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There are 52 purchasable compounds for target: Abeta-degrading protease

Wt: 354.3
BDBM31699
Wt: 177.1
BDBM34981
Wt: 305.3
BDBM37382
Wt: 426.4
BDBM46036
Wt: 453.5
BDBM48090
Wt: 364.5
BDBM48094
Wt: 280.4
BDBM47577
Wt: 362.4
BDBM47494
Wt: 424.5
BDBM50977
Wt: 302.3
BDBM49746
Wt: 268.2
BDBM59012
Wt: 480.3
BDBM60094
Wt: 388.4
BDBM65122
Wt: 441.9
BDBM75791
Wt: 294.3
BDBM75793
Displayed 1 to 15 (of 52 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 31699,34981,37382,46036,48090,48094,47577,47494,50977,49746,59012,60094,65122,75791,75793   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM37382
PNG
((1-methylbenzimidazol-2-yl)-(1-propylbenzimidazol-...)
Show SMILES CCCn1c(Nc2nc3ccccc3n2C)nc2ccccc12
Show InChI InChI=1S/C18H19N5/c1-3-12-23-16-11-7-5-9-14(16)20-18(23)21-17-19-13-8-4-6-10-15(13)22(17)2/h4-11H,3,12H2,1-2H3,(H,19,20,21)
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n/an/a>5.59E+4n/an/an/an/an/an/a



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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM46036
PNG
(2-[[3-(3-keto-1,2-benzothiazol-2-yl)phenyl]sulfony...)
Show SMILES OC(=O)c1ccccc1NS(=O)(=O)c1cccc(c1)-n1sc2ccccc2c1=O
Show InChI InChI=1S/C20H14N2O5S2/c23-19-16-9-2-4-11-18(16)28-22(19)13-6-5-7-14(12-13)29(26,27)21-17-10-3-1-8-15(17)20(24)25/h1-12,21H,(H,24,25)
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n/an/a 2.10E+3n/an/an/an/an/an/a



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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75791
PNG
(2-[3-[5-chloranyl-4-[(3,4-dimethylphenyl)amino]-6-...)
Show SMILES Cc1ccc(Nc2cnn(c(=O)c2Cl)C23CC4CC(CC(CC(O)=O)(C4)C2)C3)cc1C
Show InChI InChI=1S/C24H28ClN3O3/c1-14-3-4-18(5-15(14)2)27-19-12-26-28(22(31)21(19)25)24-9-16-6-17(10-24)8-23(7-16,13-24)11-20(29)30/h3-5,12,16-17,27H,6-11,13H2,1-2H3,(H,29,30)
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n/an/a 1.88E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM75793
PNG
(2-furfuryl-(8-methoxy-5H-pyrimid[5,4-b]indol-4-yl)...)
Show SMILES COc1ccc2[nH]c3c(NCc4ccco4)ncnc3c2c1
Show InChI InChI=1S/C16H14N4O2/c1-21-10-4-5-13-12(7-10)14-15(20-13)16(19-9-18-14)17-8-11-3-2-6-22-11/h2-7,9,20H,8H2,1H3,(H,17,18,19)
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n/an/a 2.12E+4n/an/an/an/an/an/a



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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM47577
PNG
((5Z)-3-ethyl-2-sulfanylidene-5-[(1,2,5-trimethyl-3...)
Show SMILES CCN1C(=S)S\C(=C/c2cc(C)n(C)c2C)C1=O
Show InChI InChI=1S/C13H16N2OS2/c1-5-15-12(16)11(18-13(15)17)7-10-6-8(2)14(4)9(10)3/h6-7H,5H2,1-4H3/b11-7-
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n/an/a 9.74E+3n/an/an/an/an/an/a



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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM65122
PNG
(1-[1-(2-phenoxyethyl)-2-benzimidazolyl]-3-phenylth...)
Show SMILES S=C(Nc1nc2ccccc2n1CCOc1ccccc1)Nc1ccccc1
Show InChI InChI=1S/C22H20N4OS/c28-22(23-17-9-3-1-4-10-17)25-21-24-19-13-7-8-14-20(19)26(21)15-16-27-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,28)
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n/an/a>5.59E+4n/an/an/an/an/an/a



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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM50977
PNG
((5Z)-3-(2-furanylmethyl)-5-[[1-(4-methoxyphenyl)-2...)
Show SMILES COc1ccc(cc1)-n1c(C)cc(\C=C2/SC(=S)N(Cc3ccco3)C2=O)c1C
Show InChI InChI=1S/C22H20N2O3S2/c1-14-11-16(15(2)24(14)17-6-8-18(26-3)9-7-17)12-20-21(25)23(22(28)29-20)13-19-5-4-10-27-19/h4-12H,13H2,1-3H3/b20-12-
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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM47494
PNG
(4-[3-(4-methoxyphenyl)-5-thiophen-2-yl-3,4-dihydro...)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1ccc(C=O)cc1)c1cccs1
Show InChI InChI=1S/C21H18N2O2S/c1-25-18-10-6-16(7-11-18)20-13-19(21-3-2-12-26-21)22-23(20)17-8-4-15(14-24)5-9-17/h2-12,14,20H,13H2,1H3
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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM49746
PNG
(1-(2,1,3-benzothiadiazol-5-yl)-3-[2-(1-cyclohexeny...)
Show SMILES O=C(NCCC1=CCCCC1)Nc1ccc2nsnc2c1
Show InChI InChI=1S/C15H18N4OS/c20-15(16-9-8-11-4-2-1-3-5-11)17-12-6-7-13-14(10-12)19-21-18-13/h4,6-7,10H,1-3,5,8-9H2,(H2,16,17,20)
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n/an/a>5.60E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM60094
PNG
(2-[3-[5-chloranyl-4-[(2-chloranyl-4-fluoranyl-phen...)
Show SMILES OC(=O)CC12CC3CC(C1)CC(C3)(C2)n1ncc(NCc2ccc(F)cc2Cl)c(Cl)c1=O
Show InChI InChI=1S/C23H24Cl2FN3O3/c24-17-4-16(26)2-1-15(17)10-27-18-11-28-29(21(32)20(18)25)23-7-13-3-14(8-23)6-22(5-13,12-23)9-19(30)31/h1-2,4,11,13-14,27H,3,5-10,12H2,(H,30,31)
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n/an/a 1.81E+4n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM48090
PNG
((5E)-3-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyra...)
Show SMILES COc1cc(\C=C2\SC(=S)N(C2=O)c2c(C)n(C)n(-c3ccccc3)c2=O)ccc1O
Show InChI InChI=1S/C22H19N3O4S2/c1-13-19(21(28)25(23(13)2)15-7-5-4-6-8-15)24-20(27)18(31-22(24)30)12-14-9-10-16(26)17(11-14)29-3/h4-12,26H,1-3H3/b18-12+
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n/an/a 7.99E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM48094
PNG
((5Z)-3-ethyl-5-[(2E)-2-[3-(2-hydroxyethyl)-1,3-ben...)
Show SMILES CCN1C(=S)S\C(=C/C=C2/Sc3ccccc3N2CCO)C1=O
Show InChI InChI=1S/C16H16N2O2S3/c1-2-17-15(20)13(23-16(17)21)7-8-14-18(9-10-19)11-5-3-4-6-12(11)22-14/h3-8,19H,2,9-10H2,1H3/b13-7-,14-8+
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n/an/a>5.60E+4n/an/an/an/an/an/a



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More data for this
Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM59012
PNG
(2-(3-methoxy-4-oxidanyl-phenyl)chromen-4-one | 2-(...)
Show SMILES COc1cc(ccc1O)-c1cc(=O)c2ccccc2o1
Show InChI InChI=1S/C16H12O4/c1-19-16-8-10(6-7-12(16)17)15-9-13(18)11-4-2-3-5-14(11)20-15/h2-9,17H,1H3
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n/an/a>6.21E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM34981
PNG
(2,3-bis(oxidanyl)-1H-quinolin-4-one | 2,3-dihydrox...)
Show SMILES Oc1c(O)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C9H7NO3/c11-7-5-3-1-2-4-6(5)10-9(13)8(7)12/h1-4,12H,(H2,10,11,13)
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n/an/a 3.28E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

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Ligand-Target Pair
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM31699
PNG
((4-methoxy-1,3-benzothiazol-2-yl)-[5-(4-methoxyphe...)
Show SMILES COc1ccc(cc1)-c1nnc(Nc2nc3c(OC)cccc3s2)o1
Show InChI InChI=1S/C17H14N4O3S/c1-22-11-8-6-10(7-9-11)15-20-21-16(24-15)19-17-18-14-12(23-2)4-3-5-13(14)25-17/h3-9H,1-2H3,(H,18,19,21)
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Ligand-Target Pair