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23 similar compounds to monomer 5885

Compile data set for download or QSAR
Wt: 343.3
BDBM5882
Wt: 371.4
BDBM5886
Wt: 371.4
BDBM5887
Wt: 373.4
BDBM5890
Wt: 357.4
BDBM5891
Wt: 357.4
BDBM5892
Wt: 411.3
BDBM5893
Wt: 411.3
BDBM5894
Wt: 377.8
BDBM5895
Wt: 371.4
BDBM5896
Wt: 368.3
BDBM5899
Wt: 371.4
BDBM5900
Wt: 371.4
BDBM5901
Wt: 383.4
BDBM5902
Wt: 375.3
BDBM5904
Displayed 1 to 15 (of 23 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 5882,5886,5887,5890,5891,5892,5893,5894,5895,5896,5899,5900,5901,5902,5904   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5882
PNG
(3-[4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]-1...)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)-c1cccc2C(=O)NCc12
Show InChI InChI=1S/C21H17N3O2/c25-20-18-8-4-7-17(19(18)13-22-20)14-9-11-16(12-10-14)24-21(26)23-15-5-2-1-3-6-15/h1-12H,13H2,(H,22,25)(H2,23,24,26)
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n/an/a 1.80E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5893
PNG
(3-[4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]-1...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)c1
Show InChI InChI=1S/C22H16F3N3O2/c23-22(24,25)14-3-1-4-16(11-14)28-21(30)27-15-9-7-13(8-10-15)17-5-2-6-18-19(17)12-26-20(18)29/h1-11H,12H2,(H,26,29)(H2,27,28,30)
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n/an/a 7n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KDR in presence of 1 mM ATP


Bioorg Med Chem Lett 22: 4502-5 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.009
BindingDB Entry DOI: 10.7270/Q2K35VQK
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5887
PNG
(1-methyl-1-(3-methylphenyl)-3-[4-(1-oxo-2,3-dihydr...)
Show SMILES CN(C(=O)Nc1ccc(cc1)-c1cccc2C(=O)NCc12)c1cccc(C)c1
Show InChI InChI=1S/C23H21N3O2/c1-15-5-3-6-18(13-15)26(2)23(28)25-17-11-9-16(10-12-17)19-7-4-8-20-21(19)14-24-22(20)27/h3-13H,14H2,1-2H3,(H,24,27)(H,25,28)
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n/an/a 1.90E+4n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5890
PNG
(1-(3-methylphenyl)-3-[4-(1-oxo-2,3-dihydro-1H-isoi...)
Show SMILES Cc1cccc(NC(=S)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)c1
Show InChI InChI=1S/C22H19N3OS/c1-14-4-2-5-17(12-14)25-22(27)24-16-10-8-15(9-11-16)18-6-3-7-19-20(18)13-23-21(19)26/h2-12H,13H2,1H3,(H,23,26)(H2,24,25,27)
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n/an/a 1.00E+4n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5891
PNG
(1-(2-methylphenyl)-3-[4-(1-oxo-2,3-dihydro-1H-isoi...)
Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1cccc2C(=O)NCc12
Show InChI InChI=1S/C22H19N3O2/c1-14-5-2-3-8-20(14)25-22(27)24-16-11-9-15(10-12-16)17-6-4-7-18-19(17)13-23-21(18)26/h2-12H,13H2,1H3,(H,23,26)(H2,24,25,27)
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n/an/a 4.40E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5892
PNG
(1-(4-methylphenyl)-3-[4-(1-oxo-2,3-dihydro-1H-isoi...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)cc1
Show InChI InChI=1S/C22H19N3O2/c1-14-5-9-16(10-6-14)24-22(27)25-17-11-7-15(8-12-17)18-3-2-4-19-20(18)13-23-21(19)26/h2-12H,13H2,1H3,(H,23,26)(H2,24,25,27)
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n/an/a 430n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5893
PNG
(3-[4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]-1...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)c1
Show InChI InChI=1S/C22H16F3N3O2/c23-22(24,25)14-3-1-4-16(11-14)28-21(30)27-15-9-7-13(8-10-15)17-5-2-6-18-19(17)12-26-20(18)29/h1-11H,12H2,(H,26,29)(H2,27,28,30)
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n/an/a 7n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5894
PNG
(3-[4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]-1...)
Show SMILES FC(F)(F)c1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)cc1
Show InChI InChI=1S/C22H16F3N3O2/c23-22(24,25)14-6-10-16(11-7-14)28-21(30)27-15-8-4-13(5-9-15)17-2-1-3-18-19(17)12-26-20(18)29/h1-11H,12H2,(H,26,29)(H2,27,28,30)
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n/an/a 161n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5895
PNG
(1-(3-chlorophenyl)-3-[4-(1-oxo-2,3-dihydro-1H-isoi...)
Show SMILES Clc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)c1
Show InChI InChI=1S/C21H16ClN3O2/c22-14-3-1-4-16(11-14)25-21(27)24-15-9-7-13(8-10-15)17-5-2-6-18-19(17)12-23-20(18)26/h1-11H,12H2,(H,23,26)(H2,24,25,27)
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n/an/a 46n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5896
PNG
(1-(3-ethylphenyl)-3-[4-(1-oxo-2,3-dihydro-1H-isoin...)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)c1
Show InChI InChI=1S/C23H21N3O2/c1-2-15-5-3-6-18(13-15)26-23(28)25-17-11-9-16(10-12-17)19-7-4-8-20-21(19)14-24-22(20)27/h3-13H,2,14H2,1H3,(H,24,27)(H2,25,26,28)
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n/an/a 29n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5899
PNG
(1-(3-cyanophenyl)-3-[4-(1-oxo-2,3-dihydro-1H-isoin...)
Show SMILES O=C(Nc1ccc(cc1)-c1cccc2C(=O)NCc12)Nc1cccc(c1)C#N
Show InChI InChI=1S/C22H16N4O2/c23-12-14-3-1-4-17(11-14)26-22(28)25-16-9-7-15(8-10-16)18-5-2-6-19-20(18)13-24-21(19)27/h1-11H,13H2,(H,24,27)(H2,25,26,28)
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n/an/a 370n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5900
PNG
(1-(3,4-dimethylphenyl)-3-[4-(1-oxo-2,3-dihydro-1H-...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)cc1C
Show InChI InChI=1S/C23H21N3O2/c1-14-6-9-18(12-15(14)2)26-23(28)25-17-10-7-16(8-11-17)19-4-3-5-20-21(19)13-24-22(20)27/h3-12H,13H2,1-2H3,(H,24,27)(H2,25,26,28)
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n/an/a 50n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5901
PNG
(1-(3,5-dimethylphenyl)-3-[4-(1-oxo-2,3-dihydro-1H-...)
Show SMILES Cc1cc(C)cc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)c1
Show InChI InChI=1S/C23H21N3O2/c1-14-10-15(2)12-18(11-14)26-23(28)25-17-8-6-16(7-9-17)19-4-3-5-20-21(19)13-24-22(20)27/h3-12H,13H2,1-2H3,(H,24,27)(H2,25,26,28)
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n/an/a 83n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5902
PNG
(3-2,3-dihydro-1H-inden-5-yl-1-[4-(1-oxo-2,3-dihydr...)
Show SMILES O=C(Nc1ccc(cc1)-c1cccc2C(=O)NCc12)Nc1ccc2CCCc2c1
Show InChI InChI=1S/C24H21N3O2/c28-23-21-6-2-5-20(22(21)14-25-23)16-8-10-18(11-9-16)26-24(29)27-19-12-7-15-3-1-4-17(15)13-19/h2,5-13H,1,3-4,14H2,(H,25,28)(H2,26,27,29)
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n/an/a 39n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5904
PNG
(3-[3-fluoro-4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(c(F)c2)-c2cccc3C(=O)NCc23)c1
Show InChI InChI=1S/C22H18FN3O2/c1-13-4-2-5-14(10-13)25-22(28)26-15-8-9-17(20(23)11-15)16-6-3-7-18-19(16)12-24-21(18)27/h2-11H,12H2,1H3,(H,24,27)(H2,25,26,28)
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n/an/a 52n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5886
PNG
(3-methyl-1-(3-methylphenyl)-3-[4-(1-oxo-2,3-dihydr...)
Show SMILES CN(C(=O)Nc1cccc(C)c1)c1ccc(cc1)-c1cccc2C(=O)NCc12
Show InChI InChI=1S/C23H21N3O2/c1-15-5-3-6-17(13-15)25-23(28)26(2)18-11-9-16(10-12-18)19-7-4-8-20-21(19)14-24-22(20)27/h3-13H,14H2,1-2H3,(H,24,27)(H,25,28)
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n/an/a 1.10E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair