BindingDB logo
myBDB logout

19 similar compounds to monomer 50450592

Compile data set for download or QSAR
Wt: 323.4
BDBM82378
Purchase
Wt: 337.4
BDBM50010096
Purchase
Wt: 369.4
BDBM50034869
Wt: 463.3
BDBM50034870
Wt: 383.4
BDBM50034871
Wt: 397.4
BDBM50034872
Wt: 369.4
BDBM50034873
Wt: 463.3
BDBM50034874
Wt: 383.4
BDBM50034875
Wt: 472.5
BDBM50296335
Wt: 340.4
BDBM50377964
Purchase
Wt: 337.4
BDBM50367742
Purchase
Wt: 352.4
BDBM50369230
Purchase
Wt: 275.3
BDBM50405717
Wt: 275.3
BDBM50405718
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 63 hits for monomerid = 82378,50010096,50034869,50034870,50034871,50034872,50034873,50034874,50034875,50296335,50377964,50367742,50369230,50405717,50405718   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.0450n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heart


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.0510n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 by measuring displacement of [3H]-QNB from guinea pig cerebral cortex


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50034869
PNG
((R)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Show SMILES O[C@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1
Show InChI InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20?,22-/m1/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.110n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50034869
PNG
((R)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Show SMILES O[C@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1
Show InChI InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20?,22-/m1/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.110n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50034873
PNG
((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1
Show InChI InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20?,22-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.130n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50369230
PNG
(CHEMBL1398637 | CLIDINIUM)
Show SMILES C[N+]12CCC(CC1)[C@H](C2)OC(=O)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1/t17?,20-,23?/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.130n/an/an/an/an/an/an/an/a



Groningen University Hospital

Curated by ChEMBL


Assay Description
Binding affinity towards rat Muscarinic acetylcholine receptor M1 was determined


J Med Chem 40: 117-24 (1997)


Article DOI: 10.1021/jm960374w
BindingDB Entry DOI: 10.7270/Q2VH5PG0
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50034873
PNG
((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1
Show InChI InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20?,22-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.130n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.180n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
KEGG

UniProtKB/TrEMBL

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.190n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatum


J Med Chem 31: 1463-6 (1988)


Article DOI: 10.1021/jm00402a035
BindingDB Entry DOI: 10.7270/Q2DV1KGN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50034872
PNG
((S)-[4-(3-Fluoro-propyl)-phenyl]-hydroxy-phenyl-ac...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CCCF)cc1
Show InChI InChI=1S/C24H28FNO3/c25-14-4-5-18-8-10-21(11-9-18)24(28,20-6-2-1-3-7-20)23(27)29-22-17-26-15-12-19(22)13-16-26/h1-3,6-11,19,22,28H,4-5,12-17H2/t22?,24-/m0/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.200n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
KEGG

UniProtKB/TrEMBL

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.220n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.230n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart


J Med Chem 31: 1463-6 (1988)


Article DOI: 10.1021/jm00402a035
BindingDB Entry DOI: 10.7270/Q2DV1KGN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.240n/an/an/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M3 by measuring displacement of [3H]-QNB from guinea pig parotid gland


J Med Chem 38: 473-87 (1995)


Article DOI: 10.1021/jm00003a011
BindingDB Entry DOI: 10.7270/Q25Q4V42
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50034875
PNG
((S)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CCF)cc1
Show InChI InChI=1S/C23H26FNO3/c24-13-10-17-6-8-20(9-7-17)23(27,19-4-2-1-3-5-19)22(26)28-21-16-25-14-11-18(21)12-15-25/h1-9,18,21,27H,10-16H2/t21?,23-/m0/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.260n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50034875
PNG
((S)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CCF)cc1
Show InChI InChI=1S/C23H26FNO3/c24-13-10-17-6-8-20(9-7-17)23(27,19-4-2-1-3-5-19)22(26)28-21-16-25-14-11-18(21)12-15-25/h1-9,18,21,27H,10-16H2/t21?,23-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.310n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50034874
PNG
((R)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Show SMILES O[C@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(I)cc1
Show InChI InChI=1S/C21H22INO3/c22-18-8-6-17(7-9-18)21(25,16-4-2-1-3-5-16)20(24)26-19-14-23-12-10-15(19)11-13-23/h1-9,15,19,25H,10-14H2/t19?,21-/m1/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.340n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50034872
PNG
((S)-[4-(3-Fluoro-propyl)-phenyl]-hydroxy-phenyl-ac...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CCCF)cc1
Show InChI InChI=1S/C24H28FNO3/c25-14-4-5-18-8-10-21(11-9-18)24(28,20-6-2-1-3-7-20)23(27)29-22-17-26-15-12-19(22)13-16-26/h1-3,6-11,19,22,28H,4-5,12-17H2/t22?,24-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.380n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50369230
PNG
(CHEMBL1398637 | CLIDINIUM)
Show SMILES C[N+]12CCC(CC1)[C@H](C2)OC(=O)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1/t17?,20-,23?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.430n/an/an/an/an/an/an/an/a



Groningen University Hospital

Curated by ChEMBL


Assay Description
Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determined


J Med Chem 40: 117-24 (1997)


Article DOI: 10.1021/jm960374w
BindingDB Entry DOI: 10.7270/Q2VH5PG0
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50367742
PNG
(CHEMBL1788199)
Show SMILES OC(C(=O)O[C@@H]1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2/t19-/s2
KEGG

UniProtKB/TrEMBL

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.570n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatum


J Med Chem 31: 1463-6 (1988)


Article DOI: 10.1021/jm00402a035
BindingDB Entry DOI: 10.7270/Q2DV1KGN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50369230
PNG
(CHEMBL1398637 | CLIDINIUM)
Show SMILES C[N+]12CCC(CC1)[C@H](C2)OC(=O)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1/t17?,20-,23?/m0/s1
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.650n/an/an/an/an/an/an/an/a



Groningen University Hospital

Curated by ChEMBL


Assay Description
Binding affinity towards Muscarinic acetylcholine receptor M3 was determined in guinea pig ileum


J Med Chem 40: 117-24 (1997)


Article DOI: 10.1021/jm960374w
BindingDB Entry DOI: 10.7270/Q2VH5PG0
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50377964
PNG
(Cantil | Glycophenylate | MEPENZOLATE BROMIDE | Me...)
Show SMILES C[N+]1(C)CCCC(C1)OC(=O)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H26NO3/c1-22(2)15-9-14-19(16-22)25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19,24H,9,14-16H2,1-2H3/q+1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

DrugBank
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.680n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human M2R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis


Bioorg Med Chem 22: 3488-97 (2014)


Article DOI: 10.1016/j.bmc.2014.04.029
BindingDB Entry DOI: 10.7270/Q2VD7111
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50034871
PNG
((R)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Show SMILES O[C@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CCF)cc1
Show InChI InChI=1S/C23H26FNO3/c24-13-10-17-6-8-20(9-7-17)23(27,19-4-2-1-3-5-19)22(26)28-21-16-25-14-11-18(21)12-15-25/h1-9,18,21,27H,10-16H2/t21?,23-/m1/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.840n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50034873
PNG
((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1
Show InChI InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20?,22-/m0/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.890n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50034873
PNG
((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1
Show InChI InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20?,22-/m0/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.890n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
2.20n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart


J Med Chem 31: 1463-6 (1988)


Article DOI: 10.1021/jm00402a035
BindingDB Entry DOI: 10.7270/Q2DV1KGN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50377964
PNG
(Cantil | Glycophenylate | MEPENZOLATE BROMIDE | Me...)
Show SMILES C[N+]1(C)CCCC(C1)OC(=O)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H26NO3/c1-22(2)15-9-14-19(16-22)25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19,24H,9,14-16H2,1-2H3/q+1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

DrugBank
PC cid
PC sid
UniChem

Similars

DrugBank
Article
PubMed
2.60n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from human M3R expressed in CHOK1 cells after 2 hrs by scintillation counting analysis


Bioorg Med Chem 22: 3488-97 (2014)


Article DOI: 10.1016/j.bmc.2014.04.029
BindingDB Entry DOI: 10.7270/Q2VD7111
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50405717
PNG
(CHEMBL2115341)
Show SMILES C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1
Show InChI InChI=1S/C16H21NO3/c1-16(19,13-5-3-2-4-6-13)15(18)20-14-11-17-9-7-12(14)8-10-17/h2-6,12,14,19H,7-11H2,1H3/t14-,16-/m0/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.90n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Pseudo hill coefficient at Muscarinic acetylcholine receptor M1


J Med Chem 31: 1463-6 (1988)


Article DOI: 10.1021/jm00402a035
BindingDB Entry DOI: 10.7270/Q2DV1KGN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50034874
PNG
((R)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Show SMILES O[C@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(I)cc1
Show InChI InChI=1S/C21H22INO3/c22-18-8-6-17(7-9-18)21(25,16-4-2-1-3-5-16)20(24)26-19-14-23-12-10-15(19)11-13-23/h1-9,15,19,25H,10-14H2/t19?,21-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.20n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50034870
PNG
((S)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(I)cc1
Show InChI InChI=1S/C21H22INO3/c22-18-8-6-17(7-9-18)21(25,16-4-2-1-3-5-16)20(24)26-19-14-23-12-10-15(19)11-13-23/h1-9,15,19,25H,10-14H2/t19?,21-/m0/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.60n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against bovine striatal membrane using [3H]-pirenzepine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
4.60n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against against guinea pig ileum using [3H]-N-methylscopolamine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50367742
PNG
(CHEMBL1788199)
Show SMILES OC(C(=O)O[C@@H]1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2/t19-/s2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.80n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium


J Med Chem 31: 1463-6 (1988)


Article DOI: 10.1021/jm00402a035
BindingDB Entry DOI: 10.7270/Q2DV1KGN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50034871
PNG
((R)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Show SMILES O[C@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CCF)cc1
Show InChI InChI=1S/C23H26FNO3/c24-13-10-17-6-8-20(9-7-17)23(27,19-4-2-1-3-5-19)22(26)28-21-16-25-14-11-18(21)12-15-25/h1-9,18,21,27H,10-16H2/t21?,23-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7.60n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50034874
PNG
((R)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Show SMILES O[C@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(I)cc1
Show InChI InChI=1S/C21H22INO3/c22-18-8-6-17(7-9-18)21(25,16-4-2-1-3-5-16)20(24)26-19-14-23-12-10-15(19)11-13-23/h1-9,15,19,25H,10-14H2/t19?,21-/m1/s1
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
8.10n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50034870
PNG
((S)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(I)cc1
Show InChI InChI=1S/C21H22INO3/c22-18-8-6-17(7-9-18)21(25,16-4-2-1-3-5-16)20(24)26-19-14-23-12-10-15(19)11-13-23/h1-9,15,19,25H,10-14H2/t19?,21-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
9n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50034869
PNG
((R)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Show SMILES O[C@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1
Show InChI InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20?,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50034869
PNG
((R)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Show SMILES O[C@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1
Show InChI InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20?,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
12n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against rat heart membrane using [3H]-AF-DX-384


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Bos taurus)
BDBM50405718
PNG
(CHEMBL2114396)
Show SMILES C[C@](O)(C(=O)O[C@@H]1CN2CCC1CC2)c1ccccc1
Show InChI InChI=1S/C16H21NO3/c1-16(19,13-5-3-2-4-6-13)15(18)20-14-11-17-9-7-12(14)8-10-17/h2-6,12,14,19H,7-11H2,1H3/t14-,16-/m1/s1
KEGG

UniProtKB/TrEMBL

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
19n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatum


J Med Chem 31: 1463-6 (1988)


Article DOI: 10.1021/jm00402a035
BindingDB Entry DOI: 10.7270/Q2DV1KGN
More data for this
Ligand-Target Pair
CHRM4


(Chick)
BDBM82378
PNG
(CAS_82-98-4 | NSC_4839 | Piperidolate)
Show SMILES CCN1CCCC(C1)OC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H25NO2/c1-2-22-15-9-14-19(16-22)24-21(23)20(17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19-20H,2,9,14-16H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

PubMed
36.3n/an/an/an/an/an/an/an/a



Glaxo Group Research Ltd.

Curated by PDSP Ki Database




Mol Pharmacol 38: 805-15 (1990)


BindingDB Entry DOI: 10.7270/Q2H993P0
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50405717
PNG
(CHEMBL2115341)
Show SMILES C[C@@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1
Show InChI InChI=1S/C16H21NO3/c1-16(19,13-5-3-2-4-6-13)15(18)20-14-11-17-9-7-12(14)8-10-17/h2-6,12,14,19H,7-11H2,1H3/t14-,16-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
37n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium


J Med Chem 31: 1463-6 (1988)


Article DOI: 10.1021/jm00402a035
BindingDB Entry DOI: 10.7270/Q2DV1KGN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50034873
PNG
((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1
Show InChI InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20?,22-/m0/s1
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
39n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50034873
PNG
((S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic ...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1
Show InChI InChI=1S/C22H24FNO3/c23-14-16-6-8-19(9-7-16)22(26,18-4-2-1-3-5-18)21(25)27-20-15-24-12-10-17(20)11-13-24/h1-9,17,20,26H,10-15H2/t20?,22-/m0/s1
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
39n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50034870
PNG
((S)-Hydroxy-(4-iodo-phenyl)-phenyl-acetic acid 1-a...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(I)cc1
Show InChI InChI=1S/C21H22INO3/c22-18-8-6-17(7-9-18)21(25,16-4-2-1-3-5-16)20(24)26-19-14-23-12-10-15(19)11-13-23/h1-9,15,19,25H,10-14H2/t19?,21-/m0/s1
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
41n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50034872
PNG
((S)-[4-(3-Fluoro-propyl)-phenyl]-hydroxy-phenyl-ac...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CCCF)cc1
Show InChI InChI=1S/C24H28FNO3/c25-14-4-5-18-8-10-21(11-9-18)24(28,20-6-2-1-3-7-20)23(27)29-22-17-26-15-12-19(22)13-16-26/h1-3,6-11,19,22,28H,4-5,12-17H2/t22?,24-/m0/s1
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
59n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
CHRM4


