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11 similar compounds to monomer 50383177

Compile data set for download or QSAR
Wt: 536.5
BDBM50383174
Wt: 567.6
BDBM50383178
Wt: 555.5
BDBM50383179
Wt: 481.5
BDBM50383183
Wt: 511.5
BDBM50383184
Wt: 544.5
BDBM50383169
Wt: 525.5
BDBM50383198
Wt: 525.5
BDBM50383199
Wt: 511.5
BDBM50383200
Wt: 509.5
BDBM50383203
Wt: 495.5
BDBM50383204

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 43 hits for monomerid = 50383174,50383178,50383179,50383183,50383184,50383169,50383198,50383199,50383200,50383203,50383204   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383200
PNG
(CHEMBL2032026)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CCO)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C28H25N5O5/c1-18-26(28(36)33(32(18)14-15-34)19-6-4-3-5-7-19)27(35)31-25-11-9-21(17-30-25)38-24-12-13-29-23-16-20(37-2)8-10-22(23)24/h3-13,16-17,34H,14-15H2,1-2H3,(H,30,31,35)
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0.400n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383169
PNG
(CHEMBL2032014)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(-c5ccncc5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C31H24N6O4/c1-36-29(20-12-15-32-16-13-20)28(31(39)37(36)21-6-4-3-5-7-21)30(38)35-27-11-9-23(19-34-27)41-26-14-17-33-25-18-22(40-2)8-10-24(25)26/h3-19H,1-2H3,(H,34,35,38)
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0.600n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383198
PNG
(CHEMBL2032029)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C29H27N5O5/c1-18(35)17-33-19(2)27(29(37)34(33)20-7-5-4-6-8-20)28(36)32-26-12-10-22(16-31-26)39-25-13-14-30-24-15-21(38-3)9-11-23(24)25/h4-16,18,35H,17H2,1-3H3,(H,31,32,36)
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0.800n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383203
PNG
(CHEMBL2032022)
Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O4/c1-4-16-33-19(2)27(29(36)34(33)20-8-6-5-7-9-20)28(35)32-26-13-11-22(18-31-26)38-25-14-15-30-24-17-21(37-3)10-12-23(24)25/h5-15,17-18H,4,16H2,1-3H3,(H,31,32,35)
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1.10n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383183
PNG
(CHEMBL2031901)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C27H23N5O4/c1-17-25(27(34)32(31(17)2)18-7-5-4-6-8-18)26(33)30-24-12-10-20(16-29-24)36-23-13-14-28-22-15-19(35-3)9-11-21(22)23/h4-16H,1-3H3,(H,29,30,33)
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1.20n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383199
PNG
(CHEMBL2032027)
Show SMILES COCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O5/c1-19-27(29(36)34(33(19)15-16-37-2)20-7-5-4-6-8-20)28(35)32-26-12-10-22(18-31-26)39-25-13-14-30-24-17-21(38-3)9-11-23(24)25/h4-14,17-18H,15-16H2,1-3H3,(H,31,32,35)
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1.40n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383178
PNG
(CHEMBL2031906)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN5CCCC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C32H30FN5O4/c1-36-27(20-37-16-6-7-17-37)30(32(40)38(36)22-8-4-3-5-9-22)31(39)35-21-10-13-29(25(33)18-21)42-28-14-15-34-26-19-23(41-2)11-12-24(26)28/h3-5,8-15,18-19H,6-7,16-17,20H2,1-2H3,(H,35,39)
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1.5n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383204
PNG
(CHEMBL2032021)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C28H25N5O4/c1-4-32-18(2)26(28(35)33(32)19-8-6-5-7-9-19)27(34)31-25-13-11-21(17-30-25)37-24-14-15-29-23-16-20(36-3)10-12-22(23)24/h5-17H,4H2,1-3H3,(H,30,31,34)
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1.60n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383184
PNG
(CHEMBL2031900)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C28H25N5O5/c1-17-26(28(35)33(32(17)2)18-8-6-5-7-9-18)27(34)31-25-11-10-19(16-30-25)38-22-12-13-29-21-15-24(37-4)23(36-3)14-20(21)22/h5-16H,1-4H3,(H,30,31,34)
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1.90n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383179
PNG
(CHEMBL2031905)
Show SMILES CCN(C)Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30FN5O4/c1-5-35(2)19-26-29(31(39)37(36(26)3)21-9-7-6-8-10-21)30(38)34-20-11-14-28(24(32)17-20)41-27-15-16-33-25-18-22(40-4)12-13-23(25)27/h6-18H,5,19H2,1-4H3,(H,34,38)
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2.30n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383184
PNG
(CHEMBL2031900)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C28H25N5O5/c1-17-26(28(35)33(32(17)2)18-8-6-5-7-9-18)27(34)31-25-11-10-19(16-30-25)38-22-12-13-29-21-15-24(37-4)23(36-3)14-20(21)22/h5-16H,1-4H3,(H,30,31,34)
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18n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383174
PNG
(CHEMBL2031910)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c([C@@H]5CCCN5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C30H28N6O4/c1-35-28(23-9-6-15-31-23)27(30(38)36(35)19-7-4-3-5-8-19)29(37)34-26-13-11-21(18-33-26)40-25-14-16-32-24-17-20(39-2)10-12-22(24)25/h3-5,7-8,10-14,16-18,23,31H,6,9,15H2,1-2H3,(H,33,34,37)/t23-/m0/s1
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22n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383169
PNG
(CHEMBL2032014)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(-c5ccncc5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C31H24N6O4/c1-36-29(20-12-15-32-16-13-20)28(31(39)37(36)21-6-4-3-5-7-21)30(38)35-27-11-9-23(19-34-27)41-26-14-17-33-25-18-22(40-2)8-10-24(25)26/h3-19H,1-2H3,(H,34,35,38)
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36n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383183
PNG
(CHEMBL2031901)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C27H23N5O4/c1-17-25(27(34)32(31(17)2)18-7-5-4-6-8-18)26(33)30-24-12-10-20(16-29-24)36-23-13-14-28-22-15-19(35-3)9-11-21(22)23/h4-16H,1-3H3,(H,29,30,33)
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42n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383184
PNG
(CHEMBL2031900)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C28H25N5O5/c1-17-26(28(35)33(32(17)2)18-8-6-5-7-9-18)27(34)31-25-11-10-19(16-30-25)38-22-12-13-29-21-15-24(37-4)23(36-3)14-20(21)22/h5-16H,1-4H3,(H,30,31,34)
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233n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383200
PNG
(CHEMBL2032026)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CCO)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C28H25N5O5/c1-18-26(28(36)33(32(18)14-15-34)19-6-4-3-5-7-19)27(35)31-25-11-9-21(17-30-25)38-24-12-13-29-23-16-20(37-2)8-10-22(23)24/h3-13,16-17,34H,14-15H2,1-2H3,(H,30,31,35)
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234n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383203
PNG
(CHEMBL2032022)
Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O4/c1-4-16-33-19(2)27(29(36)34(33)20-8-6-5-7-9-20)28(35)32-26-13-11-22(18-31-26)38-25-14-15-30-24-17-21(37-3)10-12-23(24)25/h5-15,17-18H,4,16H2,1-3H3,(H,31,32,35)
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309n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383199
PNG
(CHEMBL2032027)
Show SMILES COCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O5/c1-19-27(29(36)34(33(19)15-16-37-2)20-7-5-4-6-8-20)28(35)32-26-12-10-22(18-31-26)39-25-13-14-30-24-17-21(38-3)9-11-23(24)25/h4-14,17-18H,15-16H2,1-3H3,(H,31,32,35)
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325n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383204
PNG
(CHEMBL2032021)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C28H25N5O4/c1-4-32-18(2)26(28(35)33(32)19-8-6-5-7-9-19)27(34)31-25-13-11-21(17-30-25)37-24-14-15-29-23-16-20(36-3)10-12-22(23)24/h5-17H,4H2,1-3H3,(H,30,31,34)
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343n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383183
PNG
(CHEMBL2031901)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C27H23N5O4/c1-17-25(27(34)32(31(17)2)18-7-5-4-6-8-18)26(33)30-24-12-10-20(16-29-24)36-23-13-14-28-22-15-19(35-3)9-11-21(22)23/h4-16H,1-3H3,(H,29,30,33)
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618n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383204
PNG
(CHEMBL2032021)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C28H25N5O4/c1-4-32-18(2)26(28(35)33(32)19-8-6-5-7-9-19)27(34)31-25-13-11-21(17-30-25)37-24-14-15-29-23-16-20(36-3)10-12-22(23)24/h5-17H,4H2,1-3H3,(H,30,31,34)
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708n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383203
PNG
(CHEMBL2032022)
Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O4/c1-4-16-33-19(2)27(29(36)34(33)20-8-6-5-7-9-20)28(35)32-26-13-11-22(18-31-26)38-25-14-15-30-24-17-21(37-3)10-12-23(24)25/h5-15,17-18H,4,16H2,1-3H3,(H,31,32,35)
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730n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383179
PNG
(CHEMBL2031905)
Show SMILES CCN(C)Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30FN5O4/c1-5-35(2)19-26-29(31(39)37(36(26)3)21-9-7-6-8-10-21)30(38)34-20-11-14-28(24(32)17-20)41-27-15-16-33-25-18-22(40-4)12-13-23(25)27/h6-18H,5,19H2,1-4H3,(H,34,38)
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744n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383179
PNG
(CHEMBL2031905)
Show SMILES CCN(C)Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30FN5O4/c1-5-35(2)19-26-29(31(39)37(36(26)3)21-9-7-6-8-10-21)30(38)34-20-11-14-28(24(32)17-20)41-27-15-16-33-25-18-22(40-4)12-13-23(25)27/h6-18H,5,19H2,1-4H3,(H,34,38)
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903n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383198
PNG
(CHEMBL2032029)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C29H27N5O5/c1-18(35)17-33-19(2)27(29(37)34(33)20-7-5-4-6-8-20)28(36)32-26-12-10-22(16-31-26)39-25-13-14-30-24-15-21(38-3)9-11-23(24)25/h4-16,18,35H,17H2,1-3H3,(H,31,32,36)
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932n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383174
PNG
(CHEMBL2031910)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c([C@@H]5CCCN5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C30H28N6O4/c1-35-28(23-9-6-15-31-23)27(30(38)36(35)19-7-4-3-5-8-19)29(37)34-26-13-11-21(18-33-26)40-25-14-16-32-24-17-20(39-2)10-12-22(24)25/h3-5,7-8,10-14,16-18,23,31H,6,9,15H2,1-2H3,(H,33,34,37)/t23-/m0/s1
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948n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383200
PNG
(CHEMBL2032026)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CCO)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C28H25N5O5/c1-18-26(28(36)33(32(18)14-15-34)19-6-4-3-5-7-19)27(35)31-25-11-9-21(17-30-25)38-24-12-13-29-23-16-20(37-2)8-10-22(23)24/h3-13,16-17,34H,14-15H2,1-2H3,(H,30,31,35)
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1.10E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383198
PNG
(CHEMBL2032029)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C29H27N5O5/c1-18(35)17-33-19(2)27(29(37)34(33)20-7-5-4-6-8-20)28(36)32-26-12-10-22(16-31-26)39-25-13-14-30-24-15-21(38-3)9-11-23(24)25/h4-16,18,35H,17H2,1-3H3,(H,31,32,36)
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1.29E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383178
PNG
(CHEMBL2031906)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN5CCCC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C32H30FN5O4/c1-36-27(20-37-16-6-7-17-37)30(32(40)38(36)22-8-4-3-5-9-22)31(39)35-21-10-13-29(25(33)18-21)42-28-14-15-34-26-19-23(41-2)11-12-24(26)28/h3-5,8-15,18-19H,6-7,16-17,20H2,1-2H3,(H,35,39)
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1.31E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383178
PNG
(CHEMBL2031906)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN5CCCC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C32H30FN5O4/c1-36-27(20-37-16-6-7-17-37)30(32(40)38(36)22-8-4-3-5-9-22)31(39)35-21-10-13-29(25(33)18-21)42-28-14-15-34-26-19-23(41-2)11-12-24(26)28/h3-5,8-15,18-19H,6-7,16-17,20H2,1-2H3,(H,35,39)
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1.80E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383199
PNG
(CHEMBL2032027)
Show SMILES COCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O5/c1-19-27(29(36)34(33(19)15-16-37-2)20-7-5-4-6-8-20)28(35)32-26-12-10-22(18-31-26)39-25-13-14-30-24-17-21(38-3)9-11-23(24)25/h4-14,17-18H,15-16H2,1-3H3,(H,31,32,35)
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2.89E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383169
PNG
(CHEMBL2032014)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(-c5ccncc5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C31H24N6O4/c1-36-29(20-12-15-32-16-13-20)28(31(39)37(36)21-6-4-3-5-7-21)30(38)35-27-11-9-23(19-34-27)41-26-14-17-33-25-18-22(40-2)8-10-24(25)26/h3-19H,1-2H3,(H,34,35,38)
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>6.60E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383174
