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37 similar compounds to monomer 50382008

Compile data set for download or QSAR
Wt: 452.5
BDBM50381992
Wt: 559.6
BDBM50381994
Wt: 561.7
BDBM50381995
Wt: 563.6
BDBM50381996
Wt: 542.6
BDBM50381997
Wt: 560.6
BDBM50381998
Wt: 451.5
BDBM50381999
Wt: 521.6
BDBM50382000
Wt: 555.6
BDBM50382001
Wt: 541.6
BDBM50382002
Wt: 559.6
BDBM50382007
Wt: 577.6
BDBM50382009
Wt: 577.6
BDBM50382010
Wt: 623.6
BDBM50382011
Wt: 585.7
BDBM50382012
Displayed 1 to 15 (of 37 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 55 hits for monomerid = 50381992,50381994,50381995,50381996,50381997,50381998,50381999,50382000,50382001,50382002,50382007,50382009,50382010,50382011,50382012   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))
BDBM50381997
PNG
(CHEMBL2022379)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4)c3)sn2)C1
Show InChI InChI=1S/C27H30N10OS/c1-18-4-3-9-35(13-18)16-22-10-25(39-34-22)33-26-27-29-12-23(37(27)14-19(2)31-26)20-11-30-36(15-20)17-24(38)32-21-5-7-28-8-6-21/h5-8,10-12,14-15,18H,3-4,9,13,16-17H2,1-2H3,(H,31,33)(H,28,32,38)
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n/an/an/an/a 83n/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50381997
PNG
(CHEMBL2022379)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4)c3)sn2)C1
Show InChI InChI=1S/C27H30N10OS/c1-18-4-3-9-35(13-18)16-22-10-25(39-34-22)33-26-27-29-12-23(37(27)14-19(2)31-26)20-11-30-36(15-20)17-24(38)32-21-5-7-28-8-6-21/h5-8,10-12,14-15,18H,3-4,9,13,16-17H2,1-2H3,(H,31,33)(H,28,32,38)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382009
PNG
(CHEMBL2023296)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)NCc2cccc(F)c2F)c1
Show InChI InChI=1S/C28H29F2N9OS/c1-18-14-39-23(20-12-33-38(15-20)17-24(40)31-11-19-6-5-7-22(29)26(19)30)13-32-28(39)27(34-18)35-25-10-21(36-41-25)16-37-8-3-2-4-9-37/h5-7,10,12-15H,2-4,8-9,11,16-17H2,1H3,(H,31,40)(H,34,35)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50381994
PNG
(CHEMBL2023295)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)NCc2ccc(F)cc2)c1
Show InChI InChI=1S/C28H30FN9OS/c1-19-15-38-24(21-13-32-37(16-21)18-25(39)30-12-20-5-7-22(29)8-6-20)14-31-28(38)27(33-19)34-26-11-23(35-40-26)17-36-9-3-2-4-10-36/h5-8,11,13-16H,2-4,9-10,12,17-18H2,1H3,(H,30,39)(H,33,34)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382011
PNG
(CHEMBL2023298)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4cccc(c4)C(F)(F)F)c3)sn2)C1
Show InChI InChI=1S/C30H32F3N9OS/c1-19-5-4-8-40(14-19)17-24-10-27(44-39-24)38-28-29-35-13-25(42(29)15-20(2)37-28)22-12-36-41(16-22)18-26(43)34-11-21-6-3-7-23(9-21)30(31,32)33/h3,6-7,9-10,12-13,15-16,19H,4-5,8,11,14,17-18H2,1-2H3,(H,34,43)(H,37,38)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382010
PNG
(CHEMBL2023297)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)NCc2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C28H29F2N9OS/c1-18-14-39-24(20-12-33-38(15-20)17-25(40)31-11-19-7-21(29)9-22(30)8-19)13-32-28(39)27(34-18)35-26-10-23(36-41-26)16-37-5-3-2-4-6-37/h7-10,12-15H,2-6,11,16-17H2,1H3,(H,31,40)(H,34,35)
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n/an/an/an/a 389n/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50381995
PNG
(CHEMBL2022369)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4cccs4)c3)sn2)C1
Show InChI InChI=1S/C27H31N9OS2/c1-18-5-3-7-34(13-18)16-21-9-25(39-33-21)32-26-27-29-12-23(36(27)14-19(2)31-26)20-10-30-35(15-20)17-24(37)28-11-22-6-4-8-38-22/h4,6,8-10,12,14-15,18H,3,5,7,11,13,16-17H2,1-2H3,(H,28,37)(H,31,32)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of Chk1


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50381996
PNG
(CHEMBL2022373)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)Nc2cccc(F)c2F)c1
Show InChI InChI=1S/C27H27F2N9OS/c1-17-13-38-22(18-11-31-37(14-18)16-23(39)33-21-7-5-6-20(28)25(21)29)12-30-27(38)26(32-17)34-24-10-19(35-40-24)15-36-8-3-2-4-9-36/h5-7,10-14H,2-4,8-9,15-16H2,1H3,(H,32,34)(H,33,39)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382012
PNG
(CHEMBL2023301)
Show SMILES COc1cccc(CNC(=O)Cn2cc(cn2)-c2cnc3c(Nc4cc(CN5CCCC(C)C5)ns4)nc(C)cn23)c1
Show InChI InChI=1S/C30H35N9O2S/c1-20-6-5-9-37(15-20)18-24-11-28(42-36-24)35-29-30-32-14-26(39(30)16-21(2)34-29)23-13-33-38(17-23)19-27(40)31-12-22-7-4-8-25(10-22)41-3/h4,7-8,10-11,13-14,16-17,20H,5-6,9,12,15,18-19H2,1-3H3,(H,31,40)(H,34,35)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382002
PNG
(CHEMBL2022121)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccccc4)c3)sn2)C1
Show InChI InChI=1S/C28H31N9OS/c1-19-7-6-10-35(14-19)17-23-11-26(39-34-23)33-27-28-29-13-24(37(28)15-20(2)31-27)21-12-30-36(16-21)18-25(38)32-22-8-4-3-5-9-22/h3-5,8-9,11-13,15-16,19H,6-7,10,14,17-18H2,1-2H3,(H,31,33)(H,32,38)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382007
PNG
(CHEMBL2023293)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)NCc2ccccc2F)c1
Show InChI InChI=1S/C28H30FN9OS/c1-19-15-38-24(21-13-32-37(16-21)18-25(39)30-12-20-7-3-4-8-23(20)29)14-31-28(38)27(33-19)34-26-11-22(35-40-26)17-36-9-5-2-6-10-36/h3-4,7-8,11,13-16H,2,5-6,9-10,12,17-18H2,1H3,(H,30,39)(H,33,34)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50381996
PNG
(CHEMBL2022373)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)Nc2cccc(F)c2F)c1
Show InChI InChI=1S/C27H27F2N9OS/c1-17-13-38-22(18-11-31-37(14-18)16-23(39)33-21-7-5-6-20(28)25(21)29)12-30-27(38)26(32-17)34-24-10-19(35-40-24)15-36-8-3-2-4-9-36/h5-7,10-14H,2-4,8-9,15-16H2,1H3,(H,32,34)(H,33,39)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of Chk1


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50381995
PNG
(CHEMBL2022369)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4cccs4)c3)sn2)C1
Show InChI InChI=1S/C27H31N9OS2/c1-18-5-3-7-34(13-18)16-21-9-25(39-33-21)32-26-27-29-12-23(36(27)14-19(2)31-26)20-10-30-35(15-20)17-24(37)28-11-22-6-4-8-38-22/h4,6,8-10,12,14-15,18H,3,5,7,11,13,16-17H2,1-2H3,(H,28,37)(H,31,32)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50381997
PNG
(CHEMBL2022379)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4)c3)sn2)C1
Show InChI InChI=1S/C27H30N10OS/c1-18-4-3-9-35(13-18)16-22-10-25(39-34-22)33-26-27-29-12-23(37(27)14-19(2)31-26)20-11-30-36(15-20)17-24(38)32-21-5-7-28-8-6-21/h5-8,10-12,14-15,18H,3-4,9,13,16-17H2,1-2H3,(H,31,33)(H,28,32,38)
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AMRI

Curated by ChEMBL


Assay Description
Inhibition of Chk1


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50381998
PNG
(CHEMBL2022711)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4F)c3)sn2)C1
Show InChI InChI=1S/C27H29FN10OS/c1-17-4-3-7-36(12-17)15-20-8-25(40-35-20)34-26-27-30-11-23(38(27)13-18(2)32-26)19-9-31-37(14-19)16-24(39)33-22-5-6-29-10-21(22)28/h5-6,8-11,13-14,17H,3-4,7,12,15-16H2,1-2H3,(H,32,34)(H,29,33,39)
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n/an/a<4n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50381999
PNG
(CHEMBL2022114)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(N)=O)c1
Show InChI InChI=1S/C21H25N9OS/c1-14-10-30-17(15-8-24-29(11-15)13-18(22)31)9-23-21(30)20(25-14)26-19-7-16(27-32-19)12-28-5-3-2-4-6-28/h7-11H,2-6,12-13H2,1H3,(H2,22,31)(H,25,26)
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n/an/a 28n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50381992
PNG
(CHEMBL2022112)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(O)=O)c1
Show InChI InChI=1S/C21H24N8O2S/c1-14-10-29-17(15-8-23-28(11-15)13-19(30)31)9-22-21(29)20(24-14)25-18-7-16(26-32-18)12-27-5-3-2-4-6-27/h7-11H,2-6,12-13H2,1H3,(H,24,25)(H,30,31)
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n/an/a 363n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens (Human))
BDBM50381998
PNG
(CHEMBL2022711)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4F)c3)sn2)C1
Show InChI InChI=1S/C27H29FN10OS/c1-17-4-3-7-36(12-17)15-20-8-25(40-35-20)34-26-27-30-11-23(38(27)13-18(2)32-26)19-9-31-37(14-19)16-24(39)33-22-5-6-29-10-21(22)28/h5-6,8-11,13-14,17H,3-4,7,12,15-16H2,1-2H3,(H,32,34)(H,29,33,39)
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n/an/a 300n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of Chk1


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382001
PNG
(CHEMBL2022120)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4ccccc4)c3)sn2)C1
Show InChI InChI=1S/C29H33N9OS/c1-20-7-6-10-36(15-20)18-24-11-27(40-35-24)34-28-29-31-14-25(38(29)16-21(2)33-28)23-13-32-37(17-23)19-26(39)30-12-22-8-4-3-5-9-22/h3-5,8-9,11,13-14,16-17,20H,6-7,10,12,15,18-19H2,1-2H3,(H,30,39)(H,33,34)
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n/an/an/an/a 129n/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382002
PNG
(CHEMBL2022121)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccccc4)c3)sn2)C1
Show InChI InChI=1S/C28H31N9OS/c1-19-7-6-10-35(14-19)17-23-11-26(39-34-23)33-27-28-29-13-24(37(28)15-20(2)31-27)21-12-30-36(16-21)18-25(38)32-22-8-4-3-5-9-22/h3-5,8-9,11-13,15-16,19H,6-7,10,14,17-18H2,1-2H3,(H,31,33)(H,32,38)
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n/an/an/an/a 327n/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382012
PNG
(CHEMBL2023301)
Show SMILES COc1cccc(CNC(=O)Cn2cc(cn2)-c2cnc3c(Nc4cc(CN5CCCC(C)C5)ns4)nc(C)cn23)c1
Show InChI InChI=1S/C30H35N9O2S/c1-20-6-5-9-37(15-20)18-24-11-28(42-36-24)35-29-30-32-14-26(39(30)16-21(2)34-29)23-13-33-38(17-23)19-27(40)31-12-22-7-4-8-25(10-22)41-3/h4,7-8,10-11,13-14,16-17,20H,5-6,9,12,15,18-19H2,1-3H3,(H,31,40)(H,34,35)
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n/an/a 41n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382000
PNG
(CHEMBL2022116)
Show SMILES CC(C)CCNC(=O)Cn1cc(cn1)-c1cnc2c(Nc3cc(CN4CCCCC4)ns3)nc(C)cn12
Show InChI InChI=1S/C26H35N9OS/c1-18(2)7-8-27-23(36)17-34-15-20(12-29-34)22-13-28-26-25(30-19(3)14-35(22)26)31-24-11-21(32-37-24)16-33-9-5-4-6-10-33/h11-15,18H,4-10,16-17H2,1-3H3,(H,27,36)(H,30,31)
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n/an/an/an/a>1.00E+3n/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50382011
PNG
(CHEMBL2023298)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4cccc(c4)C(F)(F)F)c3)sn2)C1
Show InChI InChI=1S/C30H32F3N9OS/c1-19-5-4-8-40(14-19)17-24-10-27(44-39-24)38-28-29-35-13-25(42(29)15-20(2)37-28)22-12-36-41(16-22)18-26(43)34-11-21-6-3-7-23(9-21)30(31,32)33/h3,6-7,9-10,12-13,15-16,19H,4-5,8,11,14,17-18H2,1-2H3,(H,34,43)(H,37,38)
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n/an/a 35n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50381999
PNG
(CHEMBL2022114)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(N)=O)c1
Show InChI InChI=1S/C21H25N9OS/c1-14-10-30-17(15-8-24-29(11-15)13-18(22)31)9-23-21(30)20(25-14)26-19-7-16(27-32-19)12-28-5-3-2-4-6-28/h7-11H,2-6,12-13H2,1H3,(H2,22,31)(H,25,26)
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n/an/an/an/a>1.00E+3n/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50381998
PNG
(CHEMBL2022711)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4F)c3)sn2)C1
Show InChI InChI=1S/C27H29FN10OS/c1-17-4-3-7-36(12-17)15-20-8-25(40-35-20)34-26-27-30-11-23(38(27)13-18(2)32-26)19-9-31-37(14-19)16-24(39)33-22-5-6-29-10-21(22)28/h5-6,8-11,13-14,17H,3-4,7,12,15-16H2,1-2H3,(H,32,34)(H,29,33,39)
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n/an/an/an/a 62n/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora B kinase in human HCT116 cells assessed as inhibition of histone H3 phosphorylation incubated for 1 hr by Hoechst 33342 staining...


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381995
PNG
(CHEMBL2022369)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4cccs4)c3)sn2)C1
Show InChI InChI=1S/C27H31N9OS2/c1-18-5-3-7-34(13-18)16-21-9-25(39-33-21)32-26-27-29-12-23(36(27)14-19(2)31-26)20-10-30-35(15-20)17-24(37)28-11-22-6-4-8-38-22/h4,6,8-10,12,14-15,18H,3,5,7,11,13,16-17H2,1-2H3,(H,28,37)(H,31,32)
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n/an/a 234n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50381995
PNG
(CHEMBL2022369)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4cccs4)c3)sn2)C1
Show InChI InChI=1S/C27H31N9OS2/c1-18-5-3-7-34(13-18)16-21-9-25(39-33-21)32-26-27-29-12-23(36(27)14-19(2)31-26)20-10-30-35(15-20)17-24(37)28-11-22-6-4-8-38-22/h4,6,8-10,12,14-15,18H,3,5,7,11,13,16-17H2,1-2H3,(H,28,37)(H,31,32)
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n/an/a 7.70E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of RSK2


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50381996
PNG
(CHEMBL2022373)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)Nc2cccc(F)c2F)c1
Show InChI InChI=1S/C27H27F2N9OS/c1-17-13-38-22(18-11-31-37(14-18)16-23(39)33-21-7-5-6-20(28)25(21)29)12-30-27(38)26(32-17)34-24-10-19(35-40-24)15-36-8-3-2-4-9-36/h5-7,10-14H,2-4,8-9,15-16H2,1H3,(H,32,34)(H,33,39)
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n/an/a 1.42E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of IRAK4


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50381997
PNG
(CHEMBL2022379)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4)c3)sn2)C1
Show InChI InChI=1S/C27H30N10OS/c1-18-4-3-9-35(13-18)16-22-10-25(39-34-22)33-26-27-29-12-23(37(27)14-19(2)31-26)20-11-30-36(15-20)17-24(38)32-21-5-7-28-8-6-21/h5-8,10-12,14-15,18H,3-4,9,13,16-17H2,1-2H3,(H,31,33)(H,28,32,38)
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n/an/a 1.14E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of IRAK4


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50381998
PNG
(CHEMBL2022711)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4F)c3)sn2)C1
Show InChI InChI=1S/C27H29FN10OS/c1-17-4-3-7-36(12-17)15-20-8-25(40-35-20)34-26-27-30-11-23(38(27)13-18(2)32-26)19-9-31-37(14-19)16-24(39)33-22-5-6-29-10-21(22)28/h5-6,8-11,13-14,17H,3-4,7,12,15-16H2,1-2H3,(H,32,34)(H,29,33,39)
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n/an/a 1.22E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of IRAK4


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50381996
PNG
(CHEMBL2022373)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)Nc2cccc(F)c2F)c1
Show InChI InChI=1S/C27H27F2N9OS/c1-17-13-38-22(18-11-31-37(14-18)16-23(39)33-21-7-5-6-20(28)25(21)29)12-30-27(38)26(32-17)34-24-10-19(35-40-24)15-36-8-3-2-4-9-36/h5-7,10-14H,2-4,8-9,15-16H2,1H3,(H,32,34)(H,33,39)
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n/an/a 4.30E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of RSK2


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50381997
PNG
(CHEMBL2022379)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4)c3)sn2)C1
Show InChI InChI=1S/C27H30N10OS/c1-18-4-3-9-35(13-18)16-22-10-25(39-34-22)33-26-27-29-12-23(37(27)14-19(2)31-26)20-11-30-36(15-20)17-24(38)32-21-5-7-28-8-6-21/h5-8,10-12,14-15,18H,3-4,9,13,16-17H2,1-2H3,(H,31,33)(H,28,32,38)
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n/an/a 1.10E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of RSK2


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM50381998
PNG
(CHEMBL2022711)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4F)c3)sn2)C1
Show InChI InChI=1S/C27H29FN10OS/c1-17-4-3-7-36(12-17)15-20-8-25(40-35-20)34-26-27-30-11-23(38(27)13-18(2)32-26)19-9-31-37(14-19)16-24(39)33-22-5-6-29-10-21(22)28/h5-6,8-11,13-14,17H,3-4,7,12,15-16H2,1-2H3,(H,32,34)(H,29,33,39)
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n/an/a 6.80E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of RSK2


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381996
PNG
(CHEMBL2022373)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)Nc2cccc(F)c2F)c1
Show InChI InChI=1S/C27H27F2N9OS/c1-17-13-38-22(18-11-31-37(14-18)16-23(39)33-21-7-5-6-20(28)25(21)29)12-30-27(38)26(32-17)34-24-10-19(35-40-24)15-36-8-3-2-4-9-36/h5-7,10-14H,2-4,8-9,15-16H2,1H3,(H,32,34)(H,33,39)
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n/an/a 481n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381997
PNG
(CHEMBL2022379)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4)c3)sn2)C1
Show InChI InChI=1S/C27H30N10OS/c1-18-4-3-9-35(13-18)16-22-10-25(39-34-22)33-26-27-29-12-23(37(27)14-19(2)31-26)20-11-30-36(15-20)17-24(38)32-21-5-7-28-8-6-21/h5-8,10-12,14-15,18H,3-4,9,13,16-17H2,1-2H3,(H,31,33)(H,28,32,38)
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n/an/a 108n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50381998
PNG
(CHEMBL2022711)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4F)c3)sn2)C1
Show InChI InChI=1S/C27H29FN10OS/c1-17-4-3-7-36(12-17)15-20-8-25(40-35-20)34-26-27-30-11-23(38(27)13-18(2)32-26)19-9-31-37(14-19)16-24(39)33-22-5-6-29-10-21(22)28/h5-6,8-11,13-14,17H,3-4,7,12,15-16H2,1-2H3,(H,32,34)(H,29,33,39)
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n/an/a 253n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50381995
PNG
(CHEMBL2022369)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4cccs4)c3)sn2)C1
Show InChI InChI=1S/C27H31N9OS2/c1-18-5-3-7-34(13-18)16-21-9-25(39-33-21)32-26-27-29-12-23(36(27)14-19(2)31-26)20-10-30-35(15-20)17-24(37)28-11-22-6-4-8-38-22/h4,6,8-10,12,14-15,18H,3,5,7,11,13,16-17H2,1-2H3,(H,28,37)(H,31,32)
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n/an/a 579n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of LCK


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50381996
PNG
(CHEMBL2022373)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)Nc2cccc(F)c2F)c1
Show InChI InChI=1S/C27H27F2N9OS/c1-17-13-38-22(18-11-31-37(14-18)16-23(39)33-21-7-5-6-20(28)25(21)29)12-30-27(38)26(32-17)34-24-10-19(35-40-24)15-36-8-3-2-4-9-36/h5-7,10-14H,2-4,8-9,15-16H2,1H3,(H,32,34)(H,33,39)
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n/an/a>3.00E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of LCK


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50381997
PNG
(CHEMBL2022379)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4)c3)sn2)C1
Show InChI InChI=1S/C27H30N10OS/c1-18-4-3-9-35(13-18)16-22-10-25(39-34-22)33-26-27-29-12-23(37(27)14-19(2)31-26)20-11-30-36(15-20)17-24(38)32-21-5-7-28-8-6-21/h5-8,10-12,14-15,18H,3-4,9,13,16-17H2,1-2H3,(H,31,33)(H,28,32,38)
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n/an/a 731n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of LCK


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50381998
PNG
(CHEMBL2022711)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccncc4F)c3)sn2)C1
Show InChI InChI=1S/C27H29FN10OS/c1-17-4-3-7-36(12-17)15-20-8-25(40-35-20)34-26-27-30-11-23(38(27)13-18(2)32-26)19-9-31-37(14-19)16-24(39)33-22-5-6-29-10-21(22)28/h5-6,8-11,13-14,17H,3-4,7,12,15-16H2,1-2H3,(H,32,34)(H,29,33,39)
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n/an/a 271n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of LCK


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50381995
PNG
(CHEMBL2022369)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4cccs4)c3)sn2)C1
Show InChI InChI=1S/C27H31N9OS2/c1-18-5-3-7-34(13-18)16-21-9-25(39-33-21)32-26-27-29-12-23(36(27)14-19(2)31-26)20-10-30-35(15-20)17-24(37)28-11-22-6-4-8-38-22/h4,6,8-10,12,14-15,18H,3,5,7,11,13,16-17H2,1-2H3,(H,28,37)(H,31,32)
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n/an/a 873n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of IRAK4


