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16 similar compounds to monomer 50292991

Compile data set for download or QSAR
Wt: 266.2
BDBM52209
Wt: 324.3
BDBM52635
Wt: 294.3
BDBM52218
Wt: 360.3
BDBM50292986
Purchase
Wt: 280.3
BDBM50292990
Purchase
Wt: 418.4
BDBM50293001
Wt: 392.4
BDBM50293002
Wt: 392.4
BDBM50293003
Wt: 372.4
BDBM50293009
Wt: 388.4
BDBM50293010
Purchase
Wt: 266.2
BDBM50292989
Wt: 386.4
BDBM50328507
Wt: 422.4
BDBM50328508
Wt: 330.3
BDBM50328509
Wt: 342.3
BDBM50328510
Purchase
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 43 hits for monomerid = 52209,52635,52218,50292986,50292990,50293001,50293002,50293003,50293009,50293010,50292989,50328507,50328508,50328509,50328510   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52209
PNG
(2-amino-5-keto-4-phenyl-4,6,7,8-tetrahydrochromene...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CCC2
Show InChI InChI=1/C16H14N2O2/c17-9-11-14(10-5-2-1-3-6-10)15-12(19)7-4-8-13(15)20-16(11)18/h1-3,5-6,11,14,18H,4,7-8H2
KEGG

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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328507
PNG
(2-Amino-7-benzyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(Cc1ccccc1)C2
Show InChI InChI=1/C24H22N2O3/c1-28-18-9-7-17(8-10-18)22-19(14-25)24(26)29-21-13-16(12-20(27)23(21)22)11-15-5-3-2-4-6-15/h2-10,16,19,22,26H,11-13H2,1H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method


J Med Chem 55: 5403-12 (2012)


Article DOI: 10.1021/jm300345z
BindingDB Entry DOI: 10.7270/Q2Q81F5W
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52209
PNG
(2-amino-5-keto-4-phenyl-4,6,7,8-tetrahydrochromene...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CCC2
Show InChI InChI=1/C16H14N2O2/c17-9-11-14(10-5-2-1-3-6-10)15-12(19)7-4-8-13(15)20-16(11)18/h1-3,5-6,11,14,18H,4,7-8H2
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52218
PNG
(2-amino-5-keto-7,7-dimethyl-4-phenyl-6,8-dihydro-4...)
Show SMILES CC1(C)CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccccc1
Show InChI InChI=1/C18H18N2O2/c1-18(2)8-13(21)16-14(9-18)22-17(20)12(10-19)15(16)11-6-4-3-5-7-11/h3-7,12,15,20H,8-9H2,1-2H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52635
PNG
(2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-6,8...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C19H20N2O3/c1-19(2)8-14(22)17-15(9-19)24-18(21)13(10-20)16(17)11-4-6-12(23-3)7-5-11/h4-7,13,16,21H,8-9H2,1-3H3
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n/an/an/an/a 6.97E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM52635
PNG
(2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-6,8...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C)(C)C2
Show InChI InChI=1/C19H20N2O3/c1-19(2)8-14(22)17-15(9-19)24-18(21)13(10-20)16(17)11-4-6-12(23-3)7-5-11/h4-7,13,16,21H,8-9H2,1-3H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
Hsf1 protein


(Mus musculus)
BDBM52218
PNG
(2-amino-5-keto-7,7-dimethyl-4-phenyl-6,8-dihydro-4...)
Show SMILES CC1(C)CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccccc1
Show InChI InChI=1/C18H18N2O2/c1-18(2)8-13(21)16-14(9-18)22-17(20)12(10-19)15(16)11-6-4-3-5-7-11/h3-7,12,15,20H,8-9H2,1-2H3
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n/an/an/an/a>1.95E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2MW2FKX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292986
PNG
(2-amino-4-(2-fluorophenyl)-5-oxo-7-phenyl-5,6,7,8-...)
Show SMILES Fc1ccccc1C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C22H17FN2O2/c23-17-9-5-4-8-15(17)20-16(12-24)22(25)27-19-11-14(10-18(26)21(19)20)13-6-2-1-3-7-13/h1-9,14,16,20,25H,10-11H2
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n/an/a 4.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50292986
PNG
(2-amino-4-(2-fluorophenyl)-5-oxo-7-phenyl-5,6,7,8-...)
Show SMILES Fc1ccccc1C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C22H17FN2O2/c23-17-9-5-4-8-15(17)20-16(12-24)22(25)27-19-11-14(10-18(26)21(19)20)13-6-2-1-3-7-13/h1-9,14,16,20,25H,10-11H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50292986
PNG
(2-amino-4-(2-fluorophenyl)-5-oxo-7-phenyl-5,6,7,8-...)
Show SMILES Fc1ccccc1C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C22H17FN2O2/c23-17-9-5-4-8-15(17)20-16(12-24)22(25)27-19-11-14(10-18(26)21(19)20)13-6-2-1-3-7-13/h1-9,14,16,20,25H,10-11H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292989
PNG
(2-Amino-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chrom...)
Show SMILES N=C1OC2=C(CC1C#N)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C16H14N2O2/c17-9-12-6-13-14(19)7-11(8-15(13)20-16(12)18)10-4-2-1-3-5-10/h1-5,11-12,18H,6-8H2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292990
PNG
(2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3
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n/an/a 9.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50293001
PNG
(2-amino-4-(biphenyl-4-yl)-5-oxo-7-phenyl-5,6,7,8-t...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc(cc1)-c1ccccc1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C28H22N2O2/c29-17-23-26(21-13-11-20(12-14-21)18-7-3-1-4-8-18)27-24(31)15-22(16-25(27)32-28(23)30)19-9-5-2-6-10-19/h1-14,22-23,26,30H,15-16H2
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50293002
PNG
(2-amino-4-(naphthalen-2-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc3ccccc3c1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(19-11-10-17-8-4-5-9-18(17)12-19)25-22(29)13-20(14-23(25)30-26(21)28)16-6-2-1-3-7-16/h1-12,20-21,24,28H,13-14H2
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50293003
PNG
(2-amino-4-(naphthalen-1-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1cccc3ccccc13)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(20-12-6-10-17-9-4-5-11-19(17)20)25-22(29)13-18(14-23(25)30-26(21)28)16-7-2-1-3-8-16/h1-12,18,21,24,28H,13-14H2
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n/an/a 7.40E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50293009
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(phenyl)-5-oxo-5,6,7...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C23H20N2O3/c1-27-17-9-7-15(8-10-17)21-18(13-24)23(25)28-20-12-16(11-19(26)22(20)21)14-5-3-2-4-6-14/h2-10,16,18,21,25H,11-12H2,1H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50293010
PNG
(2-amino-4-(4-(methylthio)phenyl)-5-oxo-7-phenyl-5,...)
Show SMILES CSc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C23H20N2O2S/c1-28-17-9-7-15(8-10-17)21-18(13-24)23(25)27-20-12-16(11-19(26)22(20)21)14-5-3-2-4-6-14/h2-10,16,18,21,25H,11-12H2,1H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT1 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50292989
PNG
(2-Amino-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chrom...)
Show SMILES N=C1OC2=C(CC1C#N)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C16H14N2O2/c17-9-12-6-13-14(19)7-11(8-15(13)20-16(12)18)10-4-2-1-3-5-10/h1-5,11-12,18H,6-8H2
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University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50293001
PNG
(2-amino-4-(biphenyl-4-yl)-5-oxo-7-phenyl-5,6,7,8-t...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc(cc1)-c1ccccc1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C28H22N2O2/c29-17-23-26(21-13-11-20(12-14-21)18-7-3-1-4-8-18)27-24(31)15-22(16-25(27)32-28(23)30)19-9-5-2-6-10-19/h1-14,22-23,26,30H,15-16H2
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University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50293002
PNG
(2-amino-4-(naphthalen-2-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc3ccccc3c1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(19-11-10-17-8-4-5-9-18(17)12-19)25-22(29)13-20(14-23(25)30-26(21)28)16-6-2-1-3-7-16/h1-12,20-21,24,28H,13-14H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50293003
PNG
(2-amino-4-(naphthalen-1-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1cccc3ccccc13)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(20-12-6-10-17-9-4-5-11-19(17)20)25-22(29)13-18(14-23(25)30-26(21)28)16-7-2-1-3-8-16/h1-12,18,21,24,28H,13-14H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50293009
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(phenyl)-5-oxo-5,6,7...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C23H20N2O3/c1-27-17-9-7-15(8-10-17)21-18(13-24)23(25)28-20-12-16(11-19(26)22(20)21)14-5-3-2-4-6-14/h2-10,16,18,21,25H,11-12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50293010
PNG
(2-amino-4-(4-(methylthio)phenyl)-5-oxo-7-phenyl-5,...)
Show SMILES CSc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C23H20N2O2S/c1-28-17-9-7-15(8-10-17)21-18(13-24)23(25)27-20-12-16(11-19(26)22(20)21)14-5-3-2-4-6-14/h2-10,16,18,21,25H,11-12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50292990
PNG
(2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3
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n/an/a>3.16E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 2


(Homo sapiens (Human))
BDBM50292989
PNG
(2-Amino-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chrom...)
Show SMILES N=C1OC2=C(CC1C#N)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C16H14N2O2/c17-9-12-6-13-14(19)7-11(8-15(13)20-16(12)18)10-4-2-1-3-5-10/h1-5,11-12,18H,6-8H2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT2 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50293001
PNG
(2-amino-4-(biphenyl-4-yl)-5-oxo-7-phenyl-5,6,7,8-t...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc(cc1)-c1ccccc1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C28H22N2O2/c29-17-23-26(21-13-11-20(12-14-21)18-7-3-1-4-8-18)27-24(31)15-22(16-25(27)32-28(23)30)19-9-5-2-6-10-19/h1-14,22-23,26,30H,15-16H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50293002
PNG
(2-amino-4-(naphthalen-2-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccc3ccccc3c1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(19-11-10-17-8-4-5-9-18(17)12-19)25-22(29)13-20(14-23(25)30-26(21)28)16-6-2-1-3-7-16/h1-12,20-21,24,28H,13-14H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50293003
PNG
(2-amino-4-(naphthalen-1-yl)-5-oxo-7-phenyl-5,6,7,8...)
Show SMILES N=C1OC2=C(C(C1C#N)c1cccc3ccccc13)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C26H20N2O2/c27-15-21-24(20-12-6-10-17-9-4-5-11-19(17)20)25-22(29)13-18(14-23(25)30-26(21)28)16-7-2-1-3-8-16/h1-12,18,21,24,28H,13-14H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50293009
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(phenyl)-5-oxo-5,6,7...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C23H20N2O3/c1-27-17-9-7-15(8-10-17)21-18(13-24)23(25)28-20-12-16(11-19(26)22(20)21)14-5-3-2-4-6-14/h2-10,16,18,21,25H,11-12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50293010
PNG
(2-amino-4-(4-(methylthio)phenyl)-5-oxo-7-phenyl-5,...)
Show SMILES CSc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C23H20N2O2S/c1-28-17-9-7-15(8-10-17)21-18(13-24)23(25)27-20-12-16(11-19(26)22(20)21)14-5-3-2-4-6-14/h2-10,16,18,21,25H,11-12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(Homo sapiens (Human))
BDBM50292990
PNG
(2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]D-Asp from human EAAT3 receptor expressed in HEK293 cells


J Med Chem 52: 912-5 (2009)


