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6 similar compounds to monomer 50383175

Compile data set for download or QSAR
Wt: 536.5
BDBM50383174
Wt: 541.5
BDBM50383176
Wt: 567.6
BDBM50383178
Wt: 555.5
BDBM50383179
Wt: 613.6
BDBM50383180
Wt: 513.5
BDBM50383181

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50383174,50383176,50383178,50383179,50383180,50383181   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383181
PNG
(CHEMBL2031903)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C28H24FN5O4/c1-33-23(16-30)26(28(36)34(33)18-6-4-3-5-7-18)27(35)32-17-8-11-25(21(29)14-17)38-24-12-13-31-22-15-19(37-2)9-10-20(22)24/h3-15H,16,30H2,1-2H3,(H,32,35)
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1.40n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383178
PNG
(CHEMBL2031906)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN5CCCC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C32H30FN5O4/c1-36-27(20-37-16-6-7-17-37)30(32(40)38(36)22-8-4-3-5-9-22)31(39)35-21-10-13-29(25(33)18-21)42-28-14-15-34-26-19-23(41-2)11-12-24(26)28/h3-5,8-15,18-19H,6-7,16-17,20H2,1-2H3,(H,35,39)
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1.5n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383179
PNG
(CHEMBL2031905)
Show SMILES CCN(C)Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30FN5O4/c1-5-35(2)19-26-29(31(39)37(36(26)3)21-9-7-6-8-10-21)30(38)34-20-11-14-28(24(32)17-20)41-27-15-16-33-25-18-22(40-4)12-13-23(25)27/h6-18H,5,19H2,1-4H3,(H,34,38)
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2.30n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383174
PNG
(CHEMBL2031910)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c([C@@H]5CCCN5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C30H28N6O4/c1-35-28(23-9-6-15-31-23)27(30(38)36(35)19-7-4-3-5-8-19)29(37)34-26-13-11-21(18-33-26)40-25-14-16-32-24-17-20(39-2)10-12-22(24)25/h3-5,7-8,10-14,16-18,23,31H,6,9,15H2,1-2H3,(H,33,34,37)/t23-/m0/s1
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22n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383176
PNG
(CHEMBL2031908)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(n(C)n(-c5ccccc5)c4=O)C(C)(C)N)cc3F)ccnc2c1
Show InChI InChI=1S/C30H28FN5O4/c1-30(2,32)27-26(29(38)36(35(27)3)19-8-6-5-7-9-19)28(37)34-18-10-13-25(22(31)16-18)40-24-14-15-33-23-17-20(39-4)11-12-21(23)24/h5-17H,32H2,1-4H3,(H,34,37)
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28n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383180
PNG
(CHEMBL2031904)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CNC(=O)OC(C)(C)C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C33H32FN5O6/c1-33(2,3)45-32(42)36-19-26-29(31(41)39(38(26)4)21-9-7-6-8-10-21)30(40)37-20-11-14-28(24(34)17-20)44-27-15-16-35-25-18-22(43-5)12-13-23(25)27/h6-18H,19H2,1-5H3,(H,36,42)(H,37,40)
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29n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383181
PNG
(CHEMBL2031903)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C28H24FN5O4/c1-33-23(16-30)26(28(36)34(33)18-6-4-3-5-7-18)27(35)32-17-8-11-25(21(29)14-17)38-24-12-13-31-22-15-19(37-2)9-10-20(22)24/h3-15H,16,30H2,1-2H3,(H,32,35)
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541n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383179
PNG
(CHEMBL2031905)
Show SMILES CCN(C)Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30FN5O4/c1-5-35(2)19-26-29(31(39)37(36(26)3)21-9-7-6-8-10-21)30(38)34-20-11-14-28(24(32)17-20)41-27-15-16-33-25-18-22(40-4)12-13-23(25)27/h6-18H,5,19H2,1-4H3,(H,34,38)
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744n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383179
PNG
(CHEMBL2031905)
Show SMILES CCN(C)Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30FN5O4/c1-5-35(2)19-26-29(31(39)37(36(26)3)21-9-7-6-8-10-21)30(38)34-20-11-14-28(24(32)17-20)41-27-15-16-33-25-18-22(40-4)12-13-23(25)27/h6-18H,5,19H2,1-4H3,(H,34,38)
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903n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383181
PNG
(CHEMBL2031903)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C28H24FN5O4/c1-33-23(16-30)26(28(36)34(33)18-6-4-3-5-7-18)27(35)32-17-8-11-25(21(29)14-17)38-24-12-13-31-22-15-19(37-2)9-10-20(22)24/h3-15H,16,30H2,1-2H3,(H,32,35)
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928n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383174
PNG
(CHEMBL2031910)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c([C@@H]5CCCN5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C30H28N6O4/c1-35-28(23-9-6-15-31-23)27(30(38)36(35)19-7-4-3-5-8-19)29(37)34-26-13-11-21(18-33-26)40-25-14-16-32-24-17-20(39-2)10-12-22(24)25/h3-5,7-8,10-14,16-18,23,31H,6,9,15H2,1-2H3,(H,33,34,37)/t23-/m0/s1
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948n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383180
PNG
(CHEMBL2031904)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CNC(=O)OC(C)(C)C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C33H32FN5O6/c1-33(2,3)45-32(42)36-19-26-29(31(41)39(38(26)4)21-9-7-6-8-10-21)30(40)37-20-11-14-28(24(34)17-20)44-27-15-16-35-25-18-22(43-5)12-13-23(25)27/h6-18H,19H2,1-5H3,(H,36,42)(H,37,40)
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1.24E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383178
PNG
(CHEMBL2031906)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN5CCCC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C32H30FN5O4/c1-36-27(20-37-16-6-7-17-37)30(32(40)38(36)22-8-4-3-5-9-22)31(39)35-21-10-13-29(25(33)18-21)42-28-14-15-34-26-19-23(41-2)11-12-24(26)28/h3-5,8-15,18-19H,6-7,16-17,20H2,1-2H3,(H,35,39)
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1.31E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383178
PNG
(CHEMBL2031906)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN5CCCC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C32H30FN5O4/c1-36-27(20-37-16-6-7-17-37)30(32(40)38(36)22-8-4-3-5-9-22)31(39)35-21-10-13-29(25(33)18-21)42-28-14-15-34-26-19-23(41-2)11-12-24(26)28/h3-5,8-15,18-19H,6-7,16-17,20H2,1-2H3,(H,35,39)
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1.80E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383176
PNG
(CHEMBL2031908)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(n(C)n(-c5ccccc5)c4=O)C(C)(C)N)cc3F)ccnc2c1
Show InChI InChI=1S/C30H28FN5O4/c1-30(2,32)27-26(29(38)36(35(27)3)19-8-6-5-7-9-19)28(37)34-18-10-13-25(22(31)16-18)40-24-14-15-33-23-17-20(39-4)11-12-21(23)24/h5-17H,32H2,1-4H3,(H,34,37)
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3.10E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383176
PNG
(CHEMBL2031908)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(n(C)n(-c5ccccc5)c4=O)C(C)(C)N)cc3F)ccnc2c1
Show InChI InChI=1S/C30H28FN5O4/c1-30(2,32)27-26(29(38)36(35(27)3)19-8-6-5-7-9-19)28(37)34-18-10-13-25(22(31)16-18)40-24-14-15-33-23-17-20(39-4)11-12-21(23)24/h5-17H,32H2,1-4H3,(H,34,37)
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3.35E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383180
PNG
(CHEMBL2031904)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CNC(=O)OC(C)(C)C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C33H32FN5O6/c1-33(2,3)45-32(42)36-19-26-29(31(41)39(38(26)4)21-9-7-6-8-10-21)30(40)37-20-11-14-28(24(34)17-20)44-27-15-16-35-25-18-22(43-5)12-13-23(25)27/h6-18H,19H2,1-5H3,(H,36,42)(H,37,40)
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>6.60E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383174
PNG
(CHEMBL2031910)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c([C@@H]5CCCN5)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C30H28N6O4/c1-35-28(23-9-6-15-31-23)27(30(38)36(35)19-7-4-3-5-8-19)29(37)34-26-13-11-21(18-33-26)40-25-14-16-32-24-17-20(39-2)10-12-22(24)25/h3-5,7-8,10-14,16-18,23,31H,6,9,15H2,1-2H3,(H,33,34,37)/t23-/m0/s1
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>6.60E+3n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383181
PNG
(CHEMBL2031903)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C28H24FN5O4/c1-33-23(16-30)26(28(36)34(33)18-6-4-3-5-7-18)27(35)32-17-8-11-25(21(29)14-17)38-24-12-13-31-22-15-19(37-2)9-10-20(22)24/h3-15H,16,30H2,1-2H3,(H,32,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383178
PNG
(CHEMBL2031906)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(CN5CCCC5)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
Show InChI InChI=1S/C32H30FN5O4/c1-36-27(20-37-16-6-7-17-37)30(32(40)38(36)22-8-4-3-5-9-22)31(39)35-21-10-13-29(25(33)18-21)42-28-14-15-34-26-19-23(41-2)11-12-24(26)28/h3-5,8-15,18-19H,6-7,16-17,20H2,1-2H3,(H,35,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 84n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383179
PNG
(CHEMBL2031905)
Show SMILES CCN(C)Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30FN5O4/c1-5-35(2)19-26-29(31(39)37(36(26)3)21-9-7-6-8-10-21)30(38)34-20-11-14-28(24(32)17-20)41-27-15-16-33-25-18-22(40-4)12-13-23(25)27/h6-18H,5,19H2,1-4H3,(H,34,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 77n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair