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There are 8 purchasable compounds for target: ADAM-TS 11

Wt: 360.2
BDBM23994
Purchase
Wt: 295.3
BDBM23995
Purchase
Wt: 309.3
BDBM23996
Purchase
Wt: 295.3
BDBM23998
Purchase
Wt: 323.4
BDBM24000
Purchase
Wt: 295.3
BDBM24014
Purchase
Wt: 309.3
BDBM24017
Purchase
Wt: 415.8
BDBM28306
Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 23994,23995,23996,23998,24000,24014,24017,28306   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ADAMTS-5 (Aggrecanase-2)


(Homo sapiens (human))
BDBM24017
PNG
(1-methyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro...)
Show SMILES CN1C(=O)C2(NN=C(S2)c2ccc(C)cc2)c2ccccc12
Show InChI InChI=1S/C17H15N3OS/c1-11-7-9-12(10-8-11)15-18-19-17(22-15)13-5-3-4-6-14(13)20(2)16(17)21/h3-10,19H,1-2H3
PDB
MMDB

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 4.60E+3n/an/an/an/a7.530



Wyeth Research



Assay Description
ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...


Citation and Details
More data for this
Ligand-Target Pair
ADAMTS-5 (Aggrecanase-2)


(Homo sapiens (human))
BDBM23994
PNG
(5-bromo-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2...)
Show SMILES Brc1ccc2NC(=O)C3(NN=C(S3)c3ccccc3)c2c1
Show InChI InChI=1S/C15H10BrN3OS/c16-10-6-7-12-11(8-10)15(14(20)17-12)19-18-13(21-15)9-4-2-1-3-5-9/h1-8,19H,(H,17,20)
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MMDB

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PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/a 1.36E+4n/an/an/an/a7.530



Wyeth Research



Assay Description
ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...


Citation and Details
More data for this
Ligand-Target Pair
ADAMTS-5 (Aggrecanase-2)


(Homo sapiens (human))
BDBM23995
PNG
(5-methyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,...)
Show SMILES Cc1ccc2NC(=O)C3(NN=C(S3)c3ccccc3)c2c1
Show InChI InChI=1S/C16H13N3OS/c1-10-7-8-13-12(9-10)16(15(20)17-13)19-18-14(21-16)11-5-3-2-4-6-11/h2-9,19H,1H3,(H,17,20)
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.11E+4n/an/an/an/a7.530



Wyeth Research



Assay Description
ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...


Citation and Details
More data for this
Ligand-Target Pair
ADAMTS-5 (Aggrecanase-2)


(Homo sapiens (human))
BDBM28306
PNG
((2R)-2-{[4-(4-chlorophenyl)benzene]sulfonamido}-3-...)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClNO4S/c22-18-10-6-16(7-11-18)17-8-12-19(13-9-17)28(26,27)23-20(21(24)25)14-15-4-2-1-3-5-15/h1-13,20,23H,14H2,(H,24,25)/t20-/m1/s1
PDB
MMDB

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 3.20E+3n/an/an/an/a7.537



Japan Tobacco Inc.



Assay Description
The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...


Citation and Details
More data for this
Ligand-Target Pair
ADAMTS-5 (Aggrecanase-2)


(Homo sapiens (human))
BDBM23998
PNG
(5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro[indole-3...)
Show SMILES Cc1ccc(cc1)C1=NNC2(S1)C(=O)Nc1ccccc21
Show InChI InChI=1S/C16H13N3OS/c1-10-6-8-11(9-7-10)14-18-19-16(21-14)12-4-2-3-5-13(12)17-15(16)20/h2-9,19H,1H3,(H,17,20)
PDB
MMDB

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 3.70E+3n/an/an/an/a7.530



Wyeth Research



Assay Description
ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...


Citation and Details
More data for this
Ligand-Target Pair
ADAMTS-5 (Aggrecanase-2)


(Homo sapiens (human))
BDBM24000
PNG
(5-ethyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro[...)
Show SMILES CCc1ccc2NC(=O)C3(NN=C(S3)c3ccc(C)cc3)c2c1
Show InChI InChI=1S/C18H17N3OS/c1-3-12-6-9-15-14(10-12)18(17(22)19-15)21-20-16(23-18)13-7-4-11(2)5-8-13/h4-10,21H,3H2,1-2H3,(H,19,22)
PDB
MMDB

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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 1.90E+3n/an/an/an/a7.530



Wyeth Research



Assay Description
ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...


Citation and Details
More data for this
Ligand-Target Pair
ADAMTS-5 (Aggrecanase-2)


(Homo sapiens (human))
BDBM24014
PNG
(1-methyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,...)
Show SMILES CN1C(=O)C2(NN=C(S2)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C16H13N3OS/c1-19-13-10-6-5-9-12(13)16(15(19)20)18-17-14(21-16)11-7-3-2-4-8-11/h2-10,18H,1H3
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.41E+4n/an/an/an/a7.530



Wyeth Research



Assay Description
ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...


Citation and Details
More data for this
Ligand-Target Pair
ADAMTS-5 (Aggrecanase-2)


(Homo sapiens (human))
BDBM23996
PNG
(5-ethyl-5'-phenyl-1,2-dihydro-3'H-spiro[indole-3,2...)
Show SMILES CCc1ccc2NC(=O)C3(NN=C(S3)c3ccccc3)c2c1
Show InChI InChI=1S/C17H15N3OS/c1-2-11-8-9-14-13(10-11)17(16(21)18-14)20-19-15(22-17)12-6-4-3-5-7-12/h3-10,20H,2H2,1H3,(H,18,21)
PDB
MMDB

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 9.60E+3n/an/an/an/a7.530



Wyeth Research



Assay Description
ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...


Citation and Details
More data for this
Ligand-Target Pair