Compounds in cluster

There are 6 purchasable compounds for target: Adenylate cyclase

Wt: 287.7 BDBM82247 Purchase	Wt: 255.3 BDBM50004822 Purchase	Wt: 410.5 BDBM50010261 Purchase	Wt: 581.6 BDBM50027065 Purchase	Wt: 166.2 BDBM50035398 Purchase
Wt: 488.6 BDBM50241487 Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 82247,50004822,50010261,50027065,50035398,50241487
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Adenylate cyclase (Rattus norvegicus)	BDBM82247 (8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...) Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	39.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk Curated by PDSP K_i Database									Citation and Details
Novo Nordisk Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Adenylate cyclase (Rattus norvegicus)	BDBM50004822 ((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...) Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	415	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk Curated by PDSP K_i Database									Citation and Details
Novo Nordisk Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Adenylate cyclase ()	BDBM50035398 ((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...) Show SMILES CN1CCC[C@H]1c1cc(C)no1 Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP K_i Database									Citation and Details
Abbott Laboratories Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Adenylate cyclase (Spirulina platensis)	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ruhr-University Bochum Curated by ChEMBL					Assay Description Inhibition of Spirulina platensis adenylyl cyclase assessed as cAMP level by cAMP immunogenic assay				J Med Chem 51: 4456-64 (2008)
Ruhr-University Bochum Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens)	BDBM50004822 ((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...) Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Effective concentration required to stimulate Adenylate cyclase				Citation and Details
Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens)	BDBM50010261 ((3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
Food and Drug Administration Curated by ChEMBL					Assay Description Conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1				J Med Chem 39: 2745-52 (1996)
Food and Drug Administration Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase (Spirulina platensis)	BDBM50241487 (2,3,6,23-tetrahydroxyurs-12-en-28-oic acid \| Asiat...) Show SMILES Show InChI	PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ruhr-University Bochum Curated by ChEMBL					Assay Description Inhibition of Spirulina platensis adenylyl cyclase assessed as cAMP level by cAMP immunogenic assay				J Med Chem 51: 4456-64 (2008)
Ruhr-University Bochum Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase (Homo sapiens)	BDBM50010261 ((3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Food and Drug Administration Curated by ChEMBL					Assay Description Inhibition of [125 I]-6-IHPP-forskolin binding to adenylate cyclase 1				J Med Chem 39: 2745-52 (1996)
Food and Drug Administration Curated by ChEMBL					More data for this Ligand-Target Pair