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18 similar compounds to monomer 50420277

Compile data set for download or QSAR
Wt: 519.8
BDBM50420280
Wt: 519.8
BDBM50420261
Wt: 519.8
BDBM50420262
Wt: 503.3
BDBM50420263
Wt: 521.3
BDBM50420264
Wt: 486.9
BDBM50420265
Wt: 503.3
BDBM50420266
Wt: 515.4
BDBM50420267
Wt: 553.3
BDBM50420268
Wt: 536.9
BDBM50420269
Wt: 515.4
BDBM50420270
Wt: 499.4
BDBM50420271
Wt: 499.4
BDBM50420272
Wt: 503.3
BDBM50420273
Wt: 486.9
BDBM50420274
Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50420280,50420261,50420262,50420263,50420264,50420265,50420266,50420267,50420268,50420269,50420270,50420271,50420272,50420273,50420274   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420273
PNG
(CHEMBL2089208)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2ccc(F)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C24H17Cl2FN2O3S/c1-32-24(31)21(14-4-8-16(26)9-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-11-10-17(27)12-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)
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89n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420268
PNG
(CHEMBL2089203)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(ccc2C1=O)C(F)(F)F)c1ccc(Cl)cc1
Show InChI InChI=1/C25H17Cl2F3N2O3S/c1-35-24(34)21(14-4-9-17(27)10-5-14)32-20(13-2-7-16(26)8-3-13)22(36)31-19-12-15(25(28,29)30)6-11-18(19)23(32)33/h2-12,20-21H,1H3,(H,31,36)
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91n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420266
PNG
(CHEMBL2089201)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2ccc(Cl)cc2C1=O)c1ccc(F)cc1
Show InChI InChI=1/C24H17Cl2FN2O3S/c1-32-24(31)21(14-4-9-17(27)10-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-11-8-16(26)12-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)
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315n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420263
PNG
(CHEMBL2089152)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(F)ccc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C24H17Cl2FN2O3S/c1-32-24(31)21(14-4-8-16(26)9-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-12-17(27)10-11-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)
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707n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420262
PNG
(CHEMBL2089151)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2ccc(Cl)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C24H17Cl3N2O3S/c1-32-24(31)21(14-4-8-16(26)9-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-11-10-17(27)12-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)
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721n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420274
PNG
(CHEMBL2089209)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(F)ccc2C1=O)c1ccc(F)cc1
Show InChI InChI=1/C24H17ClF2N2O3S/c1-32-24(31)21(14-4-8-16(26)9-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-12-17(27)10-11-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)
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1.05E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420280
PNG
(CHEMBL2089149)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(Cl)ccc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C24H17Cl3N2O3S/c1-32-24(31)21(14-4-8-16(26)9-5-14)29-20(13-2-6-15(25)7-3-13)22(33)28-19-12-17(27)10-11-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)
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1.37E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420265
PNG
(CHEMBL2089200)
Show SMILES COC(=O)C(N1C(c2ccc(F)cc2)C(=S)Nc2cc(Cl)ccc2C1=O)c1ccc(F)cc1
Show InChI InChI=1/C24H17ClF2N2O3S/c1-32-24(31)21(14-4-9-17(27)10-5-14)29-20(13-2-7-16(26)8-3-13)22(33)28-19-12-15(25)6-11-18(19)23(29)30/h2-12,20-21H,1H3,(H,28,33)
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1.72E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420269
PNG
(CHEMBL2089204)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(ccc2C1=O)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1/C25H17ClF4N2O3S/c1-35-24(34)21(14-4-9-17(27)10-5-14)32-20(13-2-7-16(26)8-3-13)22(36)31-19-12-15(25(28,29)30)6-11-18(19)23(32)33/h2-12,20-21H,1H3,(H,31,36)
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3.02E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420267
PNG
(CHEMBL2089202)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2c(OC)cccc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C25H20Cl2N2O4S/c1-32-19-5-3-4-18-20(19)28-23(34)21(14-6-10-16(26)11-7-14)29(24(18)30)22(25(31)33-2)15-8-12-17(27)13-9-15/h3-13,21-22H,1-2H3,(H,28,34)
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8.18E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420272
PNG
(CHEMBL2089207)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2ccc(C)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C25H20Cl2N2O3S/c1-14-3-12-20-19(13-14)24(30)29(21(23(33)28-20)15-4-8-17(26)9-5-15)22(25(31)32-2)16-6-10-18(27)11-7-16/h3-13,21-22H,1-2H3,(H,28,33)
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3.77E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420261
PNG
(CHEMBL2089150)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2c(Cl)cccc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C24H17Cl3N2O3S/c1-32-24(31)21(14-7-11-16(26)12-8-14)29-20(13-5-9-15(25)10-6-13)22(33)28-19-17(23(29)30)3-2-4-18(19)27/h2-12,20-21H,1H3,(H,28,33)
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>1.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420271
PNG
(CHEMBL2089206)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2c(C)cccc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C25H20Cl2N2O3S/c1-14-4-3-5-19-20(14)28-23(33)21(15-6-10-17(26)11-7-15)29(24(19)30)22(25(31)32-2)16-8-12-18(27)13-9-16/h3-13,21-22H,1-2H3,(H,28,33)
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>1.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420264
PNG
(CHEMBL2089153)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(F)c(F)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C24H16Cl2F2N2O3S/c1-33-24(32)21(13-4-8-15(26)9-5-13)30-20(12-2-6-14(25)7-3-12)22(34)29-19-11-18(28)17(27)10-16(19)23(30)31/h2-11,20-21H,1H3,(H,29,34)
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>1.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420270
PNG
(CHEMBL2089205)
Show SMILES COC(=O)C(N1C(c2ccc(Cl)cc2)C(=S)Nc2cc(OC)ccc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C25H20Cl2N2O4S/c1-32-18-11-12-19-20(13-18)28-23(34)21(14-3-7-16(26)8-4-14)29(24(19)30)22(25(31)33-2)15-5-9-17(27)10-6-15/h3-13,21-22H,1-2H3,(H,28,34)
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>1.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair