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There are 13 purchasable compounds for target: AHF

Wt: 327.8
BDBM59158
Wt: 402.5
BDBM59152
Wt: 434.2
BDBM59153
Wt: 411.2
BDBM59154
Wt: 296.3
BDBM59156
Wt: 445.5
BDBM59157
Wt: 412.2
BDBM59159
Wt: 481.2
BDBM59161
Wt: 500.3
BDBM59162
Wt: 474.9
BDBM59163
Wt: 375.7
BDBM59164
Wt: 495.8
BDBM50376417
Wt: 463.4
BDBM50423622

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 59158,59152,59153,59154,59156,59157,59159,59161,59162,59163,59164,50376417,50423622   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59152
PNG
(5523453)
Show SMILES CCOC(=O)c1c(NC(=S)NC(=O)c2ccccc2)sc2CC(C)CCc12
Show InChI InChI=1S/C20H22N2O3S2/c1-3-25-19(24)16-14-10-9-12(2)11-15(14)27-18(16)22-20(26)21-17(23)13-7-5-4-6-8-13/h4-8,12H,3,9-11H2,1-2H3,(H2,21,22,23,26)
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n/an/a 2.77E+4n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM50423622
PNG
(CHEMBL1614804)
Show SMILES O[C@@H](COc1ccc(Cl)cc1Cl)Cn1c2ccccc2n(CCN2CCCCC2)c1=N
Show InChI InChI=1S/C23H28Cl2N4O2/c24-17-8-9-22(19(25)14-17)31-16-18(30)15-29-21-7-3-2-6-20(21)28(23(29)26)13-12-27-10-4-1-5-11-27/h2-3,6-9,14,18,26,30H,1,4-5,10-13,15-16H2/t18-/m1/s1
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Article
PubMed
n/an/a 7.80E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 8 binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59154
PNG
(5739991)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O
Show InChI InChI=1S/C14H7BrN2O4S2/c15-12-6-5-10(21-12)7-11-13(18)16(14(22)23-11)8-1-3-9(4-2-8)17(19)20/h1-7H/b11-7-
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PubMed
n/an/a 4.63E+3n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59156
PNG
(6072484 | cid_726942)
Show SMILES CCOc1ccc(cc1)-c1cc(C)n2nc(cc2n1)C(N)=O
Show InChI InChI=1S/C16H16N4O2/c1-3-22-12-6-4-11(5-7-12)13-8-10(2)20-15(18-13)9-14(19-20)16(17)21/h4-9H,3H2,1-2H3,(H2,17,21)
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n/an/a 2.68E+4n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59157
PNG
(6126765)
Show SMILES COc1cc(\C=C2\SC(=S)N(CC(=O)Nc3ccccn3)C2=O)cc(OC)c1OC
Show InChI InChI=1S/C20H19N3O5S2/c1-26-13-8-12(9-14(27-2)18(13)28-3)10-15-19(25)23(20(29)30-15)11-17(24)22-16-6-4-5-7-21-16/h4-10H,11H2,1-3H3,(H,21,22,24)/b15-10+
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n/an/a 1.19E+4n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59158
PNG
(6168356)
Show SMILES CCOc1ccc(Cl)cc1\C=C1\SC(=S)N(CC)C1=O
Show InChI InChI=1S/C14H14ClNO2S2/c1-3-16-13(17)12(20-14(16)19)8-9-7-10(15)5-6-11(9)18-4-2/h5-8H,3-4H2,1-2H3/b12-8+
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n/an/a 4.96E+4n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59159
PNG
(6190013)
Show SMILES [O-][N+](=O)c1cc(Cl)c(cc1Cl)-c1ccc(C=C2C(=O)NC(=S)NC2=O)o1
Show InChI InChI=1S/C15H7Cl2N3O5S/c16-9-5-11(20(23)24)10(17)4-7(9)12-2-1-6(25-12)3-8-13(21)18-15(26)19-14(8)22/h1-5H,(H2,18,19,21,22,26)
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n/an/a 8.48E+3n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59161
PNG
(5738875)
Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(I)o2)C1=O
Show InChI InChI=1S/C15H7F3INO2S2/c16-15(17,18)8-2-1-3-9(6-8)20-13(21)11(24-14(20)23)7-10-4-5-12(19)22-10/h1-7H/b11-7-
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n/an/a 5.65E+3n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59162
PNG
(8047577)
Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)cc2Cl)C1=O
Show InChI InChI=1S/C21H10Cl2F3NO2S2/c22-12-4-6-15(16(23)9-12)17-7-5-14(29-17)10-18-19(28)27(20(30)31-18)13-3-1-2-11(8-13)21(24,25)26/h1-10H/b18-10-
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n/an/a 2.44E+3n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59163
PNG
(6789536)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C\c2ccc(Sc3ccc(Cl)cc3)o2)C1=O
Show InChI InChI=1S/C20H11ClN2O4S3/c21-12-1-8-16(9-2-12)29-18-10-7-15(27-18)11-17-19(24)22(20(28)30-17)13-3-5-14(6-4-13)23(25)26/h1-11H/b17-11+
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n/an/a 5.85E+3n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59164
PNG
(8048422)
Show SMILES [O-]C(=O)c1cc(ccc1Cl)-c1ccc(C=C2C(=O)NC(=S)NC2=O)o1
Show InChI InChI=1S/C16H9ClN2O5S/c17-11-3-1-7(5-9(11)15(22)23)12-4-2-8(24-12)6-10-13(20)18-16(25)19-14(10)21/h1-6H,(H,22,23)(H2,18,19,20,21,25)/p-1
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n/an/a 4.17E+3n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59153
PNG
(5737176)
Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O
Show InChI InChI=1S/C15H7BrF3NO2S2/c16-12-5-4-10(22-12)7-11-13(21)20(14(23)24-11)9-3-1-2-8(6-9)15(17,18)19/h1-7H/b11-7-
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n/an/a 9.25E+3n/an/an/an/a8.0n/a



University of Washington



Assay Description
Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59161
PNG
(5738875)
Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(I)o2)C1=O
Show InChI InChI=1S/C15H7F3INO2S2/c16-15(17,18)8-2-1-3-9(6-8)20-13(21)11(24-14(20)23)7-10-4-5-12(19)22-10/h1-7H/b11-7-
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PubMed
n/an/a 6.83E+3n/an/an/an/a8.0n/a



University of Washington



Assay Description
Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59162
PNG
(8047577)
Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)cc2Cl)C1=O
Show InChI InChI=1S/C21H10Cl2F3NO2S2/c22-12-4-6-15(16(23)9-12)17-7-5-14(29-17)10-18-19(28)27(20(30)31-18)13-3-1-2-11(8-13)21(24,25)26/h1-10H/b18-10-
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PubMed
n/an/a 2.56E+3n/an/an/an/a8.0n/a



University of Washington



Assay Description
Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59154
PNG
(5739991)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O
Show InChI InChI=1S/C14H7BrN2O4S2/c15-12-6-5-10(21-12)7-11-13(18)16(14(22)23-11)8-1-3-9(4-2-8)17(19)20/h1-7H/b11-7-
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n/an/a 1.04E+4n/an/an/an/a8.0n/a



University of Washington



Assay Description
Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59163
PNG
(6789536)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C\c2ccc(Sc3ccc(Cl)cc3)o2)C1=O
Show InChI InChI=1S/C20H11ClN2O4S3/c21-12-1-8-16(9-2-12)29-18-10-7-15(27-18)11-17-19(24)22(20(28)30-17)13-3-5-14(6-4-13)23(25)26/h1-11H/b17-11+
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n/an/a 4.81E+3n/an/an/an/a8.0n/a



University of Washington



Assay Description
Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59159
PNG
(6190013)
Show SMILES [O-][N+](=O)c1cc(Cl)c(cc1Cl)-c1ccc(C=C2C(=O)NC(=S)NC2=O)o1
Show InChI InChI=1S/C15H7Cl2N3O5S/c16-9-5-11(20(23)24)10(17)4-7(9)12-2-1-6(25-12)3-8-13(21)18-15(26)19-14(8)22/h1-5H,(H2,18,19,21,22,26)
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n/an/a 2.11E+3n/an/an/an/a8.0n/a



University of Washington



Assay Description
Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59164
PNG
(8048422)
Show SMILES [O-]C(=O)c1cc(ccc1Cl)-c1ccc(C=C2C(=O)NC(=S)NC2=O)o1
Show InChI InChI=1S/C16H9ClN2O5S/c17-11-3-1-7(5-9(11)15(22)23)12-4-2-8(24-12)6-10-13(20)18-16(25)19-14(10)21/h1-6H,(H,22,23)(H2,18,19,20,21,25)/p-1
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n/an/a 3.89E+3n/an/an/an/a8.0n/a



University of Washington



Assay Description
Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA).


