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There are 13 purchasable compounds for target: Arylamine N-methyltransferase

Wt: 144.6
BDBM50000303
Wt: 223.1
BDBM50000118
Purchase
Wt: 152.2
BDBM50000167
Purchase
Wt: 198.1
BDBM50000063
Wt: 240.2
BDBM50000133
Wt: 266.1
BDBM50000174
Wt: 246.2
BDBM50000122
Wt: 297.3
BDBM22111
Purchase
Wt: 116.1
BDBM50000113
Purchase
Wt: 114.1
BDBM50000123
Purchase
Wt: 384.4
BDBM50009672
Purchase
Wt: 84.1
BDBM50049251
Purchase
Wt: 108.1
BDBM50000061
Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50000303,50000118,50000167,50000063,50000133,50000174,50000122,22111,50000113,50000123,50009672,50049251,50000061   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Indolethylamine N-methyltransferase


(Homo sapiens)
BDBM50009672
PNG
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
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2.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant towards indole N-methyl-transferase


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Indolethylamine N-methyltransferase


(Homo sapiens)
BDBM22111
PNG
((2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methyl...)
Show SMILES CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
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7.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant towards indole N-methyl-transferase


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50000113
PNG
(CHEMBL3228352)
Show SMILES CN1CCSC1=N
Show InChI InChI=1S/C4H8N2S.HI/c1-6-2-3-7-4(6)5;/h5H,2-3H2,1H3;1H
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n/an/a 800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50000118
PNG
(CHEMBL3228357)
Show SMILES C=CCN1CCSC1=N
Show InChI InChI=1S/C6H10N2S.BrH/c1-2-3-8-4-5-9-6(8)7;/h2,7H,1,3-5H2;1H
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n/an/a 7.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50000122
PNG
(CHEMBL3228362)
Show SMILES CC1CN(C)C(=N)S1
Show InChI InChI=1S/C5H10N2S.C4H4O4/c1-4-3-7(2)5(6)8-4;5-3(6)1-2-4(7)8/h4,6H,3H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
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n/an/a 7.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50000123
PNG
(CHEMBL3228364)
Show SMILES Cn1ccsc1=N
Show InChI InChI=1S/C4H6N2S.HI/c1-6-2-3-7-4(6)5;/h2-3,5H,1H3;1H
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50049251
PNG
(CHEMBL161318 | CHEMBL543888 | Pyrrolidin-(2Z)-ylid...)
Show SMILES NC1=NCCC1
Show InChI InChI=1S/C4H8N2/c5-4-2-1-3-6-4/h1-3H2,(H2,5,6)
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n/an/a 3.36E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50000133
PNG
(CHEMBL3228259)
Show SMILES C1CN2CCCN=C2C1
Show InChI InChI=1S/C7H12N2.C4H4O4/c1-3-7-8-4-2-6-9(7)5-1;5-3(6)1-2-4(7)8/h1-6H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
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n/an/a 1.67E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50000167
PNG
(CHEMBL1489129)
Show SMILES C1CN=C2CCCCCN2C1
Show InChI InChI=1S/C9H16N2/c1-2-5-9-10-6-4-8-11(9)7-3-1/h1-8H2
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n/an/a 8.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50000174
PNG
(CHEMBL3228330)
Show InChI InChI=1S/C7H12N2.CH3I/c1-3-7-8-4-2-6-9(7)5-1;1-2/h1-6H2;1H3
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n/an/a 3.87E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50000303
PNG
(CHEMBL3228386)
Show SMILES Cn1ccccc1=N
Show InChI InChI=1S/C6H8N2.ClH/c1-8-5-3-2-4-6(8)7;/h2-5,7H,1H3;1H
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n/an/a 1.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Homo sapiens)
BDBM50000133
PNG
(CHEMBL3228259)
Show SMILES C1CN2CCCN=C2C1
Show InChI InChI=1S/C7H12N2.C4H4O4/c1-3-7-8-4-2-6-9(7)5-1;5-3(6)1-2-4(7)8/h1-6H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
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n/an/a 1.34E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presence of S-methyl-[14C...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Homo sapiens)
BDBM50000167
PNG
(CHEMBL1489129)
Show SMILES C1CN=C2CCCCCN2C1
Show InChI InChI=1S/C9H16N2/c1-2-5-9-10-6-4-8-11(9)7-3-1/h1-8H2
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n/an/a 2.57E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presence of S-methyl-[14C...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Homo sapiens)
BDBM50000113
PNG
(CHEMBL3228352)
Show SMILES CN1CCSC1=N
Show InChI InChI=1S/C4H8N2S.HI/c1-6-2-3-7-4(6)5;/h5H,2-3H2,1H3;1H
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n/an/a 2.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presence of S-methyl-[14C...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Homo sapiens)
BDBM50000123
PNG
(CHEMBL3228364)
Show SMILES Cn1ccsc1=N
Show InChI InChI=1S/C4H6N2S.HI/c1-6-2-3-7-4(6)5;/h2-3,5H,1H3;1H
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n/an/a 6.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presence of S-methyl-[14C...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Homo sapiens)
BDBM50049251
PNG
(CHEMBL161318 | CHEMBL543888 | Pyrrolidin-(2Z)-ylid...)
Show SMILES NC1=NCCC1
Show InChI InChI=1S/C4H8N2/c5-4-2-1-3-6-4/h1-3H2,(H2,5,6)
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n/an/a>8.30E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presence of S-methyl-[14C...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Homo sapiens)
BDBM50000303
PNG
(CHEMBL3228386)
Show SMILES Cn1ccccc1=N
Show InChI InChI=1S/C6H8N2.ClH/c1-8-5-3-2-4-6(8)7;/h2-5,7H,1H3;1H
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n/an/a 1.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presence of S-methyl-[14C...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50000063
PNG
(CHEMBL3228339)
Show SMILES C1Cc2nccn2C1
Show InChI InChI=1S/C6H8N2.C2H2O4/c1-2-6-7-3-5-8(6)4-1;3-1(4)2(5)6/h3,5H,1-2,4H2;(H,3,4)(H,5,6)
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n/an/a 8.31E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Oryctolagus cuniculus)
BDBM50000061
PNG
(CHEMBL3228406)
Show SMILES Cn1ccc(=N)cc1
Show InChI InChI=1S/C6H8N2.HI/c1-8-4-2-6(7)3-5-8;/h2-5,7H,1H3;1H
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n/an/a 6.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of New Zealand white rabbit lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presen...


Citation and Details
More data for this
Ligand-Target Pair
Indolethylamine N-methyltransferase


(Homo sapiens)
BDBM50000061
PNG
(CHEMBL3228406)
Show SMILES Cn1ccc(=N)cc1
Show InChI InChI=1S/C6H8N2.HI/c1-8-4-2-6(7)3-5-8;/h2-5,7H,1H3;1H
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n/an/a 6.38E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung INMT using N-methyltryptamine as substrate after 60 to 90 mins by liquid scintillation counting in presence of S-methyl-[14C...


Citation and Details
More data for this
Ligand-Target Pair