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34 similar compounds to monomer 5931

Compile data set for download or QSAR
Wt: 339.4
BDBM5662		Wt: 353.5
BDBM5663		Wt: 355.4
BDBM5671		Wt: 401.5
BDBM5684		Wt: 401.5
BDBM5685
Wt: 353.5
BDBM5688		Wt: 394.5
BDBM5936		Wt: 394.5
BDBM5937		Wt: 340.4
BDBM5923		Wt: 393.5
BDBM5926
Wt: 379.5
BDBM5927		Wt: 366.5
BDBM5928		Wt: 380.5
BDBM5929		Wt: 394.5
BDBM5930		Wt: 394.5
BDBM5932
Displayed 1 to 15 (of 34 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 5662,5663,5671,5684,5685,5688,5936,5937,5923,5926,5927,5928,5929,5930,5932   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))		BDBM5662
PNG
(2-amino-5-thio-substituted thiazole 29 | N-(5-{[(5...)
Show SMILES CC(C)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C15H21N3O2S2/c1-9(2)13(19)18-14-17-7-12(22-14)21-8-11-16-6-10(20-11)15(3,4)5/h6-7,9H,8H2,1-5H3,(H,17,18,19)
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n/an/a 30n/an/an/an/a8.030



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
 The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))		BDBM5929
PNG
((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCCNC3)s2)o1
Show InChI InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-5-4-6-18-7-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
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n/an/a 20n/an/an/an/an/an/a



Sunesis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of CDK2/Cyclin A (unknown origin) by fluorescence polarization assay

Bioorg Med Chem Lett 18: 6236-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.099
BindingDB Entry DOI: 10.7270/Q2BG2NVC
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))		BDBM5671
PNG
(2-amino-substituted thiazole 51 | N-(5-{[(5-tert-b...)
Show SMILES CC(C)C(=O)Nc1ncc(s1)S(=O)Cc1ncc(o1)C(C)(C)C
Show InChI InChI=1S/C15H21N3O3S2/c1-9(2)13(19)18-14-17-7-12(22-14)23(20)8-11-16-6-10(21-11)15(3,4)5/h6-7,9H,8H2,1-5H3,(H,17,18,19)
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n/an/a 140n/an/an/an/a8.030



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5662
PNG
(2-amino-5-thio-substituted thiazole 29 | N-(5-{[(5...)
Show SMILES CC(C)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C15H21N3O2S2/c1-9(2)13(19)18-14-17-7-12(22-14)21-8-11-16-6-10(20-11)15(3,4)5/h6-7,9H,8H2,1-5H3,(H,17,18,19)
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
 The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5663
PNG
(2-amino-5-thio-substituted thiazole 30 | N-(5-{[(5...)
Show SMILES CC(C)(C)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C16H23N3O2S2/c1-15(2,3)10-7-17-11(21-10)9-22-12-8-18-14(23-12)19-13(20)16(4,5)6/h7-8H,9H2,1-6H3,(H,18,19,20)
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n/an/a 17n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5671
PNG
(2-amino-substituted thiazole 51 | N-(5-{[(5-tert-b...)
Show SMILES CC(C)C(=O)Nc1ncc(s1)S(=O)Cc1ncc(o1)C(C)(C)C
Show InChI InChI=1S/C15H21N3O3S2/c1-9(2)13(19)18-14-17-7-12(22-14)23(20)8-11-16-6-10(21-11)15(3,4)5/h6-7,9H,8H2,1-5H3,(H,17,18,19)
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n/an/a 140n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (human))		BDBM5662
PNG
(2-amino-5-thio-substituted thiazole 29 | N-(5-{[(5...)
Show SMILES CC(C)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C15H21N3O2S2/c1-9(2)13(19)18-14-17-7-12(22-14)21-8-11-16-6-10(20-11)15(3,4)5/h6-7,9H,8H2,1-5H3,(H,17,18,19)
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n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
 The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (human))		BDBM5663
PNG
(2-amino-5-thio-substituted thiazole 30 | N-(5-{[(5...)
Show SMILES CC(C)(C)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C16H23N3O2S2/c1-15(2,3)10-7-17-11(21-10)9-22-12-8-18-14(23-12)19-13(20)16(4,5)6/h7-8H,9H2,1-6H3,(H,18,19,20)
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n/an/a 3.48E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (human))		BDBM5671
PNG
(2-amino-substituted thiazole 51 | N-(5-{[(5-tert-b...)
Show SMILES CC(C)C(=O)Nc1ncc(s1)S(=O)Cc1ncc(o1)C(C)(C)C
Show InChI InChI=1S/C15H21N3O3S2/c1-9(2)13(19)18-14-17-7-12(22-14)23(20)8-11-16-6-10(21-11)15(3,4)5/h6-7,9H,8H2,1-5H3,(H,17,18,19)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5684
PNG
((2R)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]s...)
Show SMILES C[C@@H](C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1)c1ccccc1
Show InChI InChI=1S/C20H23N3O2S2/c1-13(14-8-6-5-7-9-14)18(24)23-19-22-11-17(27-19)26-12-16-21-10-15(25-16)20(2,3)4/h5-11,13H,12H2,1-4H3,(H,22,23,24)/t13-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
 The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5685
PNG
((2S)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]s...)
Show SMILES C[C@H](C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1)c1ccccc1
Show InChI InChI=1S/C20H23N3O2S2/c1-13(14-8-6-5-7-9-14)18(24)23-19-22-11-17(27-19)26-12-16-21-10-15(25-16)20(2,3)4/h5-11,13H,12H2,1-4H3,(H,22,23,24)/t13-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5688
PNG
(2-amino-5-thio-substituted thiazole 37 | N-(5-{[(5...)
Show SMILES CC(C)C(=O)N(C)c1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C16H23N3O2S2/c1-10(2)14(20)19(6)15-18-8-13(23-15)22-9-12-17-7-11(21-12)16(3,4)5/h7-8,10H,9H2,1-6H3
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (human))		BDBM5684
PNG
((2R)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]s...)
Show SMILES C[C@@H](C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1)c1ccccc1
Show InChI InChI=1S/C20H23N3O2S2/c1-13(14-8-6-5-7-9-14)18(24)23-19-22-11-17(27-19)26-12-16-21-10-15(25-16)20(2,3)4/h5-11,13H,12H2,1-4H3,(H,22,23,24)/t13-/m1/s1
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n/an/a 3.13E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5923
PNG
(3-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)CCN)s2)o1
Show InChI InChI=1S/C14H20N4O2S2/c1-14(2,3)9-6-16-11(20-9)8-21-12-7-17-13(22-12)18-10(19)4-5-15/h6-7H,4-5,8,15H2,1-3H3,(H,17,18,19)
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n/an/a 21n/an/an/an/a8.030



Bristol-Myers Squibb Company



Assay Description
 The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 47: 1719-28 (2004)


Article DOI: 10.1021/jm0305568
BindingDB Entry DOI: 10.7270/Q26971SZ
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5926
PNG
(BMS-387032 analog 16 | N-(5-{[(5-tert-butyl-1,3-ox...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)CC3CCCCC3)s2)o1
Show InChI InChI=1S/C19H27N3O2S2/c1-19(2,3)14-10-20-16(24-14)12-25-17-11-21-18(26-17)22-15(23)9-13-7-5-4-6-8-13/h10-11,13H,4-9,12H2,1-3H3,(H,21,22,23)
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n/an/a 50n/an/an/an/a8.030



Bristol-Myers Squibb Company



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 47: 1719-28 (2004)


Article DOI: 10.1021/jm0305568
BindingDB Entry DOI: 10.7270/Q26971SZ
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5927
PNG
(BMS-387032 analog 17 | N-(5-{[(5-tert-butyl-1,3-ox...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCCCC3)s2)o1
Show InChI InChI=1S/C18H25N3O2S2/c1-18(2,3)13-9-19-14(23-13)11-24-15-10-20-17(25-15)21-16(22)12-7-5-4-6-8-12/h9-10,12H,4-8,11H2,1-3H3,(H,20,21,22)
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n/an/a 300n/an/an/an/a8.030



Bristol-Myers Squibb Company



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 47: 1719-28 (2004)


Article DOI: 10.1021/jm0305568
BindingDB Entry DOI: 10.7270/Q26971SZ
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5928
PNG
((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCCN3)s2)o1
Show InChI InChI=1S/C16H22N4O2S2/c1-16(2,3)11-7-18-12(22-11)9-23-13-8-19-15(24-13)20-14(21)10-5-4-6-17-10/h7-8,10,17H,4-6,9H2,1-3H3,(H,19,20,21)
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n/an/a 50n/an/an/an/a8.030



Bristol-Myers Squibb Company



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 47: 1719-28 (2004)


Article DOI: 10.1021/jm0305568
BindingDB Entry DOI: 10.7270/Q26971SZ
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5929
PNG
((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCCNC3)s2)o1
Show InChI InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-5-4-6-18-7-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
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n/an/a 83n/an/an/an/a8.030



Bristol-Myers Squibb Company



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 47: 1719-28 (2004)


Article DOI: 10.1021/jm0305568
BindingDB Entry DOI: 10.7270/Q26971SZ
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5930
PNG
(BMS-387032 analog 20 | N-(5-{[(5-tert-butyl-1,3-ox...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)CC3CCNCC3)s2)o1
Show InChI InChI=1S/C18H26N4O2S2/c1-18(2,3)13-9-20-15(24-13)11-25-16-10-21-17(26-16)22-14(23)8-12-4-6-19-7-5-12/h9-10,12,19H,4-8,11H2,1-3H3,(H,21,22,23)
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n/an/a 11n/an/an/an/a8.030



Bristol-Myers Squibb Company



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 47: 1719-28 (2004)


Article DOI: 10.1021/jm0305568
BindingDB Entry DOI: 10.7270/Q26971SZ
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5932
PNG
(1-Methyl-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]...)
Show SMILES CN1CCC(CC1)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C18H26N4O2S2/c1-18(2,3)13-9-19-14(24-13)11-25-15-10-20-17(26-15)21-16(23)12-5-7-22(4)8-6-12/h9-10,12H,5-8,11H2,1-4H3,(H,20,21,23)
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n/an/a 43n/an/an/an/a8.030



Bristol-Myers Squibb Company



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 47: 1719-28 (2004)


Article DOI: 10.1021/jm0305568
BindingDB Entry DOI: 10.7270/Q26971SZ
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5936
PNG
(4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)[C@@H]3CC[C@H](N)CC3)s2)o1
Show InChI InChI=1S/C18H26N4O2S2/c1-18(2,3)13-8-20-14(24-13)10-25-15-9-21-17(26-15)22-16(23)11-4-6-12(19)7-5-11/h8-9,11-12H,4-7,10,19H2,1-3H3,(H,21,22,23)/t11-,12+
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n/an/a 22n/an/an/an/a8.030



Bristol-Myers Squibb Company



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 47: 1719-28 (2004)


Article DOI: 10.1021/jm0305568
BindingDB Entry DOI: 10.7270/Q26971SZ
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (human))		BDBM5937
PNG
(4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)[C@H]3CC[C@H](N)CC3)s2)o1
Show InChI InChI=1S/C18H26N4O2S2/c1-18(2,3)13-8-20-14(24-13)10-25-15-9-21-17(26-15)22-16(23)11-4-6-12(19)7-5-11/h8-9,11-12H,4-7,10,19H2,1-3H3,(H,21,22,23)/t11-,12-
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n/an/a 150n/an/an/an/a8.030



Bristol-Myers Squibb Company



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 47: 1719-28 (2004)


Article DOI: 10.1021/jm0305568
BindingDB Entry DOI: 10.7270/Q26971SZ
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 9


(Homo sapiens (human))		BDBM5929
PNG
((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCCNC3)s2)o1
Show InChI InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-5-4-6-18-7-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
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n/an/a 550n/an/an/an/an/an/a



Sunesis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of CDK9-mediated RNA pol 2 phosphorylation at ser2 in human HCT116 cells after 16 hrs by HCS assay

Bioorg Med Chem Lett 18: 6236-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.099
BindingDB Entry DOI: 10.7270/Q2BG2NVC
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))		BDBM5663
PNG
(2-amino-5-thio-substituted thiazole 30 | N-(5-{[(5...)
Show SMILES CC(C)(C)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C16H23N3O2S2/c1-15(2,3)10-7-17-11(21-10)9-22-12-8-18-14(23-12)19-13(20)16(4,5)6/h7-8H,9H2,1-6H3,(H,18,19,20)
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n/an/a 90n/an/an/an/a8.030



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...

J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair