BindingDB logo
myBDB logout

16 similar compounds to monomer 50317233

Wt: 477.3
BDBM6516
Wt: 442.8
BDBM6526
Wt: 493.3
BDBM6538
Wt: 476.3
BDBM6557
Wt: 477.3
BDBM6558
Wt: 540.4
BDBM50317227
Wt: 533.4
BDBM50317231
Wt: 533.4
BDBM50317232
Wt: 499.3
BDBM50317234
Wt: 513.4
BDBM50317235
Wt: 527.4
BDBM50317236
Wt: 541.4
BDBM50317237
Wt: 611.6
BDBM50317238
Wt: 483.3
BDBM50317239
Wt: 471.3
BDBM50317243
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 6516,6526,6538,6557,6558,50317227,50317231,50317232,50317234,50317235,50317236,50317237,50317238,50317239,50317243   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM6516
PNG
(4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\c4ccncc4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C25H18Cl2N4O2/c1-32-23-10-18-21(9-16(23)4-3-15-5-7-29-8-6-15)30-14-17(13-28)25(18)31-22-12-24(33-2)20(27)11-19(22)26/h3-12,14H,1-2H3,(H,30,31)/b4-3+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.20n/an/an/an/a7.537



Wyeth-Ayerst Research



Assay Description
Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...


Bioorg Med Chem Lett 15: 1743-7 (2005)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317231
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-((d...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\c4ccc(CN(C)C)cc4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C29H26Cl2N4O2/c1-35(2)17-19-7-5-18(6-8-19)9-10-20-11-25-22(12-27(20)36-3)29(21(15-32)16-33-25)34-26-14-28(37-4)24(31)13-23(26)30/h5-14,16H,17H2,1-4H3,(H,33,34)/b10-9+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src after 70 mins by FRET assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM6538
PNG
(4-[(E)-2-{3-cyano-4-[(2,4-dichloro-5-methoxyphenyl...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\c4cc[n+]([O-])cc4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C25H18Cl2N4O3/c1-33-23-10-18-21(9-16(23)4-3-15-5-7-31(32)8-6-15)29-14-17(13-28)25(18)30-22-12-24(34-2)20(27)11-19(22)26/h3-12,14H,1-2H3,(H,29,30)/b4-3+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 0.600n/an/an/an/a7.537



Wyeth-Ayerst Research



Assay Description
Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...


Bioorg Med Chem Lett 15: 1743-7 (2005)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM6557
PNG
(3-quinolinecarbonitrile deriv. 25 | 4-[(2,4-dichlo...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\c4ccccc4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C26H19Cl2N3O2/c1-32-24-11-19-22(10-17(24)9-8-16-6-4-3-5-7-16)30-15-18(14-29)26(19)31-23-13-25(33-2)21(28)12-20(23)27/h3-13,15H,1-2H3,(H,30,31)/b9-8+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 65n/an/an/an/a7.537



Wyeth Research



Assay Description
Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...


Bioorg Med Chem Lett 14: 2155-8 (2004)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM6558
PNG
(3-quinolinecarbonitrile deriv. 26 | 4-[(2,4-dichlo...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\c4cccnc4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C25H18Cl2N4O2/c1-32-23-9-18-21(8-16(23)6-5-15-4-3-7-29-13-15)30-14-17(12-28)25(18)31-22-11-24(33-2)20(27)10-19(22)26/h3-11,13-14H,1-2H3,(H,30,31)/b6-5+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.40n/an/an/an/a7.537



Wyeth Research



Assay Description
Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...


