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4 similar compounds to monomer 50383182

Compile data set for download or QSAR
Wt: 481.5
BDBM50383183
Wt: 511.5
BDBM50383184
Wt: 509.5
BDBM50383203
Wt: 495.5
BDBM50383204

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50383183,50383184,50383203,50383204   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383203
PNG
(CHEMBL2032022)
Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O4/c1-4-16-33-19(2)27(29(36)34(33)20-8-6-5-7-9-20)28(35)32-26-13-11-22(18-31-26)38-25-14-15-30-24-17-21(37-3)10-12-23(24)25/h5-15,17-18H,4,16H2,1-3H3,(H,31,32,35)
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1.10n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383183
PNG
(CHEMBL2031901)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C27H23N5O4/c1-17-25(27(34)32(31(17)2)18-7-5-4-6-8-18)26(33)30-24-12-10-20(16-29-24)36-23-13-14-28-22-15-19(35-3)9-11-21(22)23/h4-16H,1-3H3,(H,29,30,33)
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1.20n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383204
PNG
(CHEMBL2032021)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C28H25N5O4/c1-4-32-18(2)26(28(35)33(32)19-8-6-5-7-9-19)27(34)31-25-13-11-21(17-30-25)37-24-14-15-29-23-16-20(36-3)10-12-22(23)24/h5-17H,4H2,1-3H3,(H,30,31,34)
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1.60n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383184
PNG
(CHEMBL2031900)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C28H25N5O5/c1-17-26(28(35)33(32(17)2)18-8-6-5-7-9-18)27(34)31-25-11-10-19(16-30-25)38-22-12-13-29-21-15-24(37-4)23(36-3)14-20(21)22/h5-16H,1-4H3,(H,30,31,34)
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1.90n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383184
PNG
(CHEMBL2031900)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C28H25N5O5/c1-17-26(28(35)33(32(17)2)18-8-6-5-7-9-18)27(34)31-25-11-10-19(16-30-25)38-22-12-13-29-21-15-24(37-4)23(36-3)14-20(21)22/h5-16H,1-4H3,(H,30,31,34)
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18n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383183
PNG
(CHEMBL2031901)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C27H23N5O4/c1-17-25(27(34)32(31(17)2)18-7-5-4-6-8-18)26(33)30-24-12-10-20(16-29-24)36-23-13-14-28-22-15-19(35-3)9-11-21(22)23/h4-16H,1-3H3,(H,29,30,33)
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42n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383184
PNG
(CHEMBL2031900)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C28H25N5O5/c1-17-26(28(35)33(32(17)2)18-8-6-5-7-9-18)27(34)31-25-11-10-19(16-30-25)38-22-12-13-29-21-15-24(37-4)23(36-3)14-20(21)22/h5-16H,1-4H3,(H,30,31,34)
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233n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383203
PNG
(CHEMBL2032022)
Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O4/c1-4-16-33-19(2)27(29(36)34(33)20-8-6-5-7-9-20)28(35)32-26-13-11-22(18-31-26)38-25-14-15-30-24-17-21(37-3)10-12-23(24)25/h5-15,17-18H,4,16H2,1-3H3,(H,31,32,35)
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309n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50383204
PNG
(CHEMBL2032021)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C28H25N5O4/c1-4-32-18(2)26(28(35)33(32)19-8-6-5-7-9-19)27(34)31-25-13-11-21(17-30-25)37-24-14-15-29-23-16-20(36-3)10-12-22(23)24/h5-17H,4H2,1-3H3,(H,30,31,34)
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343n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383183
PNG
(CHEMBL2031901)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C27H23N5O4/c1-17-25(27(34)32(31(17)2)18-7-5-4-6-8-18)26(33)30-24-12-10-20(16-29-24)36-23-13-14-28-22-15-19(35-3)9-11-21(22)23/h4-16H,1-3H3,(H,29,30,33)
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618n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383204
PNG
(CHEMBL2032021)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C28H25N5O4/c1-4-32-18(2)26(28(35)33(32)19-8-6-5-7-9-19)27(34)31-25-13-11-21(17-30-25)37-24-14-15-29-23-16-20(36-3)10-12-22(23)24/h5-17H,4H2,1-3H3,(H,30,31,34)
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708n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50383203
PNG
(CHEMBL2032022)
Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O4/c1-4-16-33-19(2)27(29(36)34(33)20-8-6-5-7-9-20)28(35)32-26-13-11-22(18-31-26)38-25-14-15-30-24-17-21(37-3)10-12-23(24)25/h5-15,17-18H,4,16H2,1-3H3,(H,31,32,35)
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730n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383204
PNG
(CHEMBL2032021)
Show SMILES CCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C28H25N5O4/c1-4-32-18(2)26(28(35)33(32)19-8-6-5-7-9-19)27(34)31-25-13-11-21(17-30-25)37-24-14-15-29-23-16-20(36-3)10-12-22(23)24/h5-17H,4H2,1-3H3,(H,30,31,34)
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n/an/a 106n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383183
PNG
(CHEMBL2031901)
Show SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)ccnc2c1
Show InChI InChI=1S/C27H23N5O4/c1-17-25(27(34)32(31(17)2)18-7-5-4-6-8-18)26(33)30-24-12-10-20(16-29-24)36-23-13-14-28-22-15-19(35-3)9-11-21(22)23/h4-16H,1-3H3,(H,29,30,33)
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n/an/a 83n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383184
PNG
(CHEMBL2031900)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C28H25N5O5/c1-17-26(28(35)33(32(17)2)18-8-6-5-7-9-18)27(34)31-25-11-10-19(16-30-25)38-22-12-13-29-21-15-24(37-4)23(36-3)14-20(21)22/h5-16H,1-4H3,(H,30,31,34)
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n/an/a 71n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50383203
PNG
(CHEMBL2032022)
Show SMILES CCCn1c(C)c(C(=O)Nc2ccc(Oc3ccnc4cc(OC)ccc34)cn2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C29H27N5O4/c1-4-16-33-19(2)27(29(36)34(33)20-8-6-5-7-9-20)28(35)32-26-13-11-22(18-31-26)38-25-14-15-30-24-17-21(37-3)10-12-23(24)25/h5-15,17-18H,4,16H2,1-3H3,(H,31,32,35)
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n/an/a 70n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met by HTRF assay


J Med Chem 55: 1868-97 (2012)


Article DOI: 10.1021/jm201331s
BindingDB Entry DOI: 10.7270/Q23B616C
More data for this
Ligand-Target Pair