Found 47 hits for monomerid = 9047,8960,8963,8961,10404,10441,10443,10450,10458,10478,10480,10958,23411,50004000,50012170 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM10441
 ((+)-Huperzine A | (+/-)Huperzine A | (-)-Huperzine...)Show InChI InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+ | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 7.02E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Shanghai Institute of Materia Medica
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
J Med Chem 48: 655-7 (2005)
Article DOI: 10.1021/jm0496178 BindingDB Entry DOI: 10.7270/Q2FQ9TT0 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 2.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of rat serum BuChE measured after 15 mins by Ellman's method |
Bioorg Med Chem 25: 714-726 (2017)
Article DOI: 10.1016/j.bmc.2016.11.048 BindingDB Entry DOI: 10.7270/Q21C1ZVW |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM10443
 (2-methylquinolin-4-amine | 4-Aminoquinaldine 4)Show InChI InChI=1S/C10H10N2/c1-7-6-9(11)8-4-2-3-5-10(8)12-7/h2-6H,1H3,(H2,11,12) | Reactome pathway KEGG
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Patents
| Article PubMed
| n/a | n/a | 1.05E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
Bioorg Med Chem 7: 2569-75 (1999)
Article DOI: 10.1021/cb700200w BindingDB Entry DOI: 10.7270/Q22N50GZ |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM10450
 (4-Aminoquinoline 7 | quinolin-4-amine)Show InChI InChI=1S/C9H8N2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H2,10,11) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 2.55E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
Bioorg Med Chem 7: 2569-75 (1999)
Article DOI: 10.1021/cb700200w BindingDB Entry DOI: 10.7270/Q22N50GZ |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM10458
 (4-AP | 4-Aminopyridine 10 | CHEMBL284348 | DALFAMP...)Show InChI InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7) | Reactome pathway KEGG
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| n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
Bioorg Med Chem 7: 2569-75 (1999)
Article DOI: 10.1021/cb700200w BindingDB Entry DOI: 10.7270/Q22N50GZ |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Foundation for Medical Education and Research
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
J Biol Chem 271: 23646-9 (1996)
Article DOI: 10.1038/sj.bjp.0706048 BindingDB Entry DOI: 10.7270/Q2XW4H0P |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM10478
 (A2A.2HCl | Bis-THA inhibitor 1 | CHEMBL213377 | N-...)Show SMILES C(CNc1c2CCCCc2nc2ccccc12)Nc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C28H30N4/c1-5-13-23-19(9-1)27(20-10-2-6-14-24(20)31-23)29-17-18-30-28-21-11-3-7-15-25(21)32-26-16-8-4-12-22(26)28/h1,3,5,7,9,11,13,15H,2,4,6,8,10,12,14,16-18H2,(H,29,31)(H,30,32) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Hong Kong University of Science and Technology
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
Bioorg Med Chem 7: 351-7 (1999)
Article DOI: 10.1016/j.bmc.2007.08.013 BindingDB Entry DOI: 10.7270/Q2T43R9Q |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM10480
 (A4A.2HCl | Bis-THA inhibitor 3 | CHEMBL211313 | N-...)Show SMILES C(CCNc1c2CCCCc2nc2ccccc12)CNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C30H34N4/c1-5-15-25-21(11-1)29(22-12-2-6-16-26(22)33-25)31-19-9-10-20-32-30-23-13-3-7-17-27(23)34-28-18-8-4-14-24(28)30/h1,3,5,7,11,13,15,17H,2,4,6,8-10,12,14,16,18-20H2,(H,31,33)(H,32,34) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 252 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Hong Kong University of Science and Technology
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
Bioorg Med Chem 7: 351-7 (1999)
Article DOI: 10.1016/j.bmc.2007.08.013 BindingDB Entry DOI: 10.7270/Q2T43R9Q |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM9047
 (Bis-THA inhibitor 5 | CHEMBL73800 | Hexylene-Linke...)Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C32H38N4/c1(11-21-33-31-23-13-3-7-17-27(23)35-28-18-8-4-14-24(28)31)2-12-22-34-32-25-15-5-9-19-29(25)36-30-20-10-6-16-26(30)32/h3,5,7,9,13,15,17,19H,1-2,4,6,8,10-12,14,16,18,20-22H2,(H,33,35)(H,34,36) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 119 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Hong Kong University of Science and Technology
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
Bioorg Med Chem 7: 351-7 (1999)
Article DOI: 10.1016/j.bmc.2007.08.013 BindingDB Entry DOI: 10.7270/Q2T43R9Q |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Hong Kong University of Science and Technology
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
Bioorg Med Chem 7: 351-7 (1999)
Article DOI: 10.1016/j.bmc.2007.08.013 BindingDB Entry DOI: 10.7270/Q2T43R9Q |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
J Med Chem 42: 4225-31 (1999)
Article DOI: 10.1021/jm990224w BindingDB Entry DOI: 10.7270/Q2W957CH |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8963
 (CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at... |
J Med Chem 42: 4225-31 (1999)
Article DOI: 10.1021/jm990224w BindingDB Entry DOI: 10.7270/Q2W957CH |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM23411
 (5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
| Assay Description For rat AChE or BuChE inhibition assays, a reaction mixture (100 μL) containing acetylthiocholine iodide (1 mmol/L, 30 μL) (J&K Scientific)... |
Chem Biol Drug Des 86: 1168-77 (2015)
Article DOI: 10.1111/cbdd.12580 BindingDB Entry DOI: 10.7270/Q2VM4B1P |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 2.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
| Assay Description For AChE or BuChE inhibition assays, a reaction mixture (100 mL) containing acetylthiocholine iodide (1 mmol/L, 30 mL) or butyrylthiocholine iodide (... |
Bioorg Chem 71: 305-314 (2017)
Article DOI: 10.1016/j.bioorg.2017.02.016 BindingDB Entry DOI: 10.7270/Q2X9295T |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM50004000
 ((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)Show SMILES CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 Show InChI InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration of the compound against butyrylcholinesterase (BuChE) obtained from rat plasma |
J Med Chem 35: 4542-8 (1993)
Article DOI: 10.1021/jm00102a005 BindingDB Entry DOI: 10.7270/Q25M64P8 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd.
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration of the compound against Butyrylcholinesterase obtained from rat plasma |
J Med Chem 35: 4542-8 (1993)
Article DOI: 10.1021/jm00102a005 BindingDB Entry DOI: 10.7270/Q25M64P8 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio de Janeiro
Curated by ChEMBL
| Assay Description Inhibitory concentration against rat brain butyrylcholinesterase (BuChE) was determined using Ellman's method |
J Med Chem 46: 1144-52 (2003)
Article DOI: 10.1021/jm020391n BindingDB Entry DOI: 10.7270/Q26972X5 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM10478
 (A2A.2HCl | Bis-THA inhibitor 1 | CHEMBL213377 | N-...)Show SMILES C(CNc1c2CCCCc2nc2ccccc12)Nc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C28H30N4/c1-5-13-23-19(9-1)27(20-10-2-6-14-24(20)31-23)29-17-18-30-28-21-11-3-7-15-25(21)32-26-16-8-4-12-22(26)28/h1,3,5,7,9,11,13,15H,2,4,6,8,10,12,14,16-18H2,(H,29,31)(H,30,32) | Reactome pathway KEGG
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| n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science
Curated by ChEMBL
| Assay Description Inhibition of rat serum BuChE |
J Med Chem 49: 5491-500 (2006)
Article DOI: 10.1021/jm060164b BindingDB Entry DOI: 10.7270/Q2154GPX |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8963
 (CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science
Curated by ChEMBL
| Assay Description Inhibition of rat serum BuChE |
J Med Chem 49: 5491-500 (2006)
Article DOI: 10.1021/jm060164b BindingDB Entry DOI: 10.7270/Q2154GPX |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM9047
 (Bis-THA inhibitor 5 | CHEMBL73800 | Hexylene-Linke...)Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C32H38N4/c1(11-21-33-31-23-13-3-7-17-27(23)35-28-18-8-4-14-24(28)31)2-12-22-34-32-25-15-5-9-19-29(25)36-30-20-10-6-16-26(30)32/h3,5,7,9,13,15,17,19H,1-2,4,6,8,10-12,14,16,18,20-22H2,(H,33,35)(H,34,36) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science
Curated by ChEMBL
| Assay Description Inhibition of rat serum BuChE |
J Med Chem 49: 5491-500 (2006)
Article DOI: 10.1021/jm060164b BindingDB Entry DOI: 10.7270/Q2154GPX |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM10480
 (A4A.2HCl | Bis-THA inhibitor 3 | CHEMBL211313 | N-...)Show SMILES C(CCNc1c2CCCCc2nc2ccccc12)CNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C30H34N4/c1-5-15-25-21(11-1)29(22-12-2-6-16-26(22)33-25)31-19-9-10-20-32-30-23-13-3-7-17-27(23)34-28-18-8-4-14-24(28)30/h1,3,5,7,11,13,15,17H,2,4,6,8-10,12,14,16,18-20H2,(H,31,33)(H,32,34) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 252 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science
Curated by ChEMBL
| Assay Description Inhibition of rat serum BuChE |
J Med Chem 49: 5491-500 (2006)
Article DOI: 10.1021/jm060164b BindingDB Entry DOI: 10.7270/Q2154GPX |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science
Curated by ChEMBL
| Assay Description Inhibition of rat serum BuChE |
J Med Chem 49: 5491-500 (2006)
Article DOI: 10.1021/jm060164b BindingDB Entry DOI: 10.7270/Q2154GPX |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 1.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description Inhibition of BChE in rat serum using butyrylthiocholine iodide substrate incubated for 15 mins by UV spectroscopy based Ellman's method |
Bioorg Med Chem 22: 4717-25 (2014)
Article DOI: 10.1016/j.bmc.2014.07.009 BindingDB Entry DOI: 10.7270/Q22809B6 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bologna
Curated by ChEMBL
| Assay Description Inhibition of rat plasma butyrylcholine esterase in presence of butyrylcholine substrate by chemiluminescent assay |
Eur J Med Chem 43: 657-61 (2008)
Checked by Author Article DOI: 10.1016/j.ejmech.2007.04.018 BindingDB Entry DOI: 10.7270/Q2TH8MG0 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Bologna
Curated by ChEMBL
| Assay Description Inhibition of rat plasma butyrylcholine esterase in presence of butyrylcholine substrate by chemiluminescent assay |
Eur J Med Chem 43: 657-61 (2008)
Checked by Author Article DOI: 10.1016/j.ejmech.2007.04.018 BindingDB Entry DOI: 10.7270/Q2TH8MG0 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 2.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description Inhibition of BChE in rat serum after 15 mins by modified Ellman method |
Eur J Med Chem 44: 7-17 (2008)
Article DOI: 10.1016/j.ejmech.2008.03.003 BindingDB Entry DOI: 10.7270/Q29W0F8B |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 3.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description Inhibition of BuchE in rat serum by Ellman's method |
Bioorg Med Chem 16: 7646-53 (2008)
Article DOI: 10.1016/j.bmc.2008.07.014 BindingDB Entry DOI: 10.7270/Q2RR1Z2W |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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| Article
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory concentration was determined in in vitro for Butyrylcholinesterase in rat plasma |
Bioorg Med Chem Lett 2: 871-876 (1992)
Article DOI: 10.1016/S0960-894X(00)80547-8 BindingDB Entry DOI: 10.7270/Q21R6QDV |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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| n/a | n/a | 7.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory concentration was determined in in vitro for Butyrylcholinesterase in rat plasma |
Bioorg Med Chem Lett 2: 871-876 (1992)
Article DOI: 10.1016/S0960-894X(00)80547-8 BindingDB Entry DOI: 10.7270/Q21R6QDV |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM50004000
 ((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)Show SMILES CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 Show InChI InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1 | Reactome pathway KEGG
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| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory concentration was determined in in vitro for Butyrylcholinesterase in rat plasma |
Bioorg Med Chem Lett 2: 871-876 (1992)
Article DOI: 10.1016/S0960-894X(00)80547-8 BindingDB Entry DOI: 10.7270/Q21R6QDV |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was tested in vitro for inhibitory activity against Butyrylcholinesterase |
Bioorg Med Chem Lett 7: 2599-2602 (1997)
Article DOI: 10.1016/S0960-894X(97)10025-7 BindingDB Entry DOI: 10.7270/Q2KW5G10 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM50012170
 (2-Phenyl-quinolin-4-ylamine | CHEMBL50608)Show InChI InChI=1S/C15H12N2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,(H2,16,17) | Reactome pathway KEGG
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| Article
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was tested in vitro for inhibitory activity against Butyrylcholinesterase |
Bioorg Med Chem Lett 7: 2599-2602 (1997)
Article DOI: 10.1016/S0960-894X(97)10025-7 BindingDB Entry DOI: 10.7270/Q2KW5G10 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM10404
 ((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...)Show SMILES COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24 Show InChI InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description Inhibition of BChE from rat serum by Ellmans method |
Eur J Med Chem 44: 772-84 (2009)
Article DOI: 10.1016/j.ejmech.2008.04.018 BindingDB Entry DOI: 10.7270/Q24Q7TS0 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 4.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description Inhibition of BChE in rat serum after 15 mins by modified Ellman's method |
Bioorg Med Chem 17: 6692-8 (2009)
Article DOI: 10.1016/j.bmc.2009.07.072 BindingDB Entry DOI: 10.7270/Q29S1R4M |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM50004000
 ((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)Show SMILES CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 Show InChI InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description Inhibition of rat plasma BChE by Ellman's method |
Bioorg Med Chem Lett 20: 1532-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.097 BindingDB Entry DOI: 10.7270/Q29K4BCV |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM10958
 ((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)Show SMILES CN1CC[C@]2(C)[C@H]1N(C)c1ccc(OC(=O)Nc3ccccc3)cc21 Show InChI InChI=1S/C20H23N3O2/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14/h4-10,13,18H,11-12H2,1-3H3,(H,21,24)/t18-,20+/m1/s1 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description Inhibition of rat plasma BChE by Ellman's method |
Bioorg Med Chem Lett 20: 1532-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.097 BindingDB Entry DOI: 10.7270/Q29K4BCV |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology
Curated by ChEMBL
| Assay Description Inhibitory potency against rat serum Butyrylcholinesterase with BW284c51 as AChE inhibitor |
Bioorg Med Chem Lett 9: 2335-8 (1999)
Article DOI: 10.1016/s0960-894x(99)00396-0 BindingDB Entry DOI: 10.7270/Q2PK0GPF |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8963
 (CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37) | Reactome pathway KEGG
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Similars
| Article PubMed
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology
Curated by ChEMBL
| Assay Description Inhibitory potency against rat serum Butyrylcholinesterase with BW284c51 as AChE inhibitor |
Bioorg Med Chem Lett 9: 2335-8 (1999)
Article DOI: 10.1016/s0960-894x(99)00396-0 BindingDB Entry DOI: 10.7270/Q2PK0GPF |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM50004000
 ((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)Show SMILES CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 Show InChI InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Butyrylcholinesterase |
J Med Chem 38: 4821-9 (1996)
Article DOI: 10.1021/jm00024a009 BindingDB Entry DOI: 10.7270/Q2QC045T |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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Patents
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| Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Butyrylcholinesterase |
J Med Chem 38: 4821-9 (1996)
Article DOI: 10.1021/jm00024a009 BindingDB Entry DOI: 10.7270/Q2QC045T |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 7.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Company, Ltd.
Curated by ChEMBL
| Assay Description Butyrylcholinesterase |
J Med Chem 38: 4821-9 (1996)
Article DOI: 10.1021/jm00024a009 BindingDB Entry DOI: 10.7270/Q2QC045T |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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Similars
| Article PubMed
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate |
Bioorg Med Chem Lett 15: 3834-7 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.132 BindingDB Entry DOI: 10.7270/Q27H1KBV |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8963
 (CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37) | Reactome pathway KEGG
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Similars
| Article PubMed
| n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description Inhibition of rat BuChE |
J Med Chem 51: 3154-70 (2008)
Article DOI: 10.1021/jm701253t BindingDB Entry DOI: 10.7270/Q22Z16D4 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8960
 ((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)Show SMILES COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC Show InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 | Reactome pathway KEGG
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Patents
Similars
| Article PubMed
| n/a | n/a | 7.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratori de Qu�mica Farmac�utica (Unitat Associada al CSIC)
Curated by ChEMBL
| Assay Description Inhibition of rat serum BChE |
J Med Chem 51: 3588-98 (2008)
Article DOI: 10.1021/jm8001313 BindingDB Entry DOI: 10.7270/Q2F76DGK |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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Patents
Similars
| Article PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratori de Qu�mica Farmac�utica (Unitat Associada al CSIC)
Curated by ChEMBL
| Assay Description Inhibition of rat serum BChE |
J Med Chem 51: 3588-98 (2008)
Article DOI: 10.1021/jm8001313 BindingDB Entry DOI: 10.7270/Q2F76DGK |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM50004000
 ((3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydro...)Show SMILES CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 Show InChI InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1 | Reactome pathway KEGG
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Patents
Similars
| Article PubMed
| n/a | n/a | 58.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of BuChE in Wistar rat plasma using acetylthiocholine iodide as substrate after 0.5 hrs by Ellman's method |
Bioorg Med Chem 20: 4901-14 (2012)
Article DOI: 10.1016/j.bmc.2012.06.048 BindingDB Entry DOI: 10.7270/Q2W66MVP |
More data for this Ligand-Target Pair | |
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)
(Rattus norvegicus (rat)) | BDBM8961
 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | Reactome pathway KEGG
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Patents
Similars
| Article PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | 8.0 | 25 |
Shanghai Institute of Materia Medica
| Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us... |
Bioorg Med Chem Lett 14: 4639-42 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.005 BindingDB Entry DOI: 10.7270/Q23X84VR |
More data for this Ligand-Target Pair | |