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16 similar compounds to monomer 50431942

Wt: 359.4
BDBM50431924
Wt: 316.4
BDBM50431925
Wt: 316.4
BDBM50431926
Wt: 302.4
BDBM50431927
Wt: 288.3
BDBM50431928
Wt: 338.4
BDBM50431934
Wt: 408.4
BDBM50431935
Wt: 362.4
BDBM50431936
Wt: 346.4
BDBM50431937
Wt: 366.8
BDBM50431938
Wt: 360.4
BDBM50431943
Wt: 346.4
BDBM50431944
Wt: 346.4
BDBM50431945
Wt: 422.5
BDBM50431950
Wt: 300.3
BDBM50445419
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50431924,50431925,50431926,50431927,50431928,50431934,50431935,50431936,50431937,50431938,50431943,50431944,50431945,50431950,50445419   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431924
PNG
(CHEMBL2348084)
Show SMILES CN(C)C(=O)Cc1sc(\C=C2/NC(=O)CS2)nc1-c1ccccc1
Show InChI InChI=1S/C17H17N3O2S2/c1-20(2)16(22)8-12-17(11-6-4-3-5-7-11)19-15(24-12)9-14-18-13(21)10-23-14/h3-7,9H,8,10H2,1-2H3,(H,18,21)/b14-9+
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n/an/a 2.20E+3n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50445419
PNG
(CHEMBL3104676)
Show SMILES O=C1CS\C(N1)=C\c1nc-2c(CCc3ccccc-23)s1
Show InChI InChI=1S/C15H12N2OS2/c18-12-8-19-13(16-12)7-14-17-15-10-4-2-1-3-9(10)5-6-11(15)20-14/h1-4,7H,5-6,8H2,(H,16,18)/b13-7+
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n/an/a 700n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ADAMTS-5 using interglobular domain peptide of aggrecan after 60 mins by FRET assay


Eur J Med Chem 71: 250-8 (2014)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431926
PNG
(CHEMBL2348082)
Show SMILES CC(C)c1sc(\C=C2/NC(=O)CS2)nc1-c1ccccc1
Show InChI InChI=1S/C16H16N2OS2/c1-10(2)16-15(11-6-4-3-5-7-11)18-14(21-16)8-13-17-12(19)9-20-13/h3-8,10H,9H2,1-2H3,(H,17,19)/b13-8+
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n/an/a 830n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431927
PNG
(CHEMBL2348081)
Show SMILES CCc1sc(\C=C2/NC(=O)CS2)nc1-c1ccccc1
Show InChI InChI=1S/C15H14N2OS2/c1-2-11-15(10-6-4-3-5-7-10)17-14(20-11)8-13-16-12(18)9-19-13/h3-8H,2,9H2,1H3,(H,16,18)/b13-8+
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n/an/a 1.20E+3n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431928
PNG
(CHEMBL2348080)
Show SMILES Cc1sc(\C=C2/NC(=O)CS2)nc1-c1ccccc1
Show InChI InChI=1S/C14H12N2OS2/c1-9-14(10-5-3-2-4-6-10)16-13(19-9)7-12-15-11(17)8-18-12/h2-7H,8H2,1H3,(H,15,17)/b12-7+
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n/an/a 1.20E+3n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431934
PNG
(CHEMBL2348074)
Show SMILES OC(=O)Cc1sc(\C=C2/NC(=O)CS2)nc1-c1cccs1
Show InChI InChI=1S/C13H10N2O3S3/c16-9-6-20-10(14-9)5-11-15-13(7-2-1-3-19-7)8(21-11)4-12(17)18/h1-3,5H,4,6H2,(H,14,16)(H,17,18)/b10-5+
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n/an/a 4.00E+3n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431935
PNG
(CHEMBL2348073)
Show SMILES OC(=O)Cc1sc(\C=C2/NC(=O)CS2)nc1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O3S2/c24-17-12-27-18(22-17)11-19-23-21(16(28-19)10-20(25)26)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-9,11H,10,12H2,(H,22,24)(H,25,26)/b18-11+
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n/an/a 430n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431936
PNG
(CHEMBL2348072)
Show SMILES COc1ccc(cc1)-c1nc(\C=C2/NC(=O)CS2)sc1CC(O)=O
Show InChI InChI=1S/C16H14N2O4S2/c1-22-10-4-2-9(3-5-10)16-11(6-15(20)21)24-14(18-16)7-13-17-12(19)8-23-13/h2-5,7H,6,8H2,1H3,(H,17,19)(H,20,21)/b13-7+
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n/an/a 1.00E+3n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431937
PNG
(CHEMBL2348071)
Show SMILES Cc1ccc(cc1)-c1nc(\C=C2/NC(=O)CS2)sc1CC(O)=O
Show InChI InChI=1S/C16H14N2O3S2/c1-9-2-4-10(5-3-9)16-11(6-15(20)21)23-14(18-16)7-13-17-12(19)8-22-13/h2-5,7H,6,8H2,1H3,(H,17,19)(H,20,21)/b13-7+
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n/an/a 720n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431938
PNG
(CHEMBL2348070)
Show SMILES OC(=O)Cc1sc(\C=C2/NC(=O)CS2)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H11ClN2O3S2/c16-9-3-1-8(2-4-9)15-10(5-14(20)21)23-13(18-15)6-12-17-11(19)7-22-12/h1-4,6H,5,7H2,(H,17,19)(H,20,21)/b12-6+
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n/an/a 6.40E+3n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431943
PNG
(CHEMBL2348088)
Show SMILES OC(=O)CCCc1sc(\C=C2/NC(=O)CS2)nc1-c1ccccc1
Show InChI InChI=1S/C17H16N2O3S2/c20-13-10-23-14(18-13)9-15-19-17(11-5-2-1-3-6-11)12(24-15)7-4-8-16(21)22/h1-3,5-6,9H,4,7-8,10H2,(H,18,20)(H,21,22)/b14-9+
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n/an/a 500n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431944
PNG
(CHEMBL2348087)
Show SMILES OC(=O)CCc1sc(\C=C2/NC(=O)CS2)nc1-c1ccccc1
Show InChI InChI=1S/C16H14N2O3S2/c19-12-9-22-13(17-12)8-14-18-16(10-4-2-1-3-5-10)11(23-14)6-7-15(20)21/h1-5,8H,6-7,9H2,(H,17,19)(H,20,21)/b13-8+
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n/an/a 420n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431945
PNG
(CHEMBL2348086)
Show SMILES CC(C(O)=O)c1sc(\C=C2/NC(=O)CS2)nc1-c1ccccc1
Show InChI InChI=1S/C16H14N2O3S2/c1-9(16(20)21)15-14(10-5-3-2-4-6-10)18-13(23-15)7-12-17-11(19)8-22-12/h2-7,9H,8H2,1H3,(H,17,19)(H,20,21)/b12-7+
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n/an/a 730n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431950
PNG
(CHEMBL2348089)
Show SMILES OC(=O)CCc1sc(\C=C2/NC(=O)CS2)nc1-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H18N2O3S2/c25-18-13-28-19(23-18)12-20-24-22(17(29-20)10-11-21(26)27)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,12H,10-11,13H2,(H,23,25)(H,26,27)/b19-12+
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n/an/a 430n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50431925
PNG
(CHEMBL2348083)
Show SMILES CCCc1sc(\C=C2/NC(=O)CS2)nc1-c1ccccc1
Show InChI InChI=1S/C16H16N2OS2/c1-2-6-12-16(11-7-4-3-5-8-11)18-15(21-12)9-14-17-13(19)10-20-14/h3-5,7-9H,2,6,10H2,1H3,(H,17,19)/b14-9+
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n/an/a 1.40E+3n/an/an/an/an/an/a



Asahi Kasei Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method


Bioorg Med Chem Lett 23: 2106-10 (2013)

More data for this
Ligand-Target Pair