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5 similar compounds to monomer 50101782

Compile data set for download or QSAR
Wt: 339.3
BDBM72088
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Wt: 294.3
BDBM50101781
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Wt: 280.3
BDBM50101790
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Wt: 336.4
BDBM50101785
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Wt: 418.4
BDBM50219652

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 72088,50101781,50101790,50101785,50219652   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50101781
PNG
(4-Methyl-N-(4-phenyl-thiazol-2-yl)-benzamide | CHE...)
Show SMILES Cc1ccc(cc1)C(=O)Nc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C17H14N2OS/c1-12-7-9-14(10-8-12)16(20)19-17-18-15(11-21-17)13-5-3-2-4-6-13/h2-11H,1H3,(H,18,19,20)
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Article
PubMed
36n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-DPCPX from Adenosine A1 receptor of rat cortical membrane


Bioorg Med Chem Lett 11: 2017-9 (2001)


Article DOI: 10.1016/s0960-894x(01)00356-0
BindingDB Entry DOI: 10.7270/Q2HM57QP
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50101790
PNG
(CHEMBL60334 | N-(4-Phenyl-thiazol-2-yl)-benzamide)
Show SMILES O=C(Nc1nc(cs1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H12N2OS/c19-15(13-9-5-2-6-10-13)18-16-17-14(11-20-16)12-7-3-1-4-8-12/h1-11H,(H,17,18,19)
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39n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-DPCPX from Adenosine A1 receptor of rat cortical membrane


Bioorg Med Chem Lett 11: 2017-9 (2001)


Article DOI: 10.1016/s0960-894x(01)00356-0
BindingDB Entry DOI: 10.7270/Q2HM57QP
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50101785
PNG
(4-tert-Butyl-N-(4-phenyl-thiazol-2-yl)-benzamide |...)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C20H20N2OS/c1-20(2,3)16-11-9-15(10-12-16)18(23)22-19-21-17(13-24-19)14-7-5-4-6-8-14/h4-13H,1-3H3,(H,21,22,23)
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1.36E+3n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-DPCPX from Adenosine A1 receptor of rat cortical membrane


Bioorg Med Chem Lett 11: 2017-9 (2001)


Article DOI: 10.1016/s0960-894x(01)00356-0
BindingDB Entry DOI: 10.7270/Q2HM57QP
More data for this
Ligand-Target Pair
Hsf1 protein


(Mus musculus)
BDBM72088
PNG
(3-Nitro-N-(4-p-tolyl-thiazol-2-yl)-benzamide | 3-n...)
Show SMILES Cc1ccc(cc1)-c1csc(NC(=O)c2cccc(c2)[N+]([O-])=O)n1
Show InChI InChI=1S/C17H13N3O3S/c1-11-5-7-12(8-6-11)15-10-24-17(18-15)19-16(21)13-3-2-4-14(9-13)20(22)23/h2-10H,1H3,(H,18,19,21)
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n/an/an/an/a>2.60E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q2P55KXK
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))
BDBM50219652
PNG
(CHEMBL398549 | N-(4-(4-nitrophenyl)thiazol-2-yl)-4...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C20H14N6O3S/c27-19(14-1-5-15(6-2-14)23-18-9-10-21-12-22-18)25-20-24-17(11-30-20)13-3-7-16(8-4-13)26(28)29/h1-12H,(H,21,22,23)(H,24,25,27)
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Article
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Bioorg Med Chem Lett 17: 5447-54 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.038
BindingDB Entry DOI: 10.7270/Q2Q52PBC
More data for this
Ligand-Target Pair