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19 similar compounds to monomer 50408949

Compile data set for download or QSAR
Wt: 310.3
BDBM7239
Wt: 324.2
BDBM7244
Wt: 298.2
BDBM7245
Wt: 314.7
BDBM7246
Wt: 359.1
BDBM7247
Wt: 294.3
BDBM7248
Wt: 324.3
BDBM7249
Wt: 310.3
BDBM7251
Wt: 356.3
BDBM7252
Wt: 326.3
BDBM16983
Wt: 310.3
BDBM50065308
Purchase
Wt: 296.3
BDBM50065283
Wt: 432.4
BDBM50321892
Wt: 416.4
BDBM50321894
Wt: 446.4
BDBM50321895
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 70 hits for monomerid = 7239,7244,7245,7246,7247,7248,7249,7251,7252,16983,50065308,50065283,50321892,50321894,50321895   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDK2/CycE


(Homo sapiens (Human))
BDBM7239
PNG
((3Z)-5-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...)
Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-14-11(6-9)12(16(20)19-14)7-15-10-4-5-23-17(21)13(10)8-18-15/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-
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Article
PubMed
n/an/a 40n/an/an/an/a7.422



SUGEN, Inc.



Assay Description
For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM7244
PNG
((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...)
Show SMILES OC(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C17H12N2O5/c20-15-11(10-5-8(16(21)22)1-2-13(10)19-15)6-14-9-3-4-24-17(23)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)(H,21,22)/b11-6-
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n/an/a 4n/an/an/an/a7.422



SUGEN, Inc.



Assay Description
For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM7245
PNG
((3Z)-5-fluoro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Fc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11FN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a 82n/an/an/an/a7.422



SUGEN, Inc.



Assay Description
For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM7246
PNG
((3Z)-5-chloro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11ClN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a 88n/an/an/an/a7.422



SUGEN, Inc.



Assay Description
For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM7247
PNG
((3Z)-5-bromo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]py...)
Show SMILES Brc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11BrN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a 190n/an/an/an/a7.422



SUGEN, Inc.



Assay Description
For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM7248
PNG
((3Z)-4-methyl-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Cc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12
Show InChI InChI=1S/C17H14N2O3/c1-9-3-2-4-13-15(9)11(16(20)19-13)7-14-10-5-6-22-17(21)12(10)8-18-14/h2-4,7-8,18H,5-6H2,1H3,(H,19,20)/b11-7-
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n/an/a 270n/an/an/an/a7.422



SUGEN, Inc.



Assay Description
For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM7249
PNG
((3Z)-4-(2-hydroxyethyl)-3-({4-oxo-2H,4H,6H,7H-pyra...)
Show SMILES OCCc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12
Show InChI InChI=1S/C18H16N2O4/c21-6-4-10-2-1-3-14-16(10)12(17(22)20-14)8-15-11-5-7-24-18(23)13(11)9-19-15/h1-3,8-9,19,21H,4-7H2,(H,20,22)/b12-8-
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n/an/a 30n/an/an/an/a7.422



SUGEN, Inc.



Assay Description
For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM7251
PNG
((3Z)-6-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...)
Show SMILES COc1ccc2\C(=C\c3[nH]cc4c3CCOC4=O)C(=O)Nc2c1
Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-10-12(16(20)19-15(10)6-9)7-14-11-4-5-23-17(21)13(11)8-18-14/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-
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n/an/a 1.50E+3n/an/an/an/a7.422



SUGEN, Inc.



Assay Description
For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM7252
PNG
((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...)
Show SMILES O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCOC2=O)-c1ccccc1
Show InChI InChI=1S/C22H16N2O3/c25-21-17(11-19-16-8-9-27-22(26)18(16)12-23-19)15-7-6-14(10-20(15)24-21)13-4-2-1-3-5-13/h1-7,10-12,23H,8-9H2,(H,24,25)/b17-11-
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n/an/a>1.00E+4n/an/an/an/a7.422



SUGEN, Inc.



Assay Description
For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM7239
PNG
((3Z)-5-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...)
Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-14-11(6-9)12(16(20)19-14)7-15-10-4-5-23-17(21)13(10)8-18-15/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM7244
PNG
((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...)
Show SMILES OC(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C17H12N2O5/c20-15-11(10-5-8(16(21)22)1-2-13(10)19-15)6-14-9-3-4-24-17(23)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)(H,21,22)/b11-6-
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n/an/a 6.20E+3n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM7245
PNG
((3Z)-5-fluoro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Fc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11FN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a 1.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM7246
PNG
((3Z)-5-chloro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11ClN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM7247
PNG
((3Z)-5-bromo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]py...)
Show SMILES Brc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11BrN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a 1.10E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM7248
PNG
((3Z)-4-methyl-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Cc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12
Show InChI InChI=1S/C17H14N2O3/c1-9-3-2-4-13-15(9)11(16(20)19-13)7-14-10-5-6-22-17(21)12(10)8-18-14/h2-4,7-8,18H,5-6H2,1H3,(H,19,20)/b11-7-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM7249
PNG
((3Z)-4-(2-hydroxyethyl)-3-({4-oxo-2H,4H,6H,7H-pyra...)
Show SMILES OCCc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12
Show InChI InChI=1S/C18H16N2O4/c21-6-4-10-2-1-3-14-16(10)12(17(22)20-14)8-15-11-5-7-24-18(23)13(11)9-19-15/h1-3,8-9,19,21H,4-7H2,(H,20,22)/b12-8-
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n/an/a 1.20E+3n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM7251
PNG
((3Z)-6-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...)
Show SMILES COc1ccc2\C(=C\c3[nH]cc4c3CCOC4=O)C(=O)Nc2c1
Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-10-12(16(20)19-15(10)6-9)7-14-11-4-5-23-17(21)13(11)8-18-14/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM7252
PNG
((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...)
Show SMILES O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCOC2=O)-c1ccccc1
Show InChI InChI=1S/C22H16N2O3/c25-21-17(11-19-16-8-9-27-22(26)18(16)12-23-19)15-7-6-14(10-20(15)24-21)13-4-2-1-3-5-13/h1-7,10-12,23H,8-9H2,(H,24,25)/b17-11-
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n/an/a 2.00E+3n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM7239
PNG
((3Z)-5-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...)
Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-14-11(6-9)12(16(20)19-14)7-15-10-4-5-23-17(21)13(10)8-18-15/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM7244
PNG
((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...)
Show SMILES OC(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C17H12N2O5/c20-15-11(10-5-8(16(21)22)1-2-13(10)19-15)6-14-9-3-4-24-17(23)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)(H,21,22)/b11-6-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM7245
PNG
((3Z)-5-fluoro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Fc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11FN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM7246
PNG
((3Z)-5-chloro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11ClN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a 2.10E+3n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM7247
PNG
((3Z)-5-bromo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]py...)
Show SMILES Brc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11BrN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a 1.80E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM7248
PNG
((3Z)-4-methyl-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Cc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12
Show InChI InChI=1S/C17H14N2O3/c1-9-3-2-4-13-15(9)11(16(20)19-13)7-14-10-5-6-22-17(21)12(10)8-18-14/h2-4,7-8,18H,5-6H2,1H3,(H,19,20)/b11-7-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM7249
PNG
((3Z)-4-(2-hydroxyethyl)-3-({4-oxo-2H,4H,6H,7H-pyra...)
Show SMILES OCCc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12
Show InChI InChI=1S/C18H16N2O4/c21-6-4-10-2-1-3-14-16(10)12(17(22)20-14)8-15-11-5-7-24-18(23)13(11)9-19-15/h1-3,8-9,19,21H,4-7H2,(H,20,22)/b12-8-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM7251
PNG
((3Z)-6-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...)
Show SMILES COc1ccc2\C(=C\c3[nH]cc4c3CCOC4=O)C(=O)Nc2c1
Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-10-12(16(20)19-15(10)6-9)7-14-11-4-5-23-17(21)13(11)8-18-14/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-
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n/an/a 1.40E+3n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM7252
PNG
((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...)
Show SMILES O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCOC2=O)-c1ccccc1
Show InChI InChI=1S/C22H16N2O3/c25-21-17(11-19-16-8-9-27-22(26)18(16)12-23-19)15-7-6-14(10-20(15)24-21)13-4-2-1-3-5-13/h1-7,10-12,23H,8-9H2,(H,24,25)/b17-11-
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n/an/a 1.10E+3n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well microtit...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM7239
PNG
((3Z)-5-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...)
Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-14-11(6-9)12(16(20)19-14)7-15-10-4-5-23-17(21)13(10)8-18-15/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM7244
PNG
((3Z)-2-oxo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrr...)
Show SMILES OC(=O)c1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C17H12N2O5/c20-15-11(10-5-8(16(21)22)1-2-13(10)19-15)6-14-9-3-4-24-17(23)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)(H,21,22)/b11-6-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM7245
PNG
((3Z)-5-fluoro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Fc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11FN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM7246
PNG
((3Z)-5-chloro-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Clc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11ClN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM7247
PNG
((3Z)-5-bromo-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]py...)
Show SMILES Brc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c2c1
Show InChI InChI=1S/C16H11BrN2O3/c17-8-1-2-13-10(5-8)11(15(20)19-13)6-14-9-3-4-22-16(21)12(9)7-18-14/h1-2,5-7,18H,3-4H2,(H,19,20)/b11-6-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM7248
PNG
((3Z)-4-methyl-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]p...)
Show SMILES Cc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12
Show InChI InChI=1S/C17H14N2O3/c1-9-3-2-4-13-15(9)11(16(20)19-13)7-14-10-5-6-22-17(21)12(10)8-18-14/h2-4,7-8,18H,5-6H2,1H3,(H,19,20)/b11-7-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM7249
PNG
((3Z)-4-(2-hydroxyethyl)-3-({4-oxo-2H,4H,6H,7H-pyra...)
Show SMILES OCCc1cccc2NC(=O)\C(=C/c3[nH]cc4c3CCOC4=O)c12
Show InChI InChI=1S/C18H16N2O4/c21-6-4-10-2-1-3-14-16(10)12(17(22)20-14)8-15-11-5-7-24-18(23)13(11)9-19-15/h1-3,8-9,19,21H,4-7H2,(H,20,22)/b12-8-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM7251
PNG
((3Z)-6-methoxy-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]...)
Show SMILES COc1ccc2\C(=C\c3[nH]cc4c3CCOC4=O)C(=O)Nc2c1
Show InChI InChI=1S/C17H14N2O4/c1-22-9-2-3-10-12(16(20)19-15(10)6-9)7-14-11-4-5-23-17(21)13(11)8-18-14/h2-3,6-8,18H,4-5H2,1H3,(H,19,20)/b12-7-
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n/an/a>2.00E+4n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM7252
PNG
((3Z)-3-({4-oxo-2H,4H,6H,7H-pyrano[3,4-c]pyrrol-1-y...)
Show SMILES O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCOC2=O)-c1ccccc1
Show InChI InChI=1S/C22H16N2O3/c25-21-17(11-19-16-8-9-27-22(26)18(16)12-23-19)15-7-6-14(10-20(15)24-21)13-4-2-1-3-5-13/h1-7,10-12,23H,8-9H2,(H,24,25)/b17-11-
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n/an/a 8.40E+3n/an/an/an/an/a25



SUGEN, Inc.



Assay Description
The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...


Bioorg Med Chem Lett 13: 1939-42 (2003)


Article DOI: 10.1016/s0960-894x(03)00312-3
BindingDB Entry DOI: 10.7270/Q2HD7SW7
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (Human))
BDBM16983
PNG
(5-{[(3Z)-5-(carbamoylamino)-2-oxo-2,3-dihydro-1H-i...)
Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(NC(N)=O)cc23)[nH]cc1C(O)=O
Show InChI InChI=1S/C16H14N4O4/c1-7-11(15(22)23)6-18-13(7)5-10-9-4-8(19-16(17)24)2-3-12(9)20-14(10)21/h2-6,18H,1H3,(H,20,21)(H,22,23)(H3,17,19,24)/b10-5-
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n/an/a 9n/an/an/an/a7.222



Berlex Biosciences



Assay Description
The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...


Bioorg Med Chem Lett 17: 3819-25 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.060
BindingDB Entry DOI: 10.7270/Q29G5K22
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor


J Med Chem 41: 2588-603 (1998)


Article DOI: 10.1021/jm980123i
BindingDB Entry DOI: 10.7270/Q2G73CTT
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50065308
PNG
((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)


Article DOI: 10.1021/jm980123i
BindingDB Entry DOI: 10.7270/Q2G73CTT
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50065308
PNG
((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).


J Med Chem 41: 2588-603 (1998)


Article DOI: 10.1021/jm980123i
BindingDB Entry DOI: 10.7270/Q2G73CTT
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50065308
PNG
((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor


J Med Chem 41: 2588-603 (1998)


Article DOI: 10.1021/jm980123i
BindingDB Entry DOI: 10.7270/Q2G73CTT
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)


J Med Chem 41: 2588-603 (1998)


Article DOI: 10.1021/jm980123i
BindingDB Entry DOI: 10.7270/Q2G73CTT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a 180n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)


Article DOI: 10.1021/jm980123i
BindingDB Entry DOI: 10.7270/Q2G73CTT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065308
PNG
((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
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n/an/a 70n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)


Article DOI: 10.1021/jm980123i
BindingDB Entry DOI: 10.7270/Q2G73CTT
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50065308
PNG
((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)


J Med Chem 41: 2588-603 (1998)


Article DOI: 10.1021/jm980123i
BindingDB Entry DOI: 10.7270/Q2G73CTT
More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).


J Med Chem 41: 2588-603 (1998)


Article DOI: 10.1021/jm980123i
BindingDB Entry DOI: 10.7270/Q2G73CTT
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50065283
PNG
(4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylideneme...)
Show SMILES CCOC(=O)c1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C17H16N2O3/c1-3-22-17(21)13-9-18-15(10(13)2)8-12-11-6-4-5-7-14(11)19-16(12)20/h4-9,18H,3H2,1-2H3,(H,19,20)/b12-8-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)


Article DOI: 10.1021/jm980123i
BindingDB Entry DOI: 10.7270/Q2G73CTT
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50321892
PNG
((Z)-5-{6-[3-(4-Methoxyphenyl)-ureido]-2-oxo-1,2-di...)
Show SMILES COc1ccc(NC(=O)Nc2ccc3\C(=C\c4[nH]cc(C(O)=O)c4C)C(=O)Nc3c2)cc1
Show InChI InChI=1S/C23H20N4O5/c1-12-18(22(29)30)11-24-19(12)10-17-16-8-5-14(9-20(16)27-21(17)28)26-23(31)25-13-3-6-15(32-2)7-4-13/h3-11,24H,1-2H3,(H,27,28)(H,29,30)(H2,25,26,31)/b17-10-
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n/an/a 1.20n/an/an/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of AuroraB


Bioorg Med Chem 18: 4674-86 (2011)


Article DOI: 10.1016/j.bmc.2010.05.021
BindingDB Entry DOI: 10.7270/Q2QF8TVS
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50065308
PNG
((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of PDGF


Proc Natl Acad Sci USA 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50065308
PNG
((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Show SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C
Show InChI InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of bPDGFR in human PAC1 cells


Proc Natl Acad Sci USA 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
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