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There are 12 purchasable compounds for target: Activated protein C cofactor

Wt: 528.4
BDBM12676
Wt: 429.5
BDBM29388
Wt: 471.5
BDBM50112086
Wt: 451.9
BDBM50249298
Wt: 495.8
BDBM50376417
Wt: 490.4
BDBM50376418
Wt: 400.5
BDBM50376419
Wt: 459.2
BDBM50376420
Wt: 437.8
BDBM50376421
Wt: 477.3
BDBM50376423
Wt: 451.2
BDBM50376425
Wt: 463.4
BDBM50423622

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 12676,29388,50112086,50249298,50376417,50376418,50376419,50376420,50376421,50376423,50376425,50423622   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vitamin K-dependent protein C


(Homo sapiens (human))
BDBM12676
PNG
(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[...)
Show SMILES CN(C)Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C24H20F4N8O2/c1-34(2)12-21-30-7-8-35(21)13-3-5-17(16(25)10-13)31-23(37)18-11-20(24(26,27)28)32-36(18)14-4-6-19-15(9-14)22(29)33-38-19/h3-11H,12H2,1-2H3,(H2,29,33)(H,31,37)
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PubMed
>2.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human activated protein C


Citation and Details
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (human))
BDBM50112086
PNG
(3-({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-met...)
Show SMILES Cn1c(CNc2ccc(cc2)C(N)=N)nc2cc(ccc12)C(=O)N(CCC(O)=O)c1ccccn1
Show InChI InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)
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PubMed
2.09E+4n/an/an/an/an/an/an/an/a



Boehringer Ingelheim Pharma KG

Curated by ChEMBL


Assay Description
Inhibitory constant (Ki) was determined against human Activated protein C


J Med Chem 45: 1757-66 (2002)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376419
PNG
(CHEMBL1162109)
Show SMILES CC(C)NC[C@@H](O)Cn1c2-c3cnn(c3CCc2c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C25H28N4O/c1-17(2)26-14-19(30)16-28-23-11-7-6-10-20(23)21-12-13-24-22(25(21)28)15-27-29(24)18-8-4-3-5-9-18/h3-11,15,17,19,26,30H,12-14,16H2,1-2H3/t19-/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376417
PNG
(CHEMBL261865)
Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1
Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32)
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n/an/a 3.81E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376420
PNG
(CHEMBL1162110)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C22H16Cl2N2O5/c23-14-7-10-19(17(24)11-14)31-12-20(27)25-15-8-5-13(6-9-15)21(28)26-18-4-2-1-3-16(18)22(29)30/h1-11H,12H2,(H,25,27)(H,26,28)(H,29,30)
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n/an/a 4.06E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376421
PNG
(CHEMBL410426)
Show SMILES Cc1cc(-c2ccc(\C=C3\C(=O)NN(C3=O)c3cccc(Cl)c3)o2)c(cc1C)[N+]([O-])=O
Show InChI InChI=1S/C22H16ClN3O5/c1-12-8-17(19(26(29)30)9-13(12)2)20-7-6-16(31-20)11-18-21(27)24-25(22(18)28)15-5-3-4-14(23)10-15/h3-11H,1-2H3,(H,24,27)/b18-11-
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n/an/a 8.95E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376423
PNG
(CHEMBL410427)
Show SMILES COc1cc(ccc1-c1ccc(\C=C2/C(=O)NC(=O)N(C2=O)c2ccc3OCOc3c2)o1)[N+]([O-])=O
Show InChI InChI=1S/C23H15N3O9/c1-32-19-9-13(26(30)31)2-5-15(19)17-7-4-14(35-17)10-16-21(27)24-23(29)25(22(16)28)12-3-6-18-20(8-12)34-11-33-18/h2-10H,11H2,1H3,(H,24,27,29)/b16-10+
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n/an/a 4.80E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376418
PNG
(CHEMBL259312)
Show SMILES CCOc1cc(\C=C2\NC(=O)N(Cc3ccccc3F)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H23FN2O6/c1-2-35-24-14-18(9-12-23(24)36-16-17-7-10-19(11-8-17)26(32)33)13-22-25(31)30(27(34)29-22)15-20-5-3-4-6-21(20)28/h3-14H,2,15-16H2,1H3,(H,29,34)(H,32,33)/b22-13+
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n/an/a 3.51E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376417
PNG
(CHEMBL261865)
Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1
Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32)
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n/an/a 2.19E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376420
PNG
(CHEMBL1162110)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C22H16Cl2N2O5/c23-14-7-10-19(17(24)11-14)31-12-20(27)25-15-8-5-13(6-9-15)21(28)26-18-4-2-1-3-16(18)22(29)30/h1-11H,12H2,(H,25,27)(H,26,28)(H,29,30)
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n/an/a 1.64E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376421
PNG
(CHEMBL410426)
Show SMILES Cc1cc(-c2ccc(\C=C3\C(=O)NN(C3=O)c3cccc(Cl)c3)o2)c(cc1C)[N+]([O-])=O
Show InChI InChI=1S/C22H16ClN3O5/c1-12-8-17(19(26(29)30)9-13(12)2)20-7-6-16(31-20)11-18-21(27)24-25(22(18)28)15-5-3-4-14(23)10-15/h3-11H,1-2H3,(H,24,27)/b18-11-
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n/an/a 7.40E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376423
PNG
(CHEMBL410427)
Show SMILES COc1cc(ccc1-c1ccc(\C=C2/C(=O)NC(=O)N(C2=O)c2ccc3OCOc3c2)o1)[N+]([O-])=O
Show InChI InChI=1S/C23H15N3O9/c1-32-19-9-13(26(30)31)2-5-15(19)17-7-4-14(35-17)10-16-21(27)24-23(29)25(22(16)28)12-3-6-18-20(8-12)34-11-33-18/h2-10H,11H2,1H3,(H,24,27,29)/b16-10+
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n/an/a 5.53E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376423
PNG
(CHEMBL410427)
Show SMILES COc1cc(ccc1-c1ccc(\C=C2/C(=O)NC(=O)N(C2=O)c2ccc3OCOc3c2)o1)[N+]([O-])=O
Show InChI InChI=1S/C23H15N3O9/c1-32-19-9-13(26(30)31)2-5-15(19)17-7-4-14(35-17)10-16-21(27)24-23(29)25(22(16)28)12-3-6-18-20(8-12)34-11-33-18/h2-10H,11H2,1H3,(H,24,27,29)/b16-10+
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n/an/a 6.29E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376418
PNG
(CHEMBL259312)
Show SMILES CCOc1cc(\C=C2\NC(=O)N(Cc3ccccc3F)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H23FN2O6/c1-2-35-24-14-18(9-12-23(24)36-16-17-7-10-19(11-8-17)26(32)33)13-22-25(31)30(27(34)29-22)15-20-5-3-4-6-21(20)28/h3-14H,2,15-16H2,1H3,(H,29,34)(H,32,33)/b22-13+
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n/an/a 2.50E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376417
PNG
(CHEMBL261865)
Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1
Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32)
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n/an/a 1.41E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376420
PNG
(CHEMBL1162110)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C22H16Cl2N2O5/c23-14-7-10-19(17(24)11-14)31-12-20(27)25-15-8-5-13(6-9-15)21(28)26-18-4-2-1-3-16(18)22(29)30/h1-11H,12H2,(H,25,27)(H,26,28)(H,29,30)
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n/an/a 1.41E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376421
PNG
(CHEMBL410426)
Show SMILES Cc1cc(-c2ccc(\C=C3\C(=O)NN(C3=O)c3cccc(Cl)c3)o2)c(cc1C)[N+]([O-])=O
Show InChI InChI=1S/C22H16ClN3O5/c1-12-8-17(19(26(29)30)9-13(12)2)20-7-6-16(31-20)11-18-21(27)24-25(22(18)28)15-5-3-4-14(23)10-15/h3-11H,1-2H3,(H,24,27)/b18-11-
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n/an/a 8.55E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376425
PNG
(CHEMBL1162108)
Show SMILES OC(=O)c1cccc(c1)-c1ccc(C=c2c(=C)[nH]n(-c3ccc(Br)cc3)c2=O)o1
Show InChI InChI=1S/C22H15BrN2O4/c1-13-19(21(26)25(24-13)17-7-5-16(23)6-8-17)12-18-9-10-20(29-18)14-3-2-4-15(11-14)22(27)28/h2-12,24H,1H2,(H,27,28)
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n/an/a 1.81E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50423622
PNG
(CHEMBL1614804)
Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N
Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1
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n/an/a 1.57E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50423622
PNG
(CHEMBL1614804)
Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N
Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


