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6 similar compounds to monomer 50427960

Compile data set for download or QSAR
Wt: 390.5
BDBM50427950
Wt: 431.3
BDBM50427958
Wt: 431.3
BDBM50427959
Wt: 416.3
BDBM50427984
Wt: 422.5
BDBM50427987
Wt: 362.4
BDBM50427988

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50427950,50427958,50427959,50427984,50427987,50427988   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50427984
PNG
(CHEMBL2324257)
Show SMILES Clc1ccc(OCCCc2cccc(CCCOc3ccc(Cl)cc3)n2)cc1
Show InChI InChI=1S/C23H23Cl2NO2/c24-18-8-12-22(13-9-18)27-16-2-6-20-4-1-5-21(26-20)7-3-17-28-23-14-10-19(25)11-15-23/h1,4-5,8-15H,2-3,6-7,16-17H2
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PubMed
3.65E+3n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human Kv11.1 expressed in HEK293 cell membranes by competitive radioligand displacement assay


J Med Chem 58: 5916-29 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00518
BindingDB Entry DOI: 10.7270/Q2FX7C6V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50427950
PNG
(CHEMBL2325205)
Show SMILES Cc1ccc(OCCCc2cccc(CCCOc3ccc(C)cc3)[n+]2C)cc1
Show InChI InChI=1S/C26H32NO2/c1-21-11-15-25(16-12-21)28-19-5-9-23-7-4-8-24(27(23)3)10-6-20-29-26-17-13-22(2)14-18-26/h4,7-8,11-18H,5-6,9-10,19-20H2,1-3H3/q+1
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n/an/a 962n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of human ERG K+ channel expressed in HEK293 cells after 15 mins by patch clamp assay


J Med Chem 56: 2828-40 (2013)


Article DOI: 10.1021/jm301564f
BindingDB Entry DOI: 10.7270/Q22V2HG3
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50427958
PNG
(CHEMBL2324246)
Show SMILES C[n+]1c(CCCOc2ccccc2Cl)cccc1CCCOc1ccccc1Cl
Show InChI InChI=1S/C24H26Cl2NO2/c1-27-19(11-7-17-28-23-15-4-2-13-21(23)25)9-6-10-20(27)12-8-18-29-24-16-5-3-14-22(24)26/h2-6,9-10,13-16H,7-8,11-12,17-18H2,1H3/q+1
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n/an/a 74n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis


J Med Chem 56: 2828-40 (2013)


Article DOI: 10.1021/jm301564f
BindingDB Entry DOI: 10.7270/Q22V2HG3
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50427988
PNG
(CHEMBL2324242)
Show SMILES C[n+]1c(CCCOc2ccccc2)cccc1CCCOc1ccccc1
Show InChI InChI=1S/C24H28NO2/c1-25-21(13-9-19-26-23-15-4-2-5-16-23)11-8-12-22(25)14-10-20-27-24-17-6-3-7-18-24/h2-8,11-12,15-18H,9-10,13-14,19-20H2,1H3/q+1
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n/an/a 208n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis


J Med Chem 56: 2828-40 (2013)


Article DOI: 10.1021/jm301564f
BindingDB Entry DOI: 10.7270/Q22V2HG3
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50427950
PNG
(CHEMBL2325205)
Show SMILES Cc1ccc(OCCCc2cccc(CCCOc3ccc(C)cc3)[n+]2C)cc1
Show InChI InChI=1S/C26H32NO2/c1-21-11-15-25(16-12-21)28-19-5-9-23-7-4-8-24(27(23)3)10-6-20-29-26-17-13-22(2)14-18-26/h4,7-8,11-18H,5-6,9-10,19-20H2,1-3H3/q+1
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n/an/a 86n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis


J Med Chem 56: 2828-40 (2013)


Article DOI: 10.1021/jm301564f
BindingDB Entry DOI: 10.7270/Q22V2HG3
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50427984
PNG
(CHEMBL2324257)
Show SMILES Clc1ccc(OCCCc2cccc(CCCOc3ccc(Cl)cc3)n2)cc1
Show InChI InChI=1S/C23H23Cl2NO2/c24-18-8-12-22(13-9-18)27-16-2-6-20-4-1-5-21(26-20)7-3-17-28-23-14-10-19(25)11-15-23/h1,4-5,8-15H,2-3,6-7,16-17H2
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n/an/a 9.90n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis


J Med Chem 56: 2828-40 (2013)


Article DOI: 10.1021/jm301564f
BindingDB Entry DOI: 10.7270/Q22V2HG3
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50427987
PNG
(CHEMBL2324243)
Show SMILES COc1ccc(OCCCc2cccc(CCCOc3ccc(OC)cc3)[n+]2C)cc1
Show InChI InChI=1S/C26H32NO4/c1-27-21(9-5-19-30-25-15-11-23(28-2)12-16-25)7-4-8-22(27)10-6-20-31-26-17-13-24(29-3)14-18-26/h4,7-8,11-18H,5-6,9-10,19-20H2,1-3H3/q+1
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n/an/a 158n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis


J Med Chem 56: 2828-40 (2013)


Article DOI: 10.1021/jm301564f
BindingDB Entry DOI: 10.7270/Q22V2HG3
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50427984
PNG
(CHEMBL2324257)
Show SMILES Clc1ccc(OCCCc2cccc(CCCOc3ccc(Cl)cc3)n2)cc1
Show InChI InChI=1S/C23H23Cl2NO2/c24-18-8-12-22(13-9-18)27-16-2-6-20-4-1-5-21(26-20)7-3-17-28-23-14-10-19(25)11-15-23/h1,4-5,8-15H,2-3,6-7,16-17H2
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n/an/an/a 6.63E+3n/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity to human Kv11.1 expressed in HEK293 cell membranes assessed as binding affinity constant by [3H]dofetilide competition association a...


J Med Chem 58: 5916-29 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00518
BindingDB Entry DOI: 10.7270/Q2FX7C6V
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50427959
PNG
(CHEMBL2324245)
Show SMILES C[n+]1c(CCCOc2cccc(Cl)c2)cccc1CCCOc1cccc(Cl)c1
Show InChI InChI=1S/C24H26Cl2NO2/c1-27-21(11-5-15-28-23-13-2-7-19(25)17-23)9-4-10-22(27)12-6-16-29-24-14-3-8-20(26)18-24/h2-4,7-10,13-14,17-18H,5-6,11-12,15-16H2,1H3/q+1
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n/an/a 60n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis


J Med Chem 56: 2828-40 (2013)


Article DOI: 10.1021/jm301564f
BindingDB Entry DOI: 10.7270/Q22V2HG3
More data for this
Ligand-Target Pair