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14 similar compounds to monomer 50402020

Wt: 461.5
BDBM50402030
Wt: 411.4
BDBM50402032
Wt: 414.4
BDBM50402037
Wt: 414.4
BDBM50402042
Wt: 427.4
BDBM50402043
Wt: 403.4
BDBM50402044
Wt: 441.5
BDBM50402047
Wt: 379.4
BDBM50402048
Wt: 441.5
BDBM50402053
Wt: 427.4
BDBM50402060
Wt: 441.5
BDBM50402064
Wt: 441.5
BDBM50402065
Wt: 427.4
BDBM50402068
Wt: 413.4
BDBM50402026

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50402030,50402032,50402037,50402042,50402043,50402044,50402047,50402048,50402053,50402060,50402064,50402065,50402068,50402026   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402044
PNG
(CHEMBL2205423)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3cn[nH]c3)n2)c(=O)c1=O
Show InChI InChI=1S/C21H21N7O2/c1-21(2,3)28-17-16(18(29)19(17)30)26-15-8-9-22-20(27-15)25-14-6-4-12(5-7-14)13-10-23-24-11-13/h4-11,28H,1-3H3,(H,23,24)(H2,22,25,26,27)
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10n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402068
PNG
(CHEMBL2205456)
Show SMILES CCC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O
Show InChI InChI=1S/C25H25N5O2/c1-4-25(2,3)30-21-20(22(31)23(21)32)28-19-14-15-26-24(29-19)27-18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,30H,4H2,1-3H3,(H2,26,27,28,29)
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13n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402026
PNG
(CHEMBL2205457)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O
Show InChI InChI=1S/C24H23N5O2/c1-24(2,3)29-20-19(21(30)22(20)31)27-18-13-14-25-23(28-18)26-17-11-9-16(10-12-17)15-7-5-4-6-8-15/h4-14,29H,1-3H3,(H2,25,26,27,28)
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14n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged PLK1 using biotin-ahx-AKMETTFYDDALNASFLPSEKKK-amide as substrate after 30 mins by scintillation counting analysi...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402042
PNG
(CHEMBL2205425)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3cccnc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-12-25-22(28-17)26-16-8-6-14(7-9-16)15-5-4-11-24-13-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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28n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged PLK1 using biotin-ahx-AKMETTFYDDALNASFLPSEKKK-amide as substrate after 30 mins by scintillation counting analysi...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402065
PNG
(CHEMBL2205448)
Show SMILES C[C@H](Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O)C(C)(C)C
Show InChI InChI=1S/C26H27N5O2/c1-16(26(2,3)4)28-21-22(24(33)23(21)32)30-20-14-15-27-25(31-20)29-19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-16,28H,1-4H3,(H2,27,29,30,31)/t16-/m0/s1
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47n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402064
PNG
(CHEMBL2205444)
Show SMILES C[C@@H](Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O)C(C)(C)C
Show InChI InChI=1S/C26H27N5O2/c1-16(26(2,3)4)28-21-22(24(33)23(21)32)30-20-14-15-27-25(31-20)29-19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-16,28H,1-4H3,(H2,27,29,30,31)/t16-/m1/s1
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75n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402037
PNG
(CHEMBL2205424)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccn3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-11-13-25-22(28-17)26-15-9-7-14(8-10-15)16-6-4-5-12-24-16/h4-13,29H,1-3H3,(H2,25,26,27,28)
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82n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant GST-tagged PLK1 using biotin-ahx-AKMETTFYDDALNASFLPSEKKK-amide as substrate after 30 mins by scintillation counting analysi...


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402060
PNG
(CHEMBL2205450)
Show SMILES CC(C)C(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O
Show InChI InChI=1S/C25H25N5O2/c1-15(2)16(3)27-21-22(24(32)23(21)31)29-20-13-14-26-25(30-20)28-19-11-9-18(10-12-19)17-7-5-4-6-8-17/h4-16,27H,1-3H3,(H2,26,28,29,30)
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166n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402053
PNG
(CHEMBL2205446)
Show SMILES C[C@@H](Nc1c(Nc2ccnc(Nc3cccc(c3)-c3ccccc3)n2)c(=O)c1=O)C(C)(C)C
Show InChI InChI=1S/C26H27N5O2/c1-16(26(2,3)4)28-21-22(24(33)23(21)32)30-20-13-14-27-25(31-20)29-19-12-8-11-18(15-19)17-9-6-5-7-10-17/h5-16,28H,1-4H3,(H2,27,29,30,31)/t16-/m1/s1
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333n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402048
PNG
(CHEMBL2205429)
Show SMILES C[C@@H](Nc1c(Nc2ccnc(Nc3ccc(C)cc3)n2)c(=O)c1=O)C(C)(C)C
Show InChI InChI=1S/C21H25N5O2/c1-12-6-8-14(9-7-12)24-20-22-11-10-15(26-20)25-17-16(18(27)19(17)28)23-13(2)21(3,4)5/h6-11,13,23H,1-5H3,(H2,22,24,25,26)/t13-/m1/s1
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1.01E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402047
PNG
(CHEMBL2205451)
Show SMILES CC(C)CC(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O
Show InChI InChI=1S/C26H27N5O2/c1-16(2)15-17(3)28-22-23(25(33)24(22)32)30-21-13-14-27-26(31-21)29-20-11-9-19(10-12-20)18-7-5-4-6-8-18/h4-14,16-17,28H,15H2,1-3H3,(H2,27,29,30,31)
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1.18E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402043
PNG
(CHEMBL2205449)
Show SMILES CC(C)(C)CNc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O
Show InChI InChI=1S/C25H25N5O2/c1-25(2,3)15-27-20-21(23(32)22(20)31)29-19-13-14-26-24(30-19)28-18-11-9-17(10-12-18)16-7-5-4-6-8-16/h4-14,27H,15H2,1-3H3,(H2,26,28,29,30)
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1.80E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402032
PNG
(CHEMBL2205452)
Show SMILES O=c1c(NCC2CC2)c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c1=O
Show InChI InChI=1S/C24H21N5O2/c30-22-20(26-14-15-6-7-15)21(23(22)31)28-19-12-13-25-24(29-19)27-18-10-8-17(9-11-18)16-4-2-1-3-5-16/h1-5,8-13,15,26H,6-7,14H2,(H2,25,27,28,29)
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1.40E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402030
PNG
(CHEMBL2205454)
Show SMILES CC(Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O)c1ccccc1
Show InChI InChI=1S/C28H23N5O2/c1-18(19-8-4-2-5-9-19)30-24-25(27(35)26(24)34)32-23-16-17-29-28(33-23)31-22-14-12-21(13-15-22)20-10-6-3-7-11-20/h2-18,30H,1H3,(H2,29,31,32,33)
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2.49E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402042
PNG
(CHEMBL2205425)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3cccnc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-12-25-22(28-17)26-16-8-6-14(7-9-16)15-5-4-11-24-13-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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n/an/an/an/a 2.55E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402044
PNG
(CHEMBL2205423)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3cn[nH]c3)n2)c(=O)c1=O
Show InChI InChI=1S/C21H21N7O2/c1-21(2,3)28-17-16(18(29)19(17)30)26-15-8-9-22-20(27-15)25-14-6-4-12(5-7-14)13-10-23-24-11-13/h4-11,28H,1-3H3,(H,23,24)(H2,22,25,26,27)
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n/an/an/an/a 1.61E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402026
PNG
(CHEMBL2205457)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O
Show InChI InChI=1S/C24H23N5O2/c1-24(2,3)29-20-19(21(30)22(20)31)27-18-13-14-25-23(28-18)26-17-11-9-16(10-12-17)15-7-5-4-6-8-15/h4-14,29H,1-3H3,(H2,25,26,27,28)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50402037
PNG
(CHEMBL2205424)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccn3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-11-13-25-22(28-17)26-15-9-7-14(8-10-15)16-6-4-5-12-24-16/h4-13,29H,1-3H3,(H2,25,26,27,28)
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n/an/an/an/a 8.28E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay


Citation and Details
More data for this
Ligand-Target Pair