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50382002
PNG
(CHEMBL2022121)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)Nc4ccccc4)c3)sn2)C1
Show InChI InChI=1S/C28H31N9OS/c1-19-7-6-10-35(14-19)17-23-11-26(39-34-23)33-27-28-29-13-24(37(28)15-20(2)31-27)21-12-30-36(16-21)18-25(38)32-22-8-4-3-5-9-22/h3-5,8-9,11-13,15-16,19H,6-7,10,14,17-18H2,1-2H3,(H,31,33)(H,32,38)
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n/an/a 34n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50382001
PNG
(CHEMBL2022120)
Show SMILES CC1CCCN(Cc2cc(Nc3nc(C)cn4c(cnc34)-c3cnn(CC(=O)NCc4ccccc4)c3)sn2)C1
Show InChI InChI=1S/C29H33N9OS/c1-20-7-6-10-36(15-20)18-24-11-27(40-35-24)34-28-29-31-14-25(38(29)16-21(2)33-28)23-13-32-37(17-23)19-26(39)30-12-22-8-4-3-5-9-22/h3-5,8-9,11,13-14,16-17,20H,6-7,10,12,15,18-19H2,1-2H3,(H,30,39)(H,33,34)
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n/an/a 21n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50382000
PNG
(CHEMBL2022116)
Show SMILES CC(C)CCNC(=O)Cn1cc(cn1)-c1cnc2c(Nc3cc(CN4CCCCC4)ns3)nc(C)cn12
Show InChI InChI=1S/C26H35N9OS/c1-18(2)7-8-27-23(36)17-34-15-20(12-29-34)22-13-28-26-25(30-19(3)14-35(22)26)31-24-11-21(32-37-24)16-33-9-5-4-6-10-33/h11-15,18H,4-10,16-17H2,1-3H3,(H,27,36)(H,30,31)
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n/an/a 1.80E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50381999
PNG
(CHEMBL2022114)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(N)=O)c1
Show InChI InChI=1S/C21H25N9OS/c1-14-10-30-17(15-8-24-29(11-15)13-18(22)31)9-23-21(30)20(25-14)26-19-7-16(27-32-19)12-28-5-3-2-4-6-28/h7-11H,2-6,12-13H2,1H3,(H2,22,31)(H,25,26)
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n/an/a 1.57E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50381992
PNG
(CHEMBL2022112)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(O)=O)c1
Show InChI InChI=1S/C21H24N8O2S/c1-14-10-29-17(15-8-23-28(11-15)13-19(30)31)9-22-21(29)20(24-14)25-18-7-16(26-32-18)12-27-5-3-2-4-6-27/h7-11H,2-6,12-13H2,1H3,(H,24,25)(H,30,31)
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n/an/a 1.83E+3n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50382007
PNG
(CHEMBL2023293)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)NCc2ccccc2F)c1
Show InChI InChI=1S/C28H30FN9OS/c1-19-15-38-24(21-13-32-37(16-21)18-25(39)30-12-20-7-3-4-8-23(20)29)14-31-28(38)27(33-19)34-26-11-22(35-40-26)17-36-9-5-2-6-10-36/h3-4,7-8,11,13-16H,2,5-6,9-10,12,17-18H2,1H3,(H,30,39)(H,33,34)
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n/an/a 44n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50381994
PNG
(CHEMBL2023295)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)NCc2ccc(F)cc2)c1
Show InChI InChI=1S/C28H30FN9OS/c1-19-15-38-24(21-13-32-37(16-21)18-25(39)30-12-20-5-7-22(29)8-6-20)14-31-28(38)27(33-19)34-26-11-23(35-40-26)17-36-9-3-2-4-10-36/h5-8,11,13-16H,2-4,9-10,12,17-18H2,1H3,(H,30,39)(H,33,34)
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n/an/a 40n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50382009
PNG
(CHEMBL2023296)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)NCc2cccc(F)c2F)c1
Show InChI InChI=1S/C28H29F2N9OS/c1-18-14-39-23(20-12-33-38(15-20)17-24(40)31-11-19-6-5-7-22(29)26(19)30)13-32-28(39)27(34-18)35-25-10-21(36-41-25)16-37-8-3-2-4-9-37/h5-7,10,12-15H,2-4,8-9,11,16-17H2,1H3,(H,31,40)(H,34,35)
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n/an/a 45n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50382010
PNG
(CHEMBL2023297)
Show SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCCCC3)ns2)n1)-c1cnn(CC(=O)NCc2cc(F)cc(F)c2)c1
Show InChI InChI=1S/C28H29F2N9OS/c1-18-14-39-24(20-12-33-38(15-20)17-25(40)31-11-19-7-21(29)9-22(30)8-19)13-32-28(39)27(34-18)35-26-10-23(36-41-26)16-37-5-3-2-4-6-37/h7-10,12-15H,2-6,11,16-17H2,1H3,(H,31,40)(H,34,35)
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n/an/a 22n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of aurora A kinase using 5TAMRA-GRTGRRNSICOOH as substrate by fluorescent assay


Bioorg Med Chem Lett 22: 3544-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.051
BindingDB Entry DOI: 10.7270/Q2X34ZGD
More data for this
Ligand-Target Pair
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