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There are 14 purchasable compounds for target: Alanyl aminopeptidase

Wt: 278.3
BDBM50027516
Wt: 264.3
BDBM19149
Wt: 217.1
BDBM23703
Wt: 291.3
BDBM23704
Wt: 265.1
BDBM23705
Wt: 241.0
BDBM23706
Wt: 249.1
BDBM23707
Wt: 287.0
BDBM23708
Wt: 147.2
BDBM23981
Wt: 276.2
BDBM23709
Wt: 231.2
BDBM23710
Wt: 217.1
BDBM23711
Wt: 148.1
BDBM23985
Wt: 231.2
BDBM23712
Wt: 220.6
BDBM23713
Displayed 1 to 15 (of 84 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50027516,19149,23703,23704,23705,23706,23707,23708,23981,23709,23710,23711,23985,23712,23713   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23981
PNG
((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Show SMILES NC1CCc2ccccc2C1
Show InChI InChI=1S/C10H13N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-4,10H,5-7,11H2
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n/an/a>1.00E+6n/an/an/an/a7.530



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


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Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Shandong University



Assay Description
Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 C. The APN solution was mixed with compounds at v...


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Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23712
PNG
(1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole |...)
Show SMILES Cc1ccccc1C(=O)n1cc(cn1)[N+]([O-])=O
Show InChI InChI=1S/C11H9N3O3/c1-8-4-2-3-5-10(8)11(15)13-7-9(6-12-13)14(16)17/h2-7H,1H3
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n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


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More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23713
PNG
(4-chloro-1-[(2-methylphenyl)carbonyl]-1H-pyrazole ...)
Show SMILES Cc1ccccc1C(=O)n1cc(Cl)cn1
Show InChI InChI=1S/C11H9ClN2O/c1-8-4-2-3-5-10(8)11(15)14-7-9(12)6-13-14/h2-7H,1H3
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n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23706
PNG
(1-[(3,4-dichlorophenyl)carbonyl]-1H-pyrazole | N-B...)
Show SMILES Clc1ccc(cc1Cl)C(=O)n1cccn1
Show InChI InChI=1S/C10H6Cl2N2O/c11-8-3-2-7(6-9(8)12)10(15)14-5-1-4-13-14/h1-6H
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n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23707
PNG
(1-[(2-fluorophenyl)carbonyl]-5-methyl-3-nitro-1H-p...)
Show SMILES Cc1cc(nn1C(=O)c1ccccc1F)[N+]([O-])=O
Show InChI InChI=1S/C11H8FN3O3/c1-7-6-10(15(17)18)13-14(7)11(16)8-4-2-3-5-9(8)12/h2-6H,1H3
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PubMed
n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23708
PNG
(4-bromo-1-[(2,6-difluorophenyl)carbonyl]-1H-pyrazo...)
Show SMILES Fc1cccc(F)c1C(=O)n1cc(Br)cn1
Show InChI InChI=1S/C10H5BrF2N2O/c11-6-4-14-15(5-6)10(16)9-7(12)2-1-3-8(9)13/h1-5H
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n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23709
PNG
(3-methyl-1-[(3,4,5-trimethoxyphenyl)carbonyl]-1H-p...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)n1ccc(C)n1
Show InChI InChI=1S/C14H16N2O4/c1-9-5-6-16(15-9)14(17)10-7-11(18-2)13(20-4)12(8-10)19-3/h5-8H,1-4H3
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n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23710
PNG
(1-[(4-methylphenyl)carbonyl]-3-nitro-1H-pyrazole |...)
Show SMILES Cc1ccc(cc1)C(=O)n1ccc(n1)[N+]([O-])=O
Show InChI InChI=1S/C11H9N3O3/c1-8-2-4-9(5-3-8)11(15)13-7-6-10(12-13)14(16)17/h2-7H,1H3
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PubMed
n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23711
PNG
(1-benzoyl-3-nitro-1H-pyrazole | N-Benzoylpyrazole ...)
Show SMILES [O-][N+](=O)c1ccn(n1)C(=O)c1ccccc1
Show InChI InChI=1S/C10H7N3O3/c14-10(8-4-2-1-3-5-8)12-7-6-9(11-12)13(15)16/h1-7H
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n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23703
PNG
(1-benzoyl-4-nitro-1H-pyrazole | N-Benzoylpyrazole ...)
Show SMILES [O-][N+](=O)c1cnn(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C10H7N3O3/c14-10(8-4-2-1-3-5-8)12-7-9(6-11-12)13(15)16/h1-7H
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n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23704
PNG
(1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide | N-B...)
Show SMILES O=C(Nc1ccccc1)c1ccn(n1)C(=O)c1ccccc1
Show InChI InChI=1S/C17H13N3O2/c21-16(18-14-9-5-2-6-10-14)15-11-12-20(19-15)17(22)13-7-3-1-4-8-13/h1-12H,(H,18,21)
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n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23705
PNG
(4-bromo-1-[(4-methylphenyl)carbonyl]-1H-pyrazole |...)
Show SMILES Cc1ccc(cc1)C(=O)n1cc(Br)cn1
Show InChI InChI=1S/C11H9BrN2O/c1-8-2-4-9(5-3-8)11(15)14-7-10(12)6-13-14/h2-7H,1H3
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n/an/an/an/an/an/an/a7.025



Montana State University



Assay Description
Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N


(Homo sapiens)
BDBM50027516
PNG
(2-(2-Amino-3-phenyl-propionylamino)-4-methyl-penta...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C15H22N2O3/c1-10(2)8-13(15(19)20)17-14(18)12(16)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,16H2,1-2H3,(H,17,18)(H,19,20)/t12-,13-/m0/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase M.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase N (APN)


(Sus scrofa (Pig))
BDBM23985
PNG
(3,4-dihydro-1H-2-benzopyran-3-one | isochromanone,...)
Show SMILES O=C1Cc2ccccc2CO1
Show InChI InChI=1S/C9H8O2/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-4H,5-6H2
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n/an/a>1.00E+6n/an/an/an/a7.530



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Citation and Details
More data for this
Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 2 hits for monomerid = 50027516,19149,23703,23704,23705,23706,23707,23708,23981,23709,23710,23711,23985,23712,23713
Cell (A)Syringe (B)Cell
Links
Syringe
Links
Cell + Syr
Links
ΔG°
kcal/mole
-TΔS°
kcal/mole
ΔH°
kcal/mole
log KpHTemp
°C
Histone deacetylase 1/3/5/8

(Homo sapiens (human))
BDBM19149
JPEG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
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CHEBI
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PC cid
PC sid
PDB
-8.362.42-10.96.13n/a25



North Dakota State University





Biochemistry 52: 8139-49 (2013)

Histone deacetylase 8 (HDAC8)

(Homo sapiens (human))
BDBM19149
JPEG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
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PDB
CHEBI
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PC cid
PC sid
PDB
-8.360.0519-8.966.347.5-248



North Dakota State University





Biochemistry 53: 7445-58 (2014)