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2 similar compounds to monomer 50430631

Compile data set for download or QSAR
Wt: 293.3
BDBM50400538
Wt: 279.3
BDBM50435266

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50400538,50435266   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50400538
PNG
(CHEMBL2204953)
Show SMILES CC(C)C[C@H](NC(=O)NCc1ccc(C)cc1)C(=O)NO
Show InChI InChI=1S/C15H23N3O3/c1-10(2)8-13(14(19)18-21)17-15(20)16-9-12-6-4-11(3)5-7-12/h4-7,10,13,21H,8-9H2,1-3H3,(H,18,19)(H2,16,17,20)/t13-/m0/s1
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UniChem

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Article
PubMed
n/an/a 410n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substra...


ACS Med Chem Lett 3: 959-964 (2012)


Article DOI: 10.1021/ml3000758
BindingDB Entry DOI: 10.7270/Q2QJ7JFR
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50435266
PNG
(CHEMBL2393088)
Show SMILES CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C14H21N3O3/c1-10(2)8-12(13(18)17-20)16-14(19)15-9-11-6-4-3-5-7-11/h3-7,10,12,20H,8-9H2,1-2H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
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KEGG

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES-2 cells using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 1 hr by...


Bioorg Med Chem Lett 23: 2512-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.021
BindingDB Entry DOI: 10.7270/Q21G0NN4
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens (Human))
BDBM50400538
PNG
(CHEMBL2204953)
Show SMILES CC(C)C[C@H](NC(=O)NCc1ccc(C)cc1)C(=O)NO
Show InChI InChI=1S/C15H23N3O3/c1-10(2)8-13(14(19)18-21)17-15(20)16-9-12-6-4-11(3)5-7-12/h4-7,10,13,21H,8-9H2,1-3H3,(H,18,19)(H2,16,17,20)/t13-/m0/s1
PDB

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Article
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of APN in human ES2 cell surface assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substrate...


ACS Med Chem Lett 3: 959-964 (2012)


Article DOI: 10.1021/ml3000758
BindingDB Entry DOI: 10.7270/Q2QJ7JFR
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50400538
PNG
(CHEMBL2204953)
Show SMILES CC(C)C[C@H](NC(=O)NCc1ccc(C)cc1)C(=O)NO
Show InChI InChI=1S/C15H23N3O3/c1-10(2)8-13(14(19)18-21)17-15(20)16-9-12-6-4-11(3)5-7-12/h4-7,10,13,21H,8-9H2,1-3H3,(H,18,19)(H2,16,17,20)/t13-/m0/s1
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PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of recombinant MMP-2 using succinylated gelatin as substrate incubated for 10 mins before addition of substrate measured after 60 mins by ...


ACS Med Chem Lett 3: 959-964 (2012)


Article DOI: 10.1021/ml3000758
BindingDB Entry DOI: 10.7270/Q2QJ7JFR
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50435266
PNG
(CHEMBL2393088)
Show SMILES CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C14H21N3O3/c1-10(2)8-12(13(18)17-20)16-14(19)15-9-11-6-4-3-5-7-11/h3-7,10,12,20H,8-9H2,1-2H3,(H,17,18)(H2,15,16,19)/t12-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 850n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig kidney APN using L-Leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after 30 mins by UV-Vi...


Bioorg Med Chem Lett 23: 2512-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.021
BindingDB Entry DOI: 10.7270/Q21G0NN4
More data for this
Ligand-Target Pair