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27 similar compounds to monomer 50133394

Compile data set for download or QSAR
Wt: 364.3
BDBM69735
Purchase
Wt: 589.2
BDBM81332
Wt: 359.4
BDBM50027423
Wt: 371.4
BDBM50027425
Wt: 413.4
BDBM50027429
Wt: 406.2
BDBM50277893
Wt: 497.5
BDBM50084124
Wt: 515.4
BDBM50084122
Wt: 341.8
BDBM50028621
Wt: 341.8
BDBM50028622
Wt: 512.6
BDBM50029356
Wt: 346.8
BDBM50051938
Purchase
Wt: 597.6
BDBM50026800
Wt: 323.4
BDBM50034167
Wt: 291.3
BDBM50133389
Displayed 1 to 15 (of 26 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 69735,81332,50027423,50027425,50027429,50277893,50084124,50084122,50028621,50028622,50029356,50051938,50026800,50034167,50133389   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic Anhydrase XIV


(Homo sapiens (Human))
BDBM50133389
PNG
(CHEMBL3632825)
Show SMILES COC(=O)c1ccc(cc1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H13NO4S/c1-19-14(16)12-4-2-10(3-5-12)11-6-8-13(9-7-11)20(15,17)18/h2-9H,1H3,(H2,15,17,18)
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0.670n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-14 assessed as CO2 hydration activity by stopped-flow method


J Med Chem 58: 8564-72 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01144
BindingDB Entry DOI: 10.7270/Q2FF3V5V
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50133389
PNG
(CHEMBL3632825)
Show SMILES COC(=O)c1ccc(cc1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H13NO4S/c1-19-14(16)12-4-2-10(3-5-12)11-6-8-13(9-7-11)20(15,17)18/h2-9H,1H3,(H2,15,17,18)
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9n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-2 assessed as CO2 hydration activity by stopped-flow method


J Med Chem 58: 8564-72 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01144
BindingDB Entry DOI: 10.7270/Q2FF3V5V
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50133389
PNG
(CHEMBL3632825)
Show SMILES COC(=O)c1ccc(cc1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H13NO4S/c1-19-14(16)12-4-2-10(3-5-12)11-6-8-13(9-7-11)20(15,17)18/h2-9H,1H3,(H2,15,17,18)
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9.30n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-9 assessed as CO2 hydration activity by stopped-flow method


J Med Chem 58: 8564-72 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01144
BindingDB Entry DOI: 10.7270/Q2FF3V5V
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50133389
PNG
(CHEMBL3632825)
Show SMILES COC(=O)c1ccc(cc1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H13NO4S/c1-19-14(16)12-4-2-10(3-5-12)11-6-8-13(9-7-11)20(15,17)18/h2-9H,1H3,(H2,15,17,18)
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35n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-12 assessed as CO2 hydration activity by stopped-flow method


J Med Chem 58: 8564-72 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01144
BindingDB Entry DOI: 10.7270/Q2FF3V5V
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50034167
PNG
(CHEMBL3359232)
Show SMILES C(COc1nc(nc2CCCc12)-c1ccccc1)CN1CCCC1
Show InChI InChI=1S/C20H25N3O/c1-2-8-16(9-3-1)19-21-18-11-6-10-17(18)20(22-19)24-15-7-14-23-12-4-5-13-23/h1-3,8-9H,4-7,10-15H2
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59n/an/an/an/an/an/an/an/a



Huazhong University of Science and Technology

Curated by ChEMBL


Assay Description
Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in Dunkin Hartley guinea pig brain membranes after 180 mins by liquid scintillation counti...


J Med Chem 57: 10404-23 (2014)


Article DOI: 10.1021/jm501207r
BindingDB Entry DOI: 10.7270/Q2XD138B
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))
BDBM50034167
PNG
(CHEMBL3359232)
Show SMILES C(COc1nc(nc2CCCc12)-c1ccccc1)CN1CCCC1
Show InChI InChI=1S/C20H25N3O/c1-2-8-16(9-3-1)19-21-18-11-6-10-17(18)20(22-19)24-15-7-14-23-12-4-5-13-23/h1-3,8-9H,4-7,10-15H2
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59n/an/an/an/an/an/an/an/a



Renmin Hospital of Wuhan University

Curated by ChEMBL


Assay Description
Tested for neuronal nicotinic acetylcholine receptor (nAChR) binding in a whole rat brain preparation using [3H]-cystine as the radioligand.


Bioorg Med Chem Lett 26: 2051-6 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.077
BindingDB Entry DOI: 10.7270/Q25Q4XZN
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM50133389
PNG
(CHEMBL3632825)
Show SMILES COC(=O)c1ccc(cc1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H13NO4S/c1-19-14(16)12-4-2-10(3-5-12)11-6-8-13(9-7-11)20(15,17)18/h2-9H,1H3,(H2,15,17,18)
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77n/an/an/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-1 assessed as CO2 hydration activity by stopped-flow method


J Med Chem 58: 8564-72 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01144
BindingDB Entry DOI: 10.7270/Q2FF3V5V
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM50028621
PNG
(CHEMBL3342517)
Show SMILES CN(C(=O)c1ccc(s1)-c1cccc(C)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C19H16ClNOS/c1-13-5-3-6-14(11-13)17-9-10-18(23-17)19(22)21(2)16-8-4-7-15(20)12-16/h3-12H,1-2H3
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n/an/a 327n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Displacement of [3H]E2 from human placental microsomal 17beta-HSD2 after 20 mins by cell-free assay


Eur J Med Chem 87: 203-19 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.061
BindingDB Entry DOI: 10.7270/Q2F1919V
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 2


(Homo sapiens (Human))
BDBM50028622
PNG
(CHEMBL3342518)
Show SMILES CN(C(=O)c1ccc(s1)-c1cccc(Cl)c1)c1cccc(C)c1
Show InChI InChI=1S/C19H16ClNOS/c1-13-5-3-8-16(11-13)21(2)19(22)18-10-9-17(23-18)14-6-4-7-15(20)12-14/h3-12H,1-2H3
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n/an/a 474n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Displacement of [3H]E2 from human placental microsomal 17beta-HSD2 after 20 mins by cell-free assay


Eur J Med Chem 87: 203-19 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.061
BindingDB Entry DOI: 10.7270/Q2F1919V
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50028621
PNG
(CHEMBL3342517)
Show SMILES CN(C(=O)c1ccc(s1)-c1cccc(C)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C19H16ClNOS/c1-13-5-3-6-14(11-13)17-9-10-18(23-17)19(22)21(2)16-8-4-7-15(20)12-16/h3-12H,1-2H3
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n/an/a 9.41E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Displacement of [3H]E1 from human placental cytosolic17beta-HSD1 after 10 mins by cell-free assay


Eur J Med Chem 87: 203-19 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.061
BindingDB Entry DOI: 10.7270/Q2F1919V
More data for this
Ligand-Target Pair
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)


(Homo sapiens (Human))
BDBM50028622
PNG
(CHEMBL3342518)
Show SMILES CN(C(=O)c1ccc(s1)-c1cccc(Cl)c1)c1cccc(C)c1
Show InChI InChI=1S/C19H16ClNOS/c1-13-5-3-8-16(11-13)21(2)19(22)18-10-9-17(23-18)14-6-4-7-15(20)12-14/h3-12H,1-2H3
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n/an/a 2.14E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Displacement of [3H]E1 from human placental cytosolic17beta-HSD1 after 10 mins by cell-free assay


Eur J Med Chem 87: 203-19 (2014)


Article DOI: 10.1016/j.ejmech.2014.09.061
BindingDB Entry DOI: 10.7270/Q2F1919V
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50029356
PNG
(CHEMBL3343308)
Show SMILES O=C(NCc1ccccc1)Nc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)ccc23)cc1
Show InChI InChI=1S/C29H32N6O3/c36-29(30-20-22-5-2-1-3-6-22)34-24-9-7-23(8-10-24)33-28-26-12-11-25(19-27(26)31-21-32-28)38-16-4-13-35-14-17-37-18-15-35/h1-3,5-12,19,21H,4,13-18,20H2,(H2,30,34,36)(H,31,32,33)
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n/an/a 212n/an/an/an/an/an/a



Southeast University

Curated by ChEMBL


Assay Description
Inhibition of Aurora-A (unknown origin) using STK substrate 2-biotin by HTRF-KinEASE-STK assay


Bioorg Med Chem 22: 5813-23 (2014)


Article DOI: 10.1016/j.bmc.2014.09.029
BindingDB Entry DOI: 10.7270/Q279468G
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50029356
PNG
(CHEMBL3343308)
Show SMILES O=C(NCc1ccccc1)Nc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)ccc23)cc1
Show InChI InChI=1S/C29H32N6O3/c36-29(30-20-22-5-2-1-3-6-22)34-24-9-7-23(8-10-24)33-28-26-12-11-25(19-27(26)31-21-32-28)38-16-4-13-35-14-17-37-18-15-35/h1-3,5-12,19,21H,4,13-18,20H2,(H2,30,34,36)(H,31,32,33)
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n/an/a 367n/an/an/an/an/an/a



Southeast University

Curated by ChEMBL


Assay Description
Inhibition of Aurora-B (unknown origin) using STK substrate 2-biotin by HTRF-KinEASE-STK assay


Bioorg Med Chem 22: 5813-23 (2014)


Article DOI: 10.1016/j.bmc.2014.09.029
BindingDB Entry DOI: 10.7270/Q279468G
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50051938
PNG
(CHEMBL3318374)
Show SMILES COc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)c(OC)c1
Show InChI InChI=1S/C17H15ClN2O2S/c1-21-13-7-8-14(16(9-13)22-2)19-17-20-15(10-23-17)11-3-5-12(18)6-4-11/h3-10H,1-2H3,(H,19,20)
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n/an/a 600n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of partially purified recombinant 5-lipoxygenase (unknown origin) using arachidonic acid as substrate preincubated for 15 mins before subs...


Eur J Med Chem 84: 302-11 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.025
BindingDB Entry DOI: 10.7270/Q2WM1G2Z
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50051938
PNG
(CHEMBL3318374)
Show SMILES COc1ccc(Nc2nc(cs2)-c2ccc(Cl)cc2)c(OC)c1
Show InChI InChI=1S/C17H15ClN2O2S/c1-21-13-7-8-14(16(9-13)22-2)19-17-20-15(10-23-17)11-3-5-12(18)6-4-11/h3-10H,1-2H3,(H,19,20)
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n/an/a 7.30E+3n/an/an/an/an/an/a



Goethe University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in human PMNL using arachidonic acid as substrate preincubated for 15 mins before substrate addition measured after 10 m...


Eur J Med Chem 84: 302-11 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.025
BindingDB Entry DOI: 10.7270/Q2WM1G2Z
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50084122
PNG
(CHEMBL3425931)
Show SMILES O[C@@]1(CC23CCC(CC2)(CO3)NCc2ccc3OC(F)(F)Oc3c2)Cn2c3c1c(F)cnc3ccc2=O
Show InChI InChI=1S/C26H24F3N3O5/c27-16-11-30-17-2-4-20(33)32-13-25(34,21(16)22(17)32)12-24-7-5-23(6-8-24,14-35-24)31-10-15-1-3-18-19(9-15)37-26(28,29)36-18/h1-4,9,11,31,34H,5-8,10,12-14H2/t23?,24?,25-/m0/s1
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n/an/a 2.82E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ERG expressed in CHO cells measured over 5 mins by patch clamp assay


Bioorg Med Chem Lett 25: 2473-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.063
BindingDB Entry DOI: 10.7270/Q2NZ89BD
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM50084124
PNG
(CHEMBL3425934)
Show SMILES O[C@@]1(CC23CCC(CC2)(CO3)NC\C=C\c2c(F)cccc2F)Cn2c3c1c(F)cnc3ccc2=O
Show InChI InChI=1S/C27H26F3N3O3/c28-18-4-1-5-19(29)17(18)3-2-12-32-25-8-10-26(11-9-25,36-16-25)14-27(35)15-33-22(34)7-6-21-24(33)23(27)20(30)13-31-21/h1-7,13,32,35H,8-12,14-16H2/b3-2+/t25?,26?,27-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of MK499 from human ERG


Bioorg Med Chem Lett 25: 2473-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.063
BindingDB Entry DOI: 10.7270/Q2NZ89BD
More data for this
Ligand-Target Pair
Genome polyprotein


(Dengue virus 2)
BDBM50026800
PNG
(CHEMBL3335509)
Show SMILES NCCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1ccc(cc1)[N+]([O-])=O)C(N)=O
Show InChI InChI=1S/C28H39N9O6/c29-15-5-4-9-21(27(41)36-23(24(30)38)17-18-11-13-20(14-12-18)37(42)43)35-26(40)22(10-6-16-33-28(31)32)34-25(39)19-7-2-1-3-8-19/h1-3,7-8,11-14,21-23H,4-6,9-10,15-17,29H2,(H2,30,38)(H,34,39)(H,35,40)(H,36,41)(H4,31,32,33)/t21-,22-,23-/m0/s1
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n/an/a 1.75E+4n/an/an/an/an/an/a



Heidelberg University

Curated by ChEMBL


Assay Description
Inhibition of Dengue virus serotype 2 NS2B-NS3 protease by homogeneous fluorimetric assay


ACS Med Chem Lett 5: 1037-42 (2014)


Article DOI: 10.1021/ml500245v
BindingDB Entry DOI: 10.7270/Q2028T42
More data for this
Ligand-Target Pair
CDK2/Cyclin A/Cyclin A1


(Homo sapiens (Human))
BDBM50027429
PNG
(CHEMBL603543)
Show SMILES CCN1CCC(CC1)C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3)n[nH]c2C1(C)C
Show InChI InChI=1S/C22H28FN5O2/c1-4-27-11-9-15(10-12-27)21(30)28-13-17-18(22(28,2)3)25-26-19(17)24-20(29)14-5-7-16(23)8-6-14/h5-8,15H,4,9-13H2,1-3H3,(H2,24,25,26,29)
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n/an/a 30n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of human CDK2/cyclin A expressed in Escherichia coli BL21 by scintillation proximity assay


Bioorg Med Chem 18: 1844-53 (2010)


Article DOI: 10.1016/j.bmc.2010.01.042
BindingDB Entry DOI: 10.7270/Q21R6RG5
More data for this
Ligand-Target Pair
CDK2/Cyclin A/Cyclin A1


(Homo sapiens (Human))
BDBM50027425
PNG
(CHEMBL1744454)
Show SMILES CN1CCC(CC1)C(=O)N1Cc2c(NC(=O)c3ccco3)n[nH]c2C1(C)C
Show InChI InChI=1S/C19H25N5O3/c1-19(2)15-13(11-24(19)18(26)12-6-8-23(3)9-7-12)16(22-21-15)20-17(25)14-5-4-10-27-14/h4-5,10,12H,6-9,11H2,1-3H3,(H2,20,21,22,25)
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n/an/a 33n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of human CDK2/cyclin A expressed in Escherichia coli BL21 by scintillation proximity assay


Bioorg Med Chem 18: 1844-53 (2010)


Article DOI: 10.1016/j.bmc.2010.01.042
BindingDB Entry DOI: 10.7270/Q21R6RG5
More data for this
Ligand-Target Pair
CDK2/Cyclin A/Cyclin A1


(Homo sapiens (Human))
BDBM50027423
PNG
(CHEMBL1744456)
Show SMILES CN1CCC(CC1)C(=O)N1Cc2c(NC(=O)C3CCC3)n[nH]c2C1(C)C
Show InChI InChI=1S/C19H29N5O2/c1-19(2)15-14(16(22-21-15)20-17(25)12-5-4-6-12)11-24(19)18(26)13-7-9-23(3)10-8-13/h12-13H,4-11H2,1-3H3,(H2,20,21,22,25)
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n/an/a 9n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of human CDK2/cyclin A expressed in Escherichia coli BL21 by scintillation proximity assay


Bioorg Med Chem 18: 1844-53 (2010)


Article DOI: 10.1016/j.bmc.2010.01.042
BindingDB Entry DOI: 10.7270/Q21R6RG5
More data for this
Ligand-Target Pair
Fructose-1,6-bisphosphatase 1 (FBPase)


(Homo sapiens (Human))
BDBM50277893
PNG
(2-(6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydro...)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(NCCOP(O)(O)=O)nc12
Show InChI InChI=1S/C12H19N6O8P/c13-9-6-10(16-4-15-9)18(11-8(21)7(20)5(3-19)26-11)12(17-6)14-1-2-25-27(22,23)24/h4-5,7-8,11,19-21H,1-3H2,(H,14,17)(H2,13,15,16)(H2,22,23,24)/t5-,7-,8-,11-/m1/s1
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n/an/a 1.40E+5n/an/an/an/an/an/a



Metabasis Therapeutics, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry


J Med Chem 52: 2880-98 (2009)


Article DOI: 10.1021/jm900078f
BindingDB Entry DOI: 10.7270/Q2V40V20
More data for this
Ligand-Target Pair
FtsZ


(Aquifex aeolicus)
BDBM81332
PNG
(PyrrGTP (7b))
Show SMILES Nc1nc2n([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C3O)c(nc2c(=O)[nH]1)N1CCCC1
Show InChI InChI=1S/C14H23N6O14P3/c15-13-17-10-7(11(23)18-13)16-14(19-3-1-2-4-19)20(10)12-9(22)8(21)6(32-12)5-31-36(27,28)34-37(29,30)33-35(24,25)26/h6,8-9,12,21-22H,1-5H2,(H,27,28)(H,29,30)(H2,24,25,26)(H3,15,17,18,23)/p-3/t6-,8?,9?,12-/m1/s1
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n/an/a 2.14E+4n/an/an/an/a7.5n/a



University of Amsterdam



Assay Description
The binding affinities to FtsZ were determined by a fluorescent coupled assay for phosphate relase. In this GTPase studies, phosphate liberated durin...


Chem Biol 15: 189-99 (2008)


Article DOI: 10.1016/j.chembiol.2007.12.013
BindingDB Entry DOI: 10.7270/Q2P849CR
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM69735
PNG
((2R,3R,4S,5R)-2-[6-amino-8-(4-methyl-1-piperidinyl...)
Show SMILES CC1CCN(CC1)c1nc2c(N)ncnc2n1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C16H24N6O4/c1-8-2-4-21(5-3-8)16-20-10-13(17)18-7-19-14(10)22(16)15-12(25)11(24)9(6-23)26-15/h7-9,11-12,15,23-25H,2-6H2,1H3,(H2,17,18,19)/t9-,11-,12-,15-/m1/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2TX3CTT
More data for this
Ligand-Target Pair
FtsZ


(Aquifex aeolicus)
BDBM81332
PNG
(PyrrGTP (7b))
Show SMILES Nc1nc2n([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C3O)c(nc2c(=O)[nH]1)N1CCCC1
Show InChI InChI=1S/C14H23N6O14P3/c15-13-17-10-7(11(23)18-13)16-14(19-3-1-2-4-19)20(10)12-9(22)8(21)6(32-12)5-31-36(27,28)34-37(29,30)33-35(24,25)26/h6,8-9,12,21-22H,1-5H2,(H,27,28)(H,29,30)(H2,24,25,26)(H3,15,17,18,23)/p-3/t6-,8?,9?,12-/m1/s1
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n/an/a 1.50E+4 15.6n/an/an/a7.5n/a



University of Amsterdam



Assay Description
The binding affinities to FtsZ were determined by a fluorescent competition assay with 2'/3'-O-(N-methyl-anthraniloyl)-guanosine-5'-triph...


Chem Biol 15: 189-99 (2008)


Article DOI: 10.1016/j.chembiol.2007.12.013
BindingDB Entry DOI: 10.7270/Q2P849CR
More data for this
Ligand-Target Pair