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9 similar compounds to monomer 50396312

Compile data set for download or QSAR
Wt: 399.4
BDBM50396301
Wt: 385.3
BDBM50396302
Wt: 398.4
BDBM50396305
Wt: 397.4
BDBM50396306
Wt: 398.4
BDBM50396307
Wt: 384.3
BDBM50396308
Wt: 384.3
BDBM50396309
Wt: 401.3
BDBM50396310
Wt: 399.4
BDBM50396327

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50396301,50396302,50396305,50396306,50396307,50396308,50396309,50396310,50396327   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50396301
PNG
(CHEMBL2172486)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cncnc1C
Show InChI InChI=1S/C19H17N11/c1-10-13(7-21-9-22-10)12-3-4-15-27-18(26-14-5-6-23-29-14)16(30(15)8-12)17-24-11(2)25-19(20)28-17/h3-9H,1-2H3,(H2,23,26,29)(H2,20,24,25,28)
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n/an/a 68n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by AlphaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50396327
PNG
(CHEMBL2172624)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn(C)n2)nc2ccc(cn12)-c1cncnc1
Show InChI InChI=1S/C19H17N11/c1-11-23-17(27-19(20)24-11)16-18(25-14-5-6-29(2)28-14)26-15-4-3-12(9-30(15)16)13-7-21-10-22-8-13/h3-10H,1-2H3,(H,25,28)(H2,20,23,24,27)
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n/an/a 76n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR by LanthaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50396305
PNG
(CHEMBL2172482)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cnccc1C
Show InChI InChI=1S/C20H18N10/c1-11-5-7-22-9-14(11)13-3-4-16-27-19(26-15-6-8-23-29-15)17(30(16)10-13)18-24-12(2)25-20(21)28-18/h3-10H,1-2H3,(H2,23,26,29)(H2,21,24,25,28)
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n/an/a 73n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by AlphaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50396306
PNG
(CHEMBL2172481)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1ccccc1C
Show InChI InChI=1S/C21H19N9/c1-12-5-3-4-6-15(12)14-7-8-17-27-20(26-16-9-10-23-29-16)18(30(17)11-14)19-24-13(2)25-21(22)28-19/h3-11H,1-2H3,(H2,23,26,29)(H2,22,24,25,28)
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n/an/a 393n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by AlphaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50396307
PNG
(CHEMBL2172480)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cccnc1C
Show InChI InChI=1S/C20H18N10/c1-11-14(4-3-8-22-11)13-5-6-16-27-19(26-15-7-9-23-29-15)17(30(16)10-13)18-24-12(2)25-20(21)28-18/h3-10H,1-2H3,(H2,23,26,29)(H2,21,24,25,28)
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n/an/a 120n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by AlphaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50396308
PNG
(CHEMBL2172636)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cccnc1
Show InChI InChI=1S/C19H16N10/c1-11-23-17(27-19(20)24-11)16-18(25-14-6-8-22-28-14)26-15-5-4-13(10-29(15)16)12-3-2-7-21-9-12/h2-10H,1H3,(H2,22,25,28)(H2,20,23,24,27)
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n/an/a 119n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by AlphaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50396309
PNG
(CHEMBL2172640)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1ccncc1
Show InChI InChI=1S/C19H16N10/c1-11-23-17(27-19(20)24-11)16-18(25-14-6-9-22-28-14)26-15-3-2-13(10-29(15)16)12-4-7-21-8-5-12/h2-10H,1H3,(H2,22,25,28)(H2,20,23,24,27)
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n/an/a 306n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by AlphaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50396310
PNG
(CHEMBL2172639)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN9/c1-11-24-18(28-20(22)25-11)17-19(26-15-7-8-23-29-15)27-16-6-5-13(10-30(16)17)12-3-2-4-14(21)9-12/h2-10H,1H3,(H2,23,26,29)(H2,22,24,25,28)
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n/an/a 654n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by AlphaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50396301
PNG
(CHEMBL2172486)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cncnc1C
Show InChI InChI=1S/C19H17N11/c1-10-13(7-21-9-22-10)12-3-4-15-27-18(26-14-5-6-23-29-14)16(30(15)8-12)17-24-11(2)25-19(20)28-17/h3-9H,1-2H3,(H2,23,26,29)(H2,20,24,25,28)
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR by LanthaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50396302
PNG
(CHEMBL2172485)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cncnc1
Show InChI InChI=1S/C18H15N11/c1-10-23-16(27-18(19)24-10)15-17(25-13-4-5-22-28-13)26-14-3-2-11(8-29(14)15)12-6-20-9-21-7-12/h2-9H,1H3,(H2,22,25,28)(H2,19,23,24,27)
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR by LanthaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50396305
PNG
(CHEMBL2172482)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cnccc1C
Show InChI InChI=1S/C20H18N10/c1-11-5-7-22-9-14(11)13-3-4-16-27-19(26-15-6-8-23-29-15)17(30(16)10-13)18-24-12(2)25-20(21)28-18/h3-10H,1-2H3,(H2,23,26,29)(H2,21,24,25,28)
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR by LanthaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50396306
PNG
(CHEMBL2172481)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1ccccc1C
Show InChI InChI=1S/C21H19N9/c1-12-5-3-4-6-15(12)14-7-8-17-27-20(26-16-9-10-23-29-16)18(30(17)11-14)19-24-13(2)25-21(22)28-19/h3-11H,1-2H3,(H2,23,26,29)(H2,22,24,25,28)
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n/an/a 21n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR by LanthaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50396307
PNG
(CHEMBL2172480)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cccnc1C
Show InChI InChI=1S/C20H18N10/c1-11-14(4-3-8-22-11)13-5-6-16-27-19(26-15-7-9-23-29-15)17(30(16)10-13)18-24-12(2)25-20(21)28-18/h3-10H,1-2H3,(H2,23,26,29)(H2,21,24,25,28)
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR by LanthaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50396308
PNG
(CHEMBL2172636)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cccnc1
Show InChI InChI=1S/C19H16N10/c1-11-23-17(27-19(20)24-11)16-18(25-14-6-8-22-28-14)26-15-5-4-13(10-29(15)16)12-3-2-7-21-9-12/h2-10H,1H3,(H2,22,25,28)(H2,20,23,24,27)
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR by LanthaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50396309
PNG
(CHEMBL2172640)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1ccncc1
Show InChI InChI=1S/C19H16N10/c1-11-23-17(27-19(20)24-11)16-18(25-14-6-9-22-28-14)26-15-3-2-13(10-29(15)16)12-4-7-21-8-5-12/h2-10H,1H3,(H2,22,25,28)(H2,20,23,24,27)
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n/an/a 6n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR by LanthaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50396310
PNG
(CHEMBL2172639)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN9/c1-11-24-18(28-20(22)25-11)17-19(26-15-7-8-23-29-15)27-16-6-5-13(10-30(16)17)12-3-2-4-14(21)9-12/h2-10H,1H3,(H2,23,26,29)(H2,22,24,25,28)
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n/an/a 27n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR by LanthaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50396327
PNG
(CHEMBL2172624)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn(C)n2)nc2ccc(cn12)-c1cncnc1
Show InChI InChI=1S/C19H17N11/c1-11-23-17(27-19(20)24-11)16-18(25-14-5-6-29(2)28-14)26-15-4-3-12(9-30(15)16)13-7-21-10-22-8-13/h3-10H,1-2H3,(H,25,28)(H2,20,23,24,27)
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n/an/a 635n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by AlphaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50396302
PNG
(CHEMBL2172485)
Show SMILES Cc1nc(N)nc(n1)-c1c(Nc2ccn[nH]2)nc2ccc(cn12)-c1cncnc1
Show InChI InChI=1S/C18H15N11/c1-10-23-16(27-18(19)24-10)15-17(25-13-4-5-22-28-13)26-14-3-2-11(8-29(14)15)12-6-20-9-21-7-12/h2-9H,1H3,(H2,22,25,28)(H2,19,23,24,27)
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n/an/a 85n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha by AlphaScreen assay


Bioorg Med Chem Lett 22: 4967-74 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.033
BindingDB Entry DOI: 10.7270/Q2BK1DHN
More data for this
Ligand-Target Pair