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2 similar compounds to monomer 50430636

Compile data set for download or QSAR
Wt: 265.3
BDBM50400549
Wt: 299.7
BDBM50430646

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50400549,50430646   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50400549
PNG
(CHEMBL2205652)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccccc1)C(=O)NO
Show InChI InChI=1S/C13H19N3O3/c1-9(2)8-11(12(17)16-19)15-13(18)14-10-6-4-3-5-7-10/h3-7,9,11,19H,8H2,1-2H3,(H,16,17)(H2,14,15,18)/t11-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of APN in porcine kidney microsome assessed as inhibition of L-Leu-p-nitroanilide substrate hydrolysis incubated for 5 mins before substra...


ACS Med Chem Lett 3: 959-964 (2012)


Article DOI: 10.1021/ml3000758
BindingDB Entry DOI: 10.7270/Q2QJ7JFR
More data for this
Ligand-Target Pair
HDACs


(Homo sapiens (Human))
BDBM50400549
PNG
(CHEMBL2205652)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccccc1)C(=O)NO
Show InChI InChI=1S/C13H19N3O3/c1-9(2)8-11(12(17)16-19)15-13(18)14-10-6-4-3-5-7-10/h3-7,9,11,19H,8H2,1-2H3,(H,16,17)(H2,14,15,18)/t11-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of HDAC1/HDAC2 in human HeLa cells nuclear extract preincubated for 5 mins before Boc-Lys (acetyl)-AMC substrate addition for 30 mins by m...


Eur J Med Chem 108: 21-7 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.021
BindingDB Entry DOI: 10.7270/Q2ZC84RN
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50400549
PNG
(CHEMBL2205652)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccccc1)C(=O)NO
Show InChI InChI=1S/C13H19N3O3/c1-9(2)8-11(12(17)16-19)15-13(18)14-10-6-4-3-5-7-10/h3-7,9,11,19H,8H2,1-2H3,(H,16,17)(H2,14,15,18)/t11-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.15E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...


Bioorg Med Chem 21: 1621-7 (2013)


Article DOI: 10.1016/j.bmc.2013.01.068
BindingDB Entry DOI: 10.7270/Q2W95BJ0
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50430646
PNG
(CHEMBL2332511)
Show SMILES CC(C)C[C@H](NC(=O)Nc1cccc(Cl)c1)C(=O)NO
Show InChI InChI=1S/C13H18ClN3O3/c1-8(2)6-11(12(18)17-20)16-13(19)15-10-5-3-4-9(14)7-10/h3-5,7-8,11,20H,6H2,1-2H3,(H,17,18)(H2,15,16,19)/t11-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.66E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after...


Bioorg Med Chem 21: 1621-7 (2013)


Article DOI: 10.1016/j.bmc.2013.01.068
BindingDB Entry DOI: 10.7270/Q2W95BJ0
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50400549
PNG
(CHEMBL2205652)
Show SMILES CC(C)C[C@H](NC(=O)Nc1ccccc1)C(=O)NO
Show InChI InChI=1S/C13H19N3O3/c1-9(2)8-11(12(17)16-19)15-13(18)14-10-6-4-3-5-7-10/h3-7,9,11,19H,8H2,1-2H3,(H,16,17)(H2,14,15,18)/t11-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.15E+3n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of APN in porcine kidney microsomes preincubated for 5 mins before L-leu-p-nitroanilide substrate addition for 30 mins by plate reader ana...


Eur J Med Chem 108: 21-7 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.021
BindingDB Entry DOI: 10.7270/Q2ZC84RN
More data for this
Ligand-Target Pair