Compounds in cluster

19 similar compounds to monomer 82070

Wt: 238.3 BDBM50451802 Purchase	Wt: 176.2 BDBM50451805 Purchase	Wt: 162.2 BDBM82068 Purchase	Wt: 186.2 BDBM86544	Wt: 176.2 BDBM109781 Purchase
Wt: 162.2 BDBM109767 Purchase	Wt: 162.2 BDBM50004108 Purchase	Wt: 148.2 BDBM50023328 Purchase	Wt: 162.2 BDBM50026461 Purchase	Wt: 148.2 BDBM50035415 Purchase
Wt: 190.2 BDBM50052592	Wt: 186.2 BDBM50052593 Purchase	Wt: 188.2 BDBM50079456	Wt: 176.2 BDBM50079457 Purchase	Wt: 177.2 BDBM50100716 Purchase

Displayed 1 to 15 (of 19 total ) | Next | Last >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 149 hits for monomerid = 50451802,50451805,82068,86544,109781,109767,50004108,50023328,50026461,50035415,50052592,50052593,50079456,50079457,50100716
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM86544 (CAS_192231-16-6 \| CHEMBL111580 \| NSC_6442277 \| SIB...) Show SMILES CN1CCCC1c1cncc(c1)C#C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept Inc Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 619-26 (2005) Article DOI: 10.1124/jpet.104.075069 BindingDB Entry DOI: 10.7270/Q2BK19XS
Targacept Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.840	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept Inc Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 619-26 (2005) Article DOI: 10.1124/jpet.104.075069 BindingDB Entry DOI: 10.7270/Q2BK19XS
Targacept Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.840	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by PDSP K_i Database									Mol Pharmacol 57: 642-9 (2000) Article DOI: 10.1124/mol.57.3.642 BindingDB Entry DOI: 10.7270/Q21C1VF8
					More data for this Ligand-Target Pair				3D Structure (crystal)
n-AChR (RAT)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.960	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by PDSP K_i Database									Mol Pharmacol 57: 642-9 (2000) Article DOI: 10.1124/mol.57.3.642 BindingDB Entry DOI: 10.7270/Q21C1VF8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP K_i Database									Science 279: 77-81 (1998) Article DOI: 10.1021/acschembio.5b00514 BindingDB Entry DOI: 10.7270/Q2X63KGH
Abbott Laboratories Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
n-AChR (RAT)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP K_i Database									J Pharmacol Exp Ther 270: 310-8 (1994) BindingDB Entry DOI: 10.7270/Q2HH6HKJ
Abbott Laboratories Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50079456 (2-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octane \| CHEMBL...) Show SMILES C1CN2CCC1CC2c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept Inc Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 619-26 (2005) Article DOI: 10.1124/jpet.104.075069 BindingDB Entry DOI: 10.7270/Q2BK19XS
Targacept Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-MLA binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
n-AChR (RAT)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP K_i Database									Neuropharmacology 35: 725-34 (1996) Article DOI: 10.1016/0028-3908(96)84644-2 BindingDB Entry DOI: 10.7270/Q237777N
Abbott Laboratories Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP K_i Database									Neuropharmacology 35: 725-34 (1996) Article DOI: 10.1016/0028-3908(96)84644-2 BindingDB Entry DOI: 10.7270/Q237777N
Abbott Laboratories Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor Alpha-4/Beta-2 (Homo sapiens (Human))	BDBM50079456 (2-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octane \| CHEMBL...) Show SMILES C1CN2CCC1CC2c1cccnc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept Inc Curated by ChEMBL					Assay Description Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]-bungarotoxin as radioligand				J Med Chem 42: 3066-74 (1999) Article DOI: 10.1021/jm990093z BindingDB Entry DOI: 10.7270/Q2445KNP
Targacept Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	1.05	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP K_i Database									J Pharmacol Exp Ther 276: 289-97 (1996) BindingDB Entry DOI: 10.7270/Q2GM85T1
Abbott Laboratories Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-nicotine binding at the nicotinic acetylcholine receptor alpha4-beta2				J Med Chem 44: 2229-37 (2001) Article DOI: 10.1021/jm0100178 BindingDB Entry DOI: 10.7270/Q2BV7HVD
Research Triangle Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
nAChR alpha4 beta2 subtype (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	1.5	-12.0	n/a	n/a	n/a	n/a	n/a	7.4	25
Research Triangle Institute US Patent					Assay Description Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4� C.) ...				US Patent US9284322 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KCV
Research Triangle Institute US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Research Triangle Institute Curated by PDSP K_i Database									Bioorg Med Chem 16: 746-54 (2008) Article DOI: 10.1016/j.bmc.2007.10.027 BindingDB Entry DOI: 10.7270/Q2H130KC
Research Triangle Institute Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Cholinergic, Nicotinic Alpha6Beta3Beta4Alpha5 (RAT)	BDBM50079456 (2-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octane \| CHEMBL...) Show SMILES C1CN2CCC1CC2c1cccnc1 Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept Inc Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 619-26 (2005) Article DOI: 10.1124/jpet.104.075069 BindingDB Entry DOI: 10.7270/Q2BK19XS
Targacept Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition of [3H](-)-nicotine binding to rat brain (minus cerebellum) Nicotinic acetylcholine receptor alpha4-beta2				Bioorg Med Chem Lett 15: 3237-40 (2005) BindingDB Entry DOI: 10.7270/Q2DF6TZK
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Barrow Neurological Institute Curated by PDSP K_i Database									Mol Pharmacol 64: 1283-94 (2003) Article DOI: 10.1124/mol.64.6.1283 BindingDB Entry DOI: 10.7270/Q2GF0S2V
Barrow Neurological Institute Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor Alpha-4/Beta-2 (Homo sapiens (Human))	BDBM50079456 (2-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octane \| CHEMBL...) Show SMILES C1CN2CCC1CC2c1cccnc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept Inc Curated by ChEMBL					Assay Description Displacement of [3H]nicotine human alpha4beta2 nAChR in SH-EP1 cell membranes				J Med Chem 55: 9793-809 (2012) Article DOI: 10.1021/jm301048a BindingDB Entry DOI: 10.7270/Q2J67J2T
Targacept Inc Curated by ChEMBL					More data for this Ligand-Target Pair
n-AChR (RAT)	BDBM82068 (CHEMBL9732 \| Nicotine-D salicylate \| Nicotine-L sa...) Show SMILES CN1CCC[C@@H]1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
R. J. Reynolds Tobacco Company Curated by PDSP K_i Database									Mol Pharmacol 29: 448-54 (1986) BindingDB Entry DOI: 10.7270/Q269722Z
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-2 (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by PDSP K_i Database									Mol Pharmacol 64: 865-75 (2003) Article DOI: 10.1124/mol.64.4.865 BindingDB Entry DOI: 10.7270/Q2RX99PV
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SERVIER, Chemistry Research Division A Curated by PDSP K_i Database									Bioorg Med Chem Lett 18: 2188-93 (2008) Article DOI: 10.1016/j.bmcl.2007.12.075 BindingDB Entry DOI: 10.7270/Q2QF8RG1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Synthelabo Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 306: 407-20 (2003) Article DOI: 10.1124/jpet.103.049262 BindingDB Entry DOI: 10.7270/Q2GM85WX
Sanofi-Synthelabo Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	4.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by PDSP K_i Database									Mol Pharmacol 53: 950-62 (1998) BindingDB Entry DOI: 10.7270/Q2B856PT
University of Bath Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
n-AChR (RAT)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by PDSP K_i Database									J Pharmacol Exp Ther 302: 687-95 (2002) Article DOI: 10.1124/jpet.302.2.687 BindingDB Entry DOI: 10.7270/Q21R6P3D
University of Kentucky Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen					Assay Description Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...				J Biol Chem 287: 4248-59 (2012) Article DOI: 10.1074/jbc.M111.292243 BindingDB Entry DOI: 10.7270/Q2J964Z5
University of Copenhagen					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Solvay Pharmaceuticals Curated by PDSP K_i Database									Bioorg Med Chem Lett 18: 188-93 (2008) Article DOI: 10.1016/j.bmcl.2007.10.101 BindingDB Entry DOI: 10.7270/Q2C827W3
Solvay Pharmaceuticals Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
n-AChR (RAT)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	7.22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									Mol Pharmacol 54: 322-33 (1998) Article DOI: 10.1124/mol.54.2.322 BindingDB Entry DOI: 10.7270/Q2ZW1JGJ
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bath Curated by PDSP K_i Database									Mol Pharmacol 53: 950-62 (1998) BindingDB Entry DOI: 10.7270/Q2B856PT
University of Bath Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	8.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by PDSP K_i Database									Mol Pharmacol 64: 865-75 (2003) Article DOI: 10.1124/mol.64.4.865 BindingDB Entry DOI: 10.7270/Q2RX99PV
					More data for this Ligand-Target Pair				3D Structure (crystal)
n-AChR (RAT)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									Mol Pharmacol 39: 9-12 (1991) BindingDB Entry DOI: 10.7270/Q23T9FPK
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
n-AChR (RAT)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	9.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									Mol Pharmacol 48: 280-7 (1995) BindingDB Entry DOI: 10.7270/Q2280648
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
n-AChR (RAT)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by PDSP K_i Database									Mol Pharmacol 57: 642-9 (2000) Article DOI: 10.1124/mol.57.3.642 BindingDB Entry DOI: 10.7270/Q21C1VF8
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2 (Homo sapiens (Human))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University US Patent									US Patent US9993465 (2018) BindingDB Entry DOI: 10.7270/Q24T6MQ8
Georgetown University US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 310: 98-107 (2004) Article DOI: 10.1124/jpet.104.066787 BindingDB Entry DOI: 10.7270/Q2XG9PQX
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor subunit alpha-2 (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 310: 98-107 (2004) Article DOI: 10.1124/jpet.104.066787 BindingDB Entry DOI: 10.7270/Q2XG9PQX
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
n-AChR (RAT)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 310: 98-107 (2004) Article DOI: 10.1124/jpet.104.066787 BindingDB Entry DOI: 10.7270/Q2XG9PQX
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-2/Beta-2 (Homo sapiens (Human))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University US Patent					Assay Description Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...				US Patent US9993465 (2018) BindingDB Entry DOI: 10.7270/Q24T6MQ8
Georgetown University US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor (Rattus norvegicus (Rat))	BDBM50079456 (2-Pyridin-3-yl-1-aza-bicyclo[2.2.2]octane \| CHEMBL...) Show SMILES C1CN2CCC1CC2c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	12.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept Inc Curated by PDSP K_i Database									J Pharmacol Exp Ther 312: 619-26 (2005) Article DOI: 10.1124/jpet.104.075069 BindingDB Entry DOI: 10.7270/Q2BK19XS
Targacept Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2 (Homo sapiens (Human))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Synthelabo Research Curated by PDSP K_i Database									J Pharmacol Exp Ther 306: 407-20 (2003) Article DOI: 10.1124/jpet.103.049262 BindingDB Entry DOI: 10.7270/Q2GM85WX
Sanofi-Synthelabo Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50451805 (CHEMBL163042) Show SMILES CCN1CCCC1c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Affinity at alpha4-beta2 nACh receptors in rat brain (minus cerebellum) homogenates.				Bioorg Med Chem Lett 13: 733-5 (2003) Article DOI: 10.1016/s0960-894x(02)01031-4 BindingDB Entry DOI: 10.7270/Q2FT8NKF
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Cholinergic, Nicotinic Alpha6 (Chick)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Milan Curated by PDSP K_i Database									Mol Pharmacol 63: 1329-37 (2003) Article DOI: 10.1124/mol.63.6.1329 BindingDB Entry DOI: 10.7270/Q29W0D27
University of Milan Curated by PDSP K_i Database					More data for this Ligand-Target Pair
n-AChR (RAT)	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 282: 445-51 (1997) BindingDB Entry DOI: 10.7270/Q2222S97
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	26.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP K_i Database									J Pharmacol Exp Ther 276: 289-97 (1996) BindingDB Entry DOI: 10.7270/Q2GM85T1
Abbott Laboratories Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor Alpha-4/Beta-2 (Homo sapiens (Human))	BDBM50023328 (3-Pyrrolidin-2-yl-pyridine \| CHEMBL1132 \| Nornicot...) Show SMILES C1CNC(C1)c1cccnc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Targacept Inc Curated by ChEMBL					Assay Description Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]-bungarotoxin as radioligand				J Med Chem 42: 3066-74 (1999) Article DOI: 10.1021/jm990093z BindingDB Entry DOI: 10.7270/Q2445KNP
Targacept Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50023328 (3-Pyrrolidin-2-yl-pyridine \| CHEMBL1132 \| Nornicot...) Show SMILES C1CNC(C1)c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Affinity at alpha4-beta2 nACh receptors in rat brain (minus cerebellum) homogenates.				Bioorg Med Chem Lett 13: 733-5 (2003) Article DOI: 10.1016/s0960-894x(02)01031-4 BindingDB Entry DOI: 10.7270/Q2FT8NKF
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50023328 (3-Pyrrolidin-2-yl-pyridine \| CHEMBL1132 \| Nornicot...) Show SMILES C1CNC(C1)c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Binding affinity for rat brain Nicotinic acetylcholine receptor alpha4-beta2 using [3H]S-(-)-nicotine				Bioorg Med Chem Lett 15: 4308-12 (2005) BindingDB Entry DOI: 10.7270/Q2MW2KWM
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50035415 ((S)-1'-demethylnicotine \| 1'-demethyl nicotine \| 3...) Show SMILES C1CN[C@@H](C1)c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity towards alpha4-beta2 measured by using the inhibition of [3H]NIC binding to rat striatal membrane				Bioorg Med Chem Lett 13: 97-100 (2002) Article DOI: 10.1016/s0960-894x(02)00849-1 BindingDB Entry DOI: 10.7270/Q2736RF1
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2				Bioorg Med Chem Lett 15: 3237-40 (2005) BindingDB Entry DOI: 10.7270/Q2DF6TZK
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
n-AChR (RAT)	BDBM82068 (CHEMBL9732 \| Nicotine-D salicylate \| Nicotine-L sa...) Show SMILES CN1CCC[C@@H]1c1cccnc1 Show InChI	GoogleScholar	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by PDSP K_i Database									J Pharmacol Exp Ther 270: 159-66 (1994) BindingDB Entry DOI: 10.7270/Q22Z141C
University of California Curated by PDSP K_i Database					More data for this Ligand-Target Pair

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