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4 similar compounds to monomer 50405973

Compile data set for download or QSAR
Wt: 200.2
BDBM50391226
Purchase
Wt: 234.6
BDBM50405975
Wt: 263.7
BDBM50421822
Wt: 284.1
BDBM50421813

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50391226,50405975,50421822,50421813   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydrofolate reductase


(Salmonella enterica subsp. enterica serovar Typhi)
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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355n/an/an/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli dihydrofolate reductase


J Med Chem 34: 46-54 (1991)


Article DOI: 10.1021/jm00105a008
BindingDB Entry DOI: 10.7270/Q2X92CH4
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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355n/an/an/an/an/an/an/an/a



Beijing Medical University

Curated by ChEMBL


Assay Description
Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase


J Med Chem 31: 366-70 (1988)


Article DOI: 10.1021/jm00397a017
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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355n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cells


J Med Chem 25: 777-84 (1982)


Article DOI: 10.1021/jm00349a003
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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355n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound is evaluated for the inhibition of dihydrofolate reductase from Escherichia coli


J Med Chem 24: 538-44 (1981)


Article DOI: 10.1021/jm00137a012
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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646n/an/an/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibitory activity against Lactobacillus casei dihydrofolate reductase


J Med Chem 32: 1895-905 (1989)


Article DOI: 10.1021/jm00128a035
BindingDB Entry DOI: 10.7270/Q2QR4ZB9
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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646n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cells


J Med Chem 25: 777-84 (1982)


Article DOI: 10.1021/jm00349a003
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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661n/an/an/an/an/an/an/an/a



Beijing Medical University

Curated by ChEMBL


Assay Description
Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase


J Med Chem 31: 366-70 (1988)


Article DOI: 10.1021/jm00397a017
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Salmonella enterica subsp. enterica serovar Typhi)
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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661n/an/an/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli dihydrofolate reductase


J Med Chem 34: 46-54 (1991)


Article DOI: 10.1021/jm00105a008
BindingDB Entry DOI: 10.7270/Q2X92CH4
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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661n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound is evaluated for the inhibition of dihydrofolate reductase from Escherichia coli


J Med Chem 24: 538-44 (1981)


Article DOI: 10.1021/jm00137a012
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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661n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp)


J Med Chem 25: 777-84 (1982)


Article DOI: 10.1021/jm00349a003
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Bos taurus (Cattle))
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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2.14E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dihydrofolate reductase from bovine liver


J Med Chem 24: 538-44 (1981)


Article DOI: 10.1021/jm00137a012
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Bos taurus (Cattle))
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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2.14E+3n/an/an/an/an/an/a7.2n/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.


J Med Chem 25: 435-40 (1982)


Article DOI: 10.1021/jm00346a020
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Bos taurus (Cattle))
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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2.14E+3n/an/an/an/an/an/a7.2n/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.


J Med Chem 25: 435-40 (1982)


Article DOI: 10.1021/jm00346a020
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Bos taurus (Cattle))
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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2.51E+3n/an/an/an/an/an/a7.2n/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Wnt2/beta-catenin signaling in human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay


J Med Chem 25: 435-40 (1982)


Article DOI: 10.1021/jm00346a020
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Bos taurus (Cattle))
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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2.51E+3n/an/an/an/an/an/a7.2n/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2.


J Med Chem 25: 435-40 (1982)


Article DOI: 10.1021/jm00346a020
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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6.31E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cells


J Med Chem 25: 777-84 (1982)


Article DOI: 10.1021/jm00349a003
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Lactobacillus casei)
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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6.31E+3n/an/an/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibitory activity against Lactobacillus casei dihydrofolate reductase


J Med Chem 32: 1895-905 (1989)


Article DOI: 10.1021/jm00128a035
BindingDB Entry DOI: 10.7270/Q2QR4ZB9
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Bos taurus (Cattle))
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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7.94E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of dihydrofolate reductase from bovine liver


J Med Chem 24: 538-44 (1981)


Article DOI: 10.1021/jm00137a012
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Gallus gallus (Chicken))
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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1.48E+4n/an/an/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibitory activity against chicken liver dihydrofolate reductase


J Med Chem 32: 1895-905 (1989)


Article DOI: 10.1021/jm00128a035
BindingDB Entry DOI: 10.7270/Q2QR4ZB9
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Gallus gallus (Chicken))
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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1.48E+4n/an/an/an/an/an/a7.2n/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Wnt2/beta-catenin signaling in human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay


J Med Chem 25: 435-40 (1982)


Article DOI: 10.1021/jm00346a020
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Gallus gallus (Chicken))
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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1.48E+4n/an/an/an/an/an/a7.2n/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against chicken dihydrofolate reductase at pH 7.2.


J Med Chem 25: 435-40 (1982)


Article DOI: 10.1021/jm00346a020
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Gallus gallus (Chicken))
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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1.95E+4n/an/an/an/an/an/a7.2n/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Wnt2/beta-catenin signaling in human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay


J Med Chem 25: 435-40 (1982)


Article DOI: 10.1021/jm00346a020
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Gallus gallus (Chicken))
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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1.95E+4n/an/an/an/an/an/a7.2n/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against chicken dihydrofolate reductase at pH 7.2.


J Med Chem 25: 435-40 (1982)


Article DOI: 10.1021/jm00346a020
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Gallus gallus (Chicken))
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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1.95E+4n/an/an/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Inhibitory activity against chicken liver dihydrofolate reductase


J Med Chem 32: 1895-905 (1989)


Article DOI: 10.1021/jm00128a035
BindingDB Entry DOI: 10.7270/Q2QR4ZB9
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Gallus gallus (Chicken))
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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1.95E+4n/an/an/an/an/an/an/an/a



Pomona College

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against chicken dihydrofolate reductase


J Med Chem 34: 46-54 (1991)


Article DOI: 10.1021/jm00105a008
BindingDB Entry DOI: 10.7270/Q2X92CH4
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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1.00E+14n/an/an/an/an/an/an/an/a



Uniroyal Chemical Co., Inc.

Curated by ChEMBL


Assay Description
Inhibition constant against binding of Escherichia coli dihydrofolate reductase


J Med Chem 31: 1396-406 (1988)


Article DOI: 10.1021/jm00402a025
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50405975
PNG
(CHEMBL280884)
Show SMILES Nc1ncc(Cc2ccc(Cl)cc2)c(N)n1
Show InChI InChI=1S/C11H11ClN4/c12-9-3-1-7(2-4-9)5-8-6-15-11(14)16-10(8)13/h1-4,6H,5H2,(H4,13,14,15,16)
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1.00E+14n/an/an/an/an/an/an/an/a



Uniroyal Chemical Co., Inc.

Curated by ChEMBL


Assay Description
Inhibition constant against binding of Escherichia coli dihydrofolate reductase


J Med Chem 31: 1396-406 (1988)


Article DOI: 10.1021/jm00402a025
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Neisseria gonorrhoeae)
BDBM50421813
PNG
(CHEMBL120807)
Show SMILES Nc1ncc(Cc2cc(Cl)c(N)c(Cl)c2)c(N)n1
Show InChI InChI=1S/C11H11Cl2N5/c12-7-2-5(3-8(13)9(7)14)1-6-4-17-11(16)18-10(6)15/h2-4H,1,14H2,(H4,15,16,17,18)
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n/an/a 318n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea


J Med Chem 30: 348-56 (1987)


Article DOI: 10.1021/jm00385a017
BindingDB Entry DOI: 10.7270/Q28C9XH6
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Candida albicans)
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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n/an/a 9.05E+4n/an/an/an/an/an/a



Leibniz Center for Medicine and Biosciences

Curated by ChEMBL


Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans


J Med Chem 47: 240-53 (2003)