Article DOI: 10.1021/jm8013458
BindingDB Entry DOI: 10.7270/Q2PV6KCP
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292986
PNG
(2-amino-4-(2-fluorophenyl)-5-oxo-7-phenyl-5,6,7,8-...)
Show SMILES Fc1ccccc1C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C22H17FN2O2/c23-17-9-5-4-8-15(17)20-16(12-24)22(25)27-19-11-14(10-18(26)21(19)20)13-6-2-1-3-7-13/h1-9,14,16,20,25H,10-11H2
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n/an/a 4.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292990
PNG
(2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3
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n/an/a 9.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292989
PNG
(2-Amino-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chrom...)
Show SMILES N=C1OC2=C(CC1C#N)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C16H14N2O2/c17-9-12-6-13-14(19)7-11(8-15(13)20-16(12)18)10-4-2-1-3-5-10/h1-5,11-12,18H,6-8H2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328507
PNG
(2-Amino-7-benzyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(Cc1ccccc1)C2
Show InChI InChI=1/C24H22N2O3/c1-28-18-9-7-17(8-10-18)22-19(14-25)24(26)29-21-13-16(12-20(27)23(21)22)11-15-5-3-2-4-6-15/h2-10,16,19,22,26H,11-13H2,1H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328508
PNG
(2-Amino-4-(4-methoxyphenyl)-7-(naphthalene-2-yl)-5...)
Show SMILES COc1ccc(cc1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccc2ccccc2c1
Show InChI InChI=1/C27H22N2O3/c1-31-21-10-8-17(9-11-21)25-22(15-28)27(29)32-24-14-20(13-23(30)26(24)25)19-7-6-16-4-2-3-5-18(16)12-19/h2-12,20,22,25,29H,13-14H2,1H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328509
PNG
(2-Amino-4-methyl-7-(naphthalen-1-yl)-5-oxo-5,6,7,8...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C21H18N2O2/c1-12-17(11-22)21(23)25-19-10-14(9-18(24)20(12)19)16-8-4-6-13-5-2-3-7-15(13)16/h2-8,12,14,17,23H,9-10H2,1H3
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n/an/a 430n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328510
PNG
(2-Amino-5-oxo-4,7-diphenyl-5,6,7,8-tetrahydro-4H-c...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C22H18N2O2/c23-13-17-20(15-9-5-2-6-10-15)21-18(25)11-16(12-19(21)26-22(17)24)14-7-3-1-4-8-14/h1-10,16-17,20,24H,11-12H2
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n/an/a 3.80E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay


J Med Chem 53: 7180-91 (2010)


Article DOI: 10.1021/jm1009154
BindingDB Entry DOI: 10.7270/Q2VM4CGX
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292990
PNG
(2-amino-4-methyl-5-oxo-7-phenyl-5,6,7,8-tetrahydro...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C17H16N2O2/c1-10-13(9-18)17(19)21-15-8-12(7-14(20)16(10)15)11-5-3-2-4-6-11/h2-6,10,12-13,19H,7-8H2,1H3
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n/an/a 9.20E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method


J Med Chem 55: 5403-12 (2012)


Article DOI: 10.1021/jm300345z
BindingDB Entry DOI: 10.7270/Q2Q81F5W
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328509
PNG
(2-Amino-4-methyl-7-(naphthalen-1-yl)-5-oxo-5,6,7,8...)
Show SMILES CC1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1/C21H18N2O2/c1-12-17(11-22)21(23)25-19-10-14(9-18(24)20(12)19)16-8-4-6-13-5-2-3-7-15(13)16/h2-8,12,14,17,23H,9-10H2,1H3
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n/an/a 420n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method


J Med Chem 55: 5403-12 (2012)


Article DOI: 10.1021/jm300345z
BindingDB Entry DOI: 10.7270/Q2Q81F5W
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50328510
PNG
(2-Amino-5-oxo-4,7-diphenyl-5,6,7,8-tetrahydro-4H-c...)
Show SMILES N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C22H18N2O2/c23-13-17-20(15-9-5-2-6-10-15)21-18(25)11-16(12-19(21)26-22(17)24)14-7-3-1-4-8-14/h1-10,16-17,20,24H,11-12H2
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Article
PubMed
n/an/a 3.90E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method


J Med Chem 55: 5403-12 (2012)


Article DOI: 10.1021/jm300345z
BindingDB Entry DOI: 10.7270/Q2Q81F5W
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(Homo sapiens (Human))
BDBM50292989
PNG
(2-Amino-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chrom...)
Show SMILES N=C1OC2=C(CC1C#N)C(=O)CC(C2)c1ccccc1
Show InChI InChI=1/C16H14N2O2/c17-9-12-6-13-14(19)7-11(8-15(13)20-16(12)18)10-4-2-1-3-5-10/h1-5,11-12,18H,6-8H2
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method


J Med Chem 55: 5403-12 (2012)


Article DOI: 10.1021/jm300345z
BindingDB Entry DOI: 10.7270/Q2Q81F5W
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM52218
PNG
(2-amino-5-keto-7,7-dimethyl-4-phenyl-6,8-dihydro-4...)
Show SMILES CC1(C)CC(=O)C2=C(C1)OC(=N)C(C#N)C2c1ccccc1
Show InChI InChI=1/C18H18N2O2/c1-18(2)8-13(21)16-14(9-18)22-17(20)12(10-19)15(16)11-6-4-3-5-7-11/h3-7,12,15,20H,8-9H2,1-2H3
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair