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There are 10 purchasable compounds for target: Lactose-binding lectin 1

Compile data set for download or QSAR
Wt: 194.1
BDBM120768
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Wt: 358.3
BDBM50077225
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Wt: 194.1
BDBM50243888
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Wt: 194.1
BDBM50244377
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Wt: 383.3
BDBM50273604
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Wt: 342.2
BDBM50370453
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Wt: 937.1
BDBM50420903
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Wt: 180.1
BDBM50423644
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Wt: 356.3
BDBM50048093
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Wt: 194.1
BDBM50034081
Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 120768,50077225,50243888,50244377,50273604,50370453,50420903,50423644,50048093,50034081   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Galectin-1


(Homo sapiens (Human))
BDBM120768
PNG
(US8703720, Reference Compound 1)
Show SMILES CO[C@@H]1OC(CO)[C@H](O)[C@H](O)C1O
Show InChI InChI=1S/C7H14O6/c1-12-7-6(11)5(10)4(9)3(2-8)13-7/h3-11H,2H2,1H3/t3?,4-,5-,6?,7+/m0/s1
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US Patent
n/an/an/a>1.00E+7n/an/an/an/an/a



Galecto Biotech AB

US Patent


Assay Description
Compounds 7, 15-19, and 22 were evaluated for their efficiency in inhibiting galectin-1 and galectin-3 in a known fluorescence polarization-based ass...


US Patent US8703720 (2014)


BindingDB Entry DOI: 10.7270/Q2VD6X4R
More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM50243888
PNG
(CHEMBL442951 | methyl beta-D-galactopyranoside | m...)
Show SMILES CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C7H14O6/c1-12-7-6(11)5(10)4(9)3(2-8)13-7/h3-11H,2H2,1H3/t3-,4+,5+,6-,7-/m1/s1
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n/an/an/a 1.00E+7n/an/an/an/an/a



Lund University

Curated by ChEMBL


Assay Description
Antagonist activity against human galectin 1 by fluorescence polarization assay


Bioorg Med Chem Lett 24: 3516-20 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.063
BindingDB Entry DOI: 10.7270/Q2PC341V
More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM50048093
PNG
(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
Show SMILES CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C13H24O11/c1-21-12-10(20)8(18)11(5(3-15)23-12)24-13-9(19)7(17)6(16)4(2-14)22-13/h4-20H,2-3H2,1H3/t4-,5-,6+,7+,8-,9-,10-,11-,12-,13+/m1/s1
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n/an/an/a 1.90E+5n/an/an/an/an/a



Lund University

Curated by ChEMBL


Assay Description
Antagonist activity against human galectin 1 by fluorescence polarization assay


Bioorg Med Chem Lett 24: 3516-20 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.063
BindingDB Entry DOI: 10.7270/Q2PC341V
More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM50034081
PNG
(CHEBI:55507 | CHEMBL467773)
Show SMILES CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C7H14O6/c1-12-7-6(11)5(10)4(9)3(2-8)13-7/h3-11H,2H2,1H3/t3-,4+,5+,6-,7+/m1/s1
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n/an/an/a>1.00E+7n/an/an/an/an/a



Lund University

Curated by ChEMBL


Assay Description
Antagonist activity against human galectin 1 by fluorescence polarization assay


Bioorg Med Chem Lett 24: 3516-20 (2014)


Article DOI: 10.1016/j.bmcl.2014.05.063
BindingDB Entry DOI: 10.7270/Q2PC341V
More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM50244377
PNG
(CHEMBL502337 | methyl beta-D-talopyranoside)
Show SMILES CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H14O6/c1-12-7-6(11)5(10)4(9)3(2-8)13-7/h3-11H,2H2,1H3/t3-,4+,5+,6+,7-/m1/s1
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n/an/an/a>1.00E+7n/an/an/an/an/a



Lund University

Curated by ChEMBL


Assay Description
Binding affinity to human galectin1 by fluorescence polarization assay


Bioorg Med Chem Lett 18: 3691-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.066
BindingDB Entry DOI: 10.7270/Q22Z15C8
More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM50370453
PNG
(LACTOSE | Lactose, anhydrous)
Show SMILES OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11-,12+/m1/s1
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n/an/a 8.00E+5n/an/an/an/an/an/a



Universit£ du Qu£bec£ Montr£al

Curated by ChEMBL


Assay Description
Inhibition of recombinant galectin 1 in human O type red blood cells by hemagglutination assay


Bioorg Med Chem 16: 7811-23 (2008)


Article DOI: 10.1016/j.bmc.2008.06.044
BindingDB Entry DOI: 10.7270/Q2HQ40TS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Galectin-1


(Homo sapiens (Human))
BDBM50077225
PNG
((2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2S,3R,4S,5...)
Show SMILES OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C12H22O10S/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5+,6+,7+,8+,9-,10-,11+,12+/m1/s1
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n/an/an/a 2.40E+4n/an/an/an/an/a



Utrecht University

Curated by ChEMBL


Assay Description
Binding affinity to galectin-1 (unknown origin) by fluorescence polarization assay


J Med Chem 56: 1350-4 (2013)


Article DOI: 10.1021/jm301677r
BindingDB Entry DOI: 10.7270/Q2NK3GBS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Galectin-1


(Homo sapiens (Human))
BDBM50423644
PNG
(GALACTOSE)
Show SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6+/m1/s1
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n/an/a 5.00E+7n/an/an/an/an/an/a



Universit£ du Qu£bec£ Montr£al

Curated by ChEMBL


Assay Description
Inhibition of recombinant galectin 1 in human O type red blood cells by hemagglutination assay


Bioorg Med Chem 16: 7811-23 (2008)


Article DOI: 10.1016/j.bmc.2008.06.044
BindingDB Entry DOI: 10.7270/Q2HQ40TS
More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM50077225
PNG
((2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2S,3R,4S,5...)
Show SMILES OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C12H22O10S/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5+,6+,7+,8+,9-,10-,11+,12+/m1/s1
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n/an/an/a 7.80E+4n/an/an/an/an/a



Lund University

Curated by ChEMBL


Assay Description
Binding affinity to galectin 1 at 20 degC by fluorescence polarization assay


J Med Chem 51: 8109-14 (2008)


Article DOI: 10.1021/jm801077j
BindingDB Entry DOI: 10.7270/Q29W0GDJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Galectin-1


(Homo sapiens (Human))
BDBM50273604
PNG
(CHEMBL457432 | LacNAc | N-acetyllactosamine)
Show SMILES CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H]1O
Show InChI InChI=1S/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8+,9-,10+,11-,12-,13-,14+/m1/s1
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n/an/an/a 1.50E+5n/an/an/an/an/a



Lund University

Curated by ChEMBL


Assay Description
Binding affinity to galectin 1 at 20 degC by fluorescence polarization assay


J Med Chem 51: 8109-14 (2008)


Article DOI: 10.1021/jm801077j
BindingDB Entry DOI: 10.7270/Q29W0GDJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Galectin-1


(Homo sapiens (Human))
BDBM50370453
PNG
(LACTOSE | Lactose, anhydrous)
Show SMILES OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11-,12+/m1/s1
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n/an/an/a 4.20E+5n/an/an/an/an/a



Lund University

Curated by ChEMBL


Assay Description
Binding affinity to galectin 1 at 20 degC by fluorescence polarization assay


J Med Chem 51: 8109-14 (2008)


Article DOI: 10.1021/jm801077j
BindingDB Entry DOI: 10.7270/Q29W0GDJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Galectin-1


(Homo sapiens (Human))
BDBM50420903
PNG
(CHEMBL221186)
Show SMILES CN(C)CCNC(=O)COc1c2Cc3cccc(Cc4cccc(Cc5cccc(Cc1ccc2)c5OCC(=O)NCCN(C)C)c4OCC(=O)NCCN(C)C)c3OCC(=O)NCCN(C)C
Show InChI InChI=1S/C52H72N8O8/c1-57(2)25-21-53-45(61)33-65-49-37-13-9-14-38(49)30-40-16-11-18-42(51(40)67-35-47(63)55-23-27-59(5)6)32-44-20-12-19-43(52(44)68-36-48(64)56-24-28-60(7)8)31-41-17-10-15-39(29-37)50(41)66-34-46(62)54-22-26-58(3)4/h9-20H,21-36H2,1-8H3,(H,53,61)(H,54,62)(H,55,63)(H,56,64)
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n/an/an/a 5.00E+3n/an/an/an/an/a



University of Minnesota Health Sciences Center

Curated by ChEMBL


Assay Description
Binding affinity to human [15N]-labelled Galectin-1 by heteronuclear NMR spectroscopy analysis


J Med Chem 55: 5121-9 (2012)


Article DOI: 10.1021/jm300014q
BindingDB Entry DOI: 10.7270/Q2FF3TNQ
More data for this
Ligand-Target Pair