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9 similar compounds to monomer 50262685

Wt: 400.4
BDBM5410
Purchase
Wt: 399.4
BDBM5415
Wt: 401.4
BDBM5416
Wt: 373.4
BDBM36352
Wt: 387.4
BDBM50261870
Wt: 414.5
BDBM50261871
Wt: 322.4
BDBM50261926
Wt: 398.5
BDBM50261927
Wt: 449.5
BDBM50262018

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 5410,5415,5416,36352,50261870,50261871,50261926,50261927,50262018   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM5410
PNG
(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
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PubMed
n/an/a 9n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 12: 3537-41 (2002)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 1


(Homo sapiens (human))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/a 2.10E+3n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of RSK1 by Hot Spot filtration binding assay


Bioorg Med Chem Lett 20: 6394-9 (2010)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/a 11n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 12: 2767-70 (2002)

More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM36352
PNG
(dorsomorphin (6LE))
Show SMILES CN(C)CCCOc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C22H23N5O/c1-26(2)12-3-13-28-20-6-4-17(5-7-20)19-14-24-22-21(15-25-27(22)16-19)18-8-10-23-11-9-18/h4-11,14-16H,3,12-13H2,1-2H3
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n/an/an/an/a 5.00E+3n/an/an/an/a



Vanderbilt University



Assay Description
The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/an/an/a 1.00E+3n/an/an/an/a



Vanderbilt University



Assay Description
The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t...


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM36352
PNG
(dorsomorphin (6LE))
Show SMILES CN(C)CCCOc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C22H23N5O/c1-26(2)12-3-13-28-20-6-4-17(5-7-20)19-14-24-22-21(15-25-27(22)16-19)18-8-10-23-11-9-18/h4-11,14-16H,3,12-13H2,1-2H3
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n/an/an/an/a 5.00E+4n/an/an/an/a



Vanderbilt University



Assay Description
For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/an/an/a 5.00E+3n/an/an/an/a



Vanderbilt University



Assay Description
For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM5410
PNG
(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
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n/an/an/an/a 1.00E+3n/an/an/an/a



Vanderbilt University



Assay Description
For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM36352
PNG
(dorsomorphin (6LE))
Show SMILES CN(C)CCCOc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C22H23N5O/c1-26(2)12-3-13-28-20-6-4-17(5-7-20)19-14-24-22-21(15-25-27(22)16-19)18-8-10-23-11-9-18/h4-11,14-16H,3,12-13H2,1-2H3
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n/an/an/an/a>5.00E+4n/an/an/an/a



Vanderbilt University



Assay Description
For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/an/an/a 2.00E+4n/an/an/an/a



Vanderbilt University



Assay Description
For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
Bone morphogenetic protein


(Danio rerio (Zebrafish))
BDBM5410
PNG
(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
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n/an/an/an/a>5.00E+4n/an/an/an/a



Vanderbilt University



Assay Description
For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp...


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
Activin receptor type-1


(Homo sapiens)
BDBM5410
PNG
(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
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n/an/a 3.56E+3n/an/an/an/an/an/a



Vanderbilt University



Assay Description
Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
AMP-activated protein kinase (AMPK)


(Homo sapiens)
BDBM5410
PNG
(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
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n/an/a 8.04E+3n/an/an/an/an/an/a



Vanderbilt University



Assay Description
Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM5410
PNG
(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
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n/an/a 161n/an/an/an/an/an/a



Vanderbilt University



Assay Description
Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human...


ACS Chem Biol 5: 245-53 (2010)

More data for this
Ligand-Target Pair
Activin receptor type-1


(Homo sapiens)
BDBM5410
PNG
(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
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n/an/a 2.57E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...


Citation and Details
More data for this
Ligand-Target Pair
5'-AMP-activated protein kinase subunit beta-1


(Homo sapiens)
BDBM5410
PNG
(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
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n/an/a 2.92E+3n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM5410
PNG
(4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)ph...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c1-2-4-20(5-3-1)23-17-26-28-18-21(16-25-24(23)28)19-6-8-22(9-7-19)30-15-12-27-10-13-29-14-11-27/h1-9,16-18H,10-15H2
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n/an/a 235n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
Kinase assays were performed using the assay kit by Reaction Biology Corp (Malvern, Pa.). The compounds were tested at 10 concentrations by 3-fold se...


