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21 similar compounds to monomer 50236362

Compile data set for download or QSAR
Wt: 497.9
BDBM50376015
Wt: 483.9
BDBM50376016
Wt: 485.9
BDBM50376018
Wt: 502.9
BDBM50376019
Wt: 451.4
BDBM50376027
Wt: 451.4
BDBM50376028
Wt: 552.9
BDBM50376029
Wt: 519.3
BDBM50376030
Wt: 519.3
BDBM50376031
Wt: 506.5
BDBM50376032
Wt: 518.4
BDBM50376033
Wt: 464.5
BDBM50376035
Wt: 484.9
BDBM50376036
Wt: 468.4
BDBM50376037
Wt: 468.4
BDBM50376038
Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 50376015,50376016,50376018,50376019,50376027,50376028,50376029,50376030,50376031,50376032,50376033,50376035,50376036,50376037,50376038   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376015
PNG
(CHEMBL271414)
Show SMILES COc1cc2nccc(N(C)c3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C29H24ClN3O3/c1-33(26-13-14-31-25-17-28(36-3)27(35-2)16-24(25)26)21-11-12-22-18(15-21)5-4-6-23(22)29(34)32-20-9-7-19(30)8-10-20/h4-17H,1-3H3,(H,32,34)
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n/an/a>1.40E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376016
PNG
(CHEMBL270277)
Show SMILES COc1cc2nccc(Nc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H22ClN3O3/c1-34-26-15-23-24(12-13-30-25(23)16-27(26)35-2)31-20-10-11-21-17(14-20)4-3-5-22(21)28(33)32-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,30,31)(H,32,33)
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n/an/a 7.94n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376018
PNG
(CHEMBL270745)
Show SMILES COc1cc2nccc(Oc3ccc4c(ccnc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C27H20ClN3O4/c1-33-25-14-21-23(15-26(25)34-2)30-12-10-24(21)35-18-7-8-19-20(9-11-29-22(19)13-18)27(32)31-17-5-3-16(28)4-6-17/h3-15H,1-2H3,(H,31,32)
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n/an/a 22n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376019
PNG
(CHEMBL429585)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3F)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H20ClFN2O4/c1-34-25-14-21-22(15-26(25)35-2)31-13-12-23(21)36-24-11-10-18-19(27(24)30)4-3-5-20(18)28(33)32-17-8-6-16(29)7-9-17/h3-15H,1-2H3,(H,32,33)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376027
PNG
(CHEMBL272693)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccncc3)c2cc1OC
Show InChI InChI=1S/C27H21N3O4/c1-32-25-15-22-23(16-26(25)33-2)29-13-10-24(22)34-19-6-7-20-17(14-19)4-3-5-21(20)27(31)30-18-8-11-28-12-9-18/h3-16H,1-2H3,(H,28,30,31)
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376028
PNG
(CHEMBL406388)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccnc3)c2cc1OC
Show InChI InChI=1S/C27H21N3O4/c1-32-25-14-22-23(15-26(25)33-2)29-12-10-24(22)34-19-8-9-20-17(13-19)5-3-7-21(20)27(31)30-18-6-4-11-28-16-18/h3-16H,1-2H3,(H,30,31)
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n/an/a 0.800n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376029
PNG
(CHEMBL269914)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C29H20ClF3N2O4/c1-37-26-14-21-24(15-27(26)38-2)34-11-10-25(21)39-18-7-8-19-16(12-18)4-3-5-20(19)28(36)35-17-6-9-23(30)22(13-17)29(31,32)33/h3-15H,1-2H3,(H,35,36)
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376030
PNG
(CHEMBL269916)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cc(Cl)cc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H20Cl2N2O4/c1-34-26-14-23-24(15-27(26)35-2)31-9-8-25(23)36-20-6-7-21-16(10-20)4-3-5-22(21)28(33)32-19-12-17(29)11-18(30)13-19/h3-15H,1-2H3,(H,32,33)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376031
PNG
(CHEMBL270983)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3Cl)c2cc1OC
Show InChI InChI=1S/C28H20Cl2N2O4/c1-34-26-14-21-24(15-27(26)35-2)31-11-10-25(21)36-18-7-8-19-16(12-18)4-3-5-20(19)28(33)32-23-9-6-17(29)13-22(23)30/h3-15H,1-2H3,(H,32,33)
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376032
PNG
(CHEMBL407715)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(cc3)C(C)(C)C)c2cc1OC
Show InChI InChI=1S/C32H30N2O4/c1-32(2,3)21-9-11-22(12-10-21)34-31(35)25-8-6-7-20-17-23(13-14-24(20)25)38-28-15-16-33-27-19-30(37-5)29(36-4)18-26(27)28/h6-19H,1-5H3,(H,34,35)
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n/an/a 0.700n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376033
PNG
(CHEMBL270985)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(cc3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C29H21F3N2O4/c1-36-26-15-23-24(16-27(26)37-2)33-13-12-25(23)38-20-10-11-21-17(14-20)4-3-5-22(21)28(35)34-19-8-6-18(7-9-19)29(30,31)32/h3-16H,1-2H3,(H,34,35)
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376035
PNG
(AMG-6168 | CHEMBL411091)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C29H24N2O4/c1-18-7-9-20(10-8-18)31-29(32)23-6-4-5-19-15-21(11-12-22(19)23)35-26-13-14-30-25-17-28(34-3)27(33-2)16-24(25)26/h4-17H,1-3H3,(H,31,32)
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n/an/a 0.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376036
PNG
(CHEMBL270092)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-12-11-25(23)35-20-9-10-21-17(13-20)5-3-8-22(21)28(32)31-19-7-4-6-18(29)14-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376037
PNG
(CHEMBL410841)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3)c2cc1OC
Show InChI InChI=1S/C28H21FN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376038
PNG
(CHEMBL412291)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccc(F)c3)c2cc1OC
Show InChI InChI=1S/C28H21FN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-12-11-25(23)35-20-9-10-21-17(13-20)5-3-8-22(21)28(32)31-19-7-4-6-18(29)14-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50376028
PNG
(CHEMBL406388)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccnc3)c2cc1OC
Show InChI InChI=1S/C27H21N3O4/c1-32-25-14-22-23(15-26(25)33-2)29-12-10-24(22)34-19-8-9-20-17(13-19)5-3-7-21(20)27(31)30-18-6-4-11-28-16-18/h3-16H,1-2H3,(H,30,31)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50376019
PNG
(CHEMBL429585)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3F)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H20ClFN2O4/c1-34-25-14-21-22(15-26(25)35-2)31-13-12-23(21)36-24-11-10-18-19(27(24)30)4-3-5-20(18)28(33)32-17-8-6-16(29)7-9-17/h3-15H,1-2H3,(H,32,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50376027
PNG
(CHEMBL272693)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccncc3)c2cc1OC
Show InChI InChI=1S/C27H21N3O4/c1-32-25-15-22-23(16-26(25)33-2)29-13-10-24(22)34-19-6-7-20-17(14-19)4-3-5-21(20)27(31)30-18-8-11-28-12-9-18/h3-16H,1-2H3,(H,28,30,31)
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n/an/a 100n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50376028
PNG
(CHEMBL406388)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccnc3)c2cc1OC
Show InChI InChI=1S/C27H21N3O4/c1-32-25-14-22-23(15-26(25)33-2)29-12-10-24(22)34-19-8-9-20-17(13-19)5-3-7-21(20)27(31)30-18-6-4-11-28-16-18/h3-16H,1-2H3,(H,30,31)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50376019
PNG
(CHEMBL429585)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3F)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H20ClFN2O4/c1-34-25-14-21-22(15-26(25)35-2)31-13-12-23(21)36-24-11-10-18-19(27(24)30)4-3-5-20(18)28(33)32-17-8-6-16(29)7-9-17/h3-15H,1-2H3,(H,32,33)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50376027
PNG
(CHEMBL272693)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccncc3)c2cc1OC
Show InChI InChI=1S/C27H21N3O4/c1-32-25-15-22-23(16-26(25)33-2)29-13-10-24(22)34-19-6-7-20-17(14-19)4-3-5-21(20)27(31)30-18-8-11-28-12-9-18/h3-16H,1-2H3,(H,28,30,31)
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n/an/a 700n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376038
PNG
(CHEMBL412291)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccc(F)c3)c2cc1OC
Show InChI InChI=1S/C28H21FN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-12-11-25(23)35-20-9-10-21-17(13-20)5-3-8-22(21)28(32)31-19-7-4-6-18(29)14-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.603n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376037
PNG
(CHEMBL410841)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(F)cc3)c2cc1OC
Show InChI InChI=1S/C28H21FN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-13-12-25(23)35-20-10-11-21-17(14-20)4-3-5-22(21)28(32)31-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 1n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376036
PNG
(CHEMBL270092)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H21ClN2O4/c1-33-26-15-23-24(16-27(26)34-2)30-12-11-25(23)35-20-9-10-21-17(13-20)5-3-8-22(21)28(32)31-19-7-4-6-18(29)14-19/h3-16H,1-2H3,(H,31,32)
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n/an/a 0.302n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376035
PNG
(AMG-6168 | CHEMBL411091)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C29H24N2O4/c1-18-7-9-20(10-8-18)31-29(32)23-6-4-5-19-15-21(11-12-22(19)23)35-26-13-14-30-25-17-28(34-3)27(33-2)16-24(25)26/h4-17H,1-3H3,(H,31,32)
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n/an/a 0.501n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376033
PNG
(CHEMBL270985)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(cc3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C29H21F3N2O4/c1-36-26-15-23-24(16-27(26)37-2)33-13-12-25(23)38-20-10-11-21-17(14-20)4-3-5-22(21)28(35)34-19-8-6-18(7-9-19)29(30,31)32/h3-16H,1-2H3,(H,34,35)
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n/an/a 0.501n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376032
PNG
(CHEMBL407715)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(cc3)C(C)(C)C)c2cc1OC
Show InChI InChI=1S/C32H30N2O4/c1-32(2,3)21-9-11-22(12-10-21)34-31(35)25-8-6-7-20-17-23(13-14-24(20)25)38-28-15-16-33-27-19-30(37-5)29(36-4)18-26(27)28/h6-19H,1-5H3,(H,34,35)
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n/an/a 0.708n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376031
PNG
(CHEMBL270983)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3Cl)c2cc1OC
Show InChI InChI=1S/C28H20Cl2N2O4/c1-34-26-14-21-24(15-27(26)35-2)31-11-10-25(21)36-18-7-8-19-16(12-18)4-3-5-20(19)28(33)32-23-9-6-17(29)13-22(23)30/h3-15H,1-2H3,(H,32,33)
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n/an/a 2n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376030
PNG
(CHEMBL269916)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cc(Cl)cc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C28H20Cl2N2O4/c1-34-26-14-23-24(15-27(26)35-2)31-9-8-25(23)36-20-6-7-21-16(10-20)4-3-5-22(21)28(33)32-19-12-17(29)11-18(30)13-19/h3-15H,1-2H3,(H,32,33)
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n/an/a 0.302n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376029
PNG
(CHEMBL269914)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C29H20ClF3N2O4/c1-37-26-14-21-24(15-27(26)38-2)34-11-10-25(21)39-18-7-8-19-16(12-18)4-3-5-20(19)28(36)35-17-6-9-23(30)22(13-17)29(31,32)33/h3-15H,1-2H3,(H,35,36)
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n/an/a 1n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376028
PNG
(CHEMBL406388)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3cccnc3)c2cc1OC
Show InChI InChI=1S/C27H21N3O4/c1-32-25-14-22-23(15-26(25)33-2)29-12-10-24(22)34-19-8-9-20-17(13-19)5-3-7-21(20)27(31)30-18-6-4-11-28-16-18/h3-16H,1-2H3,(H,30,31)
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n/an/a 0.794n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376027
PNG
(CHEMBL272693)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3)C(=O)Nc3ccncc3)c2cc1OC
Show InChI InChI=1S/C27H21N3O4/c1-32-25-15-22-23(16-26(25)33-2)29-13-10-24(22)34-19-6-7-20-17(14-19)4-3-5-21(20)27(31)30-18-8-11-28-12-9-18/h3-16H,1-2H3,(H,28,30,31)
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n/an/a 2n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376019
PNG
(CHEMBL429585)
Show SMILES COc1cc2nccc(Oc3ccc4c(cccc4c3F)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H20ClFN2O4/c1-34-25-14-21-22(15-26(25)35-2)31-13-12-23(21)36-24-11-10-18-19(27(24)30)4-3-5-20(18)28(33)32-17-8-6-16(29)7-9-17/h3-15H,1-2H3,(H,32,33)
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n/an/a 0.302n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376018
PNG
(CHEMBL270745)
Show SMILES COc1cc2nccc(Oc3ccc4c(ccnc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C27H20ClN3O4/c1-33-25-14-21-23(15-26(25)34-2)30-12-10-24(21)35-18-7-8-19-20(9-11-29-22(19)13-18)27(32)31-17-5-3-16(28)4-6-17/h3-15H,1-2H3,(H,31,32)
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n/an/a 21.9n/an/an/an/an/an/a



Lanzhou University

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 after 60 mins


J Mol Graph Model 27: 642-54 (2008)


Article DOI: 10.1016/j.jmgm.2008.10.006
BindingDB Entry DOI: 10.7270/Q2C24XNX
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50376016
PNG
(CHEMBL270277)
Show SMILES COc1cc2nccc(Nc3ccc4c(cccc4c3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C28H22ClN3O3/c1-34-26-15-23-24(12-13-30-25(23)16-27(26)35-2)31-20-10-11-21-17(14-20)4-3-5-22(21)28(33)32-19-8-6-18(29)7-9-19/h3-16H,1-2H3,(H,30,31)(H,32,33)
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n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF assay


J Med Chem 51: 1649-67 (2008)


Article DOI: 10.1021/jm701097z
BindingDB Entry DOI: 10.7270/Q29C6Z8N
More data for this
Ligand-Target Pair