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5 similar compounds to monomer 50084139

Compile data set for download or QSAR
Wt: 187.1
BDBM85017
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Wt: 185.1
BDBM50052255
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Wt: 185.1
BDBM50052256
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Wt: 187.1
BDBM50089911
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Wt: 221.2
BDBM50400856
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 50 hits for monomerid = 85017,50052255,50052256,50089911,50400856   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIA3


(RAT)
BDBM85017
PNG
((1S,3S)-1-AMINO-1-CARBOXYCYCLOPENTANE-3-ACETIC ACI...)
Show SMILES N[C@]1(CC[C@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8+/m1/s1
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8.69E+3n/an/an/an/an/an/an/an/a



Eli Lilly and Company

Curated by PDSP Ki Database




J Pharmacol Exp Ther 298: 453-60 (2001)


Article DOI: 10.1016/j.bioorg.2016.02.004
BindingDB Entry DOI: 10.7270/Q2V986M2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM85017
PNG
((1S,3S)-1-AMINO-1-CARBOXYCYCLOPENTANE-3-ACETIC ACI...)
Show SMILES N[C@]1(CC[C@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Emory University

Curated by PDSP Ki Database




Annu Rev Pharmacol Toxicol 37: 205-37 (1997)


Article DOI: 10.1146/annurev.pharmtox.37.1.205
BindingDB Entry DOI: 10.7270/Q2M043ZH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))
BDBM85017
PNG
((1S,3S)-1-AMINO-1-CARBOXYCYCLOPENTANE-3-ACETIC ACI...)
Show SMILES N[C@]1(CC[C@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Emory University

Curated by PDSP Ki Database




Annu Rev Pharmacol Toxicol 37: 205-37 (1997)


Article DOI: 10.1146/annurev.pharmtox.37.1.205
BindingDB Entry DOI: 10.7270/Q2M043ZH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM85017
PNG
((1S,3S)-1-AMINO-1-CARBOXYCYCLOPENTANE-3-ACETIC ACI...)
Show SMILES N[C@]1(CC[C@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Emory University

Curated by PDSP Ki Database




Annu Rev Pharmacol Toxicol 37: 205-37 (1997)


Article DOI: 10.1146/annurev.pharmtox.37.1.205
BindingDB Entry DOI: 10.7270/Q2M043ZH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM85017
PNG
((1S,3S)-1-AMINO-1-CARBOXYCYCLOPENTANE-3-ACETIC ACI...)
Show SMILES N[C@]1(CC[C@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



UPR Centre

Curated by PDSP Ki Database




Mol Pharmacol 50: 923-30 (1996)


BindingDB Entry DOI: 10.7270/Q2M61HS5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM85017
PNG
((1S,3S)-1-AMINO-1-CARBOXYCYCLOPENTANE-3-ACETIC ACI...)
Show SMILES N[C@]1(CC[C@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



UPR Centre

Curated by PDSP Ki Database




Mol Pharmacol 50: 923-30 (1996)


BindingDB Entry DOI: 10.7270/Q2M61HS5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM85017
PNG
((1S,3S)-1-AMINO-1-CARBOXYCYCLOPENTANE-3-ACETIC ACI...)
Show SMILES N[C@]1(CC[C@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Emory University

Curated by PDSP Ki Database




Annu Rev Pharmacol Toxicol 37: 205-37 (1997)


Article DOI: 10.1146/annurev.pharmtox.37.1.205
BindingDB Entry DOI: 10.7270/Q2M043ZH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM85017
PNG
((1S,3S)-1-AMINO-1-CARBOXYCYCLOPENTANE-3-ACETIC ACI...)
Show SMILES N[C@]1(CC[C@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Emory University

Curated by PDSP Ki Database




Annu Rev Pharmacol Toxicol 37: 205-37 (1997)


Article DOI: 10.1146/annurev.pharmtox.37.1.205
BindingDB Entry DOI: 10.7270/Q2M043ZH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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2.50E+4n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50400856
PNG
(CHEMBL2021372)
Show SMILES N[C@H](C(O)=O)C12C3C4C1C1C2C3C41C(O)=O
Show InChI InChI=1/C11H11NO4/c12-7(8(13)14)10-1-4-2(10)6-3(10)5(1)11(4,6)9(15)16/h1-7H,12H2,(H,13,14)(H,15,16)/t1?,2?,3?,4?,5?,6?,7-,10?,11?/s2
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5.50E+4n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Partial agonist potency against cloned Metabotropic glutamate receptor 2


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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1.03E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned metabotropic glutamate receptor 5


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50089911
PNG
(1-Amino-3-carboxymethyl-cyclopentanecarboxylic aci...)
Show SMILES N[C@]1(CC[C@@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8-/m0/s1
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1.22E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 2 partial


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50400856
PNG
(CHEMBL2021372)
Show SMILES N[C@H](C(O)=O)C12C3C4C1C1C2C3C41C(O)=O
Show InChI InChI=1/C11H11NO4/c12-7(8(13)14)10-1-4-2(10)6-3(10)5(1)11(4,6)9(15)16/h1-7H,12H2,(H,13,14)(H,15,16)/t1?,2?,3?,4?,5?,6?,7-,10?,11?/s2
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2.32E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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>3.00E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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>3.00E+5n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Antagonist potency against cloned Metabotropic glutamate receptor 2


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50089911
PNG
(1-Amino-3-carboxymethyl-cyclopentanecarboxylic aci...)
Show SMILES N[C@]1(CC[C@@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human metabotropic glutamate receptor 1


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50400856
PNG
(CHEMBL2021372)
Show SMILES N[C@H](C(O)=O)C12C3C4C1C1C2C3C41C(O)=O
Show InChI InChI=1/C11H11NO4/c12-7(8(13)14)10-1-4-2(10)6-3(10)5(1)11(4,6)9(15)16/h1-7H,12H2,(H,13,14)(H,15,16)/t1?,2?,3?,4?,5?,6?,7-,10?,11?/s2
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>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned metabotropic glutamate receptor 5


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50400856
PNG
(CHEMBL2021372)
Show SMILES N[C@H](C(O)=O)C12C3C4C1C1C2C3C41C(O)=O
Show InChI InChI=1/C11H11NO4/c12-7(8(13)14)10-1-4-2(10)6-3(10)5(1)11(4,6)9(15)16/h1-7H,12H2,(H,13,14)(H,15,16)/t1?,2?,3?,4?,5?,6?,7-,10?,11?/s2
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>1.00E+6n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50089911
PNG
(1-Amino-3-carboxymethyl-cyclopentanecarboxylic aci...)
Show SMILES N[C@]1(CC[C@@H](CC(O)=O)C1)C(O)=O
Show InChI InChI=1S/C8H13NO4/c9-8(7(12)13)2-1-5(4-8)3-6(10)11/h5H,1-4,9H2,(H,10,11)(H,12,13)/t5-,8-/m0/s1
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The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)


J Med Chem 43: 2609-45 (2000)


Article DOI: 10.1021/jm000007r
BindingDB Entry DOI: 10.7270/Q2DZ090Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR4a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR2


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR2


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR4a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/an/an/a 1.03E+5n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR5a at half maximal concentration


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR5a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Università degli Studi

Curated by ChEMBL


Assay Description
Inhibitory activity against mGluR1 receptor


Bioorg Med Chem Lett 8: 1569-74 (1999)


Article DOI: 10.1016/s0960-894x(98)00265-0
BindingDB Entry DOI: 10.7270/Q2416W6X
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/an/an/a 1.03E+5n/an/an/an/a



Università degli Studi

Curated by ChEMBL


Assay Description
Concentration required to inhibit mGluR5a receptor


Bioorg Med Chem Lett 8: 1569-74 (1999)


Article DOI: 10.1016/s0960-894x(98)00265-0
BindingDB Entry DOI: 10.7270/Q2416W6X
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 2 in the rat HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Parc Club Orsay Université

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.


J Med Chem 42: 1546-55 (1999)


Article DOI: 10.1021/jm980571q
BindingDB Entry DOI: 10.7270/Q27H1HRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR2


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR1a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR1a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR5a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR5a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Universit£ Ren£ Descartes-Paris V

Curated by ChEMBL


Assay Description
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inacti...


J Med Chem 48: 2534-47 (2005)


Article DOI: 10.1021/jm049092j
BindingDB Entry DOI: 10.7270/Q23X87FM
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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Universit£ Ren£ Descartes-Paris V

Curated by ChEMBL


Assay Description
Stimulation od [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells


J Med Chem 48: 2534-47 (2005)


Article DOI: 10.1021/jm049092j
BindingDB Entry DOI: 10.7270/Q23X87FM
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Lilly Research Labs

Curated by ChEMBL


Assay Description
Antagonist activity at mGlu1 receptor


J Med Chem 50: 2563-8 (2007)


Article DOI: 10.1021/jm060950g
BindingDB Entry DOI: 10.7270/Q2XS5W7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50400856
PNG
(CHEMBL2021372)
Show SMILES N[C@H](C(O)=O)C12C3C4C1C1C2C3C41C(O)=O
Show InChI InChI=1/C11H11NO4/c12-7(8(13)14)10-1-4-2(10)6-3(10)5(1)11(4,6)9(15)16/h1-7H,12H2,(H,13,14)(H,15,16)/t1?,2?,3?,4?,5?,6?,7-,10?,11?/s2
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n/an/a 7.60E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of mGluR1b receptor


J Med Chem 54: 2529-91 (2011)


Article DOI: 10.1021/jm1013693
BindingDB Entry DOI: 10.7270/Q24M95PH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of mGluR1a receptor


