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84 similar compounds to monomer 50002474

Compile data set for download or QSAR
Wt: 678.7
BDBM50011197
Wt: 853.9
BDBM81870
Wt: 678.7
BDBM50024330
Wt: 838.9
BDBM50002482
Wt: 824.9
BDBM50002483
Wt: 853.9
BDBM50002485
Wt: 829.9
BDBM50002500
Wt: 839.9
BDBM50002507
Wt: 862.9
BDBM50002511
Wt: 831.9
BDBM50002512
Wt: 872.4
BDBM50002519
Wt: 812.9
BDBM50007918
Wt: 826.9
BDBM50007917
Wt: 826.9
BDBM50007922
Wt: 827.9
BDBM50007923
Displayed 1 to 15 (of 83 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50011197,81870,50024330,50002482,50002483,50002485,50002500,50002507,50002511,50002512,50002519,50007918,50007917,50007922,50007923   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CCKBR


(GUINEA PIG)
BDBM81870
PNG
(A-70874 | CAS_6439313 | NSC_6439313)
Show SMILES CNC(Cc1ccccc1)C(=O)N(C(=O)C(CC(O)=O)NC(=O)C(N)CCCCNC(=O)C=Cc1ccc(O)cc1)C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C45H55N7O10/c1-45(2,3)62-44(61)51-36(25-30-27-49-34-16-9-8-14-32(30)34)42(59)52(41(58)35(47-4)24-29-12-6-5-7-13-29)43(60)37(26-39(55)56)50-40(57)33(46)15-10-11-23-48-38(54)22-19-28-17-20-31(53)21-18-28/h5-9,12-14,16-22,27,33,35-37,47,49,53H,10-11,15,23-26,46H2,1-4H3,(H,48,54)(H,50,57)(H,51,61)(H,55,56)/b22-19+
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4.90n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 39: 346-51 (1991)


BindingDB Entry DOI: 10.7270/Q2222S8S
More data for this
Ligand-Target Pair
CCKBR


(GUINEA PIG)
BDBM81870
PNG
(A-70874 | CAS_6439313 | NSC_6439313)
Show SMILES CNC(Cc1ccccc1)C(=O)N(C(=O)C(CC(O)=O)NC(=O)C(N)CCCCNC(=O)C=Cc1ccc(O)cc1)C(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C45H55N7O10/c1-45(2,3)62-44(61)51-36(25-30-27-49-34-16-9-8-14-32(30)34)42(59)52(41(58)35(47-4)24-29-12-6-5-7-13-29)43(60)37(26-39(55)56)50-40(57)33(46)15-10-11-23-48-38(54)22-19-28-17-20-31(53)21-18-28/h5-9,12-14,16-22,27,33,35-37,47,49,53H,10-11,15,23-26,46H2,1-4H3,(H,48,54)(H,50,57)(H,51,61)(H,55,56)/b22-19+
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710n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Mol Pharmacol 39: 346-51 (1991)


BindingDB Entry DOI: 10.7270/Q2222S8S
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50007922
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1
Show InChI InChI=1S/C43H54N8O9/c1-26-17-19-29(20-18-26)47-41(58)45-21-11-10-16-32(38(55)50-35(24-36(52)53)40(57)49-33(37(44)54)22-27-12-6-5-7-13-27)48-39(56)34(51-42(59)60-43(2,3)4)23-28-25-46-31-15-9-8-14-30(28)31/h5-9,12-15,17-20,25,32-35,46H,10-11,16,21-24H2,1-4H3,(H2,44,54)(H,48,56)(H,49,57)(H,50,55)(H,51,59)(H,52,53)(H2,45,47,58)/t32-,33-,34-,35-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards cholecystokinin type A receptor in guinea pig pancreas by using [125I]-BH-CCK-8 as radioligand


J Med Chem 34: 2837-42 (1991)


Article DOI: 10.1021/jm00113a023
BindingDB Entry DOI: 10.7270/Q2JD4VRF
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50007917
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1
Show InChI InChI=1S/C43H54N8O9/c1-26-13-12-16-29(21-26)47-41(58)45-20-11-10-19-32(38(55)50-35(24-36(52)53)40(57)49-33(37(44)54)22-27-14-6-5-7-15-27)48-39(56)34(51-42(59)60-43(2,3)4)23-28-25-46-31-18-9-8-17-30(28)31/h5-9,12-18,21,25,32-35,46H,10-11,19-20,22-24H2,1-4H3,(H2,44,54)(H,48,56)(H,49,57)(H,50,55)(H,51,59)(H,52,53)(H2,45,47,58)/t32-,33-,34-,35-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards cholecystokinin type A receptor in guinea pig pancreas by using [125I]-BH-CCK-8 as radioligand


J Med Chem 34: 2837-42 (1991)


Article DOI: 10.1021/jm00113a023
BindingDB Entry DOI: 10.7270/Q2JD4VRF
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50007918
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H52N8O9/c1-42(2,3)59-41(58)50-33(23-27-25-45-30-19-11-10-18-29(27)30)38(55)47-31(20-12-13-21-44-40(57)46-28-16-8-5-9-17-28)37(54)49-34(24-35(51)52)39(56)48-32(36(43)53)22-26-14-6-4-7-15-26/h4-11,14-19,25,31-34,45H,12-13,20-24H2,1-3H3,(H2,43,53)(H,47,55)(H,48,56)(H,49,54)(H,50,58)(H,51,52)(H2,44,46,57)/t31-,32-,33-,34-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards cholecystokinin type A receptor in guinea pig pancreas by using [125I]-BH-CCK-8 as radioligand


J Med Chem 34: 2837-42 (1991)


Article DOI: 10.1021/jm00113a023
BindingDB Entry DOI: 10.7270/Q2JD4VRF
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50007918
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H52N8O9/c1-42(2,3)59-41(58)50-33(23-27-25-45-30-19-11-10-18-29(27)30)38(55)47-31(20-12-13-21-44-40(57)46-28-16-8-5-9-17-28)37(54)49-34(24-35(51)52)39(56)48-32(36(43)53)22-26-14-6-4-7-15-26/h4-11,14-19,25,31-34,45H,12-13,20-24H2,1-3H3,(H2,43,53)(H,47,55)(H,48,56)(H,49,54)(H,50,58)(H,51,52)(H2,44,46,57)/t31-,32-,33-,34-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards cholecystokinin type B receptor in guinea pig cortex by using [125I]-BH-CCK-8 as radioligand


J Med Chem 34: 2837-42 (1991)


Article DOI: 10.1021/jm00113a023
BindingDB Entry DOI: 10.7270/Q2JD4VRF
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50011197
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C35H46N6O8/c1-5-6-15-25(31(45)40-28(19-29(42)43)33(47)39-26(30(36)44)17-21-12-8-7-9-13-21)38-32(46)27(41-34(48)49-35(2,3)4)18-22-20-37-24-16-11-10-14-23(22)24/h7-14,16,20,25-28,37H,5-6,15,17-19H2,1-4H3,(H2,36,44)(H,38,46)(H,39,47)(H,40,45)(H,41,48)(H,42,43)/t25-,26-,27-,28-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to guinea pig cortical Cholecystokinin type A receptor


Bioorg Med Chem Lett 7: 855-860 (1997)


Article DOI: 10.1016/S0960-894X(97)00107-8
BindingDB Entry DOI: 10.7270/Q218370Q
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50011197
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C35H46N6O8/c1-5-6-15-25(31(45)40-28(19-29(42)43)33(47)39-26(30(36)44)17-21-12-8-7-9-13-21)38-32(46)27(41-34(48)49-35(2,3)4)18-22-20-37-24-16-11-10-14-23(22)24/h7-14,16,20,25-28,37H,5-6,15,17-19H2,1-4H3,(H2,36,44)(H,38,46)(H,39,47)(H,40,45)(H,41,48)(H,42,43)/t25-,26-,27-,28-/m0/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity in pancreatic cholecystokinin type A receptor in guinea pig


J Med Chem 34: 455-7 (1991)


Article DOI: 10.1021/jm00105a068
BindingDB Entry DOI: 10.7270/Q24X56RD
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50011197
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C35H46N6O8/c1-5-6-15-25(31(45)40-28(19-29(42)43)33(47)39-26(30(36)44)17-21-12-8-7-9-13-21)38-32(46)27(41-34(48)49-35(2,3)4)18-22-20-37-24-16-11-10-14-23(22)24/h7-14,16,20,25-28,37H,5-6,15,17-19H2,1-4H3,(H2,36,44)(H,38,46)(H,39,47)(H,40,45)(H,41,48)(H,42,43)/t25-,26-,27-,28-/m0/s1
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n/an/a 65n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for its inhibitory activity in cortical cholecystokinin type B receptor in guinea pig


J Med Chem 34: 455-7 (1991)


Article DOI: 10.1021/jm00105a068
BindingDB Entry DOI: 10.7270/Q24X56RD
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50002482
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CN([C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCNC(=O)C=Cc1cccnc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C44H54N8O9/c1-44(2,3)61-43(60)51-34(24-30-27-48-32-17-9-8-16-31(30)32)41(58)49-33(18-10-11-22-47-37(53)20-19-29-15-12-21-46-26-29)40(57)50-35(25-38(54)55)42(59)52(4)36(39(45)56)23-28-13-6-5-7-14-28/h5-9,12-17,19-21,26-27,33-36,48H,10-11,18,22-25H2,1-4H3,(H2,45,56)(H,47,53)(H,49,58)(H,50,57)(H,51,60)(H,54,55)/t33-,34-,35-,36-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig pancreas.


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50002507
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCCc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C45H57N7O9/c1-45(2,3)61-44(60)52-36(26-31-28-48-33-21-11-10-20-32(31)33)42(58)49-34(22-12-13-24-47-38(53)23-14-19-29-15-6-4-7-16-29)41(57)51-37(27-39(54)55)43(59)50-35(40(46)56)25-30-17-8-5-9-18-30/h4-11,15-18,20-21,28,34-37,48H,12-14,19,22-27H2,1-3H3,(H2,46,56)(H,47,53)(H,49,58)(H,50,59)(H,51,57)(H,52,60)(H,54,55)/t34-,35-,36-,37-/m0/s1
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n/an/a 910n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig pancreas.


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50002512
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C44H61N7O9/c1-44(2,3)60-43(59)51-35(25-30-27-47-32-19-11-10-18-31(30)32)41(57)48-33(20-12-13-23-46-37(52)22-21-28-14-6-4-7-15-28)40(56)50-36(26-38(53)54)42(58)49-34(39(45)55)24-29-16-8-5-9-17-29/h5,8-11,16-19,27-28,33-36,47H,4,6-7,12-15,20-26H2,1-3H3,(H2,45,55)(H,46,52)(H,48,57)(H,49,58)(H,50,56)(H,51,59)(H,53,54)/t33-,34-,35-,36-/m0/s1
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n/an/a 310n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig pancreas.


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50002500
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)C=Cc1cccs1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H51N7O9S/c1-42(2,3)58-41(57)49-33(23-27-25-45-30-16-8-7-15-29(27)30)39(55)46-31(17-9-10-20-44-35(50)19-18-28-14-11-21-59-28)38(54)48-34(24-36(51)52)40(56)47-32(37(43)53)22-26-12-5-4-6-13-26/h4-8,11-16,18-19,21,25,31-34,45H,9-10,17,20,22-24H2,1-3H3,(H2,43,53)(H,44,50)(H,46,55)(H,47,56)(H,48,54)(H,49,57)(H,51,52)/t31-,32-,33-,34-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig pancreas.


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50002511
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)C=Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C46H54N8O9/c1-46(2,3)63-45(62)54-37(24-30-27-50-34-18-10-8-16-32(30)34)43(60)51-35(19-11-12-22-48-39(55)21-20-29-26-49-33-17-9-7-15-31(29)33)42(59)53-38(25-40(56)57)44(61)52-36(41(47)58)23-28-13-5-4-6-14-28/h4-10,13-18,20-21,26-27,35-38,49-50H,11-12,19,22-25H2,1-3H3,(H2,47,58)(H,48,55)(H,51,60)(H,52,61)(H,53,59)(H,54,62)(H,56,57)/t35-,36-,37-,38-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig pancreas.


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50002483
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)C=Cc1cccnc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C43H52N8O9/c1-43(2,3)60-42(59)51-34(23-29-26-47-31-16-8-7-15-30(29)31)40(57)48-32(17-9-10-21-46-36(52)19-18-28-14-11-20-45-25-28)39(56)50-35(24-37(53)54)41(58)49-33(38(44)55)22-27-12-5-4-6-13-27/h4-8,11-16,18-20,25-26,32-35,47H,9-10,17,21-24H2,1-3H3,(H2,44,55)(H,46,52)(H,48,57)(H,49,58)(H,50,56)(H,51,59)(H,53,54)/t32-,33-,34-,35-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig pancreas.


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50002485
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CN([C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCNC(=O)C=Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C45H55N7O10/c1-45(2,3)62-44(61)51-35(25-30-27-48-33-15-9-8-14-32(30)33)42(59)49-34(16-10-11-23-47-38(54)22-19-28-17-20-31(53)21-18-28)41(58)50-36(26-39(55)56)43(60)52(4)37(40(46)57)24-29-12-6-5-7-13-29/h5-9,12-15,17-22,27,34-37,48,53H,10-11,16,23-26H2,1-4H3,(H2,46,57)(H,47,54)(H,49,59)(H,50,58)(H,51,61)(H,55,56)/t34-,35-,36-,37-/m0/s1
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n/an/a 4.20n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig pancreas.


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50002511
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)C=Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C46H54N8O9/c1-46(2,3)63-45(62)54-37(24-30-27-50-34-18-10-8-16-32(30)34)43(60)51-35(19-11-12-22-48-39(55)21-20-29-26-49-33-17-9-7-15-31(29)33)42(59)53-38(25-40(56)57)44(61)52-36(41(47)58)23-28-13-5-4-6-14-28/h4-10,13-18,20-21,26-27,35-38,49-50H,11-12,19,22-25H2,1-3H3,(H2,47,58)(H,48,55)(H,51,60)(H,52,61)(H,53,59)(H,54,62)(H,56,57)/t35-,36-,37-,38-/m0/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50024330
PNG
(3-(3-Benzyl-ureido)-3-{2-[2-tert-butoxycarbonylami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C35H46N6O8/c1-20(2)15-26(31(45)40-28(18-29(42)43)33(47)38-25(30(36)44)16-21-11-7-6-8-12-21)39-32(46)27(41-34(48)49-35(3,4)5)17-22-19-37-24-14-10-9-13-23(22)24/h6-14,19-20,25-28,37H,15-18H2,1-5H3,(H2,36,44)(H,38,47)(H,39,46)(H,40,45)(H,41,48)(H,42,43)/t25-,26-,27-,28-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Invitro inhibition of binding of [125I]-(Nle)-HG-13 labeled Cholecystokinin type B receptor on isolated gastric mucosal cells of rabbit


J Med Chem 32: 522-8 (1989)


Article DOI: 10.1021/jm00123a003
BindingDB Entry DOI: 10.7270/Q2MW2G4H
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50007923
PNG
(3-[5-aminocarboxybenzyl-1-[2-(1H-3-indolyl)-1-buty...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C43H53N7O10/c1-43(2,3)60-42(58)50-34(23-29-25-46-31-19-11-10-18-30(29)31)39(55)47-32(20-12-13-21-45-41(57)59-26-28-16-8-5-9-17-28)38(54)49-35(24-36(51)52)40(56)48-33(37(44)53)22-27-14-6-4-7-15-27/h4-11,14-19,25,32-35,46H,12-13,20-24,26H2,1-3H3,(H2,44,53)(H,45,57)(H,47,55)(H,48,56)(H,49,54)(H,50,58)(H,51,52)/t32-,33-,34-,35-/m0/s1
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n/an/a 510n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8 from Cholecystokinin type A receptor in guinea pig pancreas


J Med Chem 33: 2950-2 (1990)


Article DOI: 10.1021/jm00173a006
BindingDB Entry DOI: 10.7270/Q2M32WCP
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50007918
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H52N8O9/c1-42(2,3)59-41(58)50-33(23-27-25-45-30-19-11-10-18-29(27)30)38(55)47-31(20-12-13-21-44-40(57)46-28-16-8-5-9-17-28)37(54)49-34(24-35(51)52)39(56)48-32(36(43)53)22-26-14-6-4-7-15-26/h4-11,14-19,25,31-34,45H,12-13,20-24H2,1-3H3,(H2,43,53)(H,47,55)(H,48,56)(H,49,54)(H,50,58)(H,51,52)(H2,44,46,57)/t31-,32-,33-,34-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8 from Cholecystokinin type A receptor in guinea pig pancreas


J Med Chem 33: 2950-2 (1990)


Article DOI: 10.1021/jm00173a006
BindingDB Entry DOI: 10.7270/Q2M32WCP
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50007922
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1
Show InChI InChI=1S/C43H54N8O9/c1-26-17-19-29(20-18-26)47-41(58)45-21-11-10-16-32(38(55)50-35(24-36(52)53)40(57)49-33(37(44)54)22-27-12-6-5-7-13-27)48-39(56)34(51-42(59)60-43(2,3)4)23-28-25-46-31-15-9-8-14-30(28)31/h5-9,12-15,17-20,25,32-35,46H,10-11,16,21-24H2,1-4H3,(H2,44,54)(H,48,56)(H,49,57)(H,50,55)(H,51,59)(H,52,53)(H2,45,47,58)/t32-,33-,34-,35-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8 from Cholecystokinin type A receptor in guinea pig pancreas


J Med Chem 33: 2950-2 (1990)


Article DOI: 10.1021/jm00173a006
BindingDB Entry DOI: 10.7270/Q2M32WCP
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50007917
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1
Show InChI InChI=1S/C43H54N8O9/c1-26-13-12-16-29(21-26)47-41(58)45-20-11-10-19-32(38(55)50-35(24-36(52)53)40(57)49-33(37(44)54)22-27-14-6-5-7-15-27)48-39(56)34(51-42(59)60-43(2,3)4)23-28-25-46-31-18-9-8-17-30(28)31/h5-9,12-18,21,25,32-35,46H,10-11,19-20,22-24H2,1-4H3,(H2,44,54)(H,48,56)(H,49,57)(H,50,55)(H,51,59)(H,52,53)(H2,45,47,58)/t32-,33-,34-,35-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8 from Cholecystokinin type A receptor in guinea pig pancreas


J Med Chem 33: 2950-2 (1990)


Article DOI: 10.1021/jm00173a006
BindingDB Entry DOI: 10.7270/Q2M32WCP
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50024330
PNG
(3-(3-Benzyl-ureido)-3-{2-[2-tert-butoxycarbonylami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C35H46N6O8/c1-20(2)15-26(31(45)40-28(18-29(42)43)33(47)38-25(30(36)44)16-21-11-7-6-8-12-21)39-32(46)27(41-34(48)49-35(3,4)5)17-22-19-37-24-14-10-9-13-23(22)24/h6-14,19-20,25-28,37H,15-18H2,1-5H3,(H2,36,44)(H,38,47)(H,39,46)(H,40,45)(H,41,48)(H,42,43)/t25-,26-,27-,28-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity for binding of [125I]-(Nle11)-HG-13 to gastrin receptor on isolated rabbit gastric mucosal cells.


J Med Chem 30: 758-63 (1987)


Article DOI: 10.1021/jm00388a002
BindingDB Entry DOI: 10.7270/Q2CV4GRT
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50011197
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C35H46N6O8/c1-5-6-15-25(31(45)40-28(19-29(42)43)33(47)39-26(30(36)44)17-21-12-8-7-9-13-21)38-32(46)27(41-34(48)49-35(2,3)4)18-22-20-37-24-16-11-10-14-23(22)24/h7-14,16,20,25-28,37H,5-6,15,17-19H2,1-4H3,(H2,36,44)(H,38,46)(H,39,47)(H,40,45)(H,41,48)(H,42,43)/t25-,26-,27-,28-/m0/s1
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n/an/a 65n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to guinea pig pancreatic Cholecystokinin type B receptor


Bioorg Med Chem Lett 7: 855-860 (1997)


Article DOI: 10.1016/S0960-894X(97)00107-8
BindingDB Entry DOI: 10.7270/Q218370Q
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50007922
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1
Show InChI InChI=1S/C43H54N8O9/c1-26-17-19-29(20-18-26)47-41(58)45-21-11-10-16-32(38(55)50-35(24-36(52)53)40(57)49-33(37(44)54)22-27-12-6-5-7-13-27)48-39(56)34(51-42(59)60-43(2,3)4)23-28-25-46-31-15-9-8-14-30(28)31/h5-9,12-15,17-20,25,32-35,46H,10-11,16,21-24H2,1-4H3,(H2,44,54)(H,48,56)(H,49,57)(H,50,55)(H,51,59)(H,52,53)(H2,45,47,58)/t32-,33-,34-,35-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex


J Med Chem 33: 2950-2 (1990)


Article DOI: 10.1021/jm00173a006
BindingDB Entry DOI: 10.7270/Q2M32WCP
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50007923
PNG
(3-[5-aminocarboxybenzyl-1-[2-(1H-3-indolyl)-1-buty...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C43H53N7O10/c1-43(2,3)60-42(58)50-34(23-29-25-46-31-19-11-10-18-30(29)31)39(55)47-32(20-12-13-21-45-41(57)59-26-28-16-8-5-9-17-28)38(54)49-35(24-36(51)52)40(56)48-33(37(44)53)22-27-14-6-4-7-15-27/h4-11,14-19,25,32-35,46H,12-13,20-24,26H2,1-3H3,(H2,44,53)(H,45,57)(H,47,55)(H,48,56)(H,49,54)(H,50,58)(H,51,52)/t32-,33-,34-,35-/m0/s1
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n/an/a 4.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex


J Med Chem 33: 2950-2 (1990)


Article DOI: 10.1021/jm00173a006
BindingDB Entry DOI: 10.7270/Q2M32WCP
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50007917
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1
Show InChI InChI=1S/C43H54N8O9/c1-26-13-12-16-29(21-26)47-41(58)45-20-11-10-19-32(38(55)50-35(24-36(52)53)40(57)49-33(37(44)54)22-27-14-6-5-7-15-27)48-39(56)34(51-42(59)60-43(2,3)4)23-28-25-46-31-18-9-8-17-30(28)31/h5-9,12-18,21,25,32-35,46H,10-11,19-20,22-24H2,1-4H3,(H2,44,54)(H,48,56)(H,49,57)(H,50,55)(H,51,59)(H,52,53)(H2,45,47,58)/t32-,33-,34-,35-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex


J Med Chem 33: 2950-2 (1990)


Article DOI: 10.1021/jm00173a006
BindingDB Entry DOI: 10.7270/Q2M32WCP
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50007918
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)Nc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H52N8O9/c1-42(2,3)59-41(58)50-33(23-27-25-45-30-19-11-10-18-29(27)30)38(55)47-31(20-12-13-21-44-40(57)46-28-16-8-5-9-17-28)37(54)49-34(24-35(51)52)39(56)48-32(36(43)53)22-26-14-6-4-7-15-26/h4-11,14-19,25,31-34,45H,12-13,20-24H2,1-3H3,(H2,43,53)(H,47,55)(H,48,56)(H,49,54)(H,50,58)(H,51,52)(H2,44,46,57)/t31-,32-,33-,34-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex


J Med Chem 33: 2950-2 (1990)


Article DOI: 10.1021/jm00173a006
BindingDB Entry DOI: 10.7270/Q2M32WCP
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50002483
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)C=Cc1cccnc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C43H52N8O9/c1-43(2,3)60-42(59)51-34(23-29-26-47-31-16-8-7-15-30(29)31)40(57)48-32(17-9-10-21-46-36(52)19-18-28-14-11-20-45-25-28)39(56)50-35(24-37(53)54)41(58)49-33(38(44)55)22-27-12-5-4-6-13-27/h4-8,11-16,18-20,25-26,32-35,47H,9-10,17,21-24H2,1-3H3,(H2,44,55)(H,46,52)(H,48,57)(H,49,58)(H,50,56)(H,51,59)(H,53,54)/t32-,33-,34-,35-/m0/s1
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n/an/a 87n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50002485
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CN([C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCNC(=O)C=Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C45H55N7O10/c1-45(2,3)62-44(61)51-35(25-30-27-48-33-15-9-8-14-32(30)33)42(59)49-34(16-10-11-23-47-38(54)22-19-28-17-20-31(53)21-18-28)41(58)50-36(26-39(55)56)43(60)52(4)37(40(46)57)24-29-12-6-5-7-13-29/h5-9,12-15,17-22,27,34-37,48,53H,10-11,16,23-26H2,1-4H3,(H2,46,57)(H,47,54)(H,49,59)(H,50,58)(H,51,61)(H,55,56)/t34-,35-,36-,37-/m0/s1
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n/an/a 710n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50002512
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCC1CCCCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C44H61N7O9/c1-44(2,3)60-43(59)51-35(25-30-27-47-32-19-11-10-18-31(30)32)41(57)48-33(20-12-13-23-46-37(52)22-21-28-14-6-4-7-15-28)40(56)50-36(26-38(53)54)42(58)49-34(39(45)55)24-29-16-8-5-9-17-29/h5,8-11,16-19,27-28,33-36,47H,4,6-7,12-15,20-26H2,1-3H3,(H2,45,55)(H,46,52)(H,48,57)(H,49,58)(H,50,56)(H,51,59)(H,53,54)/t33-,34-,35-,36-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50002507
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)CCCc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C45H57N7O9/c1-45(2,3)61-44(60)52-36(26-31-28-48-33-21-11-10-20-32(31)33)42(58)49-34(22-12-13-24-47-38(53)23-14-19-29-15-6-4-7-16-29)41(57)51-37(27-39(54)55)43(59)50-35(40(46)56)25-30-17-8-5-9-18-30/h4-11,15-18,20-21,28,34-37,48H,12-14,19,22-27H2,1-3H3,(H2,46,56)(H,47,53)(H,49,58)(H,50,59)(H,51,57)(H,52,60)(H,54,55)/t34-,35-,36-,37-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50002500
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)C=Cc1cccs1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H51N7O9S/c1-42(2,3)58-41(57)49-33(23-27-25-45-30-16-8-7-15-29(27)30)39(55)46-31(17-9-10-20-44-35(50)19-18-28-14-11-21-59-28)38(54)48-34(24-36(51)52)40(56)47-32(37(43)53)22-26-12-5-4-6-13-26/h4-8,11-16,18-19,21,25,31-34,45H,9-10,17,20,22-24H2,1-3H3,(H2,43,53)(H,44,50)(H,46,55)(H,47,56)(H,48,54)(H,49,57)(H,51,52)/t31-,32-,33-,34-/m0/s1
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n/an/a 840n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50002519
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CN([C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCNC(=O)C=Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C45H54ClN7O9/c1-45(2,3)62-44(61)52-35(25-30-27-49-33-15-9-8-14-32(30)33)42(59)50-34(16-10-11-23-48-38(54)22-19-28-17-20-31(46)21-18-28)41(58)51-36(26-39(55)56)43(60)53(4)37(40(47)57)24-29-12-6-5-7-13-29/h5-9,12-15,17-22,27,34-37,49H,10-11,16,23-26H2,1-4H3,(H2,47,57)(H,48,54)(H,50,59)(H,51,58)(H,52,61)(H,55,56)/t34-,35-,36-,37-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50002482
PNG
(3-[2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CN([C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCNC(=O)C=Cc1cccnc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C44H54N8O9/c1-44(2,3)61-43(60)51-34(24-30-27-48-32-17-9-8-16-31(30)32)41(58)49-33(18-10-11-22-47-37(53)20-19-29-15-12-21-46-26-29)40(57)50-35(25-38(54)55)42(59)52(4)36(39(45)56)23-28-13-6-5-7-14-28/h5-9,12-17,19-21,26-27,33-36,48H,10-11,18,22-25H2,1-4H3,(H2,45,56)(H,47,53)(H,49,58)(H,50,57)(H,51,60)(H,54,55)/t33-,34-,35-,36-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig cortex


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50007922
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES Cc1ccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)cc1
Show InChI InChI=1S/C43H54N8O9/c1-26-17-19-29(20-18-26)47-41(58)45-21-11-10-16-32(38(55)50-35(24-36(52)53)40(57)49-33(37(44)54)22-27-12-6-5-7-13-27)48-39(56)34(51-42(59)60-43(2,3)4)23-28-25-46-31-15-9-8-14-30(28)31/h5-9,12-15,17-20,25,32-35,46H,10-11,16,21-24H2,1-4H3,(H2,44,54)(H,48,56)(H,49,57)(H,50,55)(H,51,59)(H,52,53)(H2,45,47,58)/t32-,33-,34-,35-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards cholecystokinin type A receptor in guinea pig pancreas by using [125I]-BH-CCK-8 as radioligand


J Med Chem 34: 2837-42 (1991)


Article DOI: 10.1021/jm00113a023
BindingDB Entry DOI: 10.7270/Q2JD4VRF
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50007917
PNG
(3-{1-[1-aminobutyl oxycarbonylamino-2-(1H-3-indoly...)
Show SMILES Cc1cccc(NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)c1
Show InChI InChI=1S/C43H54N8O9/c1-26-13-12-16-29(21-26)47-41(58)45-20-11-10-19-32(38(55)50-35(24-36(52)53)40(57)49-33(37(44)54)22-27-14-6-5-7-15-27)48-39(56)34(51-42(59)60-43(2,3)4)23-28-25-46-31-18-9-8-17-30(28)31/h5-9,12-18,21,25,32-35,46H,10-11,19-20,22-24H2,1-4H3,(H2,44,54)(H,48,56)(H,49,57)(H,50,55)(H,51,59)(H,52,53)(H2,45,47,58)/t32-,33-,34-,35-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for Cholecystokinin type B receptor in guinea pig cortex by using [125I]-BH-CCK-8 as radioligand


J Med Chem 34: 2837-42 (1991)


Article DOI: 10.1021/jm00113a023
BindingDB Entry DOI: 10.7270/Q2JD4VRF
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50002519
PNG
(3-{2-[2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)...)
Show SMILES CN([C@@H](Cc1ccccc1)C(N)=O)C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCNC(=O)C=Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C45H54ClN7O9/c1-45(2,3)62-44(61)52-35(25-30-27-49-33-15-9-8-14-32(30)33)42(59)50-34(16-10-11-23-48-38(54)22-19-28-17-20-31(46)21-18-28)41(58)51-36(26-39(55)56)43(60)53(4)37(40(47)57)24-29-12-6-5-7-13-29/h5-9,12-15,17-22,27,34-37,49H,10-11,16,23-26H2,1-4H3,(H2,47,57)(H,48,54)(H,50,59)(H,51,58)(H,52,61)(H,55,56)/t34-,35-,36-,37-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [125I]BH-CCK-8 in guinea pig pancreas.


J Med Chem 35: 2007-14 (1992)


Article DOI: 10.1021/jm00089a010
BindingDB Entry DOI: 10.7270/Q21J9BDC
More data for this
Ligand-Target Pair