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21 similar compounds to monomer 52067

Compile data set for download or QSAR
Wt: 324.3
BDBM52635
Wt: 384.4
BDBM52212
Wt: 326.3
BDBM52614
Wt: 370.3
BDBM52199
Wt: 354.3
BDBM52551
Wt: 384.4
BDBM52202
Wt: 370.3
BDBM52206
Wt: 368.3
BDBM53015
Wt: 340.3
BDBM53137
Wt: 453.5
BDBM52850
Wt: 368.3
BDBM53062
Wt: 338.3
BDBM53066
Wt: 310.3
BDBM53068
Wt: 324.3
BDBM50292988
Wt: 422.4
BDBM50292997
Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 52635,52212,52614,52199,52551,52202,52206,53015,53137,52850,53062,53066,53068,50292988,50292997   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52850
PNG
(2-Amino-4-[3-methoxy-4-(2-morpholin-4-yl-ethoxy)-p...)
Show SMILES COc1cc(ccc1OCCN1CCOCC1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C25H31N3O5/c1-25(2)13-18(29)23-21(14-25)33-24(27)17(15-26)22(23)16-4-5-19(20(12-16)30-3)32-11-8-28-6-9-31-10-7-28/h4-5,12,17,22,27H,6-11,13-14H2,1-3H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292997
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,22,25,29H,13-14H2,1H3
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Article
PubMed
n/an/a 660n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method


J Med Chem 55: 5403-12 (2012)