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59153
PNG
(5737176)
Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O
Show InChI InChI=1S/C15H7BrF3NO2S2/c16-12-5-4-10(22-12)7-11-13(21)20(14(23)24-11)9-3-1-2-8(6-9)15(17,18)19/h1-7H/b11-7-
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n/an/a 8.50E+3n/an/an/an/a7.9n/a



University of Washington



Assay Description
Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59161
PNG
(5738875)
Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(I)o2)C1=O
Show InChI InChI=1S/C15H7F3INO2S2/c16-15(17,18)8-2-1-3-9(6-8)20-13(21)11(24-14(20)23)7-10-4-5-12(19)22-10/h1-7H/b11-7-
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n/an/a 5.00E+3n/an/an/an/a7.9n/a



University of Washington



Assay Description
Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59162
PNG
(8047577)
Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(o2)-c2ccc(Cl)cc2Cl)C1=O
Show InChI InChI=1S/C21H10Cl2F3NO2S2/c22-12-4-6-15(16(23)9-12)17-7-5-14(29-17)10-18-19(28)27(20(30)31-18)13-3-1-2-11(8-13)21(24,25)26/h1-10H/b18-10-
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n/an/a 2.10E+3n/an/an/an/a7.9n/a



University of Washington



Assay Description
Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59154
PNG
(5739991)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O
Show InChI InChI=1S/C14H7BrN2O4S2/c15-12-6-5-10(21-12)7-11-13(18)16(14(22)23-11)8-1-3-9(4-2-8)17(19)20/h1-7H/b11-7-
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PubMed
n/an/a 1.17E+4n/an/an/an/a7.9n/a



University of Washington



Assay Description
Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59163
PNG
(6789536)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C\c2ccc(Sc3ccc(Cl)cc3)o2)C1=O
Show InChI InChI=1S/C20H11ClN2O4S3/c21-12-1-8-16(9-2-12)29-18-10-7-15(27-18)11-17-19(24)22(20(28)30-17)13-3-5-14(6-4-13)23(25)26/h1-11H/b17-11+
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n/an/a 5.60E+3n/an/an/an/a7.9n/a



University of Washington



Assay Description
Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...


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Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59159
PNG
(6190013)
Show SMILES [O-][N+](=O)c1cc(Cl)c(cc1Cl)-c1ccc(C=C2C(=O)NC(=S)NC2=O)o1
Show InChI InChI=1S/C15H7Cl2N3O5S/c16-9-5-11(20(23)24)10(17)4-7(9)12-2-1-6(25-12)3-8-13(21)18-15(26)19-14(8)22/h1-5H,(H2,18,19,21,22,26)
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n/an/a 7.50E+3n/an/an/an/a7.9n/a



University of Washington



Assay Description
Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59164
PNG
(8048422)
Show SMILES [O-]C(=O)c1cc(ccc1Cl)-c1ccc(C=C2C(=O)NC(=S)NC2=O)o1
Show InChI InChI=1S/C16H9ClN2O5S/c17-11-3-1-7(5-9(11)15(22)23)12-4-2-8(24-12)6-10-13(20)18-16(25)19-14(10)21/h1-6H,(H,22,23)(H2,18,19,20,21,25)/p-1
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n/an/a 6.70E+3n/an/an/an/a7.9n/a



University of Washington



Assay Description
Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit...


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM50376417
PNG
(CHEMBL261865)
Show SMILES [O-][N+](=O)c1ccc(COc2ccc(Cl)cc2C=C2C(=O)NC(=O)N(C2=O)c2ccccc2F)cc1
Show InChI InChI=1S/C24H15ClFN3O6/c25-16-7-10-21(35-13-14-5-8-17(9-6-14)29(33)34)15(11-16)12-18-22(30)27-24(32)28(23(18)31)20-4-2-1-3-19(20)26/h1-12H,13H2,(H,27,30,32)
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n/an/a 8.90E+3n/an/an/an/an/an/a



Maastricht University

Curated by ChEMBL


Assay Description
Inhibition of human factor 8 binding to immobilized phospholipid by surface plasmon resonance assay


Citation and Details
More data for this
Ligand-Target Pair
Coagulation Factor VIII


(Homo sapiens (Human))
BDBM59153
PNG
(5737176)
Show SMILES FC(F)(F)c1cccc(c1)N1C(=S)S\C(=C/c2ccc(Br)o2)C1=O
Show InChI InChI=1S/C15H7BrF3NO2S2/c16-12-5-4-10(22-12)7-11-13(21)20(14(23)24-11)9-3-1-2-8(6-9)15(17,18)19/h1-7H/b11-7-
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n/an/a 6.66E+3n/an/an/an/an/a37



University of Washington



Assay Description
Inhibition of factor VIII C2 domain.


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Ligand-Target Pair