Citation and Details
More data for this
Ligand-Target Pair
Bone morphogenetic protein 4


(Homo sapiens)
BDBM50261927
PNG
(3-phenyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyr...)
Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-3-7-21(8-4-1)24-18-27-29-19-22(17-26-25(24)29)20-9-11-23(12-10-20)30-16-15-28-13-5-2-6-14-28/h1,3-4,7-12,17-19H,2,5-6,13-16H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of BMP4 (unknown origin)-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA


Bioorg Med Chem Lett 18: 4388-92 (2008)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 4


(Homo sapiens)
BDBM5415
PNG
(3-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[...)
Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccnc1
Show InChI InChI=1S/C24H25N5O/c1-2-11-28(12-3-1)13-14-30-22-8-6-19(7-9-22)21-16-26-24-23(17-27-29(24)18-21)20-5-4-10-25-15-20/h4-10,15-18H,1-3,11-14H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of BMP4 (unknown origin)-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA


Bioorg Med Chem Lett 18: 4388-92 (2008)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 4


(Homo sapiens)
BDBM50261926
PNG
(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo[1,5...)
Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2ccnn2c1
Show InChI InChI=1S/C19H22N4O/c1-2-10-22(11-3-1)12-13-24-18-6-4-16(5-7-18)17-14-20-19-8-9-21-23(19)15-17/h4-9,14-15H,1-3,10-13H2
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n/an/a>2.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of BMP4 (unknown origin)-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA


Bioorg Med Chem Lett 18: 4388-92 (2008)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 4


(Homo sapiens)
BDBM50262018
PNG
(4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo[...)
Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12
Show InChI InChI=1S/C28H27N5O/c1-4-14-32(15-5-1)16-17-34-23-10-8-21(9-11-23)22-18-30-28-26(19-31-33(28)20-22)24-12-13-29-27-7-3-2-6-25(24)27/h2-3,6-13,18-20H,1,4-5,14-17H2
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n/an/a 90n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of BMP4 (unknown origin)-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA


Bioorg Med Chem Lett 18: 4388-92 (2008)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 4


(Homo sapiens)
BDBM50261871
PNG
(6-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-3-(...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cnc3c(cnn3c2)-c2ccncc2)CC1
Show InChI InChI=1S/C24H26N6O/c1-28-10-12-29(13-11-28)14-15-31-22-4-2-19(3-5-22)21-16-26-24-23(17-27-30(24)18-21)20-6-8-25-9-7-20/h2-9,16-18H,10-15H2,1H3
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n/an/a 450n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of BMP4 (unknown origin)-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA


Bioorg Med Chem Lett 18: 4388-92 (2008)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 4


(Homo sapiens)
BDBM50261870
PNG
(CHEMBL511216 | N,N-diethyl-2-(4-(3-(pyridin-4-yl)p...)
Show SMILES CCN(CC)CCOc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H25N5O/c1-3-27(4-2)13-14-29-21-7-5-18(6-8-21)20-15-25-23-22(16-26-28(23)17-20)19-9-11-24-12-10-19/h5-12,15-17H,3-4,13-14H2,1-2H3
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n/an/a 500n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of BMP4 (unknown origin)-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA


Bioorg Med Chem Lett 18: 4388-92 (2008)

More data for this
Ligand-Target Pair
Bone morphogenetic protein 4


(Homo sapiens)
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of BMP4 (unknown origin)-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA


Bioorg Med Chem Lett 18: 4388-92 (2008)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/a 50n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of c-SRC by Hot Spot filtration binding assay


Bioorg Med Chem Lett 20: 6394-9 (2010)

More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/a 250n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of EphA2 by Hot Spot filtration binding assay


Bioorg Med Chem Lett 20: 6394-9 (2010)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/a 210n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of FLT1 by Hot Spot filtration binding assay


Bioorg Med Chem Lett 20: 6394-9 (2010)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/a 1n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of FLT3 by Hot Spot filtration binding assay


Bioorg Med Chem Lett 20: 6394-9 (2010)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/a 56n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of KDR by Hot Spot filtration binding assay


Bioorg Med Chem Lett 20: 6394-9 (2010)

More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/a 300n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of LCK by Hot Spot filtration binding assay


Bioorg Med Chem Lett 20: 6394-9 (2010)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase MNK1


(Homo sapiens (human))
BDBM5416
PNG
(4-(2-{4-[3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-...)
Show SMILES C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C23H23N5O2/c1-3-21(30-14-11-27-9-12-29-13-10-27)4-2-18(1)20-15-25-23-22(16-26-28(23)17-20)19-5-7-24-8-6-19/h1-8,15-17H,9-14H2
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n/an/a 130n/an/an/an/an/an/a



Ansaris

Curated by ChEMBL


Assay Description
Inhibition of MNK1 by Hot Spot filtration binding assay


Bioorg Med Chem Lett 20: 6394-9 (2010)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM5415
PNG
(3-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[...)
Show SMILES C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccnc1
Show InChI InChI=1S/C24H25N5O/c1-2-11-28(12-3-1)13-14-30-22-8-6-19(7-9-22)21-16-26-24-23(17-27-29(24)18-21)20-5-4-10-25-15-20/h4-10,15-18H,1-3,11-14H2
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n/an/a 20n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 12: 3537-41 (2002)

More data for this
Ligand-Target Pair