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3 similar compounds to monomer 50429629

Compile data set for download or QSAR
Wt: 225.2
BDBM7641
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Wt: 239.2
BDBM50429627
Wt: 239.2
BDBM50429628

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 7641,50429627,50429628   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDK2/CycE


(Homo sapiens (Human))
BDBM7641
PNG
(4-{2-methylimidazo[1,2-a]pyridin-3-yl}pyrimidin-2-...)
Show SMILES Cc1nc2ccccn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C12H11N5/c1-8-11(9-5-6-14-12(13)16-9)17-7-3-2-4-10(17)15-8/h2-7H,1H3,(H2,13,14,16)
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Article
PubMed
n/an/a 4.00E+3n/an/an/an/a7.022



AstraZeneca



Assay Description
The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.


Bioorg Med Chem Lett 13: 3021-6 (2003)


Article DOI: 10.1016/S0960-894X(03)00638-3
BindingDB Entry DOI: 10.7270/Q2610XJ5
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 4 (CDK4)


(Homo sapiens (Human))
BDBM7641
PNG
(4-{2-methylimidazo[1,2-a]pyridin-3-yl}pyrimidin-2-...)
Show SMILES Cc1nc2ccccn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C12H11N5/c1-8-11(9-5-6-14-12(13)16-9)17-7-3-2-4-10(17)15-8/h2-7H,1H3,(H2,13,14,16)
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MMDB

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Article
PubMed
n/an/a 8.00E+3n/an/an/an/a7.022



AstraZeneca



Assay Description
The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.


Bioorg Med Chem Lett 13: 3021-6 (2003)


Article DOI: 10.1016/S0960-894X(03)00638-3
BindingDB Entry DOI: 10.7270/Q2610XJ5
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14


(Homo sapiens (Human))
BDBM50429628
PNG
(CHEMBL2334575)
Show SMILES Cc1nc2cc(C)ccn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C13H13N5/c1-8-4-6-18-11(7-8)16-9(2)12(18)10-3-5-15-13(14)17-10/h3-7H,1-2H3,(H2,14,15,17)
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PubMed
n/an/a>8.00E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Bioorg Med Chem Lett 23: 1238-44 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.012
BindingDB Entry DOI: 10.7270/Q2J967RQ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14


(Homo sapiens (Human))
BDBM50429627
PNG
(CHEMBL2334576)
Show SMILES Cc1nc2c(C)cccn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C13H13N5/c1-8-4-3-7-18-11(9(2)16-12(8)18)10-5-6-15-13(14)17-10/h3-7H,1-2H3,(H2,14,15,17)
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Article
PubMed
n/an/a>8.00E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Bioorg Med Chem Lett 23: 1238-44 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.012
BindingDB Entry DOI: 10.7270/Q2J967RQ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14


(Homo sapiens (Human))
BDBM7641
PNG
(4-{2-methylimidazo[1,2-a]pyridin-3-yl}pyrimidin-2-...)
Show SMILES Cc1nc2ccccn2c1-c1ccnc(N)n1
Show InChI InChI=1S/C12H11N5/c1-8-11(9-5-6-14-12(13)16-9)17-7-3-2-4-10(17)15-8/h2-7H,1H3,(H2,13,14,16)
PDB

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KEGG

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antibodypedia
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Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>8.00E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay


Bioorg Med Chem Lett 23: 1238-44 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.012
BindingDB Entry DOI: 10.7270/Q2J967RQ
More data for this
Ligand-Target Pair