(RABBIT)
BDBM82378
PNG
(CAS_82-98-4 | NSC_4839 | Piperidolate)
Show SMILES CCN1CCCC(C1)OC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H25NO2/c1-2-22-15-9-14-19(16-22)24-21(23)20(17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19-20H,2,9,14-16H2,1H3
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

PubMed
64.6n/an/an/an/an/an/an/an/a



Glaxo Group Research Ltd.

Curated by PDSP Ki Database




Mol Pharmacol 38: 805-15 (1990)


BindingDB Entry DOI: 10.7270/Q2H993P0
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM82378
PNG
(CAS_82-98-4 | NSC_4839 | Piperidolate)
Show SMILES CCN1CCCC(C1)OC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H25NO2/c1-2-22-15-9-14-19(16-22)24-21(23)20(17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19-20H,2,9,14-16H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

PubMed
64.6n/an/an/an/an/an/an/an/a



Glaxo Group Research Ltd.

Curated by PDSP Ki Database




Mol Pharmacol 38: 805-15 (1990)


BindingDB Entry DOI: 10.7270/Q2H993P0
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Cavia porcellus)
BDBM50034875
PNG
((S)-[4-(2-Fluoro-ethyl)-phenyl]-hydroxy-phenyl-ace...)
Show SMILES O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CCF)cc1
Show InChI InChI=1S/C23H26FNO3/c24-13-10-17-6-8-20(9-7-17)23(27,19-4-2-1-3-5-19)22(26)28-21-16-25-14-11-18(21)12-15-25/h1-9,18,21,27H,10-16H2/t21?,23-/m0/s1
MMDB

Reactome pathway
KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
85n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
In vitro binding affinity against guinea pig ileum using [3H]-N-methylscopolamine


J Med Chem 38: 1711-9 (1995)


Article DOI: 10.1021/jm00010a016
BindingDB Entry DOI: 10.7270/Q2PV6JDQ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50367742
PNG
(CHEMBL1788199)
Show SMILES OC(C(=O)O[C@@H]1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2/t19-/s2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
123n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Evaluated for the inhibition of adenylate cyclase at M2 receptor in rat heart


J Med Chem 31: 1463-6 (1988)


Article DOI: 10.1021/jm00402a035
BindingDB Entry DOI: 10.7270/Q2DV1KGN
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM82378
PNG
(CAS_82-98-4 | NSC_4839 | Piperidolate)
Show SMILES CCN1CCCC(C1)OC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H25NO2/c1-2-22-15-9-14-19(16-22)24-21(23)20(17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19-20H,2,9,14-16H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

PubMed
141n/an/an/an/an/an/an/an/a



Glaxo Group Research Ltd.

Curated by PDSP Ki Database




Mol Pharmacol 38: 805-15 (1990)


BindingDB Entry DOI: 10.7270/Q2H993P0
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM82378
PNG
(CAS_82-98-4 | NSC_4839 | Piperidolate)
Show SMILES CCN1CCCC(C1)OC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H25NO2/c1-2-22-15-9-14-19(16-22)24-21(23)20(17-10-5-3-6-11-17)18-12-7-4-8-13-18/h3-8,10-13,19-20H,2,9,14-16H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

PubMed
155n/an/an/an/an/an/an/an/a



Glaxo Group Research Ltd.

Curated by PDSP Ki Database




Mol Pharmacol 38: 805-15 (1990)


BindingDB Entry DOI: 10.7270/Q2H993P0
More data for this
Ligand-Target Pair
Vesicular acetylcholine transporter


(Rattus norvegicus)
BDBM50010096
PNG
(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Show SMILES OC(C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
582n/an/an/an/an/an/an/an/a



Kanazawa University

Curated by ChEMBL


Assay Description
Displacement of [125I]O-iodo-trans-decalinvesamicol from VAChT in Sprague-Dawley rat cerebral membrane after 1 hr by gamma counting


Bioorg Med Chem 20: 4936-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.040
BindingDB Entry DOI: 10.7270/Q24B32DN
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 63 total )  |  Next  |  Last  >>