Bioorg Med Chem Lett 14: 2155-8 (2004)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317231
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-((d...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\c4ccc(CN(C)C)cc4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C29H26Cl2N4O2/c1-35(2)17-19-7-5-18(6-8-19)9-10-20-11-25-22(12-27(20)36-3)29(21(15-32)16-33-25)34-26-14-28(37-4)24(31)13-23(26)30/h5-14,16H,17H2,1-4H3,(H,33,34)/b10-9+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317232
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(3-((d...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\c4cccc(CN(C)C)c4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C29H26Cl2N4O2/c1-35(2)17-19-7-5-6-18(10-19)8-9-20-11-25-22(12-27(20)36-3)29(21(15-32)16-33-25)34-26-14-28(37-4)24(31)13-23(26)30/h5-14,16H,17H2,1-4H3,(H,33,34)/b9-8+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src after 70 mins by FRET assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317232
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(3-((d...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\c4cccc(CN(C)C)c4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C29H26Cl2N4O2/c1-35(2)17-19-7-5-6-18(10-19)8-9-20-11-25-22(12-27(20)36-3)29(21(15-32)16-33-25)34-26-14-28(37-4)24(31)13-23(26)30/h5-14,16H,17H2,1-4H3,(H,33,34)/b9-8+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317234
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C25H24Cl2N4O3/c1-32-23-11-18-21(10-16(23)4-3-5-31-6-8-34-9-7-31)29-15-17(14-28)25(18)30-22-13-24(33-2)20(27)12-19(22)26/h3-4,10-13,15H,5-9H2,1-2H3,(H,29,30)/b4-3+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src after 70 mins by FRET assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317234
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C25H24Cl2N4O3/c1-32-23-11-18-21(10-16(23)4-3-5-31-6-8-34-9-7-31)29-15-17(14-28)25(18)30-22-13-24(33-2)20(27)12-19(22)26/h3-4,10-13,15H,5-9H2,1-2H3,(H,29,30)/b4-3+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317235
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C26H26Cl2N4O3/c1-33-24-12-19-22(11-17(24)5-3-4-6-32-7-9-35-10-8-32)30-16-18(15-29)26(19)31-23-14-25(34-2)21(28)13-20(23)27/h3,5,11-14,16H,4,6-10H2,1-2H3,(H,30,31)/b5-3+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.80n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src after 70 mins by FRET assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317235
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C26H26Cl2N4O3/c1-33-24-12-19-22(11-17(24)5-3-4-6-32-7-9-35-10-8-32)30-16-18(15-29)26(19)31-23-14-25(34-2)21(28)13-20(23)27/h3,5,11-14,16H,4,6-10H2,1-2H3,(H,30,31)/b5-3+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317236
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C27H28Cl2N4O3/c1-34-25-13-20-23(12-18(25)6-4-3-5-7-33-8-10-36-11-9-33)31-17-19(16-30)27(20)32-24-15-26(35-2)22(29)14-21(24)28/h4,6,12-15,17H,3,5,7-11H2,1-2H3,(H,31,32)/b6-4+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 5.40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src after 70 mins by FRET assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317236
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C27H28Cl2N4O3/c1-34-25-13-20-23(12-18(25)6-4-3-5-7-33-8-10-36-11-9-33)31-17-19(16-30)27(20)32-24-15-26(35-2)22(29)14-21(24)28/h4,6,12-15,17H,3,5,7-11H2,1-2H3,(H,31,32)/b6-4+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 350n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317237
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C28H30Cl2N4O3/c1-35-26-14-21-24(13-19(26)7-5-3-4-6-8-34-9-11-37-12-10-34)32-18-20(17-31)28(21)33-25-16-27(36-2)23(30)15-22(25)29/h5,7,13-16,18H,3-4,6,8-12H2,1-2H3,(H,32,33)/b7-5+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src after 70 mins by FRET assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317237
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C28H30Cl2N4O3/c1-35-26-14-21-24(13-19(26)7-5-3-4-6-8-34-9-11-37-12-10-34)32-18-20(17-31)28(21)33-25-16-27(36-2)23(30)15-22(25)29/h5,7,13-16,18H,3-4,6,8-12H2,1-2H3,(H,32,33)/b7-5+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317238
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCCCCCCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C33H40Cl2N4O3/c1-40-31-19-26-29(37-23-25(22-36)33(26)38-30-21-32(41-2)28(35)20-27(30)34)18-24(31)12-10-8-6-4-3-5-7-9-11-13-39-14-16-42-17-15-39/h10,12,18-21,23H,3-9,11,13-17H2,1-2H3,(H,37,38)/b12-10+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src after 70 mins by FRET assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317238
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-6-methox...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCCCCCCCCN4CCOCC4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C33H40Cl2N4O3/c1-40-31-19-26-29(37-23-25(22-36)33(26)38-30-21-32(41-2)28(35)20-27(30)34)18-24(31)12-10-8-6-4-3-5-7-9-11-13-39-14-16-42-17-15-39/h10,12,18-21,23H,3-9,11,13-17H2,1-2H3,(H,37,38)/b12-10+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317239
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-mor...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCN4CCOCC4)ccc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C25H24Cl2N4O2/c1-32-24-14-23(20(26)13-21(24)27)30-25-18(15-28)16-29-22-12-17(5-6-19(22)25)4-2-3-7-31-8-10-33-11-9-31/h2,4-6,12-14,16H,3,7-11H2,1H3,(H,29,30)/b4-2+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src after 70 mins by FRET assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317239
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-mor...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCN4CCOCC4)ccc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C25H24Cl2N4O2/c1-32-24-14-23(20(26)13-21(24)27)30-25-18(15-28)16-29-22-12-17(5-6-19(22)25)4-2-3-7-31-8-10-33-11-9-31/h2,4-6,12-14,16H,3,7-11H2,1H3,(H,29,30)/b4-2+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317243
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(di...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCN(C)C)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C24H24Cl2N4O2/c1-30(2)8-6-5-7-15-9-20-17(10-22(15)31-3)24(16(13-27)14-28-20)29-21-12-23(32-4)19(26)11-18(21)25/h5,7,9-12,14H,6,8H2,1-4H3,(H,28,29)/b7-5+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src after 70 mins by FRET assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317243
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(di...)
Show SMILES COc1cc(Nc2c(cnc3cc(\C=C\CCN(C)C)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C24H24Cl2N4O2/c1-30(2)8-6-5-7-15-9-20-17(10-22(15)31-3)24(16(13-27)14-28-20)29-21-12-23(32-4)19(26)11-18(21)25/h5,7,9-12,14H,6,8H2,1-4H3,(H,28,29)/b7-5+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 62n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317227
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(4-...)
Show SMILES CCN1CCN(CC\C=C\c2cc3ncc(C#N)c(Nc4cc(OC)c(Cl)cc4Cl)c3cc2OC)CC1
Show InChI InChI=1S/C28H31Cl2N5O2/c1-4-34-9-11-35(12-10-34)8-6-5-7-19-13-24-21(14-26(19)36-2)28(20(17-31)18-32-24)33-25-16-27(37-3)23(30)15-22(25)29/h5,7,13-16,18H,4,6,8-12H2,1-3H3,(H,32,33)/b7-5+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Src after 70 mins by FRET assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50317227
PNG
((E)-4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(4-...)
Show SMILES CCN1CCN(CC\C=C\c2cc3ncc(C#N)c(Nc4cc(OC)c(Cl)cc4Cl)c3cc2OC)CC1
Show InChI InChI=1S/C28H31Cl2N5O2/c1-4-34-9-11-35(12-10-34)8-6-5-7-19-13-24-21(14-26(19)36-2)28(20(17-31)18-32-24)33-25-16-27(37-3)23(30)15-22(25)29/h5,7,13-16,18H,4,6,8-12H2,1-3H3,(H,32,33)/b7-5+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 67n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Src-mediated cell proliferation in rat Rat-2 fibroblasts after 4 days by MTS assay


Bioorg Med Chem Lett 20: 2924-7 (2010)

More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM6526
PNG
(4-[(2-chloro-5-methoxyphenyl)amino]-6-methoxy-7-[(...)
Show SMILES COc1ccc(Cl)c(Nc2c(cnc3cc(\C=C\c4ccncc4)c(OC)cc23)C#N)c1
Show InChI InChI=1S/C25H19ClN4O2/c1-31-19-5-6-21(26)23(12-19)30-25-18(14-27)15-29-22-11-17(24(32-2)13-20(22)25)4-3-16-7-9-28-10-8-16/h3-13,15H,1-2H3,(H,29,30)/b4-3+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.70n/an/an/an/a7.537



Wyeth-Ayerst Research



Assay Description
Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...


Bioorg Med Chem Lett 15: 1743-7 (2005)

More data for this
Ligand-Target Pair