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There are 12 purchasable compounds for target: Activated protein C cofactor

Wt: 528.4
BDBM12676
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Wt: 429.5
BDBM29388
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Wt: 471.5
BDBM50112086
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Wt: 451.9
BDBM50249298
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Wt: 495.8
BDBM50376417
Wt: 490.4
BDBM50376418
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Wt: 400.5
BDBM50376419
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Wt: 459.2
BDBM50376420
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Wt: 437.8
BDBM50376421
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Wt: 477.3
BDBM50376423
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Wt: 451.2
BDBM50376425
Wt: 463.4
BDBM50423622
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 12676,29388,50112086,50249298,50376417,50376418,50376419,50376420,50376421,50376423,50376425,50423622   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vitamin K-dependent protein C


(Homo sapiens (human))
BDBM12676
PNG
(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[...)
Show SMILES CN(C)Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C24H20F4N8O2/c1-34(2)12-21-30-7-8-35(21)13-3-5-17(16(25)10-13)31-23(37)18-11-20(24(26,27)28)32-36(18)14-4-6-19-15(9-14)22(29)33-38-19/h3-11H,12H2,1-2H3,(H2,29,33)(H,31,37)
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>2.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human activated protein C


Bioorg Med Chem Lett 18: 749-54 (2008)

More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (human))
BDBM50112086
PNG
(3-({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-met...)
Show SMILES Cn1c(CNc2ccc(cc2)C(N)=N)nc2cc(ccc12)C(=O)N(CCC(O)=O)c1ccccn1
Show InChI InChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)
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2.09E+4n/an/an/an/an/an/an/an/a



Boehringer Ingelheim Pharma KG

Curated by ChEMBL


Assay Description
Inhibitory constant (Ki) was determined against human Activated protein C


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50423622
PNG
(CHEMBL1614804)
Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N
Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50423622
PNG
(CHEMBL1614804)
Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N
Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1
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n/an/a 3.24E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376418
PNG
(CHEMBL259312)
Show SMILES CCOc1cc(\C=C2\NC(=O)N(Cc3ccccc3F)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H23FN2O6/c1-2-35-24-14-18(9-12-23(24)36-16-17-7-10-19(11-8-17)26(32)33)13-22-25(31)30(27(34)29-22)15-20-5-3-4-6-21(20)28/h3-14H,2,15-16H2,1H3,(H,29,34)(H,32,33)/b22-13+
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n/an/a 1.86E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376419
PNG
(CHEMBL1162109)
Show SMILES CC(C)NC[C@@H](O)Cn1c2-c3cnn(c3CCc2c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C25H28N4O/c1-17(2)26-14-19(30)16-28-23-11-7-6-10-20(23)21-12-13-24-22(25(21)28)15-27-29(24)18-8-4-3-5-9-18/h3-11,15,17,19,26,30H,12-14,16H2,1-2H3/t19-/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376417
PNG
(CHEMBL261865)
Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1
Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32)
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n/an/a 3.81E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376420
PNG
(CHEMBL1162110)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C22H16Cl2N2O5/c23-14-7-10-19(17(24)11-14)31-12-20(27)25-15-8-5-13(6-9-15)21(28)26-18-4-2-1-3-16(18)22(29)30/h1-11H,12H2,(H,25,27)(H,26,28)(H,29,30)
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n/an/a 4.06E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376421
PNG
(CHEMBL410426)
Show SMILES Cc1cc(-c2ccc(\C=C3\C(=O)NN(C3=O)c3cccc(Cl)c3)o2)c(cc1C)[N+]([O-])=O
Show InChI InChI=1S/C22H16ClN3O5/c1-12-8-17(19(26(29)30)9-13(12)2)20-7-6-16(31-20)11-18-21(27)24-25(22(18)28)15-5-3-4-14(23)10-15/h3-11H,1-2H3,(H,24,27)/b18-11-
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n/an/a 8.95E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376423
PNG
(CHEMBL410427)
Show SMILES COc1cc(ccc1-c1ccc(\C=C2/C(=O)NC(=O)N(C2=O)c2ccc3OCOc3c2)o1)[N+]([O-])=O
Show InChI InChI=1S/C23H15N3O9/c1-32-19-9-13(26(30)31)2-5-15(19)17-7-4-14(35-17)10-16-21(27)24-23(29)25(22(16)28)12-3-6-18-20(8-12)34-11-33-18/h2-10H,11H2,1H3,(H,24,27,29)/b16-10+
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n/an/a 4.80E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376418
PNG
(CHEMBL259312)
Show SMILES CCOc1cc(\C=C2\NC(=O)N(Cc3ccccc3F)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H23FN2O6/c1-2-35-24-14-18(9-12-23(24)36-16-17-7-10-19(11-8-17)26(32)33)13-22-25(31)30(27(34)29-22)15-20-5-3-4-6-21(20)28/h3-14H,2,15-16H2,1H3,(H,29,34)(H,32,33)/b22-13+
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n/an/a 3.51E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376417
PNG
(CHEMBL261865)
Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1
Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32)
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n/an/a 2.19E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376420
PNG
(CHEMBL1162110)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C22H16Cl2N2O5/c23-14-7-10-19(17(24)11-14)31-12-20(27)25-15-8-5-13(6-9-15)21(28)26-18-4-2-1-3-16(18)22(29)30/h1-11H,12H2,(H,25,27)(H,26,28)(H,29,30)
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n/an/a 1.64E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376421
PNG
(CHEMBL410426)
Show SMILES Cc1cc(-c2ccc(\C=C3\C(=O)NN(C3=O)c3cccc(Cl)c3)o2)c(cc1C)[N+]([O-])=O
Show InChI InChI=1S/C22H16ClN3O5/c1-12-8-17(19(26(29)30)9-13(12)2)20-7-6-16(31-20)11-18-21(27)24-25(22(18)28)15-5-3-4-14(23)10-15/h3-11H,1-2H3,(H,24,27)/b18-11-
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n/an/a 7.40E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376423
PNG
(CHEMBL410427)
Show SMILES COc1cc(ccc1-c1ccc(\C=C2/C(=O)NC(=O)N(C2=O)c2ccc3OCOc3c2)o1)[N+]([O-])=O
Show InChI InChI=1S/C23H15N3O9/c1-32-19-9-13(26(30)31)2-5-15(19)17-7-4-14(35-17)10-16-21(27)24-23(29)25(22(16)28)12-3-6-18-20(8-12)34-11-33-18/h2-10H,11H2,1H3,(H,24,27,29)/b16-10+
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n/an/a 5.53E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant factor 5a C2 domain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376423
PNG
(CHEMBL410427)
Show SMILES COc1cc(ccc1-c1ccc(\C=C2/C(=O)NC(=O)N(C2=O)c2ccc3OCOc3c2)o1)[N+]([O-])=O
Show InChI InChI=1S/C23H15N3O9/c1-32-19-9-13(26(30)31)2-5-15(19)17-7-4-14(35-17)10-16-21(27)24-23(29)25(22(16)28)12-3-6-18-20(8-12)34-11-33-18/h2-10H,11H2,1H3,(H,24,27,29)/b16-10+
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n/an/a 6.29E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376418
PNG
(CHEMBL259312)
Show SMILES CCOc1cc(\C=C2\NC(=O)N(Cc3ccccc3F)C2=O)ccc1OCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H23FN2O6/c1-2-35-24-14-18(9-12-23(24)36-16-17-7-10-19(11-8-17)26(32)33)13-22-25(31)30(27(34)29-22)15-20-5-3-4-6-21(20)28/h3-14H,2,15-16H2,1H3,(H,29,34)(H,32,33)/b22-13+
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n/an/a 2.50E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376417
PNG
(CHEMBL261865)
Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1
Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32)
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n/an/a 1.41E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376420
PNG
(CHEMBL1162110)
Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(NC(=O)COc2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C22H16Cl2N2O5/c23-14-7-10-19(17(24)11-14)31-12-20(27)25-15-8-5-13(6-9-15)21(28)26-18-4-2-1-3-16(18)22(29)30/h1-11H,12H2,(H,25,27)(H,26,28)(H,29,30)
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n/an/a 1.41E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376421
PNG
(CHEMBL410426)
Show SMILES Cc1cc(-c2ccc(\C=C3\C(=O)NN(C3=O)c3cccc(Cl)c3)o2)c(cc1C)[N+]([O-])=O
Show InChI InChI=1S/C22H16ClN3O5/c1-12-8-17(19(26(29)30)9-13(12)2)20-7-6-16(31-20)11-18-21(27)24-25(22(18)28)15-5-3-4-14(23)10-15/h3-11H,1-2H3,(H,24,27)/b18-11-
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Article
PubMed
n/an/a 8.55E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50376425
PNG
(CHEMBL1162108)
Show SMILES OC(=O)c1cccc(c1)-c1ccc(C=c2c(=C)[nH]n(-c3ccc(Br)cc3)c2=O)o1
Show InChI InChI=1S/C22H15BrN2O4/c1-13-19(21(26)25(24-13)17-7-5-16(23)6-8-17)12-18-9-10-20(29-18)14-3-2-4-15(11-14)22(27)28/h2-12,24H,1H2,(H,27,28)
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n/an/a 1.81E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of factor 5a-mediated prothrombin activation in human plasma by prothrombinase assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Coagulation factor V


(Homo sapiens)
BDBM50423622
PNG
(CHEMBL1614804)
Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N
Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1
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n/an/a 1.57E+4n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 5a light chain binding to immobilized phospholipid by surface plasmon resonance assay


Proc Natl Acad Sci USA 104: 12697-702 (2007)

More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (human))
BDBM29388
PNG
(Exanta | Melagatran)
Show SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2CCN2C(=O)[C@H](NCC(O)=O)C2CCCCC2)cc1
Show InChI InChI=1S/C22H31N5O4/c23-20(24)16-8-6-14(7-9-16)12-26-21(30)17-10-11-27(17)22(31)19(25-13-18(28)29)15-4-2-1-3-5-15/h6-9,15,17,19,25H,1-5,10-13H2,(H3,23,24)(H,26,30)(H,28,29)/t17-,19+/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human APC using S-2366 as substrate preincubated for 300 seconds followed by substrate addition measured after 40 mins by spectrophotom...


Bioorg Med Chem Lett 24: 821-7 (2014)

More data for this
Ligand-Target Pair
Vitamin K-dependent protein C


(Homo sapiens (human))
BDBM50249298
PNG
(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Show SMILES COc1ccc(NC(=O)c2ccc(cc2)C(=N)N(C)C)c(c1)C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C23H22ClN5O3/c1-29(2)21(25)14-4-6-15(7-5-14)22(30)27-19-10-9-17(32-3)12-18(19)23(31)28-20-11-8-16(24)13-26-20/h4-13,25H,1-3H3,(H,27,30)(H,26,28,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of activated anticoagulant protein C (unknown origin)


Bioorg Med Chem Lett 19: 2179-85 (2009)

More data for this
Ligand-Target Pair