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There are 6 purchasable compounds for target: Activator protein 1

Wt: 366.4
BDBM50067033Purchase		Wt: 360.3
BDBM50133496Purchase		Wt: 424.5
BDBM50279699Purchase		Wt: 335.3
BDBM50375643		Wt: 720.6
BDBM50446664Purchase
Wt: 517.5
BDBM50044561Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50067033,50133496,50279699,50375643,50446664,50044561   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50067033
PNG
((2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyc...)
Show SMILES COc1cc(\C=C2/CCC\C(=C/c3ccc(O)c(OC)c3)C2=O)ccc1O
Show InChI InChI=1S/C22H22O5/c1-26-20-12-14(6-8-18(20)23)10-16-4-3-5-17(22(16)25)11-15-7-9-19(24)21(13-15)27-2/h6-13,23-24H,3-5H2,1-2H3/b16-10+,17-11+
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n/an/a 7.30E+3n/an/an/an/an/an/a



STC.UNM

US Patent


Assay Description
TRAP Assay: The first procedure called for antioxidant activity to be measured as the ability of the analogs to react with the pre-formed radical mon...

US Patent US9187397 (2015)


BindingDB Entry DOI: 10.7270/Q2Q52NF9
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50279699
PNG
(2-(4-Methyl-2-phenylamino-thiazol-5-yl)-3-o-tolyl-...)
Show SMILES Cc1nc(Nc2ccccc2)sc1-c1nc2ccccc2c(=O)n1-c1ccccc1C
Show InChI InChI=1S/C25H20N4OS/c1-16-10-6-9-15-21(16)29-23(28-20-14-8-7-13-19(20)24(29)30)22-17(2)26-25(31-22)27-18-11-4-3-5-12-18/h3-15H,1-2H3,(H,26,27)
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in HEK293 cells by luciferase reporter gene assay

J Med Chem 57: 6930-48 (2014)


Article DOI: 10.1021/jm5004733
BindingDB Entry DOI: 10.7270/Q2222WDT
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50044561
PNG
(CHEMBL3222137)
Show SMILES OC(=O)CCc1cc(ccc1OCc1ccc2c(O)noc2c1)C(=O)c1ccc(OC2CCCC2)cc1O
Show InChI InChI=1S/C29H27NO8/c31-24-15-21(37-20-3-1-2-4-20)8-10-22(24)28(34)19-6-11-25(18(14-19)7-12-27(32)33)36-16-17-5-9-23-26(13-17)38-30-29(23)35/h5-6,8-11,13-15,20,31H,1-4,7,12,16H2,(H,30,35)(H,32,33)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1 bZIP domain DNA binding activity (unknown origin) by ELISA

J Med Chem 57: 6930-48 (2014)


Article DOI: 10.1021/jm5004733
BindingDB Entry DOI: 10.7270/Q2222WDT
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50375643
PNG
(CHEMBL261237 | SL-327)
Show SMILES Nc1ccc(SC(=N)C(C#N)c2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8,13,22H,21H2
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n/an/a 2.03E+3n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of AP1 activity

Proc Natl Acad Sci USA 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50279699
PNG
(2-(4-Methyl-2-phenylamino-thiazol-5-yl)-3-o-tolyl-...)
Show SMILES Cc1nc(Nc2ccccc2)sc1-c1nc2ccccc2c(=O)n1-c1ccccc1C
Show InChI InChI=1S/C25H20N4OS/c1-16-10-6-9-15-21(16)29-23(28-20-14-8-7-13-19(20)24(29)30)22-17(2)26-25(31-22)27-18-11-4-3-5-12-18/h3-15H,1-2H3,(H,26,27)
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n/an/a 5.50E+3n/an/an/an/an/an/a



B.V. Patel Pharmaceutical Education and Research Development Centre

Curated by ChEMBL


Assay Description
Inhibition of AP1 (unknown origin) expressed in HEK293 cells assessed as inhibition of TNFalpha-induced transcriptional activation treated 24 hrs bef...

Eur J Med Chem 44: 2184-9 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.031
BindingDB Entry DOI: 10.7270/Q25X28SV
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50133496
PNG
((2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydr...)
Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
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n/an/a 1.62E+4n/an/an/an/an/an/a



National Defense Medical Center, Taiwan

Curated by ChEMBL


Assay Description
Inhibition of transcription factor AP-1 binding to oligonucleotide containing TPA-responsive element in TPA-activated human HeLa cells after 1 hr by ...

Bioorg Med Chem 22: 1766-72 (2014)


Article DOI: 10.1016/j.bmc.2014.01.009
BindingDB Entry DOI: 10.7270/Q2ZP47K7
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50446664
PNG
(CHEMBL3113338)
Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)[C@H]1[C@@H]([C@@H]([C@H]1c1ccc(O)c(O)c1)c1ccc(O)c(O)c1)C(=O)O[C@H](Cc1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C36H32O16/c37-19-5-1-15(9-23(19)41)11-27(33(45)46)51-35(49)31-29(17-3-7-21(39)25(43)13-17)30(18-4-8-22(40)26(44)14-18)32(31)36(50)52-28(34(47)48)12-16-2-6-20(38)24(42)10-16/h1-10,13-14,27-32,37-44H,11-12H2,(H,45,46)(H,47,48)/t27-,28-,29-,30-,31-,32-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



National Defense Medical Center, Taiwan

Curated by ChEMBL


Assay Description
Inhibition of transcription factor AP-1 binding to oligonucleotide containing TPA-responsive element in TPA-activated human HeLa cells after 1 hr by ...

Bioorg Med Chem 22: 1766-72 (2014)


Article DOI: 10.1016/j.bmc.2014.01.009
BindingDB Entry DOI: 10.7270/Q2ZP47K7
More data for this
Ligand-Target Pair
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50044561
PNG
(CHEMBL3222137)
Show SMILES OC(=O)CCc1cc(ccc1OCc1ccc2c(O)noc2c1)C(=O)c1ccc(OC2CCCC2)cc1O
Show InChI InChI=1S/C29H27NO8/c31-24-15-21(37-20-3-1-2-4-20)8-10-22(24)28(34)19-6-11-25(18(14-19)7-12-27(32)33)36-16-17-5-9-23-26(13-17)38-30-29(23)35/h5-6,8-11,13-15,20,31H,1-4,7,12,16H2,(H,30,35)(H,32,33)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1 (unknown origin) expressed in TPA-stimulated mouse NIH3T3 cells by luciferase reporter gene assay

J Med Chem 57: 6930-48 (2014)


Article DOI: 10.1021/jm5004733
BindingDB Entry DOI: 10.7270/Q2222WDT
More data for this
Ligand-Target Pair