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54 similar compounds to monomer 17747

Wt: 253.2
BDBM72891
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Wt: 313.3
BDBM77454
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Wt: 341.4
BDBM90066
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Wt: 266.2
BDBM108083
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Wt: 318.4
BDBM50065293
Wt: 278.3
BDBM50065294
Wt: 251.2
BDBM50065296
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Wt: 263.3
BDBM50065297
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Wt: 282.3
BDBM50065298
Wt: 237.2
BDBM50065304
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Wt: 300.1
BDBM50065305
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Wt: 333.3
BDBM50065306
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Wt: 321.4
BDBM50065271
Wt: 290.3
BDBM50065314
Wt: 278.3
BDBM50065315
Displayed 1 to 15 (of 53 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 88 hits for monomerid = 72891,77454,90066,108083,50065293,50065294,50065296,50065297,50065298,50065304,50065305,50065306,50065271,50065314,50065315   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM50065315
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)N(C)c3ccccc23)cc1
Show InChI InChI=1S/C18H18N2O/c1-19(2)14-10-8-13(9-11-14)12-16-15-6-4-5-7-17(15)20(3)18(16)21/h4-12H,1-3H3/b16-12-
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155n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Thio-T from amyloid beta (1 to 42) (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Beta amyloid A4 protein


(Homo sapiens (human))
BDBM108083
PNG
(3-(4-nitrobenzylidene)indolin-2-one (Compound 24))
Show SMILES [O-][N+](=O)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H10N2O3/c18-15-13(12-3-1-2-4-14(12)16-15)9-10-5-7-11(8-6-10)17(19)20/h1-9H,(H,16,18)/b13-9-
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325n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Thio-T from amyloid beta (1 to 42) (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Alpha-synuclein


(Homo sapiens (Human))
BDBM108083
PNG
(3-(4-nitrobenzylidene)indolin-2-one (Compound 24))
Show SMILES [O-][N+](=O)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H10N2O3/c18-15-13(12-3-1-2-4-14(12)16-15)9-10-5-7-11(8-6-10)17(19)20/h1-9H,(H,16,18)/b13-9-
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347n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM108083
PNG
(3-(4-nitrobenzylidene)indolin-2-one (Compound 24))
Show SMILES [O-][N+](=O)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H10N2O3/c18-15-13(12-3-1-2-4-14(12)16-15)9-10-5-7-11(8-6-10)17(19)20/h1-9H,(H,16,18)/b13-9-
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363n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Thio-T from human recombinant tau (243 to 375) expressed in Escherichia coli BL21(DE3)RIL after 1.5 hrs by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Alpha-synuclein


(Homo sapiens (Human))
BDBM50065315
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)N(C)c3ccccc23)cc1
Show InChI InChI=1S/C18H18N2O/c1-19(2)14-10-8-13(9-11-14)12-16-15-6-4-5-7-17(15)20(3)18(16)21/h4-12H,1-3H3/b16-12-
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508n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Tau


(Homo sapiens (Human))
BDBM50065315
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)N(C)c3ccccc23)cc1
Show InChI InChI=1S/C18H18N2O/c1-19(2)14-10-8-13(9-11-14)12-16-15-6-4-5-7-17(15)20(3)18(16)21/h4-12H,1-3H3/b16-12-
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618n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Displacement of Thio-T from human recombinant tau (243 to 375) expressed in Escherichia coli BL21(DE3)RIL after 1.5 hrs by fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM50065304
PNG
(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Show SMILES Oc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H11NO2/c17-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9-
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n/an/a 2.50E+4n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assay


J Med Chem 56: 6069-87 (2013)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens)
BDBM50065304
PNG
(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Show SMILES Oc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H11NO2/c17-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9-
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n/an/a 230n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ...


J Med Chem 56: 6069-87 (2013)

More data for this
Ligand-Target Pair
Hsf1 protein


(Mus musculus)
BDBM72891
PNG
((3Z)-3-(4-fluorobenzylidene)-5-methyl-1,3-dihydro-...)
Show SMILES Cc1ccc2NC(=O)\C(=C/c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C16H12FNO/c1-10-2-7-15-13(8-10)14(16(19)18-15)9-11-3-5-12(17)6-4-11/h2-9H,1H3,(H,18,19)/b14-9-
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n/an/an/an/a>2.60E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Confirmation testing of small molecules identifie...


