20(2)9-15-30)16-23(25)24-19-29(13-10-26(24)31)18-21-5-4-11-28-17-21/h3-7,11,16-17,20H,1,8-10,12-15,18-19H2,2H3
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n/an/an/an/a>1.40E+4n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364951
PNG
(CHEMBL1950336)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(Cc3c2c1)C1CCOCC1
Show InChI InChI=1S/C26H35N3O2/c1-3-11-29-24-5-4-20(26(30)27-12-6-19(2)7-13-27)17-22(24)23-18-28(14-8-25(23)29)21-9-15-31-16-10-21/h3-5,17,19,21H,1,6-16,18H2,2H3
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n/an/an/an/a 60n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364924
PNG
(CHEMBL1950335)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(Cc3c2c1)C1CCCCC1
Show InChI InChI=1S/C27H37N3O/c1-3-14-30-25-10-9-21(27(31)28-15-11-20(2)12-16-28)18-23(25)24-19-29(17-13-26(24)30)22-7-5-4-6-8-22/h3,9-10,18,20,22H,1,4-8,11-17,19H2,2H3
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n/an/an/an/a 60n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50364947
PNG
(CHEMBL1950490)
Show SMILES Cn1c2CCN(Cc2c2cc(ccc12)C(=O)N1CCCCC1)C1CCOCC1
Show InChI InChI=1S/C23H31N3O2/c1-24-21-6-5-17(23(27)25-10-3-2-4-11-25)15-19(21)20-16-26(12-7-22(20)24)18-8-13-28-14-9-18/h5-6,15,18H,2-4,7-14,16H2,1H3
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n/an/a 1.80E+4n/an/an/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Inhibition of human Erg by voltage ion flux electrophysiological assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364949
PNG
(CHEMBL1950332)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(CC4CCCC4)Cc3c2c1
Show InChI InChI=1S/C27H37N3O/c1-3-13-30-25-9-8-22(27(31)29-15-10-20(2)11-16-29)17-23(25)24-19-28(14-12-26(24)30)18-21-6-4-5-7-21/h3,8-9,17,20-21H,1,4-7,10-16,18-19H2,2H3
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n/an/an/an/a 115n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364948
PNG
(CHEMBL1950331)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(Cc4ccccc4)Cc3c2c1
Show InChI InChI=1S/C28H33N3O/c1-3-14-31-26-10-9-23(28(32)30-16-11-21(2)12-17-30)18-24(26)25-20-29(15-13-27(25)31)19-22-7-5-4-6-8-22/h3-10,18,21H,1,11-17,19-20H2,2H3
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n/an/an/an/a 103n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364922
PNG
(CHEMBL1950330)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(CC4CC4)Cc3c2c1
Show InChI InChI=1S/C25H33N3O/c1-3-11-28-23-7-6-20(25(29)27-13-8-18(2)9-14-27)15-21(23)22-17-26(12-10-24(22)28)16-19-4-5-19/h3,6-7,15,18-19H,1,4-5,8-14,16-17H2,2H3
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n/an/an/an/a 768n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50364950
PNG
(CHEMBL1950334)
Show SMILES CC1CCN(CC1)C(=O)c1ccc2n(CC=C)c3CCN(Cc3c2c1)C1CCSC1
Show InChI InChI=1/C25H33N3OS/c1-3-10-28-23-5-4-19(25(29)26-11-6-18(2)7-12-26)15-21(23)22-16-27(13-8-24(22)28)20-9-14-30-17-20/h3-5,15,18,20H,1,6-14,16-17H2,2H3
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n/an/an/an/a 5n/an/an/an/a



AstraZeneca R&D Montreal

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay


Bioorg Med Chem Lett 22: 1619-24 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.124
BindingDB Entry DOI: 10.7270/Q24J0FJX
More data for this
Ligand-Target Pair