Wt: 286.2 BDBM7459 ![]() | Wt: 264.3 BDBM17747 ![]() | Wt: 241.2 BDBM21360 ![]() | Wt: 138.1 BDBM26193 ![]() | Wt: 365.5 BDBM75309 ![]() |
Wt: 266.2 BDBM108083 ![]() | Wt: 256.3 BDBM50052701 ![]() | Wt: 226.2 BDBM50052702 ![]() | Wt: 242.2 BDBM50052710 ![]() | Wt: 368.3 BDBM50067040 ![]() |
Wt: 458.3 BDBM50070942 ![]() | Wt: 244.2 BDBM50074922 ![]() | Wt: 650.6 BDBM50079267 ![]() | Wt: 311.4 BDBM50089192 ![]() | Wt: 311.4 BDBM50089193 ![]() |
Displayed 1 to 15 (of 34 total ) | Next | Last >> |
Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50067040![]() (((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | 0.208 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sungkyunkwan University School of Medicine Curated by ChEMBL | Assay Description Displacement of [125I]IMSB from beta amyloid protein 40 | J Med Chem 49: 6111-9 (2006) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50052701![]() (2-(4-Aminophenyl)-6-methoxybenzothiazole | 4-(6-Me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1. | J Med Chem 46: 2740-54 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50052702![]() (2-(4-Aminophenyl)benzothiazole | 4-Benzothiazol-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1. | J Med Chem 46: 2740-54 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50052710![]() (2-(4-Amino-phenyl)-benzothiazol-6-ol | CHEMBL93884) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh Curated by ChEMBL | Assay Description Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1. | J Med Chem 46: 2740-54 (2003) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM17747![]() ((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | PubMed | 92 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Displacement of Thio-T from amyloid beta (1 to 42) (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assay | J Med Chem 58: 6002-17 (2015) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM21360![]() (7-ethoxy-3H-phenoxazin-3-one | 7-ethoxyresorufin |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase KEGG PC cid PC sid UniChem Patents AffyNet ![]() | US Patent | 262 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WASHINGTON UNIVERSITY US Patent | Assay Description To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ... | US Patent US9216974 (2015) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM108083![]() (3-(4-nitrobenzylidene)indolin-2-one (Compound 24)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | 325 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine Curated by ChEMBL | Assay Description Displacement of Thio-T from amyloid beta (1 to 42) (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assay | J Med Chem 58: 6002-17 (2015) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50079267![]() (Congo Red | Direct red 28 | Kongorot | Sodium diph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nagasaki University Curated by ChEMBL | Assay Description Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-42) protein aggregates | J Med Chem 48: 7253-60 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50079267![]() (Congo Red | Direct red 28 | Kongorot | Sodium diph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid PDB UniChem Similars AffyNet ![]() | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nagasaki University Curated by ChEMBL | Assay Description Displacement of [125I]6-iodo-4'-dimethyaminofl avone from beta amyloid (1-40) protein aggregates | J Med Chem 48: 7253-60 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM26193![]() (2-Hydroxybenzoate, I | 2-hydroxybenzoic acid | CHE...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet ![]() | PubMed | >1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Inhibitory activity against binding of [125I]-IMSB to amyloid beta in brain | J Med Chem 44: 2270-5 (2001) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM75309![]() ((2Z)-3-ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars AffyNet ![]() | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Torino Curated by ChEMBL | Assay Description Inhibition of Amyloid beta (1 to 42) (unknown origin) aggregation assessed as amount of fibrils formation after 2 hrs by thioflavin T based spectrofl... | Bioorg Med Chem 23: 4688-98 (2015) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50067040![]() (((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation after 48 hrs by thioflavin T fluorescence assay | J Nat Prod 78: 1593-9 (2015) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50070942![]() ((-)-Epigallocatechin gallate | (-)-Epigallocatechi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University Curated by ChEMBL | Assay Description Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation incubated at 37 degC for 16 hrs by thioflavin T fluorescence assay | J Nat Prod 78: 1221-30 (2015) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50074922![]() ((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 3.05E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiesi Farmaceutici S.p.A. Curated by ChEMBL | Assay Description Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL) | J Med Chem 48: 5705-20 (2005) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50089193![]() (4-Fluoro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Curated by ChEMBL | Assay Description Inhibition of Abeta42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of hum... | J Med Chem 43: 2297-9 (2000) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50089192![]() (4-Fluoro-N-(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars AffyNet ![]() | PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Curated by ChEMBL | Assay Description Inhibition of Abeta42 production by inhibiting Gamma-secretase proteolytic pathway in HEK293 cell stably transfected with a double mutant form of hum... | J Med Chem 43: 2297-9 (2000) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM7459![]() (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIRO Manufacturing Flagship (Biomedical) Curated by ChEMBL | Assay Description Inhibition of amyloid beta1-42 (unknown origin) aggregation assessed as amyloid fibril formation tested after 17 hrs by thioflavin T fluorescence met... | Bioorg Med Chem Lett 24: 3108-12 (2014) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50067040![]() (((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Science and Technology Curated by ChEMBL | Assay Description Inhibition of amyloid beta42 fibril formation by thioflavin T formation | Bioorg Med Chem Lett 18: 5591-3 (2008) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta amyloid A4 protein (Homo sapiens (human)) | BDBM50070942![]() ((-)-Epigallocatechin gallate | (-)-Epigallocatechi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars AffyNet ![]() | Article PubMed | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIRO Manufacturing Flagship (Biomedical) Curated by ChEMBL | Assay Description Inhibition of amyloid beta1-42 (unknown origin) aggregation assessed as amyloid fibril formation tested after 17 hrs by thioflavin T fluorescence met... | Bioorg Med Chem Lett 24: 3108-12 (2014) | |||||||||||
More data for this Ligand-Target Pair |
Cell (A) | Syringe (B) | Cell Links | Syringe Links | Cell + Syr Links | ΔG° kcal/mole | -TΔS° kcal/mole | ΔH° kcal/mole | log K | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|
Transcriptional Regulator TtgR (Pseudomonas putida) | BDBM7459![]() (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...) | GoogleScholar PDB | CHEBI KEGG MMDB PC cid PC sid PDB | -7.12 | -4.08 | -3.05 | 5.14 | 7 | 30 | |
Estacion Experimental del Zaidin | J Biol Chem 281: 7102-9 (2006) |