Article DOI: 10.1021/jm030931w
BindingDB Entry DOI: 10.7270/Q2DB831H
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50421813
PNG
(CHEMBL120807)
Show SMILES Nc1ncc(Cc2cc(Cl)c(N)c(Cl)c2)c(N)n1
Show InChI InChI=1S/C11H11Cl2N5/c12-7-2-5(3-8(13)9(7)14)1-6-4-17-11(16)18-10(6)15/h2-4H,1,14H2,(H4,15,16,17,18)
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n/an/a 1.30E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver


J Med Chem 30: 348-56 (1987)


Article DOI: 10.1021/jm00385a017
BindingDB Entry DOI: 10.7270/Q28C9XH6
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50421822
PNG
(CHEMBL116828)
Show SMILES Cc1cc(Cc2cnc(N)nc2N)cc(Cl)c1N
Show InChI InChI=1S/C12H14ClN5/c1-6-2-7(4-9(13)10(6)14)3-8-5-17-12(16)18-11(8)15/h2,4-5H,3,14H2,1H3,(H4,15,16,17,18)
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n/an/a 130n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli


J Med Chem 30: 348-56 (1987)


Article DOI: 10.1021/jm00385a017
BindingDB Entry DOI: 10.7270/Q28C9XH6
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50421822
PNG
(CHEMBL116828)
Show SMILES Cc1cc(Cc2cnc(N)nc2N)cc(Cl)c1N
Show InChI InChI=1S/C12H14ClN5/c1-6-2-7(4-9(13)10(6)14)3-8-5-17-12(16)18-11(8)15/h2,4-5H,3,14H2,1H3,(H4,15,16,17,18)
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n/an/a 1.60E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver


J Med Chem 30: 348-56 (1987)


Article DOI: 10.1021/jm00385a017
BindingDB Entry DOI: 10.7270/Q28C9XH6
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Escherichia coli)
BDBM50421813
PNG
(CHEMBL120807)
Show SMILES Nc1ncc(Cc2cc(Cl)c(N)c(Cl)c2)c(N)n1
Show InChI InChI=1S/C11H11Cl2N5/c12-7-2-5(3-8(13)9(7)14)1-6-4-17-11(16)18-10(6)15/h2-4H,1,14H2,(H4,15,16,17,18)
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n/an/a 110n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli


J Med Chem 30: 348-56 (1987)


Article DOI: 10.1021/jm00385a017
BindingDB Entry DOI: 10.7270/Q28C9XH6
More data for this
Ligand-Target Pair
Dihydrofolate reductase


(Rattus norvegicus (rat))
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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n/an/a 1.15E+5n/an/an/an/an/an/a



Leibniz Center for Medicine and Biosciences

Curated by ChEMBL


Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from rat


J Med Chem 47: 240-53 (2003)


Article DOI: 10.1021/jm030931w
BindingDB Entry DOI: 10.7270/Q2DB831H
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Candida albicans)
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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n/an/a 9.05E+4n/an/an/an/an/an/a



Leibniz Center for Medicine and Biosciences

Curated by ChEMBL


Assay Description
Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans


J Med Chem 47: 240-53 (2003)


Article DOI: 10.1021/jm030931w
BindingDB Entry DOI: 10.7270/Q2DB831H
More data for this
Ligand-Target Pair
Dihydrofolate Reductase (DHFR)


(Candida albicans)
BDBM50391226
PNG
(CHEMBL265493)
Show SMILES Nc1ncc(Cc2ccccc2)c(N)n1
Show InChI InChI=1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
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n/an/a 1.48E+4n/an/an/an/an/an/a



Leibniz Center for Medicine and Biosciences

Curated by ChEMBL


Assay Description
Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufu


J Med Chem 47: 240-53 (2003)


Article DOI: 10.1021/jm030931w
BindingDB Entry DOI: 10.7270/Q2DB831H
More data for this
Ligand-Target Pair