Article DOI: 10.1021/jm300345z
BindingDB Entry DOI: 10.7270/Q2Q81F5W
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM53062
PNG
(2-Amino-4-(6-methoxy-benzo[1,3]dioxol-5-yl)-7,7-di...)
Show SMILES COc1cc2OCOc2cc1C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C20H20N2O5/c1-20(2)6-12(23)18-16(7-20)27-19(22)11(8-21)17(18)10-4-14-15(26-9-25-14)5-13(10)24-3/h4-5,11,17,22H,6-7,9H2,1-3H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM53066
PNG
(2-Amino-4-benzo[1,3]dioxol-5-yl-7,7-dimethyl-5-oxo...)
Show SMILES CC1(C)CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccc2OCOc2c1
Show InChI InChI=1/C19H18N2O4/c1-19(2)6-12(22)17-15(7-19)25-18(21)11(8-20)16(17)10-3-4-13-14(5-10)24-9-23-13/h3-5,11,16,21H,6-7,9H2,1-2H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM53068
PNG
(2-Amino-4-benzo[1,3]dioxol-5-yl-5-oxo-5,6,7,8-tetr...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc3OCOc3c1)C(=O)CCC2
Show InChI InChI=1/C17H14N2O4/c18-7-10-15(9-4-5-12-14(6-9)22-8-21-12)16-11(20)2-1-3-13(16)23-17(10)19/h4-6,10,15,19H,1-3,8H2
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM53137
PNG
(2-amino-4-(7-methoxy-1,3-benzodioxol-5-yl)-5-oxo-4...)
Show SMILES COc1cc(cc2OCOc12)C1C(C#N)C(=N)OC2=C1C(=O)CCC2
Show InChI InChI=1/C18H16N2O5/c1-22-13-5-9(6-14-17(13)24-8-23-14)15-10(7-19)18(20)25-12-4-2-3-11(21)16(12)15/h5-6,10,15,20H,2-4,8H2,1H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM53015
PNG
(2-amino-4-(7-methoxy-1,3-benzodioxol-5-yl)-7,7-dim...)
Show SMILES COc1cc(cc2OCOc12)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C20H20N2O5/c1-20(2)6-12(23)17-15(7-20)27-19(22)11(8-21)16(17)10-4-13(24-3)18-14(5-10)25-9-26-18/h4-5,11,16,22H,6-7,9H2,1-3H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM53062
PNG
(2-Amino-4-(6-methoxy-benzo[1,3]dioxol-5-yl)-7,7-di...)
Show SMILES COc1cc2OCOc2cc1C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C20H20N2O5/c1-20(2)6-12(23)18-16(7-20)27-19(22)11(8-21)17(18)10-4-14-15(26-9-25-14)5-13(10)24-3/h4-5,11,17,22H,6-7,9H2,1-3H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM53066
PNG
(2-Amino-4-benzo[1,3]dioxol-5-yl-7,7-dimethyl-5-oxo...)
Show SMILES CC1(C)CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccc2OCOc2c1
Show InChI InChI=1/C19H18N2O4/c1-19(2)6-12(22)17-15(7-19)25-18(21)11(8-20)16(17)10-3-4-13-14(5-10)24-9-23-13/h3-5,11,16,21H,6-7,9H2,1-2H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM53068
PNG
(2-Amino-4-benzo[1,3]dioxol-5-yl-5-oxo-5,6,7,8-tetr...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc3OCOc3c1)C(=O)CCC2
Show InChI InChI=1/C17H14N2O4/c18-7-10-15(9-4-5-12-14(6-9)22-8-21-12)16-11(20)2-1-3-13(16)23-17(10)19/h4-6,10,15,19H,1-3,8H2
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM53137
PNG
(2-amino-4-(7-methoxy-1,3-benzodioxol-5-yl)-5-oxo-4...)
Show SMILES COc1cc(cc2OCOc12)C1C(C#N)C(=N)OC2=C1C(=O)CCC2
Show InChI InChI=1/C18H16N2O5/c1-22-13-5-9(6-14-17(13)24-8-23-14)15-10(7-19)18(20)25-12-4-2-3-11(21)16(12)15/h5-6,10,15,20H,2-4,8H2,1H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52199
PNG
(2-amino-4-asaryl-5-keto-7-methyl-4,6,7,8-tetrahydr...)
Show SMILES COc1cc(OC)c(cc1OC)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)C2
Show InChI InChI=1/C20H22N2O5/c1-10-5-13(23)19-17(6-10)27-20(22)12(9-21)18(19)11-7-15(25-3)16(26-4)8-14(11)24-2/h7-8,10,12,18,22H,5-6H2,1-4H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52202
PNG
(2-amino-5-keto-7,7-dimethyl-4-(2,3,4-trimethoxyphe...)
Show SMILES COc1ccc(C2C(C#N)C(=N)OC3=C2C(=O)CC(C)(C)C3)c(OC)c1OC
Show InChI InChI=1/C21H24N2O5/c1-21(2)8-13(24)17-15(9-21)28-20(23)12(10-22)16(17)11-6-7-14(25-3)19(27-5)18(11)26-4/h6-7,12,16,23H,8-9H2,1-5H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52206
PNG
(2-amino-5-keto-7-methyl-4-(2,3,4-trimethoxyphenyl)...)
Show SMILES COc1ccc(C2C(C#N)C(=N)OC3=C2C(=O)CC(C)C3)c(OC)c1OC
Show InChI InChI=1/C20H22N2O5/c1-10-7-13(23)17-15(8-10)27-20(22)12(9-21)16(17)11-5-6-14(24-2)19(26-4)18(11)25-3/h5-6,10,12,16,22H,7-8H2,1-4H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52212
PNG
(2-amino-4-asaryl-5-keto-7,7-dimethyl-6,8-dihydro-4...)
Show SMILES COc1cc(OC)c(cc1OC)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C21H24N2O5/c1-21(2)8-13(24)19-17(9-21)28-20(23)12(10-22)18(19)11-6-15(26-4)16(27-5)7-14(11)25-3/h6-7,12,18,23H,8-9H2,1-5H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52199
PNG
(2-amino-4-asaryl-5-keto-7-methyl-4,6,7,8-tetrahydr...)
Show SMILES COc1cc(OC)c(cc1OC)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)C2
Show InChI InChI=1/C20H22N2O5/c1-10-5-13(23)19-17(6-10)27-20(22)12(9-21)18(19)11-7-15(25-3)16(26-4)8-14(11)24-2/h7-8,10,12,18,22H,5-6H2,1-4H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52202
PNG
(2-amino-5-keto-7,7-dimethyl-4-(2,3,4-trimethoxyphe...)
Show SMILES COc1ccc(C2C(C#N)C(=N)OC3=C2C(=O)CC(C)(C)C3)c(OC)c1OC
Show InChI InChI=1/C21H24N2O5/c1-21(2)8-13(24)17-15(9-21)28-20(23)12(10-22)16(17)11-6-7-14(25-3)19(27-5)18(11)26-4/h6-7,12,16,23H,8-9H2,1-5H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52206
PNG
(2-amino-5-keto-7-methyl-4-(2,3,4-trimethoxyphenyl)...)
Show SMILES COc1ccc(C2C(C#N)C(=N)OC3=C2C(=O)CC(C)C3)c(OC)c1OC
Show InChI InChI=1/C20H22N2O5/c1-10-7-13(23)17-15(8-10)27-20(22)12(9-21)16(17)11-5-6-14(24-2)19(26-4)18(11)25-3/h5-6,10,12,16,22H,7-8H2,1-4H3
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Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52212
PNG
(2-amino-4-asaryl-5-keto-7,7-dimethyl-6,8-dihydro-4...)
Show SMILES COc1cc(OC)c(cc1OC)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C21H24N2O5/c1-21(2)8-13(24)19-17(9-21)28-20(23)12(10-22)18(19)11-6-15(26-4)16(27-5)7-14(11)25-3/h6-7,12,18,23H,8-9H2,1-5H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52551
PNG
(2-amino-4-(3,4-dimethoxyphenyl)-5-keto-7,7-dimethy...)
Show SMILES COc1ccc(cc1OC)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C20H22N2O4/c1-20(2)8-13(23)18-16(9-20)26-19(22)12(10-21)17(18)11-5-6-14(24-3)15(7-11)25-4/h5-7,12,17,22H,8-9H2,1-4H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52614
PNG
(2-amino-4-(3,4-dimethoxyphenyl)-5-keto-4,6,7,8-tet...)
Show SMILES COc1ccc(cc1OC)C1C(C#N)C(=N)OC2=C1C(=O)CCC2
Show InChI InChI=1/C18H18N2O4/c1-22-13-7-6-10(8-15(13)23-2)16-11(9-19)18(20)24-14-5-3-4-12(21)17(14)16/h6-8,11,16,20H,3-5H2,1-2H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52551
PNG
(2-amino-4-(3,4-dimethoxyphenyl)-5-keto-7,7-dimethy...)
Show SMILES COc1ccc(cc1OC)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C20H22N2O4/c1-20(2)8-13(23)18-16(9-20)26-19(22)12(10-21)17(18)11-5-6-14(24-3)15(7-11)25-4/h5-7,12,17,22H,8-9H2,1-4H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52635
PNG
(2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-6,8...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C19H20N2O3/c1-19(2)8-14(22)17-15(9-19)24-18(21)13(10-20)16(17)11-4-6-12(23-3)7-5-11/h4-7,13,16,21H,8-9H2,1-3H3
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n/an/an/an/a 6.97E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52614
PNG
(2-amino-4-(3,4-dimethoxyphenyl)-5-keto-4,6,7,8-tet...)
Show SMILES COc1ccc(cc1OC)C1C(C#N)C(=N)OC2=C1C(=O)CCC2
Show InChI InChI=1/C18H18N2O4/c1-22-13-7-6-10(8-15(13)23-2)16-11(9-19)18(20)24-14-5-3-4-12(21)17(14)16/h6-8,11,16,20H,3-5H2,1-2H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52635
PNG
(2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-6,8...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C19H20N2O3/c1-19(2)8-14(22)17-15(9-19)24-18(21)13(10-20)16(17)11-4-6-12(23-3)7-5-11/h4-7,13,16,21H,8-9H2,1-3H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52850
PNG
(2-Amino-4-[3-methoxy-4-(2-morpholin-4-yl-ethoxy)-p...)
Show SMILES COc1cc(ccc1OCCN1CCOCC1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C25H31N3O5/c1-25(2)13-18(29)23-21(14-25)33-24(27)17(15-26)22(23)16-4-5-19(20(12-16)30-3)32-11-8-28-6-9-31-10-7-28/h4-5,12,17,22,27H,6-11,13-14H2,1-3H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM52212
PNG
(2-amino-4-asaryl-5-keto-7,7-dimethyl-6,8-dihydro-4...)
Show SMILES COc1cc(OC)c(cc1OC)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C21H24N2O5/c1-21(2)8-13(24)19-17(9-21)28-20(23)12(10-22)18(19)11-6-15(26-4)16(27-5)7-14(11)25-3/h6-7,12,18,23H,8-9H2,1-5H3
PDB
MMDB

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n/an/a 6.95E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: Torrey Pines Institute for Molecul...


PubChem Bioassay (2014)


BindingDB Entry DOI: 10.7270/Q2DV1HJQ
More data for this
Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)


(Homo sapiens (Human))
BDBM52212
PNG
(2-amino-4-asaryl-5-keto-7,7-dimethyl-6,8-dihydro-4...)
Show SMILES COc1cc(OC)c(cc1OC)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C21H24N2O5/c1-21(2)8-13(24)19-17(9-21)28-20(23)12(10-22)18(19)11-6-15(26-4)16(27-5)7-14(11)25-3/h6-7,12,18,23H,8-9H2,1-5H3
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n/an/a 8.80E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: Torrey Pines Institute for Molecul...


PubChem Bioassay (2014)


BindingDB Entry DOI: 10.7270/Q2930RT9
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292988
PNG
(2-amino-4-(benzo[d][1,3]dioxol-5-yl)-7-methyl-5-ox...)
Show SMILES CC1CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccc2OCOc2c1
Show InChI InChI=1/C18H16N2O4/c1-9-4-12(21)17-15(5-9)24-18(20)11(7-19)16(17)10-2-3-13-14(6-10)23-8-22-13/h2-3,6,9,11,16,20H,4-5,8H2,1H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292997
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,22,25,29H,13-14H2,1H3
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n/an/a 660n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50292988
PNG
(2-amino-4-(benzo[d][1,3]dioxol-5-yl)-7-methyl-5-ox...)
Show SMILES CC1CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccc2OCOc2c1
Show InChI InChI=1/C18H16N2O4/c1-9-4-12(21)17-15(5-9)24-18(20)11(7-19)16(17)10-2-3-13-14(6-10)23-8-22-13/h2-3,6,9,11,16,20H,4-5,8H2,1H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50292997
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,22,25,29H,13-14H2,1H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50292988
PNG
(2-amino-4-(benzo[d][1,3]dioxol-5-yl)-7-methyl-5-ox...)
Show SMILES CC1CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccc2OCOc2c1
Show InChI InChI=1/C18H16N2O4/c1-9-4-12(21)17-15(5-9)24-18(20)11(7-19)16(17)10-2-3-13-14(6-10)23-8-22-13/h2-3,6,9,11,16,20H,4-5,8H2,1H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50292997
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,22,25,29H,13-14H2,1H3
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University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292997
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,22,25,29H,13-14H2,1H3
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n/an/a 120n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at human EAAT1 expressed in HEK293 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Rattus norvegicus)
BDBM50292997
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,22,25,29H,13-14H2,1H3
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n/an/a 970n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Activity at rat EAAT1 expressed in TSA201 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292997
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-1-yl)-5...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C27H22N2O3/c1-31-19-11-9-17(10-12-19)25-22(15-28)27(29)32-24-14-18(13-23(30)26(24)25)21-8-4-6-16-5-2-3-7-20(16)21/h2-12,18,22,25,29H,13-14H2,1H3
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n/an/a 660n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292988
PNG
(2-amino-4-(benzo[d][1,3]dioxol-5-yl)-7-methyl-5-ox...)
Show SMILES CC1CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccc2OCOc2c1
Show InChI InChI=1/C18H16N2O4/c1-9-4-12(21)17-15(5-9)24-18(20)11(7-19)16(17)10-2-3-13-14(6-10)23-8-22-13/h2-3,6,9,11,16,20H,4-5,8H2,1H3
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n/an/a>3.16E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM53015
PNG
(2-amino-4-(7-methoxy-1,3-benzodioxol-5-yl)-7,7-dim...)
Show SMILES COc1cc(cc2OCOc12)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C20H20N2O5/c1-20(2)6-12(23)17-15(7-20)27-19(22)11(8-21)16(17)10-4-13(24-3)18-14(5-10)25-9-26-18/h4-5,11,16,22H,6-7,9H2,1-3H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair