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9 similar compounds to monomer 50389252

Compile data set for download or QSAR
Wt: 435.8
BDBM50389250
Wt: 405.3
BDBM50389256
Wt: 419.4
BDBM50389258
Wt: 415.4
BDBM50389261
Wt: 435.8
BDBM50389262
Wt: 379.4
BDBM50389263
Wt: 393.4
BDBM50389265
Wt: 469.4
BDBM50389238
Wt: 405.3
BDBM50389241

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50389250,50389256,50389258,50389261,50389262,50389263,50389265,50389238,50389241   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Chk1 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 2.09E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a<3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50389238
PNG
(CHEMBL2063460)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4ccc(cc4)C(F)(F)F)c3)c12
Show InChI InChI=1S/C22H18F3N7O2/c23-22(24,25)14-4-6-15(7-5-14)31-21(34)27-11-13-2-1-3-16(10-13)30-20(33)17-8-9-32-18(17)19(26)28-12-29-32/h1-10,12H,11H2,(H,30,33)(H2,26,28,29)(H2,27,31,34)
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n/an/a 24n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50389262
PNG
(CHEMBL2063459)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4ccc(Cl)cc4)c3)c12
Show InChI InChI=1S/C21H18ClN7O2/c22-14-4-6-15(7-5-14)28-21(31)24-11-13-2-1-3-16(10-13)27-20(30)17-8-9-29-18(17)19(23)25-12-26-29/h1-10,12H,11H2,(H,27,30)(H2,23,25,26)(H2,24,28,31)
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n/an/a 0.900n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora A kinase in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 9n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50389261
PNG
(CHEMBL2063461)
Show SMILES Cc1ccc(NC(=O)NCc2cccc(NC(=O)c3ccn4ncnc(N)c34)c2)cc1
Show InChI InChI=1S/C22H21N7O2/c1-14-5-7-16(8-6-14)28-22(31)24-12-15-3-2-4-17(11-15)27-21(30)18-9-10-29-19(18)20(23)25-13-26-29/h2-11,13H,12H2,1H3,(H,27,30)(H2,23,25,26)(H2,24,28,31)
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n/an/a 1n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50389250
PNG
(CHEMBL2063463)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4cccc(Cl)c4)c3)c12
Show InChI InChI=1S/C21H18ClN7O2/c22-14-4-2-6-16(10-14)28-21(31)24-11-13-3-1-5-15(9-13)27-20(30)17-7-8-29-18(17)19(23)25-12-26-29/h1-10,12H,11H2,(H,27,30)(H2,23,25,26)(H2,24,28,31)
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n/an/a 10n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50389258
PNG
(CHEMBL2063462)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4cccc(F)c4)c3)c12
Show InChI InChI=1S/C21H18FN7O2/c22-14-4-2-6-16(10-14)28-21(31)24-11-13-3-1-5-15(9-13)27-20(30)17-7-8-29-18(17)19(23)25-12-26-29/h1-10,12H,11H2,(H,27,30)(H2,23,25,26)(H2,24,28,31)
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n/an/a 4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50389265
PNG
(CHEMBL2063467)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4ccsc4)cc3)c12
Show InChI InChI=1S/C18H15N7O2S/c19-16-15-14(5-7-25(15)21-10-20-16)17(26)22-11-1-3-12(4-2-11)23-18(27)24-13-6-8-28-9-13/h1-10H,(H,22,26)(H2,19,20,21)(H2,23,24,27)
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n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50389263
PNG
(CHEMBL2063466)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)NC4CCCC4)cc3)c12
Show InChI InChI=1S/C19H21N7O2/c20-17-16-15(9-10-26(16)22-11-21-17)18(27)23-13-5-7-14(8-6-13)25-19(28)24-12-3-1-2-4-12/h5-12H,1-4H2,(H,23,27)(H2,20,21,22)(H2,24,25,28)
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n/an/a 33n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50389256
PNG
(CHEMBL2063465)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-1-3-14(4-2-12)26-20(30)27-15-7-5-13(6-8-15)25-19(29)16-9-10-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 36n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM50389238
PNG
(CHEMBL2063460)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4ccc(cc4)C(F)(F)F)c3)c12
Show InChI InChI=1S/C22H18F3N7O2/c23-22(24,25)14-4-6-15(7-5-14)31-21(34)27-11-13-2-1-3-16(10-13)30-20(33)17-8-9-32-18(17)19(26)28-12-29-32/h1-10,12H,11H2,(H,30,33)(H2,26,28,29)(H2,27,31,34)
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n/an/a 786n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora A kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Src in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 1.87E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of TrkA in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 1.18E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Flt3 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 566n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of lck in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 340n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Irak4 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 296n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Erk2 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM50389250
PNG
(CHEMBL2063463)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4cccc(Cl)c4)c3)c12
Show InChI InChI=1S/C21H18ClN7O2/c22-14-4-2-6-16(10-14)28-21(31)24-11-13-3-1-5-15(9-13)27-20(30)17-7-8-29-18(17)19(23)25-12-26-29/h1-10,12H,11H2,(H,27,30)(H2,23,25,26)(H2,24,28,31)
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n/an/a 186n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora A kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM50389256
PNG
(CHEMBL2063465)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-1-3-14(4-2-12)26-20(30)27-15-7-5-13(6-8-15)25-19(29)16-9-10-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 88n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora A kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM50389258
PNG
(CHEMBL2063462)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4cccc(F)c4)c3)c12
Show InChI InChI=1S/C21H18FN7O2/c22-14-4-2-6-16(10-14)28-21(31)24-11-13-3-1-5-15(9-13)27-20(30)17-7-8-29-18(17)19(23)25-12-26-29/h1-10,12H,11H2,(H,27,30)(H2,23,25,26)(H2,24,28,31)
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n/an/a 67n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora A kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM50389261
PNG
(CHEMBL2063461)
Show SMILES Cc1ccc(NC(=O)NCc2cccc(NC(=O)c3ccn4ncnc(N)c34)c2)cc1
Show InChI InChI=1S/C22H21N7O2/c1-14-5-7-16(8-6-14)28-22(31)24-12-15-3-2-4-17(11-15)27-21(30)18-9-10-29-19(18)20(23)25-13-26-29/h2-11,13H,12H2,1H3,(H,27,30)(H2,23,25,26)(H2,24,28,31)
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n/an/a 46n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora A kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM50389262
PNG
(CHEMBL2063459)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4ccc(Cl)cc4)c3)c12
Show InChI InChI=1S/C21H18ClN7O2/c22-14-4-6-15(7-5-14)28-21(31)24-11-13-2-1-3-16(10-13)27-20(30)17-8-9-29-18(17)19(23)25-12-26-29/h1-10,12H,11H2,(H,27,30)(H2,23,25,26)(H2,24,28,31)
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n/an/a 46n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora A kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM50389263
PNG
(CHEMBL2063466)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)NC4CCCC4)cc3)c12
Show InChI InChI=1S/C19H21N7O2/c20-17-16-15(9-10-26(16)22-11-21-17)18(27)23-13-5-7-14(8-6-13)25-19(28)24-12-3-1-2-4-12/h5-12H,1-4H2,(H,23,27)(H2,20,21,22)(H2,24,25,28)
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n/an/a 37n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora A kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM50389265
PNG
(CHEMBL2063467)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4ccsc4)cc3)c12
Show InChI InChI=1S/C18H15N7O2S/c19-16-15-14(5-7-25(15)21-10-20-16)17(26)22-11-1-3-12(4-2-11)23-18(27)24-13-6-8-28-9-13/h1-10H,(H,22,26)(H2,19,20,21)(H2,23,24,27)
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n/an/a 8n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Aurora A kinase by HTRF analysis in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Rho-associated protein kinase 2


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Rock2 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of c-Met in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Jnk1 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Jak2 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of IGF1R in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
CaM kinase IV


(Homo sapiens)
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Camk4 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Alk1 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 8.14E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Jak3 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a 5.34E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Gsk3alpha in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens)
BDBM50389241
PNG
(CHEMBL1990583)
Show SMILES Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H16FN7O2/c21-12-2-1-3-15(10-12)27-20(30)26-14-6-4-13(5-7-14)25-19(29)16-8-9-28-17(16)18(22)23-11-24-28/h1-11H,(H,25,29)(H2,22,23,24)(H2,26,27,30)
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n/an/a<3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Plk4 in presence of 10 uM ATP


Bioorg Med Chem Lett 22: 4528-31 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.125
BindingDB Entry DOI: 10.7270/Q2T154RT
More data for this
Ligand-Target Pair