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20 similar compounds to monomer 50436643

Compile data set for download or QSAR
Wt: 377.4
BDBM50436627
Wt: 479.8
BDBM50436634
Wt: 391.4
BDBM50436635
Wt: 376.4
BDBM50436636
Wt: 377.4
BDBM50436637
Wt: 421.4
BDBM50436639
Wt: 377.4
BDBM50436640
Wt: 411.8
BDBM50436641
Wt: 446.3
BDBM50436642
Wt: 490.7
BDBM50436644
Wt: 363.3
BDBM50436649
Wt: 490.7
BDBM50436650
Wt: 392.4
BDBM50436652
Wt: 377.4
BDBM50436653
Wt: 429.8
BDBM50436654
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50436627,50436634,50436635,50436636,50436637,50436639,50436640,50436641,50436642,50436644,50436649,50436650,50436652,50436653,50436654   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BCL-W


(Homo sapiens (Human))
BDBM50436627
PNG
(CHEMBL2398290)
Show SMILES Cc1c(cccc1-c1ccc(CN=Nc2nc3ccccc3s2)o1)C(O)=O
Show InChI InChI=1S/C20H15N3O3S/c1-12-14(5-4-6-15(12)19(24)25)17-10-9-13(26-17)11-21-23-20-22-16-7-2-3-8-18(16)27-20/h2-10H,11H2,1H3,(H,24,25)
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n/an/a>3.30E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to Bcl-w (unknown origin) by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436654
PNG
(CHEMBL2398277)
Show SMILES CC(N=Nc1nc2c(F)cccc2s1)c1ccc(o1)-c1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C20H13ClFN3O3S/c1-10(24-25-20-23-18-14(22)3-2-4-17(18)29-20)15-7-8-16(28-15)11-5-6-13(21)12(9-11)19(26)27/h2-10H,1H3,(H,26,27)
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n/an/a 5.20E+3n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436634
PNG
(CHEMBL2398275)
Show SMILES CC(N=Nc1nc2ccc(cc2s1)C(F)(F)F)c1ccc(o1)-c1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C21H13ClF3N3O3S/c1-10(16-6-7-17(31-16)11-2-4-14(22)13(8-11)19(29)30)27-28-20-26-15-5-3-12(21(23,24)25)9-18(15)32-20/h2-10H,1H3,(H,29,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436635
PNG
(CHEMBL2398271)
Show SMILES CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1cccc(CC(O)=O)c1
Show InChI InChI=1S/C21H17N3O3S/c1-13(23-24-21-22-16-7-2-3-8-19(16)28-21)17-9-10-18(27-17)15-6-4-5-14(11-15)12-20(25)26/h2-11,13H,12H2,1H3,(H,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436636
PNG
(CHEMBL2398270)
Show SMILES CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C20H16N4O2S/c1-12(23-24-20-22-15-7-2-3-8-18(15)27-20)16-9-10-17(26-16)13-5-4-6-14(11-13)19(21)25/h2-12H,1H3,(H2,21,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436637
PNG
(CHEMBL2398269)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CN=Nc2nc3ccccc3s2)o1
Show InChI InChI=1S/C20H15N3O3S/c1-25-19(24)14-6-4-5-13(11-14)17-10-9-15(26-17)12-21-23-20-22-16-7-2-3-8-18(16)27-20/h2-11H,12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436639
PNG
(CHEMBL2398298)
Show SMILES CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1cc(cc(c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C21H15N3O5S/c1-11(23-24-21-22-15-4-2-3-5-18(15)30-21)16-6-7-17(29-16)12-8-13(19(25)26)10-14(9-12)20(27)28/h2-11H,1H3,(H,25,26)(H,27,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436640
PNG
(CHEMBL2398293)
Show SMILES CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H15N3O3S/c1-12(22-23-20-21-15-4-2-3-5-18(15)27-20)16-10-11-17(26-16)13-6-8-14(9-7-13)19(24)25/h2-12H,1H3,(H,24,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436641
PNG
(CHEMBL2398295)
Show SMILES CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1cc(ccc1Cl)C(O)=O
Show InChI InChI=1S/C20H14ClN3O3S/c1-11(23-24-20-22-15-4-2-3-5-18(15)28-20)16-8-9-17(27-16)13-10-12(19(25)26)6-7-14(13)21/h2-11H,1H3,(H,25,26)
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n/an/a 7.60E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436627
PNG
(CHEMBL2398290)
Show SMILES Cc1c(cccc1-c1ccc(CN=Nc2nc3ccccc3s2)o1)C(O)=O
Show InChI InChI=1S/C20H15N3O3S/c1-12-14(5-4-6-15(12)19(24)25)17-10-9-13(26-17)11-21-23-20-22-16-7-2-3-8-18(16)27-20/h2-10H,11H2,1H3,(H,24,25)
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n/an/a 2.00E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Displacement of biotinylated-Bim from Bcl-Xl (unknown origin) by fluorescence polarization assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436642
PNG
(CHEMBL2398273)
Show SMILES CC(N=Nc1nc2ccc(Cl)cc2s1)c1ccc(o1)-c1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C20H13Cl2N3O3S/c1-10(24-25-20-23-15-5-3-12(21)9-18(15)29-20)16-6-7-17(28-16)11-2-4-14(22)13(8-11)19(26)27/h2-10H,1H3,(H,26,27)
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n/an/a 1.70E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436644
PNG
(CHEMBL2398276)
Show SMILES CC(N=Nc1nc2cc(Br)ccc2s1)c1ccc(o1)-c1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C20H13BrClN3O3S/c1-10(24-25-20-23-15-9-12(21)3-7-18(15)29-20)16-5-6-17(28-16)11-2-4-14(22)13(8-11)19(26)27/h2-10H,1H3,(H,26,27)
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n/an/a 1.50E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436649
PNG
(CHEMBL2398291)
Show SMILES OC(=O)c1cccc(c1)-c1ccc(CN=Nc2nc3ccccc3s2)o1
Show InChI InChI=1S/C19H13N3O3S/c23-18(24)13-5-3-4-12(10-13)16-9-8-14(25-16)11-20-22-19-21-15-6-1-2-7-17(15)26-19/h1-10H,11H2,(H,23,24)
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n/an/a 1.00E+4n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436650
PNG
(CHEMBL2398274)
Show SMILES CC(N=Nc1nc2ccc(Br)cc2s1)c1ccc(o1)-c1ccc(Cl)c(c1)C(O)=O
Show InChI InChI=1S/C20H13BrClN3O3S/c1-10(24-25-20-23-15-5-3-12(21)9-18(15)29-20)16-6-7-17(28-16)11-2-4-14(22)13(8-11)19(26)27/h2-10H,1H3,(H,26,27)
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n/an/a 9.30E+3n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436627
PNG
(CHEMBL2398290)
Show SMILES Cc1c(cccc1-c1ccc(CN=Nc2nc3ccccc3s2)o1)C(O)=O
Show InChI InChI=1S/C20H15N3O3S/c1-12-14(5-4-6-15(12)19(24)25)17-10-9-13(26-17)11-21-23-20-22-16-7-2-3-8-18(16)27-20/h2-10H,11H2,1H3,(H,24,25)
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n/an/a 7.70E+3n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436627
PNG
(CHEMBL2398290)
Show SMILES Cc1c(cccc1-c1ccc(CN=Nc2nc3ccccc3s2)o1)C(O)=O
Show InChI InChI=1S/C20H15N3O3S/c1-12-14(5-4-6-15(12)19(24)25)17-10-9-13(26-17)11-21-23-20-22-16-7-2-3-8-18(16)27-20/h2-10H,11H2,1H3,(H,24,25)
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n/an/a 6.80E+3n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Displacement of biotinylated-Bak from Bcl-Xl (unknown origin) by fluorescence polarization assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436652
PNG
(CHEMBL2398267)
Show SMILES CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1ccc(N)c(c1)C(O)=O
Show InChI InChI=1S/C20H16N4O3S/c1-11(23-24-20-22-15-4-2-3-5-18(15)28-20)16-8-9-17(27-16)12-6-7-14(21)13(10-12)19(25)26/h2-11H,21H2,1H3,(H,25,26)
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n/an/a 6.70E+3n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens (Human))
BDBM50436653
PNG
(CHEMBL2398294)
Show SMILES CC(N=Nc1nc2ccccc2s1)c1ccc(o1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C20H15N3O3S/c1-12(22-23-20-21-15-8-4-5-9-18(15)27-20)16-10-11-17(26-16)13-6-2-3-7-14(13)19(24)25/h2-12H,1H3,(H,24,25)
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n/an/a 6.30E+3n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1


(Homo sapiens (Human))
BDBM50436627
PNG
(CHEMBL2398290)
Show SMILES Cc1c(cccc1-c1ccc(CN=Nc2nc3ccccc3s2)o1)C(O)=O
Show InChI InChI=1S/C20H15N3O3S/c1-12-14(5-4-6-15(12)19(24)25)17-10-9-13(26-17)11-21-23-20-22-16-7-2-3-8-18(16)27-20/h2-10H,11H2,1H3,(H,24,25)
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n/an/a 1.67E+5n/an/an/an/an/an/a



The Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Binding affinity to human/mouse chimeric Mcl-1 by fluorescence polarization assay


J Med Chem 56: 5514-40 (2014)


Article DOI: 10.1021/jm400556w
BindingDB Entry DOI: 10.7270/Q2X92CQT
More data for this
Ligand-Target Pair