J Med Chem 54: 2529-91 (2011)


Article DOI: 10.1021/jm1013693
BindingDB Entry DOI: 10.7270/Q24M95PH
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50400856
PNG
(CHEMBL2021372)
Show SMILES N[C@H](C(O)=O)C12C3C4C1C1C2C3C41C(O)=O
Show InChI InChI=1/C11H11NO4/c12-7(8(13)14)10-1-4-2(10)6-3(10)5(1)11(4,6)9(15)16/h1-7H,12H2,(H,13,14)(H,15,16)/t1?,2?,3?,4?,5?,6?,7-,10?,11?/s2
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n/an/an/an/a 2.00E+4n/an/an/an/a



Università degli Studi

Curated by ChEMBL


Assay Description
Concentration required to inhibit mGluR4a receptor


Bioorg Med Chem Lett 8: 1569-74 (1999)


Article DOI: 10.1016/s0960-894x(98)00265-0
BindingDB Entry DOI: 10.7270/Q2416W6X
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50400856
PNG
(CHEMBL2021372)
Show SMILES N[C@H](C(O)=O)C12C3C4C1C1C2C3C41C(O)=O
Show InChI InChI=1/C11H11NO4/c12-7(8(13)14)10-1-4-2(10)6-3(10)5(1)11(4,6)9(15)16/h1-7H,12H2,(H,13,14)(H,15,16)/t1?,2?,3?,4?,5?,6?,7-,10?,11?/s2
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n/an/an/an/a 1.00E+3n/an/an/an/a



Università degli Studi

Curated by ChEMBL


Assay Description
Concentration required to inhibit mGluR5a receptor


Bioorg Med Chem Lett 8: 1569-74 (1999)


Article DOI: 10.1016/s0960-894x(98)00265-0
BindingDB Entry DOI: 10.7270/Q2416W6X
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50400856
PNG
(CHEMBL2021372)
Show SMILES N[C@H](C(O)=O)C12C3C4C1C1C2C3C41C(O)=O
Show InChI InChI=1/C11H11NO4/c12-7(8(13)14)10-1-4-2(10)6-3(10)5(1)11(4,6)9(15)16/h1-7H,12H2,(H,13,14)(H,15,16)/t1?,2?,3?,4?,5?,6?,7-,10?,11?/s2
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n/an/a 2.32E+5n/an/an/an/an/an/a



Università degli Studi

Curated by ChEMBL


Assay Description
Inhibitory activity against mGluR1 receptor


Bioorg Med Chem Lett 8: 1569-74 (1999)


Article DOI: 10.1016/s0960-894x(98)00265-0
BindingDB Entry DOI: 10.7270/Q2416W6X
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50400856
PNG
(CHEMBL2021372)
Show SMILES N[C@H](C(O)=O)C12C3C4C1C1C2C3C41C(O)=O
Show InChI InChI=1/C11H11NO4/c12-7(8(13)14)10-1-4-2(10)6-3(10)5(1)11(4,6)9(15)16/h1-7H,12H2,(H,13,14)(H,15,16)/t1?,2?,3?,4?,5?,6?,7-,10?,11?/s2
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n/an/an/an/a 1.00E+4n/an/an/an/a



Università degli Studi

Curated by ChEMBL


Assay Description
Concentration required to inhibit mGluR2 receptor


Bioorg Med Chem Lett 8: 1569-74 (1999)


Article DOI: 10.1016/s0960-894x(98)00265-0
BindingDB Entry DOI: 10.7270/Q2416W6X
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50400856
PNG
(CHEMBL2021372)
Show SMILES N[C@H](C(O)=O)C12C3C4C1C1C2C3C41C(O)=O
Show InChI InChI=1/C11H11NO4/c12-7(8(13)14)10-1-4-2(10)6-3(10)5(1)11(4,6)9(15)16/h1-7H,12H2,(H,13,14)(H,15,16)/t1?,2?,3?,4?,5?,6?,7-,10?,11?/s2
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n/an/a 2.30E+5n/an/an/an/an/an/a



Lilly Research Labs

Curated by ChEMBL


Assay Description
Antagonist activity at mGlu1 receptor


J Med Chem 50: 2563-8 (2007)


Article DOI: 10.1021/jm060950g
BindingDB Entry DOI: 10.7270/Q2XS5W7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR1a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR4a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50052256
PNG
((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Show SMILES N[C@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR4a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR5a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for effect on second messenger formation in BHK cells expressing mGluR2


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50052255
PNG
(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Show SMILES N[C@@H](C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m0/s1
PDB

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CHEMBL
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Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory effect on second messenger formation in BHK cells expressing mGluR1a


J Med Chem 39: 2874-6 (1996)


Article DOI: 10.1021/jm960254o
BindingDB Entry DOI: 10.7270/Q2HT2NDJ
More data for this
Ligand-Target Pair