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More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50423622
PNG
(CHEMBL1614804)
Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N
Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1
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n/an/a 3.24E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376418
PNG
(CHEMBL259312)
Show SMILES CCOc1cc(\C=C2\NC(=O)N(Cc3ccccc3F)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H23FN2O6/c1-2-35-24-14-18(9-12-23(24)36-16-17-7-10-19(11-8-17)26(32)33)13-22-25(31)30(27(34)29-22)15-20-5-3-4-6-21(20)28/h3-14H,2,15-16H2,1H3,(H,29,34)(H,32,33)/b22-13+
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n/an/a 1.86E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Citation and Details
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (human))
BDBM29388
PNG
(Exanta | Melagatran)
Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCN2C(=O)[C@H](NCC(O)=O)C2CCCCC2)cc1
Show InChI InChI=1S/C22H31N5O4/c23-20(24)16-8-6-14(7-9-16)12-26-21(30)17-10-11-27(17)22(31)19(25-13-18(28)29)15-4-2-1-3-5-15/h6-9,15,17,19,25H,1-5,10-13H2,(H3,23,24)(H,26,30)(H,28,29)/t17-,19+/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...


Citation and Details
More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (human))
BDBM50249298
PNG
(CHEMBL512351 | N-(5-chloropyridin-2-yl)-2-(4-(N,N-...)
Show SMILES COc1ccc(NC(=O)c2ccc(cc2)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C23H22ClN5O3/c1-29(2)21(25)14-4-6-15(7-5-14)22(30)27-19-10-9-17(32-3)12-18(19)23(31)28-20-11-8-16(24)13-26-20/h4-13,25H,1-3H3,(H,27,30)(H,26,28,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of activated anticoagulant protein C (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair