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13 similar compounds to monomer 50401152

Compile data set for download or QSAR
Wt: 332.3
BDBM50389428
Wt: 346.4
BDBM50387529
Wt: 364.3
BDBM50401150
Wt: 332.3
BDBM50401151
Wt: 372.3
BDBM50401153
Wt: 366.3
BDBM50401142
Wt: 304.3
BDBM50401143
Wt: 346.4
BDBM50401144
Wt: 380.4
BDBM50401145
Wt: 358.4
BDBM50401146
Wt: 400.3
BDBM50401147
Wt: 332.3
BDBM50401148
Wt: 290.3
BDBM50401149

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 58 hits for monomerid = 50389428,50387529,50401150,50401151,50401153,50401142,50401143,50401144,50401145,50401146,50401147,50401148,50401149   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50401151
PNG
(CHEMBL2205764)
Show SMILES CCCNS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C14H16N6O2S/c1-2-4-17-23(21,22)12-6-11(8-16-9-12)10-3-5-20-13(7-10)18-14(15)19-20/h3,5-9,17H,2,4H2,1H3,(H2,15,19)
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n/an/a>2.00E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kdelta assessed as change in pIC50 by kinobeads assay


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50387529
PNG
(CHEMBL2059909)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(N)nn2c1
Show InChI InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(7-17-8-12)10-4-5-13-18-14(16)19-21(13)9-10/h4-9,20H,1-3H3,(H2,16,19)
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n/an/a 2.51E+3n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha in human HL60 cell lysate by kinobead assay


Bioorg Med Chem Lett 22: 4546-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.121
BindingDB Entry DOI: 10.7270/Q2J38TMN
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50401143
PNG
(CHEMBL2205774)
Show SMILES CNS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C12H12N6O2S/c1-14-21(19,20)10-4-9(6-15-7-10)8-2-3-18-11(5-8)16-12(13)17-18/h2-7,14H,1H3,(H2,13,17)
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n/an/a 2.51E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cd


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401144
PNG
(CHEMBL2205771)
Show SMILES CCN(CC)S(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C15H18N6O2S/c1-3-20(4-2)24(22,23)13-7-12(9-17-10-13)11-5-6-21-14(8-11)18-15(16)19-21/h5-10H,3-4H2,1-2H3,(H2,16,19)
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n/an/a 2.51E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401145
PNG
(CHEMBL2205770)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C18H16N6O2S/c19-18-22-17-9-14(6-7-24(17)23-18)15-8-16(12-20-11-15)27(25,26)21-10-13-4-2-1-3-5-13/h1-9,11-12,21H,10H2,(H2,19,23)
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n/an/a 2.51E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50401146
PNG
(CHEMBL2205772)
Show SMILES CC1(C)CCN1S(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C16H18N6O2S/c1-16(2)4-6-22(16)25(23,24)13-7-12(9-18-10-13)11-3-5-21-14(8-11)19-15(17)20-21/h3,5,7-10H,4,6H2,1-2H3,(H2,17,20)
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n/an/a 3.16E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cd


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50401147
PNG
(CHEMBL2205768)
Show SMILES CC(C)(NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1)C(F)(F)F
Show InChI InChI=1S/C15H15F3N6O2S/c1-14(2,15(16,17)18)23-27(25,26)11-5-10(7-20-8-11)9-3-4-24-12(6-9)21-13(19)22-24/h3-8,23H,1-2H3,(H2,19,22)
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n/an/a 3.16E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cd


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50401148
PNG
(CHEMBL2205765)
Show SMILES CC(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C14H16N6O2S/c1-9(2)19-23(21,22)12-5-11(7-16-8-12)10-3-4-20-13(6-10)17-14(15)18-20/h3-9,19H,1-2H3,(H2,15,18)
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n/an/a 3.16E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cd


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50401149
PNG
(CHEMBL2205773)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(N)(=O)=O
Show InChI InChI=1S/C11H10N6O2S/c12-11-15-10-4-7(1-2-17(10)16-11)8-3-9(6-14-5-8)20(13,18)19/h1-6H,(H2,12,16)(H2,13,18,19)
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n/an/a 3.16E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cd


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401150
PNG
(CHEMBL2205763)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1cc(F)n2nc(N)nc2c1
Show InChI InChI=1S/C15H17FN6O2S/c1-15(2,3)21-25(23,24)11-4-10(7-18-8-11)9-5-12(16)22-13(6-9)19-14(17)20-22/h4-8,21H,1-3H3,(H2,17,20)
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n/an/a 3.16E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401142
PNG
(CHEMBL2205769)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C17H14N6O2S/c18-17-20-16-9-12(6-7-23(16)21-17)13-8-15(11-19-10-13)26(24,25)22-14-4-2-1-3-5-14/h1-11,22H,(H2,18,21)
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n/an/a 3.16E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401147
PNG
(CHEMBL2205768)
Show SMILES CC(C)(NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1)C(F)(F)F
Show InChI InChI=1S/C15H15F3N6O2S/c1-14(2,15(16,17)18)23-27(25,26)11-5-10(7-20-8-11)9-3-4-24-12(6-9)21-13(19)22-24/h3-8,23H,1-2H3,(H2,19,22)
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n/an/a 3.16E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401151
PNG
(CHEMBL2205764)
Show SMILES CCCNS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C14H16N6O2S/c1-2-4-17-23(21,22)12-6-11(8-16-9-12)10-3-5-20-13(7-10)18-14(15)19-20/h3,5-9,17H,2,4H2,1H3,(H2,15,19)
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n/an/a 3.16E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401143
PNG
(CHEMBL2205774)
Show SMILES CNS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C12H12N6O2S/c1-14-21(19,20)10-4-9(6-15-7-10)8-2-3-18-11(5-8)16-12(13)17-18/h2-7,14H,1H3,(H2,13,17)
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n/an/a 3.98E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401149
PNG
(CHEMBL2205773)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(N)(=O)=O
Show InChI InChI=1S/C11H10N6O2S/c12-11-15-10-4-7(1-2-17(10)16-11)8-3-9(6-14-5-8)20(13,18)19/h1-6H,(H2,12,16)(H2,13,18,19)
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n/an/a 3.98E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401142
PNG
(CHEMBL2205769)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C17H14N6O2S/c18-17-20-16-9-12(6-7-23(16)21-17)13-8-15(11-19-10-13)26(24,25)22-14-4-2-1-3-5-14/h1-11,22H,(H2,18,21)
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n/an/a 3.98E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401146
PNG
(CHEMBL2205772)
Show SMILES CC1(C)CCN1S(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C16H18N6O2S/c1-16(2)4-6-22(16)25(23,24)13-7-12(9-18-10-13)11-3-5-21-14(8-11)19-15(17)20-21/h3,5,7-10H,4,6H2,1-2H3,(H2,17,20)
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n/an/a 5.01E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401144
PNG
(CHEMBL2205771)
Show SMILES CCN(CC)S(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C15H18N6O2S/c1-3-20(4-2)24(22,23)13-7-12(9-17-10-13)11-5-6-21-14(8-11)18-15(16)19-21/h5-10H,3-4H2,1-2H3,(H2,16,19)
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n/an/a 7.90n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401150
PNG
(CHEMBL2205763)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1cc(F)n2nc(N)nc2c1
Show InChI InChI=1S/C15H17FN6O2S/c1-15(2,3)21-25(23,24)11-4-10(7-18-8-11)9-5-12(16)22-13(6-9)19-14(17)20-22/h4-8,21H,1-3H3,(H2,17,20)
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n/an/a 16n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401147
PNG
(CHEMBL2205768)
Show SMILES CC(C)(NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1)C(F)(F)F
Show InChI InChI=1S/C15H15F3N6O2S/c1-14(2,15(16,17)18)23-27(25,26)11-5-10(7-20-8-11)9-3-4-24-12(6-9)21-13(19)22-24/h3-8,23H,1-2H3,(H2,19,22)
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n/an/a 20n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401153
PNG
(CHEMBL2205767)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)NCC(F)(F)F
Show InChI InChI=1S/C13H11F3N6O2S/c14-13(15,16)7-19-25(23,24)10-3-9(5-18-6-10)8-1-2-22-11(4-8)20-12(17)21-22/h1-6,19H,7H2,(H2,17,21)
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n/an/a 20n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401146
PNG
(CHEMBL2205772)
Show SMILES CC1(C)CCN1S(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C16H18N6O2S/c1-16(2)4-6-22(16)25(23,24)13-7-12(9-18-10-13)11-3-5-21-14(8-11)19-15(17)20-21/h3,5,7-10H,4,6H2,1-2H3,(H2,17,20)
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n/an/a 25n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401148
PNG
(CHEMBL2205765)
Show SMILES CC(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C14H16N6O2S/c1-9(2)19-23(21,22)12-5-11(7-16-8-12)10-3-4-20-13(6-10)17-14(15)18-20/h3-9,19H,1-2H3,(H2,15,18)
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n/an/a 25n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401143
PNG
(CHEMBL2205774)
Show SMILES CNS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C12H12N6O2S/c1-14-21(19,20)10-4-9(6-15-7-10)8-2-3-18-11(5-8)16-12(13)17-18/h2-7,14H,1H3,(H2,13,17)
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n/an/a 25n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401151
PNG
(CHEMBL2205764)
Show SMILES CCCNS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C14H16N6O2S/c1-2-4-17-23(21,22)12-6-11(8-16-9-12)10-3-5-20-13(7-10)18-14(15)19-20/h3,5-9,17H,2,4H2,1H3,(H2,15,19)
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n/an/a 32n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401142
PNG
(CHEMBL2205769)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C17H14N6O2S/c18-17-20-16-9-12(6-7-23(16)21-17)13-8-15(11-19-10-13)26(24,25)22-14-4-2-1-3-5-14/h1-11,22H,(H2,18,21)
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n/an/a 40n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401145
PNG
(CHEMBL2205770)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C18H16N6O2S/c19-18-22-17-9-14(6-7-24(17)23-18)15-8-16(12-20-11-15)27(25,26)21-10-13-4-2-1-3-5-13/h1-9,11-12,21H,10H2,(H2,19,23)
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n/an/a 100n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401150
PNG
(CHEMBL2205763)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1cc(F)n2nc(N)nc2c1
Show InChI InChI=1S/C15H17FN6O2S/c1-15(2,3)21-25(23,24)11-4-10(7-18-8-11)9-5-12(16)22-13(6-9)19-14(17)20-22/h4-8,21H,1-3H3,(H2,17,20)
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n/an/a 3.98E+6n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50401150
PNG
(CHEMBL2205763)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1cc(F)n2nc(N)nc2c1
Show InChI InChI=1S/C15H17FN6O2S/c1-15(2,3)21-25(23,24)11-4-10(7-18-8-11)9-5-12(16)22-13(6-9)19-14(17)20-22/h4-8,21H,1-3H3,(H2,17,20)
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n/an/a 7.94E+6n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cd


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50401153
PNG
(CHEMBL2205767)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)NCC(F)(F)F
Show InChI InChI=1S/C13H11F3N6O2S/c14-13(15,16)7-19-25(23,24)10-3-9(5-18-6-10)8-1-2-22-11(4-8)20-12(17)21-22/h1-6,19H,7H2,(H2,17,21)
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n/an/a 7.94E+6n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cd


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401144
PNG
(CHEMBL2205771)
Show SMILES CCN(CC)S(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C15H18N6O2S/c1-3-20(4-2)24(22,23)13-7-12(9-17-10-13)11-5-6-21-14(8-11)18-15(16)19-21/h5-10H,3-4H2,1-2H3,(H2,16,19)
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n/an/a 7.94E+6n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401153
PNG
(CHEMBL2205767)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)NCC(F)(F)F
Show InChI InChI=1S/C13H11F3N6O2S/c14-13(15,16)7-19-25(23,24)10-3-9(5-18-6-10)8-1-2-22-11(4-8)20-12(17)21-22/h1-6,19H,7H2,(H2,17,21)
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n/an/a 7.94E+6n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401145
PNG
(CHEMBL2205770)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C18H16N6O2S/c19-18-22-17-9-14(6-7-24(17)23-18)15-8-16(12-20-11-15)27(25,26)21-10-13-4-2-1-3-5-13/h1-9,11-12,21H,10H2,(H2,19,23)
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n/an/a 1.00E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401147
PNG
(CHEMBL2205768)
Show SMILES CC(C)(NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1)C(F)(F)F
Show InChI InChI=1S/C15H15F3N6O2S/c1-14(2,15(16,17)18)23-27(25,26)11-5-10(7-20-8-11)9-3-4-24-12(6-9)21-13(19)22-24/h3-8,23H,1-2H3,(H2,19,22)
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n/an/a 1.00E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50401144
PNG
(CHEMBL2205771)
Show SMILES CCN(CC)S(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C15H18N6O2S/c1-3-20(4-2)24(22,23)13-7-12(9-17-10-13)11-5-6-21-14(8-11)18-15(16)19-21/h5-10H,3-4H2,1-2H3,(H2,16,19)
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n/an/a 1.26E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cd


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401153
PNG
(CHEMBL2205767)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)NCC(F)(F)F
Show InChI InChI=1S/C13H11F3N6O2S/c14-13(15,16)7-19-25(23,24)10-3-9(5-18-6-10)8-1-2-22-11(4-8)20-12(17)21-22/h1-6,19H,7H2,(H2,17,21)
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n/an/a 1.26E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401146
PNG
(CHEMBL2205772)
Show SMILES CC1(C)CCN1S(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C16H18N6O2S/c1-16(2)4-6-22(16)25(23,24)13-7-12(9-18-10-13)11-3-5-21-14(8-11)19-15(17)20-21/h3,5,7-10H,4,6H2,1-2H3,(H2,17,20)
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n/an/a 1.26E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401148
PNG
(CHEMBL2205765)
Show SMILES CC(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C14H16N6O2S/c1-9(2)19-23(21,22)12-5-11(7-16-8-12)10-3-4-20-13(6-10)17-14(15)18-20/h3-9,19H,1-2H3,(H2,15,18)
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n/an/a 1.26E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401151
PNG
(CHEMBL2205764)
Show SMILES CCCNS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C14H16N6O2S/c1-2-4-17-23(21,22)12-6-11(8-16-9-12)10-3-5-20-13(7-10)18-14(15)19-20/h3,5-9,17H,2,4H2,1H3,(H2,15,19)
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n/an/a 1.26E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401143
PNG
(CHEMBL2205774)
Show SMILES CNS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C12H12N6O2S/c1-14-21(19,20)10-4-9(6-15-7-10)8-2-3-18-11(5-8)16-12(13)17-18/h2-7,14H,1H3,(H2,13,17)
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n/an/a 1.26E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50401149
PNG
(CHEMBL2205773)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(N)(=O)=O
Show InChI InChI=1S/C11H10N6O2S/c12-11-15-10-4-7(1-2-17(10)16-11)8-3-9(6-14-5-8)20(13,18)19/h1-6H,(H2,12,16)(H2,13,18,19)
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n/an/a 1.58E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Ca


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50401149
PNG
(CHEMBL2205773)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(N)(=O)=O
Show InChI InChI=1S/C11H10N6O2S/c12-11-15-10-4-7(1-2-17(10)16-11)8-3-9(6-14-5-8)20(13,18)19/h1-6H,(H2,12,16)(H2,13,18,19)
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n/an/a 20n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cg


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50401145
PNG
(CHEMBL2205770)
Show SMILES Nc1nc2cc(ccn2n1)-c1cncc(c1)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C18H16N6O2S/c19-18-22-17-9-14(6-7-24(17)23-18)15-8-16(12-20-11-15)27(25,26)21-10-13-4-2-1-3-5-13/h1-9,11-12,21H,10H2,(H2,19,23)
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n/an/a 2.00E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cd


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50401148
PNG
(CHEMBL2205765)
Show SMILES CC(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1
Show InChI InChI=1S/C14H16N6O2S/c1-9(2)19-23(21,22)12-5-11(7-16-8-12)10-3-4-20-13(6-10)17-14(15)18-20/h3-9,19H,1-2H3,(H2,15,18)
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n/an/a 6.31E+7n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PIK3Cb


Bioorg Med Chem Lett 22: 4613-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50387529
PNG
(CHEMBL2059909)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(N)nn2c1
Show InChI InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(7-17-8-12)10-4-5-13-18-14(16)19-21(13)9-10/h4-9,20H,1-3H3,(H2,16,19)
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n/an/a 25.1n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma by high throughput chemoproteomics binding assay


Bioorg Med Chem Lett 22: 5257-63 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.049
BindingDB Entry DOI: 10.7270/Q2CR5VFP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50387529
PNG
(CHEMBL2059909)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(N)nn2c1
Show InChI InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(7-17-8-12)10-4-5-13-18-14(16)19-21(13)9-10/h4-9,20H,1-3H3,(H2,16,19)
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n/an/a 1.58E+3n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kdelta by high throughput chemoproteomics binding assay


Bioorg Med Chem Lett 22: 5257-63 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.049
BindingDB Entry DOI: 10.7270/Q2CR5VFP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50389428
PNG
(CHEMBL2064511)
Show SMILES CC(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(N)nn2c1
Show InChI InChI=1S/C14H16N6O2S/c1-9(2)19-23(21,22)12-5-11(6-16-7-12)10-3-4-13-17-14(15)18-20(13)8-10/h3-9,19H,1-2H3,(H2,15,18)
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n/an/a 1.58E+3n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kdelta by high throughput chemoproteomics binding assay


Bioorg Med Chem Lett 22: 5257-63 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.049
BindingDB Entry DOI: 10.7270/Q2CR5VFP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50389428
PNG
(CHEMBL2064511)
Show SMILES CC(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(N)nn2c1
Show InChI InChI=1S/C14H16N6O2S/c1-9(2)19-23(21,22)12-5-11(6-16-7-12)10-3-4-13-17-14(15)18-20(13)8-10/h3-9,19H,1-2H3,(H2,15,18)
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n/an/a 2.51E+3n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by high throughput chemoproteomics binding assay


Bioorg Med Chem Lett 22: 5257-63 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.049
BindingDB Entry DOI: 10.7270/Q2CR5VFP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50387529
PNG
(CHEMBL2059909)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(N)nn2c1
Show InChI InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(7-17-8-12)10-4-5-13-18-14(16)19-21(13)9-10/h4-9,20H,1-3H3,(H2,16,19)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma assessed as inhibition of C5a-induced AKT phosphorylation at Ser473 by cell based assay


Bioorg Med Chem Lett 22: 5257-63 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.049
BindingDB Entry DOI: 10.7270/Q2CR5VFP
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50387529
PNG
(CHEMBL2059909)
Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccc2nc(N)nn2c1
Show InChI InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(7-17-8-12)10-4-5-13-18-14(16)19-21(13)9-10/h4-9,20H,1-3H3,(H2,16,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Cellzome Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma assessed as inhibition of fMLP-induced neutrophil migration assay by cell based assay


Bioorg Med Chem Lett 22: 5257-63 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.049
BindingDB Entry DOI: 10.7270/Q2CR5VFP
More data for this
Ligand-Target Pair
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