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10 similar compounds to monomer 50292989

Compile data set for download or QSAR
Wt: 266.2
BDBM52209
Wt: 294.3
BDBM52218
Wt: 280.3
BDBM50292990
Purchase
Wt: 356.4
BDBM50292991
Purchase
Wt: 418.4
BDBM50293001
Wt: 392.4
BDBM50293002
Wt: 392.4
BDBM50293003
Wt: 330.3
BDBM50328509
Wt: 342.3
BDBM50328510
Purchase
Wt: 294.3
BDBM50389174

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 52209,52218,50292990,50292991,50293001,50293002,50293003,50328509,50328510,50389174   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52209
PNG
(2-amino-5-keto-4-phenyl-4,6,7,8-tetrahydrochromene...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CCC2
Show InChI InChI=1/C16H14N2O2/c17-9-11-14(10-5-2-1-3-6-10)15-12(19)7-4-8-13(15)20-16(11)18/h1-3,5-6,11,14,18H,4,7-8H2
KEGG

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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50389174
PNG
(CHEMBL2062777)
Show SMILES CC1(C)C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C18H18N2O2/c1-18(2)13(10-19)17(20)22-15-9-12(8-14(21)16(15)18)11-6-4-3-5-7-11/h3-7,12-13,20H,8-9H2,1-2H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method


J Med Chem 55: 5403-12 (2012)


Article DOI: 10.1021/jm300345z
BindingDB Entry DOI: 10.7270/Q2Q81F5W
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52209
PNG
(2-amino-5-keto-4-phenyl-4,6,7,8-tetrahydrochromene...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CCC2
Show InChI InChI=1/C16H14N2O2/c17-9-11-14(10-5-2-1-3-6-10)15-12(19)7-4-8-13(15)20-16(11)18/h1-3,5-6,11,14,18H,4,7-8H2
KEGG

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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52218
PNG
(2-amino-5-keto-7,7-dimethyl-4-phenyl-6,8-dihydro-4...)
Show SMILES CC1(C)CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccccc1
Show InChI InChI=1/C18H18N2O2/c1-18(2)8-13(21)16-14(9-18)22-17(20)12(10-19)15(16)11-6-4-3-5-7-11/h3-7,12,15,20H,8-9H2,1-2H3
KEGG

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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
Hsf1 protein


(Mus musculus)
BDBM52218
PNG
(2-amino-5-keto-7,7-dimethyl-4-phenyl-6,8-dihydro-4...)
Show SMILES CC1(C)CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccccc1
Show InChI InChI=1/C18H18N2O2/c1-18(2)8-13(21)16-14(9-18)22-17(20)12(10-19)15(16)11-6-4-3-5-7-11/h3-7,12,15,20H,8-9H2,1-2H3
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KEGG

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B.MOAD
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n/an/an/an/a>1.95E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2MW2FKX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292990
PNG
(2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3
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n/an/a 9.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292991
PNG
(2-amino-4-benzyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES N=C1OC2=C(C(Cc3ccccc3)C1C#N)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C23H20N2O2/c24-14-19-18(11-15-7-3-1-4-8-15)22-20(26)12-17(13-21(22)27-23(19)25)16-9-5-2-6-10-16/h1-10,17-19,25H,11-13H2
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50293001
PNG
(2-amino-4-(biphenyl-4-yl)-5-oxo-7-phenyl-5,6,7,8-t...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc(cc1)-c1ccccc1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C28H22N2O2/c29-17-23-26(21-13-11-20(12-14-21)18-7-3-1-4-8-18)27-24(31)15-22(16-25(27)32-28(23)30)19-9-5-2-6-10-19/h1-14,22-23,26,30H,15-16H2
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50293002
PNG
(2-amino-4-(naphthalen-2-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc3ccccc3c1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(19-11-10-17-8-4-5-9-18(17)12-19)25-22(29)13-20(14-23(25)30-26(21)28)16-6-2-1-3-7-16/h1-12,20-21,24,28H,13-14H2
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50293003
PNG
(2-amino-4-(naphthalen-1-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1cccc3ccccc13)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(20-12-6-10-17-9-4-5-11-19(17)20)25-22(29)13-18(14-23(25)30-26(21)28)16-7-2-1-3-8-16/h1-12,18,21,24,28H,13-14H2
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n/an/a 7.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50292991
PNG
(2-amino-4-benzyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES N=C1OC2=C(C(Cc3ccccc3)C1C#N)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C23H20N2O2/c24-14-19-18(11-15-7-3-1-4-8-15)22-20(26)12-17(13-21(22)27-23(19)25)16-9-5-2-6-10-16/h1-10,17-19,25H,11-13H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50293001
PNG
(2-amino-4-(biphenyl-4-yl)-5-oxo-7-phenyl-5,6,7,8-t...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc(cc1)-c1ccccc1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C28H22N2O2/c29-17-23-26(21-13-11-20(12-14-21)18-7-3-1-4-8-18)27-24(31)15-22(16-25(27)32-28(23)30)19-9-5-2-6-10-19/h1-14,22-23,26,30H,15-16H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50293002
PNG
(2-amino-4-(naphthalen-2-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc3ccccc3c1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(19-11-10-17-8-4-5-9-18(17)12-19)25-22(29)13-20(14-23(25)30-26(21)28)16-6-2-1-3-7-16/h1-12,20-21,24,28H,13-14H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50293003
PNG
(2-amino-4-(naphthalen-1-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1cccc3ccccc13)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(20-12-6-10-17-9-4-5-11-19(17)20)25-22(29)13-18(14-23(25)30-26(21)28)16-7-2-1-3-8-16/h1-12,18,21,24,28H,13-14H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50292990
PNG
(2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3
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n/an/a>3.16E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50292991
PNG
(2-amino-4-benzyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES N=C1OC2=C(C(Cc3ccccc3)C1C#N)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C23H20N2O2/c24-14-19-18(11-15-7-3-1-4-8-15)22-20(26)12-17(13-21(22)27-23(19)25)16-9-5-2-6-10-16/h1-10,17-19,25H,11-13H2
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University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50293001
PNG
(2-amino-4-(biphenyl-4-yl)-5-oxo-7-phenyl-5,6,7,8-t...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc(cc1)-c1ccccc1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C28H22N2O2/c29-17-23-26(21-13-11-20(12-14-21)18-7-3-1-4-8-18)27-24(31)15-22(16-25(27)32-28(23)30)19-9-5-2-6-10-19/h1-14,22-23,26,30H,15-16H2
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University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50293002
PNG
(2-amino-4-(naphthalen-2-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc3ccccc3c1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(19-11-10-17-8-4-5-9-18(17)12-19)25-22(29)13-20(14-23(25)30-26(21)28)16-6-2-1-3-7-16/h1-12,20-21,24,28H,13-14H2
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University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50293003
PNG
(2-amino-4-(naphthalen-1-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1cccc3ccccc13)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(20-12-6-10-17-9-4-5-11-19(17)20)25-22(29)13-18(14-23(25)30-26(21)28)16-7-2-1-3-8-16/h1-12,18,21,24,28H,13-14H2
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University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50292990
PNG
(2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292990
PNG
(2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3
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PubMed
n/an/a 9.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328509
PNG
(2-Amino-4-methyl-7-(naphthalen-1-yl)-5-oxo-5,6,7,8...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C21H18N2O2/c1-12-17(11-22)21(23)25-19-10-14(9-18(24)20(12)19)16-8-4-6-13-5-2-3-7-15(13)16/h2-8,12,14,17,23H,9-10H2,1H3
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n/an/a 430n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328510
PNG
(2-Amino-5-oxo-4,7-diphenyl-5,6,7,8-tetrahydro-4H-c...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C22H18N2O2/c23-13-17-20(15-9-5-2-6-10-15)21-18(25)11-16(12-19(21)26-22(17)24)14-7-3-1-4-8-14/h1-10,16-17,20,24H,11-12H2
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292990
PNG
(2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3
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n/an/a 9.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method


J Med Chem 55: 5403-12 (2012)


Article DOI: 10.1021/jm300345z
BindingDB Entry DOI: 10.7270/Q2Q81F5W
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328509
PNG
(2-Amino-4-methyl-7-(naphthalen-1-yl)-5-oxo-5,6,7,8...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C21H18N2O2/c1-12-17(11-22)21(23)25-19-10-14(9-18(24)20(12)19)16-8-4-6-13-5-2-3-7-15(13)16/h2-8,12,14,17,23H,9-10H2,1H3
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n/an/a 420n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method


J Med Chem 55: 5403-12 (2012)


Article DOI: 10.1021/jm300345z
BindingDB Entry DOI: 10.7270/Q2Q81F5W
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328510
PNG
(2-Amino-5-oxo-4,7-diphenyl-5,6,7,8-tetrahydro-4H-c...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C22H18N2O2/c23-13-17-20(15-9-5-2-6-10-15)21-18(25)11-16(12-19(21)26-22(17)24)14-7-3-1-4-8-14/h1-10,16-17,20,24H,11-12H2
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n/an/a 3.90E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method


J Med Chem 55: 5403-12 (2012)


Article DOI: 10.1021/jm300345z
BindingDB Entry DOI: 10.7270/Q2Q81F5W
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52218
PNG
(2-amino-5-keto-7,7-dimethyl-4-phenyl-6,8-dihydro-4...)
Show SMILES CC1(C)CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccccc1
Show InChI InChI=1/C18H18N2O2/c1-18(2)8-13(21)16-14(9-18)22-17(20)12(10-19)15(16)11-6-4-3-5-7-11/h3-7,12,15,20H,8-9H2,1-2H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair