Wt: 366.4 BDBM50067033 ![]() | Wt: 360.3 BDBM50133496 ![]() | Wt: 424.5 BDBM50279699 ![]() | Wt: 335.3 BDBM50375643 ![]() | Wt: 720.6 BDBM50446664 ![]() |
Wt: 517.5 BDBM50044561 ![]() |
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transcription factor AP-1 (Homo sapiens (Human)) | BDBM50067033![]() ((2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyc...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
STC.UNM US Patent | Assay Description TRAP Assay: The first procedure called for antioxidant activity to be measured as the ability of the analogs to react with the pre-formed radical mon... | US Patent US9187397 (2015) BindingDB Entry DOI: 10.7270/Q2Q52NF9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor AP-1 (Homo sapiens (Human)) | BDBM50279699![]() (2-(4-Methyl-2-phenylamino-thiazol-5-yl)-3-o-tolyl-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Inhibition of AP-1-mediated transcriptional activation in HEK293 cells by luciferase reporter gene assay | J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor AP-1 (Homo sapiens (Human)) | BDBM50044561![]() (CHEMBL3222137) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Inhibition of AP-1 bZIP domain DNA binding activity (unknown origin) by ELISA | J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor AP-1 (Homo sapiens (Human)) | BDBM50375643![]() (CHEMBL261237 | SL-327) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford Curated by ChEMBL | Assay Description Inhibition of AP1 activity | Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor AP-1 (Homo sapiens (Human)) | BDBM50279699![]() (2-(4-Methyl-2-phenylamino-thiazol-5-yl)-3-o-tolyl-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
B.V. Patel Pharmaceutical Education and Research Development Centre Curated by ChEMBL | Assay Description Inhibition of AP1 (unknown origin) expressed in HEK293 cells assessed as inhibition of TNFalpha-induced transcriptional activation treated 24 hrs bef... | Eur J Med Chem 44: 2184-9 (2009) Article DOI: 10.1016/j.ejmech.2008.10.031 BindingDB Entry DOI: 10.7270/Q25X28SV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor AP-1 (Homo sapiens (Human)) | BDBM50133496![]() ((2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Defense Medical Center, Taiwan Curated by ChEMBL | Assay Description Inhibition of transcription factor AP-1 binding to oligonucleotide containing TPA-responsive element in TPA-activated human HeLa cells after 1 hr by ... | Bioorg Med Chem 22: 1766-72 (2014) Article DOI: 10.1016/j.bmc.2014.01.009 BindingDB Entry DOI: 10.7270/Q2ZP47K7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor AP-1 (Homo sapiens (Human)) | BDBM50446664![]() (CHEMBL3113338) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Defense Medical Center, Taiwan Curated by ChEMBL | Assay Description Inhibition of transcription factor AP-1 binding to oligonucleotide containing TPA-responsive element in TPA-activated human HeLa cells after 1 hr by ... | Bioorg Med Chem 22: 1766-72 (2014) Article DOI: 10.1016/j.bmc.2014.01.009 BindingDB Entry DOI: 10.7270/Q2ZP47K7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor AP-1 (Homo sapiens (Human)) | BDBM50044561![]() (CHEMBL3222137) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch Curated by ChEMBL | Assay Description Inhibition of AP-1 (unknown origin) expressed in TPA-stimulated mouse NIH3T3 cells by luciferase reporter gene assay | J Med Chem 57: 6930-48 (2014) Article DOI: 10.1021/jm5004733 BindingDB Entry DOI: 10.7270/Q2222WDT | |||||||||||
More data for this Ligand-Target Pair |