Found 7 hits for monomerid = 50393249,50417100 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuronal acetylcholine receptor
(Rattus norvegicus (Rat)) | BDBM50393249
(CHEMBL2151441)Show SMILES Cc1ccc(s1)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1 Show InChI InChI=1S/C19H23N3OS/c1-13-4-5-17(24-13)19(23)21-18-15-6-9-22(10-7-15)16(18)11-14-3-2-8-20-12-14/h2-5,8,12,15-16,18H,6-7,9-11H2,1H3,(H,21,23)/t16-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Targacept Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-MLA from alpha7 nAChR in rat hippocampal synaptosomes |
J Med Chem 54: 7943-61 (2011)
Article DOI: 10.1021/jm2007672
BindingDB Entry DOI: 10.7270/Q29P32QP |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor protein alpha-7 subunit
(Homo sapiens (Human)) | BDBM50393249
(CHEMBL2151441)Show SMILES Cc1ccc(s1)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1 Show InChI InChI=1S/C19H23N3OS/c1-13-4-5-17(24-13)19(23)21-18-15-6-9-22(10-7-15)16(18)11-14-3-2-8-20-12-14/h2-5,8,12,15-16,18H,6-7,9-11H2,1H3,(H,21,23)/t16-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Targacept Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]epibatidine form human alpha7 nAchR expressed in HEK293 cells |
J Med Chem 55: 9793-809 (2012)
Article DOI: 10.1021/jm301048a
BindingDB Entry DOI: 10.7270/Q2J67J2T |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor protein alpha-7 subunit
(Homo sapiens (Human)) | BDBM50417100
(CHEMBL1258125)Show SMILES O=C(N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1)c1cccs1 Show InChI InChI=1S/C18H21N3OS/c22-18(16-4-2-10-23-16)20-17-14-5-8-21(9-6-14)15(17)11-13-3-1-7-19-12-13/h1-4,7,10,12,14-15,17H,5-6,8-9,11H2,(H,20,22)/t15-,17+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 43.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam
Curated by ChEMBL
| Assay Description
Displacement of [3H]-MLA from human alpha7 nAChR expressed in human SH-SY5Y cells |
J Med Chem 53: 7192-201 (2010)
Article DOI: 10.1021/jm100834y
BindingDB Entry DOI: 10.7270/Q21J9C1V |
More data for this
Ligand-Target Pair | |
Acetylcholine Binding protein
(Lymnaea stagnalis) | BDBM50417100
(CHEMBL1258125)Show SMILES O=C(N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1)c1cccs1 Show InChI InChI=1S/C18H21N3OS/c22-18(16-4-2-10-23-16)20-17-14-5-8-21(9-6-14)15(17)11-13-3-1-7-19-12-13/h1-4,7,10,12,14-15,17H,5-6,8-9,11H2,(H,20,22)/t15-,17+/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 148 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam
Curated by ChEMBL
| Assay Description
Displacement of [3H]epibatidine from Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system |
J Med Chem 53: 7192-201 (2010)
Article DOI: 10.1021/jm100834y
BindingDB Entry DOI: 10.7270/Q21J9C1V |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor Alpha-4/Beta-2
(Homo sapiens (Human)) | BDBM50393249
(CHEMBL2151441)Show SMILES Cc1ccc(s1)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1 Show InChI InChI=1S/C19H23N3OS/c1-13-4-5-17(24-13)19(23)21-18-15-6-9-22(10-7-15)16(18)11-14-3-2-8-20-12-14/h2-5,8,12,15-16,18H,6-7,9-11H2,1H3,(H,21,23)/t16-,18+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Targacept Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]nicotine human alpha4beta2 nAChR in SH-EP1 cell membranes |
J Med Chem 55: 9793-809 (2012)
Article DOI: 10.1021/jm301048a
BindingDB Entry DOI: 10.7270/Q2J67J2T |
More data for this
Ligand-Target Pair | |
Acetylcholine Binding protein
(Lymnaea stagnalis) | BDBM50417100
(CHEMBL1258125)Show SMILES O=C(N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1)c1cccs1 Show InChI InChI=1S/C18H21N3OS/c22-18(16-4-2-10-23-16)20-17-14-5-8-21(9-6-14)15(17)11-13-3-1-7-19-12-13/h1-4,7,10,12,14-15,17H,5-6,8-9,11H2,(H,20,22)/t15-,17+/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam
Curated by ChEMBL
| Assay Description
Binding affinity to Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system by surface plasmon resonance biosensor assay |
J Med Chem 53: 7192-201 (2010)
Article DOI: 10.1021/jm100834y
BindingDB Entry DOI: 10.7270/Q21J9C1V |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor
(Rattus norvegicus (Rat)) | BDBM50393249
(CHEMBL2151441)Show SMILES Cc1ccc(s1)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1 Show InChI InChI=1S/C19H23N3OS/c1-13-4-5-17(24-13)19(23)21-18-15-6-9-22(10-7-15)16(18)11-14-3-2-8-20-12-14/h2-5,8,12,15-16,18H,6-7,9-11H2,1H3,(H,21,23)/t16-,18+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
Targacept Inc
Curated by ChEMBL
| Assay Description
Agonist activity at rat alpha7 nAchR expressed in GH4C1 cells by whole cell patch clamp assay |
J Med Chem 55: 9793-809 (2012)
Article DOI: 10.1021/jm301048a
BindingDB Entry DOI: 10.7270/Q2J67J2T |
More data for this
Ligand-Target Pair | |
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