Citation and Details
More data for this
Ligand-Target Pair
Calcium channel (Type T,L)


()
BDBM77454
PNG
((E)-N-(2-methylphenyl)-2,3-diphenyl-2-propenamide ...)
Show SMILES Cc1ccccc1NC(=O)C(=C\c1ccccc1)\c1ccccc1
Show InChI InChI=1S/C22H19NO/c1-17-10-8-9-15-21(17)23-22(24)20(19-13-6-3-7-14-19)16-18-11-4-2-5-12-18/h2-16H,1H3,(H,23,24)/b20-16+
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n/an/an/an/a 9.09E+3n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assay Provider: Xinmin Xie Assay Provider Affiliation: Bioscience Division, SRI International, Menlo Park, CA Grant Title: HTS Assay for Cav3 T-Type ...


Citation and Details
More data for this
Ligand-Target Pair
cysteine protease ATG4B isoform a


(Homo sapiens)
BDBM77454
PNG
((E)-N-(2-methylphenyl)-2,3-diphenyl-2-propenamide ...)
Show SMILES Cc1ccccc1NC(=O)C(=C\c1ccccc1)\c1ccccc1
Show InChI InChI=1S/C22H19NO/c1-17-10-8-9-15-21(17)23-22(24)20(19-13-6-3-7-14-19)16-18-11-4-2-5-12-18/h2-16H,1H3,(H,23,24)/b20-16+
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n/an/a 1.08E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2


(Homo sapiens (Human))
BDBM77454
PNG
((E)-N-(2-methylphenyl)-2,3-diphenyl-2-propenamide ...)
Show SMILES Cc1ccccc1NC(=O)C(=C\c1ccccc1)\c1ccccc1
Show InChI InChI=1S/C22H19NO/c1-17-10-8-9-15-21(17)23-22(24)20(19-13-6-3-7-14-19)16-18-11-4-2-5-12-18/h2-16H,1H3,(H,23,24)/b20-16+
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n/an/a 9.58E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...


Citation and Details
More data for this
Ligand-Target Pair
corticotropin releasing factor-binding protein


(Homo sapiens)
BDBM90066
PNG
((E)-2,3-diphenyl-N-(2,4,6-trimethylphenyl)-2-prope...)
Show SMILES Cc1cc(C)c(NC(=O)C(=C\c2ccccc2)\c2ccccc2)c(C)c1
Show InChI InChI=1S/C24H23NO/c1-17-14-18(2)23(19(3)15-17)25-24(26)22(21-12-8-5-9-13-21)16-20-10-6-4-7-11-20/h4-16H,1-3H3,(H,25,26)/b22-16+
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n/an/an/an/a>5.30E+4n/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...


Citation and Details
More data for this
Ligand-Target Pair
corticotropin releasing factor-binding protein


(Homo sapiens)
BDBM90066
PNG
((E)-2,3-diphenyl-N-(2,4,6-trimethylphenyl)-2-prope...)
Show SMILES Cc1cc(C)c(NC(=O)C(=C\c2ccccc2)\c2ccccc2)c(C)c1
Show InChI InChI=1S/C24H23NO/c1-17-14-18(2)23(19(3)15-17)25-24(26)22(21-12-8-5-9-13-21)16-20-10-6-4-7-11-20/h4-16H,1-3H3,(H,25,26)/b22-16+
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n/an/a 2.00E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




Citation and Details
More data for this
Ligand-Target Pair
Chorismate mutase (MTB CM)


(Mycobacterium tuberculosis H37Rv)
BDBM108083
PNG
(3-(4-nitrobenzylidene)indolin-2-one (Compound 24))
Show SMILES [O-][N+](=O)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H10N2O3/c18-15-13(12-3-1-2-4-14(12)16-15)9-10-5-7-11(8-6-10)17(19)20/h1-9H,(H,16,18)/b13-9-
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n/an/a 1.01E+3n/an/an/an/an/an/a



Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, R.R. District, Hyderabad, Andhra Pradesh, 500078, India



Assay Description
The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...


Chem Biol Drug Des 83: 498-506 (2014)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50065297
PNG
(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Show SMILES CC(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C18H17NO/c1-12(2)14-9-7-13(8-10-14)11-16-15-5-3-4-6-17(15)19-18(16)20/h3-12H,1-2H3,(H,19,20)/b16-11+
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n/an/a 5.25E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50065293
PNG
(3-[1-(4-Piperidin-1-yl-phenyl)-eth-(E)-ylidene]-1,...)
Show SMILES C\C(=C1/C(=O)Nc2ccccc12)c1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C21H22N2O/c1-15(20-18-7-3-4-8-19(18)22-21(20)24)16-9-11-17(12-10-16)23-13-5-2-6-14-23/h3-4,7-12H,2,5-6,13-14H2,1H3,(H,22,24)/b20-15+
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n/an/a 1.00E+6n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50065306
PNG
(3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indol...)
Show SMILES O=CN1CCN(CC1)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C20H19N3O2/c24-14-22-9-11-23(12-10-22)16-7-5-15(6-8-16)13-18-17-3-1-2-4-19(17)21-20(18)25/h1-8,13-14H,9-12H2,(H,21,25)/b18-13-
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n/an/a 5.13E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Mus musculus)
BDBM50065294
PNG
(3-(4-Dimethylamino-benzylidene)-4-methyl-1,3-dihyd...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3cccc(C)c23)cc1
Show InChI InChI=1S/C18H18N2O/c1-12-5-4-6-16-17(12)15(18(21)19-16)11-13-7-9-14(10-8-13)20(2)3/h4-11H,1-3H3,(H,19,21)/b15-11-
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n/an/a 3.02E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (human))
BDBM50065306
PNG
(3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indol...)
Show SMILES O=CN1CCN(CC1)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C20H19N3O2/c24-14-22-9-11-23(12-10-22)16-7-5-15(6-8-16)13-18-17-3-1-2-4-19(17)21-20(18)25/h1-8,13-14H,9-12H2,(H,21,25)/b18-13-
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n/an/a 1.00E+4n/an/an/an/an/an/a



New York University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of FGFR1K (unknown origin) autophosphorylation activity assessed as [32P] incorporation


Citation and Details
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Mus musculus)
BDBM50065306
PNG
(3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indol...)
Show SMILES O=CN1CCN(CC1)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C20H19N3O2/c24-14-22-9-11-23(12-10-22)16-7-5-15(6-8-16)13-18-17-3-1-2-4-19(17)21-20(18)25/h1-8,13-14H,9-12H2,(H,21,25)/b18-13-
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n/an/a 2.00E+4n/an/an/an/an/an/a



New York University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of acidic FGF-stimulated FGFR1 tyrosine autophosphorylation in mouse NIH/3T3 cells by immunoblotting


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50065271
PNG
(3-(4-hydroxy-3,5-diisopropylbenzylidene)indolin-2-...)
Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccccc23)cc(C(C)C)c1O
Show InChI InChI=1S/C21H23NO2/c1-12(2)16-9-14(10-17(13(3)4)20(16)23)11-18-15-7-5-6-8-19(15)22-21(18)24/h5-13,23H,1-4H3,(H,22,24)/b18-11-
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n/an/a 1.75E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50065293
PNG
(3-[1-(4-Piperidin-1-yl-phenyl)-eth-(E)-ylidene]-1,...)
Show SMILES C\C(=C1/C(=O)Nc2ccccc12)c1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C21H22N2O/c1-15(20-18-7-3-4-8-19(18)22-21(20)24)16-9-11-17(12-10-16)23-13-5-2-6-14-23/h3-4,7-12H,2,5-6,13-14H2,1H3,(H,22,24)/b20-15+
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50065294
PNG
(3-(4-Dimethylamino-benzylidene)-4-methyl-1,3-dihyd...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3cccc(C)c23)cc1
Show InChI InChI=1S/C18H18N2O/c1-12-5-4-6-16-17(12)15(18(21)19-16)11-13-7-9-14(10-8-13)20(2)3/h4-11H,1-3H3,(H,19,21)/b15-11-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50065297
PNG
(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Show SMILES CC(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C18H17NO/c1-12(2)14-9-7-13(8-10-14)11-16-15-5-3-4-6-17(15)19-18(16)20/h3-12H,1-2H3,(H,19,20)/b16-11+
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n/an/a 1.00E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50065296
PNG
(3-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Show SMILES COc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C16H13NO2/c1-19-12-8-6-11(7-9-12)10-14-13-4-2-3-5-15(13)17-16(14)18/h2-10H,1H3,(H,17,18)/b14-10-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50065298
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-6-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3cc(F)ccc23)cc1
Show InChI InChI=1S/C17H15FN2O/c1-20(2)13-6-3-11(4-7-13)9-15-14-8-5-12(18)10-16(14)19-17(15)21/h3-10H,1-2H3,(H,19,21)/b15-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor and ErbB2 (HER1 and HER2)


(Homo sapiens (human))
BDBM50065304
PNG
(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Show SMILES Oc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H11NO2/c17-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50065306
PNG
(3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indol...)
Show SMILES O=CN1CCN(CC1)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C20H19N3O2/c24-14-22-9-11-23(12-10-22)16-7-5-15(6-8-16)13-18-17-3-1-2-4-19(17)21-20(18)25/h1-8,13-14H,9-12H2,(H,21,25)/b18-13-
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n/an/a 5.10E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50065305
PNG
(3-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-1,3-dihydr...)
Show SMILES Brc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H10BrNO/c16-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)17-15(13)18/h1-9H,(H,17,18)/b13-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50065271
PNG
(3-(4-hydroxy-3,5-diisopropylbenzylidene)indolin-2-...)
Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccccc23)cc(C(C)C)c1O
Show InChI InChI=1S/C21H23NO2/c1-12(2)16-9-14(10-17(13(3)4)20(16)23)11-18-15-7-5-6-8-19(15)22-21(18)24/h5-13,23H,1-4H3,(H,22,24)/b18-11-
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n/an/a 1.01E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50065294
PNG
(3-(4-Dimethylamino-benzylidene)-4-methyl-1,3-dihyd...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3cccc(C)c23)cc1
Show InChI InChI=1S/C18H18N2O/c1-12-5-4-6-16-17(12)15(18(21)19-16)11-13-7-9-14(10-8-13)20(2)3/h4-11H,1-3H3,(H,19,21)/b15-11-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065298
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-6-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3cc(F)ccc23)cc1
Show InChI InChI=1S/C17H15FN2O/c1-20(2)13-6-3-11(4-7-13)9-15-14-8-5-12(18)10-16(14)19-17(15)21/h3-10H,1-2H3,(H,19,21)/b15-9-
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n/an/a 4.60E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor and ErbB2 (HER1 and HER2)


(Homo sapiens (human))
BDBM50065296
PNG
(3-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Show SMILES COc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C16H13NO2/c1-19-12-8-6-11(7-9-12)10-14-13-4-2-3-5-15(13)17-16(14)18/h2-10H,1H3,(H,17,18)/b14-10-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50065304
PNG
(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Show SMILES Oc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H11NO2/c17-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9-
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n/an/a 8.39E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50065298
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-6-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3cc(F)ccc23)cc1
Show InChI InChI=1S/C17H15FN2O/c1-20(2)13-6-3-11(4-7-13)9-15-14-8-5-12(18)10-16(14)19-17(15)21/h3-10H,1-2H3,(H,19,21)/b15-9-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065293
PNG
(3-[1-(4-Piperidin-1-yl-phenyl)-eth-(E)-ylidene]-1,...)
Show SMILES C\C(=C1/C(=O)Nc2ccccc12)c1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C21H22N2O/c1-15(20-18-7-3-4-8-19(18)22-21(20)24)16-9-11-17(12-10-16)23-13-5-2-6-14-23/h3-4,7-12H,2,5-6,13-14H2,1H3,(H,22,24)/b20-15+
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50065314
PNG
(3-[1-(4-Pyrrolidin-1-yl-phenyl)-meth-(Z)-ylidene]-...)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C19H18N2O/c22-19-17(16-5-1-2-6-18(16)20-19)13-14-7-9-15(10-8-14)21-11-3-4-12-21/h1-2,5-10,13H,3-4,11-12H2,(H,20,22)/b17-13-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065304
PNG
(3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihy...)
Show SMILES Oc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C15H11NO2/c17-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9-
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n/an/a 2.70E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50065306
PNG
(3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indol...)
Show SMILES O=CN1CCN(CC1)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C20H19N3O2/c24-14-22-9-11-23(12-10-22)16-7-5-15(6-8-16)13-18-17-3-1-2-4-19(17)21-20(18)25/h1-8,13-14H,9-12H2,(H,21,25)/b18-13-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065271
PNG
(3-(4-hydroxy-3,5-diisopropylbenzylidene)indolin-2-...)
Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccccc23)cc(C(C)C)c1O
Show InChI InChI=1S/C21H23NO2/c1-12(2)16-9-14(10-17(13(3)4)20(16)23)11-18-15-7-5-6-8-19(15)22-21(18)24/h5-13,23H,1-4H3,(H,22,24)/b18-11-
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n/an/a 8.50E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065314
PNG
(3-[1-(4-Pyrrolidin-1-yl-phenyl)-meth-(Z)-ylidene]-...)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C19H18N2O/c22-19-17(16-5-1-2-6-18(16)20-19)13-14-7-9-15(10-8-14)21-11-3-4-12-21/h1-2,5-10,13H,3-4,11-12H2,(H,20,22)/b17-13-
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n/an/a 3.00E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50065271
PNG
(3-(4-hydroxy-3,5-diisopropylbenzylidene)indolin-2-...)
Show SMILES CC(C)c1cc(\C=C2/C(=O)Nc3ccccc23)cc(C(C)C)c1O
Show InChI InChI=1S/C21H23NO2/c1-12(2)16-9-14(10-17(13(3)4)20(16)23)11-18-15-7-5-6-8-19(15)22-21(18)24/h5-13,23H,1-4H3,(H,22,24)/b18-11-
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n/an/a 1.53E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50065315
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)N(C)c3ccccc23)cc1
Show InChI InChI=1S/C18H18N2O/c1-19(2)14-10-8-13(9-11-14)12-16-15-6-4-5-7-17(15)20(3)18(16)21/h4-12H,1-3H3/b16-12-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50065298
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-6-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)Nc3cc(F)ccc23)cc1
Show InChI InChI=1S/C17H15FN2O/c1-20(2)13-6-3-11(4-7-13)9-15-14-8-5-12(18)10-16(14)19-17(15)21/h3-10H,1-2H3,(H,19,21)/b15-9-
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n/an/a 6.60E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor and ErbB2 (HER1 and HER2)


(Homo sapiens (human))
BDBM50065315
PNG
(3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-...)
Show SMILES CN(C)c1ccc(\C=C2/C(=O)N(C)c3ccccc23)cc1
Show InChI InChI=1S/C18H18N2O/c1-19(2)14-10-8-13(9-11-14)12-16-15-6-4-5-7-17(15)20(3)18(16)21/h4-12H,1-3H3/b16-12-
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n/an/a>1.00E+5n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065297
PNG
(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Show SMILES CC(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C18H17NO/c1-12(2)14-9-7-13(8-10-14)11-16-15-5-3-4-6-17(15)19-18(16)20/h3-12H,1-2H3,(H,19,20)/b16-11+
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n/an/a 5.20E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Mus musculus)
BDBM50065306
PNG
(3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indol...)
Show SMILES O=CN1CCN(CC1)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C20H19N3O2/c24-14-22-9-11-23(12-10-22)16-7-5-15(6-8-16)13-18-17-3-1-2-4-19(17)21-20(18)25/h1-8,13-14H,9-12H2,(H,21,25)/b18-13-
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n/an/a 1.60E+3n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50065297
PNG
(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Show SMILES CC(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C18H17NO/c1-12(2)14-9-7-13(8-10-14)11-16-15-5-3-4-6-17(15)19-18(16)20/h3-12H,1-2H3,(H,19,20)/b16-11+
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n/an/a 2.42E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50065297
PNG
(3-(4-Isopropyl-benzylidene)-1,3-dihydro-indol-2-on...)
Show SMILES CC(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1
Show InChI InChI=1S/C18H17NO/c1-12(2)14-9-7-13(8-10-14)11-16-15-5-3-4-6-17(15)19-18(16)20/h3-12H,1-2H3,(H,19,20)/b16-11+
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n/an/a 1.85E+4n/an/an/an/an/an/a



SUGEN, Inc.

Curated by ChEMBL


Assay Description
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).


J Med Chem 41: 2588-603 (1998)

More data for this
Ligand-Target Pair
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