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10 similar compounds to monomer 50247678

Wt: 286.3
BDBM86251
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Wt: 286.3
BDBM50010132
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Wt: 286.3
BDBM50044253
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Wt: 366.3
BDBM50247707
Wt: 391.2
BDBM50247708
Wt: 382.7
BDBM50247861
Wt: 356.8
BDBM50247679
Wt: 356.8
BDBM50247680
Wt: 356.8
BDBM50247681
Wt: 347.3
BDBM50247682

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 86251,50010132,50044253,50247707,50247708,50247861,50247679,50247680,50247681,50247682   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86251
PNG
(CAS_94535-50-9 | CROMAKALIM (-) | NSC_93504)
Show SMILES CC1(C)Oc2ccc(cc2C(C1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3
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PubMed
157n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Potassium channel (ATP modulatory)


(GUINEA PIG)
BDBM86251
PNG
(CAS_94535-50-9 | CROMAKALIM (-) | NSC_93504)
Show SMILES CC1(C)Oc2ccc(cc2C(C1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3
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542n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50044253
PNG
((3R,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H]([C@H]1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m0/s1
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1.10E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


Citation and Details
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50044253
PNG
((3R,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H]([C@H]1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m0/s1
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7.20E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity was determined by displacement of [3H]-P1075 from its binding sites in canine cardiac membranes


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50010132
PNG
((3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
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n/an/an/an/a 1.25E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247708
PNG
(3,4-dichloro-N-((3S,4R)-6-cyano-3-hydroxy-2,2-dime...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H](NC(=O)c2ccc(Cl)c(Cl)c2)[C@@H]1O)C#N
Show InChI InChI=1S/C19H16Cl2N2O3/c1-19(2)17(24)16(12-7-10(9-22)3-6-15(12)26-19)23-18(25)11-4-5-13(20)14(21)8-11/h3-8,16-17,24H,1-2H3,(H,23,25)/t16-,17+/m1/s1
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n/an/an/an/a 7.06E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Mitochondrial complex V; ATP synthase


(Bos taurus)
BDBM50010132
PNG
((3S,4R)-3-Hydroxy-2,2-dimethyl-4-(2-oxo-pyrrolidin...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N1CCCC1=O)C#N
Show InChI InChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration towards rat mitochondrial F1F0 ATP hydrolase using a pyruvate kinase / lactate dehydrogenase system


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247861
PNG
((3S,4R)-4-(5-Chloro-1,3-dioxo-1,3-dihydro-isoindol...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N1C(=O)c2ccc(Cl)cc2C1=O)C#N
Show InChI InChI=1S/C20H15ClN2O4/c1-20(2)17(24)16(14-7-10(9-22)3-6-15(14)27-20)23-18(25)12-5-4-11(21)8-13(12)19(23)26/h3-8,16-17,24H,1-2H3/t16-,17+/m1/s1
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n/an/an/an/a 3.16E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247682
PNG
((+/-)-4-cyanophenyl 6-cyano-3-hydroxy-2,2-dimethyl...)
Show SMILES CC1(C)Oc2ccc(cc2C(NC(=O)c2ccc(cc2)C#N)C1O)C#N
Show InChI InChI=1S/C20H17N3O3/c1-20(2)18(24)17(15-9-13(11-22)5-8-16(15)26-20)23-19(25)14-6-3-12(10-21)4-7-14/h3-9,17-18,24H,1-2H3,(H,23,25)
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n/an/an/an/a 2.11E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247681
PNG
((+/-)-4-chlorophenyl 6-cyano-3-hydroxy-2,2-dimethy...)
Show SMILES CC1(C)Oc2ccc(cc2C(NC(=O)c2ccc(Cl)cc2)C1O)C#N
Show InChI InChI=1S/C19H17ClN2O3/c1-19(2)17(23)16(14-9-11(10-21)3-8-15(14)25-19)22-18(24)12-4-6-13(20)7-5-12/h3-9,16-17,23H,1-2H3,(H,22,24)
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n/an/an/an/a 780n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247680
PNG
((-)-3-chlorophenyl (3S,4R)-6-cyano-3-hydroxy-2,2-d...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H](NC(=O)c2cccc(Cl)c2)[C@@H]1O)C#N
Show InChI InChI=1S/C19H17ClN2O3/c1-19(2)17(23)16(14-8-11(10-21)6-7-15(14)25-19)22-18(24)12-4-3-5-13(20)9-12/h3-9,16-17,23H,1-2H3,(H,22,24)/t16-,17+/m1/s1
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n/an/an/an/a 70n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247679
PNG
((+)-3-chlorophenyl (3R,4S)-6-cyano-3-hydroxy-2,2-d...)
Show SMILES CC1(C)Oc2ccc(cc2[C@H](NC(=O)c2cccc(Cl)c2)[C@H]1O)C#N
Show InChI InChI=1S/C19H17ClN2O3/c1-19(2)17(23)16(14-8-11(10-21)6-7-15(14)25-19)22-18(24)12-4-3-5-13(20)9-12/h3-9,16-17,23H,1-2H3,(H,22,24)/t16-,17+/m0/s1
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n/an/an/an/a 2.07E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens)
BDBM50247707
PNG
(CHEMBL454166 | N-((3S,4R)-6-cyano-3-hydroxy-2,2-di...)
Show SMILES CC1(C)Oc2ccc(cc2[C@@H](NC(=O)c2ccc3OCOc3c2)[C@@H]1O)C#N
Show InChI InChI=1S/C20H18N2O5/c1-20(2)18(23)17(13-7-11(9-21)3-5-14(13)27-20)22-19(24)12-4-6-15-16(8-12)26-10-25-15/h3-8,17-18,23H,10H2,1-2H3,(H,22,24)/t17-,18+/m1/s1
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n/an/an/an/a 810n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Channel opening activity at SUR2B/Kir6.2 potassium ATP channel in human TE671 cells assessed as isometric force by FLIPR


Citation and Details
More data for this
Ligand-Target Pair