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17 similar compounds to monomer 50436738

Compile data set for download or QSAR
Wt: 402.4
BDBM50436720
Wt: 408.4
BDBM50436722
Wt: 394.4
BDBM50436723
Wt: 406.4
BDBM50436725
Wt: 442.4
BDBM50436726
Wt: 418.4
BDBM50436727
Wt: 412.4
BDBM50436728
Wt: 462.4
BDBM50436730
Wt: 453.4
BDBM50436731
Wt: 448.4
BDBM50436732
Wt: 502.3
BDBM50436733
Wt: 418.4
BDBM50436734
Wt: 432.4
BDBM50436735
Wt: 410.4
BDBM50436737
Wt: 376.4
BDBM50436744
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50436720,50436722,50436723,50436725,50436726,50436727,50436728,50436730,50436731,50436732,50436733,50436734,50436735,50436737,50436744   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436727
PNG
(CHEMBL2402078)
Show SMILES CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H19FN8O/c1-3-16-20(31)28(2)17-12-24-21(27-19(17)30(16)15-10-25-26-11-15)29-9-8-23-18(29)13-4-6-14(22)7-5-13/h4-12,16H,3H2,1-2H3,(H,25,26)/t16-/s2
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n/an/a 1.87E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL...


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436728
PNG
(CHEMBL2402077)
Show SMILES CC[C@H]1N(c2cncnc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1
Show InChI InChI=1/C22H20N8O/c1-3-17-21(31)28(2)18-13-26-22(27-20(18)30(17)16-11-23-14-24-12-16)29-10-9-25-19(29)15-7-5-4-6-8-15/h4-14,17H,3H2,1-2H3/t17-/s2
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n/an/a 3.87E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL...


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436734
PNG
(CHEMBL2402079)
Show SMILES CCC1N(c2ccn[nH]2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H19FN8O/c1-3-15-20(31)28(2)16-12-24-21(26-19(16)30(15)17-8-9-25-27-17)29-11-10-23-18(29)13-4-6-14(22)7-5-13/h4-12,15H,3H2,1-2H3,(H,25,27)
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n/an/a 740n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL...


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436732
PNG
(CHEMBL2401967)
Show SMILES CC[C@H]1N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H20F4N6O/c1-3-15-19(32)29(2)16-12-27-20(28-18(16)30(15)10-8-21(23,24)25)31-11-9-26-17(31)13-4-6-14(22)7-5-13/h4-7,9,11-12,15H,3,8,10H2,1-2H3/t15-/s2
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n/an/a 2.56E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL...


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))
BDBM50436720
PNG
(CHEMBL2401963)
Show SMILES CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1
Show InChI InChI=1/C23H26N6O/c1-3-18-22(30)27(2)19-15-25-23(26-21(19)29(18)17-11-7-8-12-17)28-14-13-24-20(28)16-9-5-4-6-10-16/h4-6,9-10,13-15,17-18H,3,7-8,11-12H2,1-2H3/t18-/s2
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n/an/a 9.40E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk3 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 15 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436722
PNG
(CHEMBL2401970)
Show SMILES CC[C@H]1N(C2COC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H21FN6O2/c1-3-16-20(29)26(2)17-10-24-21(25-19(17)28(16)15-11-30-12-15)27-9-8-23-18(27)13-4-6-14(22)7-5-13/h4-10,15-16H,3,11-12H2,1-2H3/t16-/s2
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n/an/a>5.00E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436723
PNG
(CHEMBL2401961)
Show SMILES CC(C)N1c2nc(ncc2N(C)C(=O)C1(C)C)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1S/C21H23FN6O/c1-13(2)28-18-16(26(5)19(29)21(28,3)4)12-24-20(25-18)27-11-10-23-17(27)14-6-8-15(22)9-7-14/h6-13H,1-5H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436725
PNG
(CHEMBL2401960)
Show SMILES CC(C)N1c2nc(ncc2N(C)C(=O)C11CCC1)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1S/C22H23FN6O/c1-14(2)29-19-17(27(3)20(30)22(29)9-4-10-22)13-25-21(26-19)28-12-11-24-18(28)15-5-7-16(23)8-6-15/h5-8,11-14H,4,9-10H2,1-3H3
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n/an/a 2.53E+4n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436726
PNG
(CHEMBL2401969)
Show SMILES CC[C@H]1N(C2CC(F)(F)C2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C22H21F3N6O/c1-3-16-20(32)29(2)17-12-27-21(28-19(17)31(16)15-10-22(24,25)11-15)30-9-8-26-18(30)13-4-6-14(23)7-5-13/h4-9,12,15-16H,3,10-11H2,1-2H3/t16-/s2
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n/an/a 9.39E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436727
PNG
(CHEMBL2402078)
Show SMILES CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H19FN8O/c1-3-16-20(31)28(2)17-12-24-21(27-19(17)30(16)15-10-25-26-11-15)29-9-8-23-18(29)13-4-6-14(22)7-5-13/h4-12,16H,3H2,1-2H3,(H,25,26)/t16-/s2
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n/an/a 8.67E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436728
PNG
(CHEMBL2402077)
Show SMILES CC[C@H]1N(c2cncnc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1
Show InChI InChI=1/C22H20N8O/c1-3-17-21(31)28(2)18-13-26-22(27-20(18)30(17)16-11-23-14-24-12-16)29-10-9-25-19(29)15-7-5-4-6-8-15/h4-14,17H,3H2,1-2H3/t17-/s2
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n/an/a 7.76E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436730
PNG
(CHEMBL2401959)
Show SMILES CCC1(C)N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C22H22F4N6O/c1-4-21(2)19(33)30(3)16-13-28-20(29-18(16)32(21)11-9-22(24,25)26)31-12-10-27-17(31)14-5-7-15(23)8-6-14/h5-8,10,12-13H,4,9,11H2,1-3H3
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n/an/a 7.16E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436731
PNG
(CHEMBL2402076)
Show SMILES CCC1N(c2ccc(cc2)C#N)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C25H20FN7O/c1-3-20-24(34)31(2)21-15-29-25(30-23(21)33(20)19-10-4-16(14-27)5-11-19)32-13-12-28-22(32)17-6-8-18(26)9-7-17/h4-13,15,20H,3H2,1-2H3
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n/an/a 3.76E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436732
PNG
(CHEMBL2401967)
Show SMILES CC[C@H]1N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H20F4N6O/c1-3-15-19(32)29(2)16-12-27-20(28-18(16)30(15)10-8-21(23,24)25)31-11-9-26-17(31)13-4-6-14(22)7-5-13/h4-7,9,11-12,15H,3,8,10H2,1-2H3/t15-/s2
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n/an/a 3.55E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436733
PNG
(CHEMBL2401958)
Show SMILES CN1C(=O)C(CC(F)(F)F)N(CCC(F)(F)F)c2nc(ncc12)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H17F7N6O/c1-32-15-11-30-19(34-9-7-29-16(34)12-2-4-13(22)5-3-12)31-17(15)33(8-6-20(23,24)25)14(18(32)35)10-21(26,27)28/h2-5,7,9,11,14H,6,8,10H2,1H3
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n/an/a 3.48E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436734
PNG
(CHEMBL2402079)
Show SMILES CCC1N(c2ccn[nH]2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H19FN8O/c1-3-15-20(31)28(2)16-12-24-21(26-19(16)30(15)17-8-9-25-27-17)29-11-10-23-18(29)13-4-6-14(22)7-5-13/h4-12,15H,3H2,1-2H3,(H,25,27)
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n/an/a 3.42E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436735
PNG
(CHEMBL2402080)
Show SMILES CC[C@H]1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C22H21FN8O/c1-4-17-21(32)29(3)18-12-25-22(27-20(18)31(17)16-11-26-28(2)13-16)30-10-9-24-19(30)14-5-7-15(23)8-6-14/h5-13,17H,4H2,1-3H3/t17-/s2
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n/an/a 3.29E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436737
PNG
(CHEMBL2401974)
Show SMILES CCC1N(c2ccccc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1
Show InChI InChI=1/C24H22N6O/c1-3-19-23(31)28(2)20-16-26-24(27-22(20)30(19)18-12-8-5-9-13-18)29-15-14-25-21(29)17-10-6-4-7-11-17/h4-16,19H,3H2,1-2H3
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n/an/a 2.83E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436744
PNG
(CHEMBL2401965)
Show SMILES CC[C@H]1N(C(C)C)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1
Show InChI InChI=1/C21H24N6O/c1-5-16-20(28)25(4)17-13-23-21(24-19(17)27(16)14(2)3)26-12-11-22-18(26)15-9-7-6-8-10-15/h6-14,16H,5H2,1-4H3/t16-/s2
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n/an/a 870n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50436720
PNG
(CHEMBL2401963)
Show SMILES CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1
Show InChI InChI=1/C23H26N6O/c1-3-18-22(30)27(2)19-15-25-23(26-21(19)29(18)17-11-7-8-12-17)28-14-13-24-20(28)16-9-5-4-6-10-16/h4-6,9-10,13-15,17-18H,3,7-8,11-12H2,1-2H3/t18-/s2
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk1 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436723
PNG
(CHEMBL2401961)
Show SMILES CC(C)N1c2nc(ncc2N(C)C(=O)C1(C)C)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1S/C21H23FN6O/c1-13(2)28-18-16(26(5)19(29)21(28,3)4)12-24-20(25-18)27-11-10-23-17(27)14-6-8-15(22)9-7-14/h6-13H,1-5H3
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n/an/a 2.71E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436725
PNG
(CHEMBL2401960)
Show SMILES CC(C)N1c2nc(ncc2N(C)C(=O)C11CCC1)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1S/C22H23FN6O/c1-14(2)29-19-17(27(3)20(30)22(29)9-4-10-22)13-25-21(26-19)28-12-11-24-18(28)15-5-7-16(23)8-6-15/h5-8,11-14H,4,9-10H2,1-3H3
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n/an/a 1.15E+3n/an/an/an/an/an/a



Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436722
PNG
(CHEMBL2401970)
Show SMILES CC[C@H]1N(C2COC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H21FN6O2/c1-3-16-20(29)26(2)17-10-24-21(25-19(17)28(16)15-11-30-12-15)27-9-8-23-18(27)13-4-6-14(22)7-5-13/h4-10,15-16H,3,11-12H2,1-2H3/t16-/s2
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436733
PNG
(CHEMBL2401958)
Show SMILES CN1C(=O)C(CC(F)(F)F)N(CCC(F)(F)F)c2nc(ncc12)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H17F7N6O/c1-32-15-11-30-19(34-9-7-29-16(34)12-2-4-13(22)5-3-12)31-17(15)33(8-6-20(23,24)25)14(18(32)35)10-21(26,27)28/h2-5,7,9,11,14H,6,8,10H2,1H3
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436728
PNG
(CHEMBL2402077)
Show SMILES CC[C@H]1N(c2cncnc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1
Show InChI InChI=1/C22H20N8O/c1-3-17-21(31)28(2)18-13-26-22(27-20(18)30(17)16-11-23-14-24-12-16)29-10-9-25-19(29)15-7-5-4-6-8-15/h4-14,17H,3H2,1-2H3/t17-/s2
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436732
PNG
(CHEMBL2401967)
Show SMILES CC[C@H]1N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H20F4N6O/c1-3-15-19(32)29(2)16-12-27-20(28-18(16)30(15)10-8-21(23,24)25)31-11-9-26-17(31)13-4-6-14(22)7-5-13/h4-7,9,11-12,15H,3,8,10H2,1-2H3/t15-/s2
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436731
PNG
(CHEMBL2402076)
Show SMILES CCC1N(c2ccc(cc2)C#N)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C25H20FN7O/c1-3-20-24(34)31(2)21-15-29-25(30-23(21)33(20)19-10-4-16(14-27)5-11-19)32-13-12-28-22(32)17-6-8-18(26)9-7-17/h4-13,15,20H,3H2,1-2H3
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436730
PNG
(CHEMBL2401959)
Show SMILES CCC1(C)N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C22H22F4N6O/c1-4-21(2)19(33)30(3)16-13-28-20(29-18(16)32(21)11-9-22(24,25)26)31-12-10-27-17(31)14-5-7-15(23)8-6-14/h5-8,10,12-13H,4,9,11H2,1-3H3
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436744
PNG
(CHEMBL2401965)
Show SMILES CC[C@H]1N(C(C)C)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1
Show InChI InChI=1/C21H24N6O/c1-5-16-20(28)25(4)17-13-23-21(24-19(17)27(16)14(2)3)26-12-11-22-18(26)15-9-7-6-8-10-15/h6-14,16H,5H2,1-4H3/t16-/s2
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436735
PNG
(CHEMBL2402080)
Show SMILES CC[C@H]1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C22H21FN8O/c1-4-17-21(32)29(3)18-12-25-22(27-20(18)31(17)16-11-26-28(2)13-16)30-10-9-24-19(30)14-5-7-15(23)8-6-14/h5-13,17H,4H2,1-3H3/t17-/s2
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436737
PNG
(CHEMBL2401974)
Show SMILES CCC1N(c2ccccc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1
Show InChI InChI=1/C24H22N6O/c1-3-19-23(31)28(2)20-16-26-24(27-22(20)30(19)18-12-8-5-9-13-18)29-15-14-25-21(29)17-10-6-4-7-11-17/h4-16,19H,3H2,1-2H3
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436727
PNG
(CHEMBL2402078)
Show SMILES CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H19FN8O/c1-3-16-20(31)28(2)17-12-24-21(27-19(17)30(16)15-10-25-26-11-15)29-9-8-23-18(29)13-4-6-14(22)7-5-13/h4-12,16H,3H2,1-2H3,(H,25,26)/t16-/s2
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436726
PNG
(CHEMBL2401969)
Show SMILES CC[C@H]1N(C2CC(F)(F)C2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C22H21F3N6O/c1-3-16-20(32)29(2)17-12-27-21(28-19(17)31(16)15-10-22(24,25)11-15)30-9-8-26-18(30)13-4-6-14(23)7-5-13/h4-9,12,15-16H,3,10-11H2,1-2H3/t16-/s2
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436734
PNG
(CHEMBL2402079)
Show SMILES CCC1N(c2ccn[nH]2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C21H19FN8O/c1-3-15-20(31)28(2)16-12-24-21(26-19(16)30(15)17-8-9-25-27-17)29-11-10-23-18(29)13-4-6-14(22)7-5-13/h4-12,15H,3H2,1-2H3,(H,25,27)
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436720
PNG
(CHEMBL2401963)
Show SMILES CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1
Show InChI InChI=1/C23H26N6O/c1-3-18-22(30)27(2)19-15-25-23(26-21(19)29(18)17-11-7-8-12-17)28-14-13-24-20(28)16-9-5-4-6-10-16/h4-6,9-10,13-15,17-18H,3,7-8,11-12H2,1-2H3/t18-/s2
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Plk2 (unknown origin) assessed as inhibition of DEKTDDED phosphorylation at Thr1342 after 60 mins by TR-FRET assay


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50436735
PNG
(CHEMBL2402080)
Show SMILES CC[C@H]1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1
Show InChI InChI=1/C22H21FN8O/c1-4-17-21(32)29(3)18-12-25-22(27-20(18)31(17)16-11-26-28(2)13-16)30-10-9-24-19(30)14-5-7-15(23)8-6-14/h5-13,17H,4H2,1-3H3/t17-/s2
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Elan Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Plk2 (unknown origin) transfected in HEK293 cells assessed as inhibition of alpha-synuclein phosphorylation at ser129 after 2 hrs by EL...


Bioorg Med Chem Lett 23: 2743-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.065
BindingDB Entry DOI: 10.7270/Q28G8N4M
More data for this
Ligand-Target Pair