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14 similar compounds to monomer 50380700

Compile data set for download or QSAR
Wt: 388.4
BDBM50380683
Wt: 406.4
BDBM50380690
Wt: 406.4
BDBM50380692
Wt: 406.4
BDBM50380693
Wt: 422.9
BDBM50380694
Wt: 467.3
BDBM50380695
Wt: 402.4
BDBM50380696
Wt: 456.4
BDBM50380697
Wt: 418.4
BDBM50380698
Wt: 456.4
BDBM50380699
Wt: 424.4
BDBM50380701
Wt: 424.4
BDBM50380702
Wt: 457.3
BDBM50380703
Wt: 452.4
BDBM50380713

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50380683,50380690,50380692,50380693,50380694,50380695,50380696,50380697,50380698,50380699,50380701,50380702,50380703,50380713   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380683
PNG
(CHEMBL2017507)
Show SMILES CCOP(=O)(OCC)C(Cc1ccccc1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H25O3PS/c1-4-23-25(22,24-5-2)19(15-17-11-7-6-8-12-17)21-16(3)18-13-9-10-14-20(18)26-21/h6-14,19H,4-5,15H2,1-3H3
KEGG

UniProtKB/TrEMBL

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n/an/a 360n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380690
PNG
(CHEMBL2017505)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)cc1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H24FO3PS/c1-4-24-26(23,25-5-2)19(14-16-10-12-17(22)13-11-16)21-15(3)18-8-6-7-9-20(18)27-21/h6-13,19H,4-5,14H2,1-3H3
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n/an/a 184n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380692
PNG
(CHEMBL2017508)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H24FO3PS/c1-4-24-26(23,25-5-2)19(14-16-9-8-10-17(22)13-16)21-15(3)18-11-6-7-12-20(18)27-21/h6-13,19H,4-5,14H2,1-3H3
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n/an/a 31n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380693
PNG
(CHEMBL2017509)
Show SMILES CCOP(=O)(OCC)C(Cc1ccccc1F)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H24FO3PS/c1-4-24-26(23,25-5-2)19(14-16-10-6-8-12-18(16)22)21-15(3)17-11-7-9-13-20(17)27-21/h6-13,19H,4-5,14H2,1-3H3
KEGG

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n/an/a 114n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380694
PNG
(CHEMBL2017510)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(Cl)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H24ClO3PS/c1-4-24-26(23,25-5-2)19(14-16-9-8-10-17(22)13-16)21-15(3)18-11-6-7-12-20(18)27-21/h6-13,19H,4-5,14H2,1-3H3
KEGG

UniProtKB/TrEMBL

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n/an/a 22n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380695
PNG
(CHEMBL2017511)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(Br)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H24BrO3PS/c1-4-24-26(23,25-5-2)19(14-16-9-8-10-17(22)13-16)21-15(3)18-11-6-7-12-20(18)27-21/h6-13,19H,4-5,14H2,1-3H3
KEGG

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n/an/a 145n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380713
PNG
(CHEMBL2017671)
Show SMILES CC(C)OP(=O)(OC(C)C)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C23H27F2O3PS/c1-14(2)27-29(26,28-15(3)4)21(13-17-10-11-19(24)20(25)12-17)23-16(5)18-8-6-7-9-22(18)30-23/h6-12,14-15,21H,13H2,1-5H3
KEGG

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n/an/a 24n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380697
PNG
(CHEMBL2017513)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(c1)C(F)(F)F)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H24F3O3PS/c1-4-27-29(26,28-5-2)19(14-16-9-8-10-17(13-16)22(23,24)25)21-15(3)18-11-6-7-12-20(18)30-21/h6-13,19H,4-5,14H2,1-3H3
KEGG

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n/an/a 138n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380698
PNG
(CHEMBL2017514)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(OC)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H27O4PS/c1-5-25-27(23,26-6-2)20(15-17-10-9-11-18(14-17)24-4)22-16(3)19-12-7-8-13-21(19)28-22/h7-14,20H,5-6,15H2,1-4H3
KEGG

UniProtKB/TrEMBL

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n/an/a 121n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380699
PNG
(CHEMBL2017655)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(cc1)C(F)(F)F)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H24F3O3PS/c1-4-27-29(26,28-5-2)19(14-16-10-12-17(13-11-16)22(23,24)25)21-15(3)18-8-6-7-9-20(18)30-21/h6-13,19H,4-5,14H2,1-3H3
KEGG

UniProtKB/TrEMBL

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Article
PubMed
n/an/a 365n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380701
PNG
(CHEMBL2017657)
Show SMILES CCOP(=O)(OCC)C(Cc1cc(F)cc(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H23F2O3PS/c1-4-25-27(24,26-5-2)19(12-15-10-16(22)13-17(23)11-15)21-14(3)18-8-6-7-9-20(18)28-21/h6-11,13,19H,4-5,12H2,1-3H3
KEGG

UniProtKB/TrEMBL

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n/an/a 58n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380702
PNG
(CHEMBL2017658)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H23F2O3PS/c1-4-25-27(24,26-5-2)19(13-15-10-11-17(22)18(23)12-15)21-14(3)16-8-6-7-9-20(16)28-21/h6-12,19H,4-5,13H2,1-3H3
KEGG

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n/an/a 64n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380703
PNG
(CHEMBL2017659)
Show SMILES CCOP(=O)(OCC)C(Cc1ccc(Cl)c(Cl)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C21H23Cl2O3PS/c1-4-25-27(24,26-5-2)19(13-15-10-11-17(22)18(23)12-15)21-14(3)16-8-6-7-9-20(16)28-21/h6-12,19H,4-5,13H2,1-3H3
KEGG

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n/an/a 300n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM50380696
PNG
(CHEMBL2017512)
Show SMILES CCOP(=O)(OCC)C(Cc1cccc(C)c1)c1sc2ccccc2c1C
Show InChI InChI=1S/C22H27O3PS/c1-5-24-26(23,25-6-2)20(15-18-11-9-10-16(3)14-18)22-17(4)19-12-7-8-13-21(19)27-22/h7-14,20H,5-6,15H2,1-4H3
KEGG

UniProtKB/TrEMBL

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PC sid
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Article
PubMed
n/an/a 65n/an/an/an/an/an/a



Janssen Pharmaceutica NV

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ level measured eve...


Bioorg Med Chem Lett 22: 2922-6 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.060
BindingDB Entry DOI: 10.7270/Q2TM7C48
More data for this
Ligand-Target Pair