PNG
(CHEMBL2031910)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c([C@@H]5CCCN5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C30H28N6O4/c1-35-28(23-9-6-15-31-23)27(30(38)36(35)19-7-4-3-5-8-19)29(37)34-26-13-11-21(18-33-26)40-25-14-16-32-24-17-20(39-2)10-12-22(24)25/h3-5,7-8,10-14,16-18,23,31H,6,9,15H2,1-2H3,(H,33,34,37)/t23-/m0/s1
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>6.60E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383199
PNG
(CHEMBL2032027)
Show SMILES COCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O5/c1-19-27(29(36)34(33(19)15-16-37-2)20-7-5-4-6-8-20)28(35)32-26-12-10-22(18-31-26)39-25-13-14-30-24-17-21(38-3)9-11-23(24)25/h4-14,17-18H,15-16H2,1-3H3,(H,31,32,35)
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n/an/a 89n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383184
PNG
(CHEMBL2031900)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C28H25N5O5/c1-17-26(28(35)33(32(17)2)18-8-6-5-7-9-18)27(34)31-25-11-10-19(16-30-25)38-22-12-13-29-21-15-24(37-4)23(36-3)14-20(21)22/h5-16H,1-4H3,(H,30,31,34)
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n/an/a 71n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383198
PNG
(CHEMBL2032029)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C29H27N5O5/c1-18(35)17-33-19(2)27(29(37)34(33)20-7-5-4-6-8-20)28(36)32-26-12-10-22(16-31-26)39-25-13-14-30-24-15-21(38-3)9-11-23(24)25/h4-16,18,35H,17H2,1-3H3,(H,31,32,36)
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n/an/a 45n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383203
PNG
(CHEMBL2032022)
Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O4/c1-4-16-33-19(2)27(29(36)34(33)20-8-6-5-7-9-20)28(35)32-26-13-11-22(18-31-26)38-25-14-15-30-24-17-21(37-3)10-12-23(24)25/h5-15,17-18H,4,16H2,1-3H3,(H,31,32,35)
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n/an/a 70n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383179
PNG
(CHEMBL2031905)
Show SMILES CCN(C)Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30FN5O4/c1-5-35(2)19-26-29(31(39)37(36(26)3)21-9-7-6-8-10-21)30(38)34-20-11-14-28(24(32)17-20)41-27-15-16-33-25-18-22(40-4)12-13-23(25)27/h6-18H,5,19H2,1-4H3,(H,34,38)
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n/an/a 77n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383204
PNG
(CHEMBL2032021)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C28H25N5O4/c1-4-32-18(2)26(28(35)33(32)19-8-6-5-7-9-19)27(34)31-25-13-11-21(17-30-25)37-24-14-15-29-23-16-20(36-3)10-12-22(23)24/h5-17H,4H2,1-3H3,(H,30,31,34)
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n/an/a 106n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383178
PNG
(CHEMBL2031906)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN5CCCC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C32H30FN5O4/c1-36-27(20-37-16-6-7-17-37)30(32(40)38(36)22-8-4-3-5-9-22)31(39)35-21-10-13-29(25(33)18-21)42-28-14-15-34-26-19-23(41-2)11-12-24(26)28/h3-5,8-15,18-19H,6-7,16-17,20H2,1-2H3,(H,35,39)
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n/an/a 84n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383200
PNG
(CHEMBL2032026)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CCO)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C28H25N5O5/c1-18-26(28(36)33(32(18)14-15-34)19-6-4-3-5-7-19)27(35)31-25-11-9-21(17-30-25)38-24-12-13-29-23-16-20(37-2)8-10-22(23)24/h3-13,16-17,34H,14-15H2,1-2H3,(H,30,31,35)
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n/an/a 96n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383169
PNG
(CHEMBL2032014)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(-c5ccncc5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C31H24N6O4/c1-36-29(20-12-15-32-16-13-20)28(31(39)37(36)21-6-4-3-5-7-21)30(38)35-27-11-9-23(19-34-27)41-26-14-17-33-25-18-22(40-2)8-10-24(25)26/h3-19H,1-2H3,(H,34,35,38)
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383183
PNG
(CHEMBL2031901)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C27H23N5O4/c1-17-25(27(34)32(31(17)2)18-7-5-4-6-8-18)26(33)30-24-12-10-20(16-29-24)36-23-13-14-28-22-15-19(35-3)9-11-21(22)23/h4-16H,1-3H3,(H,29,30,33)
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n/an/a 83n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair